Amino acid dipepetide frequency for Breda virus 1 (BRV-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.946AlaAla: 2.946 ± 1.215
1.326AlaCys: 1.326 ± 0.231
2.504AlaAsp: 2.504 ± 0.512
1.105AlaGlu: 1.105 ± 0.168
2.21AlaPhe: 2.21 ± 0.148
2.21AlaGly: 2.21 ± 0.351
1.031AlaHis: 1.031 ± 0.361
3.094AlaIle: 3.094 ± 0.705
2.357AlaLys: 2.357 ± 0.372
5.156AlaLeu: 5.156 ± 0.941
0.81AlaMet: 0.81 ± 0.259
3.094AlaAsn: 3.094 ± 0.288
1.989AlaPro: 1.989 ± 0.551
1.621AlaGln: 1.621 ± 0.822
1.4AlaArg: 1.4 ± 0.206
2.799AlaSer: 2.799 ± 0.803
3.757AlaThr: 3.757 ± 0.822
4.641AlaVal: 4.641 ± 0.402
0.516AlaTrp: 0.516 ± 0.263
3.388AlaTyr: 3.388 ± 0.409
0.147AlaXaa: 0.147 ± 0.048
Cys
1.252CysAla: 1.252 ± 0.392
0.737CysCys: 0.737 ± 0.122
3.241CysAsp: 3.241 ± 0.656
1.621CysGlu: 1.621 ± 0.367
1.621CysPhe: 1.621 ± 0.201
2.136CysGly: 2.136 ± 0.321
0.442CysHis: 0.442 ± 0.414
0.958CysIle: 0.958 ± 0.39
0.737CysLys: 0.737 ± 0.108
3.315CysLeu: 3.315 ± 0.553
0.516CysMet: 0.516 ± 0.262
2.062CysAsn: 2.062 ± 0.248
2.357CysPro: 2.357 ± 0.249
1.105CysGln: 1.105 ± 0.301
1.326CysArg: 1.326 ± 0.12
2.21CysSer: 2.21 ± 0.443
2.283CysThr: 2.283 ± 0.407
2.799CysVal: 2.799 ± 0.216
0.516CysTrp: 0.516 ± 0.161
1.326CysTyr: 1.326 ± 0.243
0.0CysXaa: 0.0 ± 0.0
Asp
2.504AspAla: 2.504 ± 0.392
1.989AspCys: 1.989 ± 0.299
3.241AspAsp: 3.241 ± 0.742
3.241AspGlu: 3.241 ± 0.378
5.303AspPhe: 5.303 ± 0.977
2.799AspGly: 2.799 ± 0.525
0.442AspHis: 0.442 ± 0.04
2.283AspIle: 2.283 ± 0.26
2.062AspLys: 2.062 ± 0.264
5.451AspLeu: 5.451 ± 1.139
0.442AspMet: 0.442 ± 0.04
2.283AspAsn: 2.283 ± 0.275
1.768AspPro: 1.768 ± 0.304
2.357AspGln: 2.357 ± 0.333
1.031AspArg: 1.031 ± 0.214
3.757AspSer: 3.757 ± 0.623
2.799AspThr: 2.799 ± 0.29
5.672AspVal: 5.672 ± 0.724
0.368AspTrp: 0.368 ± 0.137
2.873AspTyr: 2.873 ± 0.326
0.0AspXaa: 0.0 ± 0.0
Glu
1.768GluAla: 1.768 ± 0.195
2.799GluCys: 2.799 ± 0.384
2.21GluAsp: 2.21 ± 0.215
2.504GluGlu: 2.504 ± 0.504
2.652GluPhe: 2.652 ± 0.687
1.768GluGly: 1.768 ± 0.349
0.737GluHis: 0.737 ± 0.089
1.179GluIle: 1.179 ± 0.495
1.989GluLys: 1.989 ± 0.544
3.83GluLeu: 3.83 ± 0.363
1.4GluMet: 1.4 ± 0.259
2.725GluAsn: 2.725 ± 0.401
2.21GluPro: 2.21 ± 0.466
2.652GluGln: 2.652 ± 0.183
1.473GluArg: 1.473 ± 0.214
3.462GluSer: 3.462 ± 0.389
2.062GluThr: 2.062 ± 0.252
3.978GluVal: 3.978 ± 0.852
0.663GluTrp: 0.663 ± 0.086
1.031GluTyr: 1.031 ± 0.349
0.0GluXaa: 0.0 ± 0.0
Phe
2.578PheAla: 2.578 ± 0.467
1.768PheCys: 1.768 ± 0.327
3.757PheAsp: 3.757 ± 0.542
2.946PheGlu: 2.946 ± 0.49
2.799PhePhe: 2.799 ± 0.289
3.978PheGly: 3.978 ± 0.549
1.031PheHis: 1.031 ± 0.096
2.431PheIle: 2.431 ± 0.513
5.672PheLys: 5.672 ± 0.923
4.567PheLeu: 4.567 ± 0.266
1.252PheMet: 1.252 ± 0.235
2.946PheAsn: 2.946 ± 0.132
1.179PhePro: 1.179 ± 0.358
2.578PheGln: 2.578 ± 0.423
2.357PheArg: 2.357 ± 0.356
5.303PheSer: 5.303 ± 0.288
3.094PheThr: 3.094 ± 0.177
6.556PheVal: 6.556 ± 0.83
0.958PheTrp: 0.958 ± 0.158
4.199PheTyr: 4.199 ± 0.539
0.0PheXaa: 0.0 ± 0.0
Gly
2.357GlyAla: 2.357 ± 0.364
1.768GlyCys: 1.768 ± 0.148
3.02GlyAsp: 3.02 ± 0.593
2.873GlyGlu: 2.873 ± 0.625
3.167GlyPhe: 3.167 ± 0.491
3.094GlyGly: 3.094 ± 0.415
1.031GlyHis: 1.031 ± 0.177
1.989GlyIle: 1.989 ± 0.179
2.578GlyLys: 2.578 ± 0.343
5.082GlyLeu: 5.082 ± 0.505
0.442GlyMet: 0.442 ± 0.142
1.915GlyAsn: 1.915 ± 0.729
1.326GlyPro: 1.326 ± 0.168
2.431GlyGln: 2.431 ± 0.346
1.768GlyArg: 1.768 ± 0.206
3.241GlySer: 3.241 ± 0.872
3.315GlyThr: 3.315 ± 0.485
6.187GlyVal: 6.187 ± 0.521
0.368GlyTrp: 0.368 ± 0.361
2.799GlyTyr: 2.799 ± 0.243
0.0GlyXaa: 0.0 ± 0.0
His
0.663HisAla: 0.663 ± 0.185
0.442HisCys: 0.442 ± 0.183
0.737HisAsp: 0.737 ± 0.208
0.516HisGlu: 0.516 ± 0.065
1.179HisPhe: 1.179 ± 0.258
1.4HisGly: 1.4 ± 0.276
0.737HisHis: 0.737 ± 0.122
0.958HisIle: 0.958 ± 0.268
0.442HisLys: 0.442 ± 0.142
2.578HisLeu: 2.578 ± 0.336
0.737HisMet: 0.737 ± 0.123
1.105HisAsn: 1.105 ± 0.113
0.958HisPro: 0.958 ± 0.416
1.473HisGln: 1.473 ± 0.214
0.442HisArg: 0.442 ± 0.142
2.136HisSer: 2.136 ± 0.214
0.516HisThr: 0.516 ± 0.162
2.21HisVal: 2.21 ± 0.547
0.663HisTrp: 0.663 ± 0.25
2.136HisTyr: 2.136 ± 0.29
0.0HisXaa: 0.0 ± 0.0
Ile
2.283IleAla: 2.283 ± 0.891
1.4IleCys: 1.4 ± 0.365
1.252IleAsp: 1.252 ± 0.235
1.989IleGlu: 1.989 ± 0.319
3.094IlePhe: 3.094 ± 0.435
2.283IleGly: 2.283 ± 0.258
1.252IleHis: 1.252 ± 0.144
2.652IleIle: 2.652 ± 0.27
1.989IleLys: 1.989 ± 0.315
5.082IleLeu: 5.082 ± 1.005
1.179IleMet: 1.179 ± 0.413
0.958IleAsn: 0.958 ± 0.171
2.504IlePro: 2.504 ± 0.194
1.621IleGln: 1.621 ± 0.303
1.252IleArg: 1.252 ± 0.254
3.536IleSer: 3.536 ± 0.909
3.315IleThr: 3.315 ± 0.524
4.125IleVal: 4.125 ± 0.26
0.516IleTrp: 0.516 ± 0.272
2.283IleTyr: 2.283 ± 0.243
0.0IleXaa: 0.0 ± 0.0
Lys
2.062LysAla: 2.062 ± 0.183
1.768LysCys: 1.768 ± 0.433
2.21LysAsp: 2.21 ± 0.367
1.473LysGlu: 1.473 ± 0.312
2.799LysPhe: 2.799 ± 0.353
1.989LysGly: 1.989 ± 0.478
1.179LysHis: 1.179 ± 0.332
2.136LysIle: 2.136 ± 0.402
1.621LysLys: 1.621 ± 0.259
5.745LysLeu: 5.745 ± 0.346
0.663LysMet: 0.663 ± 0.202
2.652LysAsn: 2.652 ± 0.433
2.799LysPro: 2.799 ± 0.576
3.315LysGln: 3.315 ± 0.411
1.915LysArg: 1.915 ± 0.351
4.42LysSer: 4.42 ± 0.373
2.578LysThr: 2.578 ± 0.387
5.377LysVal: 5.377 ± 0.846
0.589LysTrp: 0.589 ± 0.191
1.915LysTyr: 1.915 ± 0.309
0.0LysXaa: 0.0 ± 0.0
Leu
6.335LeuAla: 6.335 ± 0.233
2.431LeuCys: 2.431 ± 0.291
6.335LeuAsp: 6.335 ± 0.666
4.641LeuGlu: 4.641 ± 0.608
6.187LeuPhe: 6.187 ± 0.592
5.598LeuGly: 5.598 ± 0.483
2.062LeuHis: 2.062 ± 0.346
4.346LeuIle: 4.346 ± 0.29
4.567LeuLys: 4.567 ± 0.926
7.44LeuLeu: 7.44 ± 0.945
1.915LeuMet: 1.915 ± 0.355
2.431LeuAsn: 2.431 ± 0.197
6.261LeuPro: 6.261 ± 0.404
4.641LeuGln: 4.641 ± 0.705
3.683LeuArg: 3.683 ± 0.163
10.46LeuSer: 10.46 ± 0.882
6.85LeuThr: 6.85 ± 0.608
8.029LeuVal: 8.029 ± 0.583
1.4LeuTrp: 1.4 ± 0.339
3.904LeuTyr: 3.904 ± 0.419
0.0LeuXaa: 0.0 ± 0.0
Met
0.958MetAla: 0.958 ± 0.475
0.958MetCys: 0.958 ± 0.296
0.442MetAsp: 0.442 ± 0.217
0.442MetGlu: 0.442 ± 0.139
1.915MetPhe: 1.915 ± 0.483
0.442MetGly: 0.442 ± 0.112
0.442MetHis: 0.442 ± 0.04
0.884MetIle: 0.884 ± 0.123
0.663MetLys: 0.663 ± 0.213
2.873MetLeu: 2.873 ± 0.308
1.179MetMet: 1.179 ± 0.468
0.663MetAsn: 0.663 ± 0.444
0.884MetPro: 0.884 ± 0.173
1.031MetGln: 1.031 ± 0.55
0.884MetArg: 0.884 ± 0.21
1.694MetSer: 1.694 ± 0.188
1.252MetThr: 1.252 ± 0.254
1.621MetVal: 1.621 ± 0.245
0.884MetTrp: 0.884 ± 0.307
1.031MetTyr: 1.031 ± 0.199
0.0MetXaa: 0.0 ± 0.0
Asn
1.841AsnAla: 1.841 ± 0.249
2.062AsnCys: 2.062 ± 0.235
1.179AsnAsp: 1.179 ± 0.124
1.694AsnGlu: 1.694 ± 0.299
2.799AsnPhe: 2.799 ± 0.215
2.578AsnGly: 2.578 ± 0.801
1.4AsnHis: 1.4 ± 0.43
2.578AsnIle: 2.578 ± 0.207
2.578AsnLys: 2.578 ± 0.229
4.272AsnLeu: 4.272 ± 0.794
0.81AsnMet: 0.81 ± 0.229
1.915AsnAsn: 1.915 ± 0.964
2.799AsnPro: 2.799 ± 0.356
1.4AsnGln: 1.4 ± 0.633
1.621AsnArg: 1.621 ± 1.169
2.21AsnSer: 2.21 ± 0.302
1.841AsnThr: 1.841 ± 0.34
4.788AsnVal: 4.788 ± 0.371
0.737AsnTrp: 0.737 ± 0.089
2.725AsnTyr: 2.725 ± 0.492
0.0AsnXaa: 0.0 ± 0.0
Pro
1.694ProAla: 1.694 ± 0.209
0.81ProCys: 0.81 ± 0.351
1.694ProAsp: 1.694 ± 0.132
2.21ProGlu: 2.21 ± 0.256
3.757ProPhe: 3.757 ± 0.507
2.357ProGly: 2.357 ± 0.912
1.105ProHis: 1.105 ± 0.131
3.388ProIle: 3.388 ± 0.483
2.357ProLys: 2.357 ± 0.162
5.23ProLeu: 5.23 ± 0.252
1.473ProMet: 1.473 ± 0.326
2.431ProAsn: 2.431 ± 0.593
2.136ProPro: 2.136 ± 0.282
2.283ProGln: 2.283 ± 0.559
2.283ProArg: 2.283 ± 0.501
4.567ProSer: 4.567 ± 0.627
3.315ProThr: 3.315 ± 0.269
4.051ProVal: 4.051 ± 0.384
0.442ProTrp: 0.442 ± 0.142
1.768ProTyr: 1.768 ± 0.534
0.0ProXaa: 0.0 ± 0.0
Gln
2.283GlnAla: 2.283 ± 0.861
1.179GlnCys: 1.179 ± 0.225
3.167GlnAsp: 3.167 ± 0.316
1.621GlnGlu: 1.621 ± 0.367
1.841GlnPhe: 1.841 ± 0.542
1.915GlnGly: 1.915 ± 0.273
0.958GlnHis: 0.958 ± 0.321
2.431GlnIle: 2.431 ± 0.702
1.105GlnLys: 1.105 ± 0.274
6.04GlnLeu: 6.04 ± 0.557
0.884GlnMet: 0.884 ± 0.237
1.547GlnAsn: 1.547 ± 0.913
3.167GlnPro: 3.167 ± 0.334
3.83GlnGln: 3.83 ± 0.586
1.989GlnArg: 1.989 ± 0.619
3.388GlnSer: 3.388 ± 0.332
1.915GlnThr: 1.915 ± 0.549
4.199GlnVal: 4.199 ± 0.799
0.295GlnTrp: 0.295 ± 0.179
2.21GlnTyr: 2.21 ± 0.437
0.147GlnXaa: 0.147 ± 0.048
Arg
1.473ArgAla: 1.473 ± 0.2
1.179ArgCys: 1.179 ± 0.322
2.283ArgAsp: 2.283 ± 0.562
0.958ArgGlu: 0.958 ± 0.165
2.136ArgPhe: 2.136 ± 0.336
1.915ArgGly: 1.915 ± 0.801
1.179ArgHis: 1.179 ± 0.246
0.958ArgIle: 0.958 ± 0.19
1.547ArgLys: 1.547 ± 0.171
3.094ArgLeu: 3.094 ± 0.384
0.884ArgMet: 0.884 ± 0.158
1.179ArgAsn: 1.179 ± 0.738
2.431ArgPro: 2.431 ± 0.286
1.621ArgGln: 1.621 ± 0.948
2.578ArgArg: 2.578 ± 0.934
1.989ArgSer: 1.989 ± 0.125
2.136ArgThr: 2.136 ± 0.669
3.978ArgVal: 3.978 ± 0.391
0.221ArgTrp: 0.221 ± 0.071
2.357ArgTyr: 2.357 ± 0.288
0.0ArgXaa: 0.0 ± 0.0
Ser
3.757SerAla: 3.757 ± 0.76
2.578SerCys: 2.578 ± 0.509
4.935SerAsp: 4.935 ± 0.818
2.799SerGlu: 2.799 ± 0.294
4.199SerPhe: 4.199 ± 0.509
3.315SerGly: 3.315 ± 0.935
1.841SerHis: 1.841 ± 0.375
3.462SerIle: 3.462 ± 0.957
4.199SerLys: 4.199 ± 0.997
7.587SerLeu: 7.587 ± 1.047
2.431SerMet: 2.431 ± 0.591
3.315SerAsn: 3.315 ± 0.585
4.125SerPro: 4.125 ± 0.855
2.799SerGln: 2.799 ± 0.27
2.504SerArg: 2.504 ± 0.375
6.703SerSer: 6.703 ± 1.376
4.125SerThr: 4.125 ± 0.86
7.882SerVal: 7.882 ± 0.997
1.547SerTrp: 1.547 ± 0.385
3.757SerTyr: 3.757 ± 0.691
0.0SerXaa: 0.0 ± 0.0
Thr
2.652ThrAla: 2.652 ± 0.473
1.621ThrCys: 1.621 ± 0.272
2.725ThrAsp: 2.725 ± 0.286
1.694ThrGlu: 1.694 ± 0.282
2.799ThrPhe: 2.799 ± 0.357
3.683ThrGly: 3.683 ± 0.217
1.621ThrHis: 1.621 ± 0.367
3.02ThrIle: 3.02 ± 1.072
3.167ThrLys: 3.167 ± 0.294
5.672ThrLeu: 5.672 ± 0.528
0.737ThrMet: 0.737 ± 0.427
2.431ThrAsn: 2.431 ± 0.346
3.388ThrPro: 3.388 ± 0.905
2.431ThrGln: 2.431 ± 0.544
2.062ThrArg: 2.062 ± 0.137
5.303ThrSer: 5.303 ± 0.423
5.303ThrThr: 5.303 ± 0.943
3.609ThrVal: 3.609 ± 0.5
1.252ThrTrp: 1.252 ± 0.206
2.21ThrTyr: 2.21 ± 0.506
0.0ThrXaa: 0.0 ± 0.0
Val
6.114ValAla: 6.114 ± 0.797
2.799ValCys: 2.799 ± 0.62
4.272ValAsp: 4.272 ± 0.733
6.261ValGlu: 6.261 ± 1.398
6.482ValPhe: 6.482 ± 1.508
5.009ValGly: 5.009 ± 0.482
1.768ValHis: 1.768 ± 0.352
3.02ValIle: 3.02 ± 0.556
5.819ValLys: 5.819 ± 0.625
10.091ValLeu: 10.091 ± 0.896
2.283ValMet: 2.283 ± 0.431
5.303ValAsn: 5.303 ± 0.424
4.199ValPro: 4.199 ± 0.284
4.199ValGln: 4.199 ± 0.283
2.357ValArg: 2.357 ± 0.176
5.966ValSer: 5.966 ± 0.106
3.757ValThr: 3.757 ± 0.646
11.638ValVal: 11.638 ± 1.916
1.4ValTrp: 1.4 ± 0.43
5.156ValTyr: 5.156 ± 0.581
0.0ValXaa: 0.0 ± 0.0
Trp
0.368TrpAla: 0.368 ± 0.24
0.737TrpCys: 0.737 ± 0.198
0.442TrpAsp: 0.442 ± 0.217
0.221TrpGlu: 0.221 ± 0.071
1.989TrpPhe: 1.989 ± 0.293
0.074TrpGly: 0.074 ± 0.113
0.368TrpHis: 0.368 ± 0.075
0.368TrpIle: 0.368 ± 0.239
0.589TrpLys: 0.589 ± 0.18
1.989TrpLeu: 1.989 ± 0.351
0.221TrpMet: 0.221 ± 0.071
0.442TrpAsn: 0.442 ± 0.139
1.031TrpPro: 1.031 ± 0.203
0.442TrpGln: 0.442 ± 0.143
0.737TrpArg: 0.737 ± 0.169
1.252TrpSer: 1.252 ± 0.525
0.663TrpThr: 0.663 ± 0.099
1.179TrpVal: 1.179 ± 0.127
0.442TrpTrp: 0.442 ± 0.232
0.958TrpTyr: 0.958 ± 0.279
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.21TyrAla: 2.21 ± 0.372
2.21TyrCys: 2.21 ± 0.229
2.873TyrAsp: 2.873 ± 0.546
2.283TyrGlu: 2.283 ± 0.272
3.02TyrPhe: 3.02 ± 0.435
2.21TyrGly: 2.21 ± 0.325
1.473TyrHis: 1.473 ± 0.212
2.431TyrIle: 2.431 ± 0.307
3.167TyrLys: 3.167 ± 0.42
4.42TyrLeu: 4.42 ± 0.216
0.81TyrMet: 0.81 ± 0.32
2.431TyrAsn: 2.431 ± 0.226
1.841TyrPro: 1.841 ± 0.917
2.283TyrGln: 2.283 ± 0.154
2.283TyrArg: 2.283 ± 0.28
3.462TyrSer: 3.462 ± 0.868
2.504TyrThr: 2.504 ± 1.05
5.377TyrVal: 5.377 ± 0.426
0.737TyrTrp: 0.737 ± 0.642
3.094TyrTyr: 3.094 ± 0.458
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.147XaaAsp: 0.147 ± 0.048
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.147XaaArg: 0.147 ± 0.048
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (13577 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski