Amino acid dipepetide frequency for Paenibacillus antarcticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.56AlaAla: 5.56 ± 0.074	0.62AlaCys: 0.62 ± 0.022	3.372AlaAsp: 3.372 ± 0.052	4.365AlaGlu: 4.365 ± 0.059	2.908AlaPhe: 2.908 ± 0.046	5.059AlaGly: 5.059 ± 0.071	1.244AlaHis: 1.244 ± 0.033	5.62AlaIle: 5.62 ± 0.066	3.968AlaLys: 3.968 ± 0.057	7.069AlaLeu: 7.069 ± 0.064	2.009AlaMet: 2.009 ± 0.04	2.823AlaAsn: 2.823 ± 0.051	2.128AlaPro: 2.128 ± 0.041	2.448AlaGln: 2.448 ± 0.039	2.695AlaArg: 2.695 ± 0.049	4.591AlaSer: 4.591 ± 0.067	3.938AlaThr: 3.938 ± 0.068	5.212AlaVal: 5.212 ± 0.061	0.735AlaTrp: 0.735 ± 0.022	2.346AlaTyr: 2.346 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.449CysAla: 0.449 ± 0.018	0.089CysCys: 0.089 ± 0.007	0.412CysAsp: 0.412 ± 0.018	0.428CysGlu: 0.428 ± 0.019	0.296CysPhe: 0.296 ± 0.015	0.716CysGly: 0.716 ± 0.023	0.193CysHis: 0.193 ± 0.011	0.563CysIle: 0.563 ± 0.019	0.398CysLys: 0.398 ± 0.016	0.703CysLeu: 0.703 ± 0.025	0.22CysMet: 0.22 ± 0.012	0.298CysAsn: 0.298 ± 0.015	0.319CysPro: 0.319 ± 0.016	0.233CysGln: 0.233 ± 0.015	0.355CysArg: 0.355 ± 0.015	0.567CysSer: 0.567 ± 0.018	0.406CysThr: 0.406 ± 0.014	0.489CysVal: 0.489 ± 0.02	0.08CysTrp: 0.08 ± 0.007	0.283CysTyr: 0.283 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.379AspAla: 3.379 ± 0.053	0.374AspCys: 0.374 ± 0.018	2.587AspAsp: 2.587 ± 0.048	3.818AspGlu: 3.818 ± 0.051	2.133AspPhe: 2.133 ± 0.042	3.775AspGly: 3.775 ± 0.067	1.258AspHis: 1.258 ± 0.035	4.363AspIle: 4.363 ± 0.053	3.079AspLys: 3.079 ± 0.048	5.032AspLeu: 5.032 ± 0.061	1.525AspMet: 1.525 ± 0.032	2.229AspAsn: 2.229 ± 0.043	2.176AspPro: 2.176 ± 0.043	2.101AspGln: 2.101 ± 0.037	2.4AspArg: 2.4 ± 0.042	2.997AspSer: 2.997 ± 0.047	2.864AspThr: 2.864 ± 0.048	3.848AspVal: 3.848 ± 0.052	0.721AspTrp: 0.721 ± 0.028	2.158AspTyr: 2.158 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	4.893GluAla: 4.893 ± 0.067	0.365GluCys: 0.365 ± 0.015	3.441GluAsp: 3.441 ± 0.049	5.215GluGlu: 5.215 ± 0.076	2.317GluPhe: 2.317 ± 0.043	4.363GluGly: 4.363 ± 0.058	1.568GluHis: 1.568 ± 0.034	5.016GluIle: 5.016 ± 0.065	3.95GluLys: 3.95 ± 0.062	6.967GluLeu: 6.967 ± 0.075	2.175GluMet: 2.175 ± 0.037	2.709GluAsn: 2.709 ± 0.042	1.916GluPro: 1.916 ± 0.04	3.45GluGln: 3.45 ± 0.052	3.368GluArg: 3.368 ± 0.058	3.819GluSer: 3.819 ± 0.057	3.064GluThr: 3.064 ± 0.05	4.862GluVal: 4.862 ± 0.061	0.868GluTrp: 0.868 ± 0.025	2.178GluTyr: 2.178 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	2.848PheAla: 2.848 ± 0.041	0.359PheCys: 0.359 ± 0.017	2.352PheAsp: 2.352 ± 0.051	2.468PheGlu: 2.468 ± 0.041	1.818PhePhe: 1.818 ± 0.044	3.039PheGly: 3.039 ± 0.046	0.894PheHis: 0.894 ± 0.023	3.446PheIle: 3.446 ± 0.069	2.241PheLys: 2.241 ± 0.039	3.759PheLeu: 3.759 ± 0.058	1.25PheMet: 1.25 ± 0.028	1.923PheAsn: 1.923 ± 0.039	1.446PhePro: 1.446 ± 0.028	1.506PheGln: 1.506 ± 0.034	1.724PheArg: 1.724 ± 0.038	2.963PheSer: 2.963 ± 0.048	2.593PheThr: 2.593 ± 0.045	2.906PheVal: 2.906 ± 0.046	0.48PheTrp: 0.48 ± 0.016	1.442PheTyr: 1.442 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	4.744GlyAla: 4.744 ± 0.065	0.662GlyCys: 0.662 ± 0.02	3.358GlyAsp: 3.358 ± 0.057	4.197GlyGlu: 4.197 ± 0.063	3.167GlyPhe: 3.167 ± 0.053	4.934GlyGly: 4.934 ± 0.077	1.399GlyHis: 1.399 ± 0.035	6.054GlyIle: 6.054 ± 0.069	4.426GlyLys: 4.426 ± 0.059	6.792GlyLeu: 6.792 ± 0.072	2.319GlyMet: 2.319 ± 0.042	2.968GlyAsn: 2.968 ± 0.051	1.635GlyPro: 1.635 ± 0.036	2.47GlyGln: 2.47 ± 0.041	2.9GlyArg: 2.9 ± 0.048	4.766GlySer: 4.766 ± 0.064	4.298GlyThr: 4.298 ± 0.061	5.123GlyVal: 5.123 ± 0.067	0.891GlyTrp: 0.891 ± 0.024	2.947GlyTyr: 2.947 ± 0.048	0.001GlyXaa: 0.001 ± 0.001
His	1.342HisAla: 1.342 ± 0.031	0.209HisCys: 0.209 ± 0.011	1.045HisAsp: 1.045 ± 0.031	1.273HisGlu: 1.273 ± 0.031	0.984HisPhe: 0.984 ± 0.026	1.422HisGly: 1.422 ± 0.034	0.636HisHis: 0.636 ± 0.023	1.65HisIle: 1.65 ± 0.043	1.035HisLys: 1.035 ± 0.03	2.1HisLeu: 2.1 ± 0.05	0.632HisMet: 0.632 ± 0.021	0.857HisAsn: 0.857 ± 0.022	1.086HisPro: 1.086 ± 0.03	0.757HisGln: 0.757 ± 0.022	0.964HisArg: 0.964 ± 0.027	1.295HisSer: 1.295 ± 0.029	1.159HisThr: 1.159 ± 0.028	1.443HisVal: 1.443 ± 0.033	0.299HisTrp: 0.299 ± 0.016	0.907HisTyr: 0.907 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.948IleAla: 5.948 ± 0.069	0.724IleCys: 0.724 ± 0.022	4.239IleAsp: 4.239 ± 0.048	4.933IleGlu: 4.933 ± 0.066	2.919IlePhe: 2.919 ± 0.057	5.72IleGly: 5.72 ± 0.075	1.792IleHis: 1.792 ± 0.04	5.909IleIle: 5.909 ± 0.083	3.801IleLys: 3.801 ± 0.06	7.065IleLeu: 7.065 ± 0.078	2.071IleMet: 2.071 ± 0.037	3.228IleAsn: 3.228 ± 0.048	3.474IlePro: 3.474 ± 0.048	3.12IleGln: 3.12 ± 0.051	3.632IleArg: 3.632 ± 0.054	5.848IleSer: 5.848 ± 0.066	4.842IleThr: 4.842 ± 0.06	5.861IleVal: 5.861 ± 0.07	0.735IleTrp: 0.735 ± 0.025	2.481IleTyr: 2.481 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	3.891LysAla: 3.891 ± 0.057	0.306LysCys: 0.306 ± 0.016	3.48LysAsp: 3.48 ± 0.057	4.933LysGlu: 4.933 ± 0.058	1.786LysPhe: 1.786 ± 0.031	3.937LysGly: 3.937 ± 0.054	1.114LysHis: 1.114 ± 0.027	3.742LysIle: 3.742 ± 0.054	3.869LysLys: 3.869 ± 0.059	5.552LysLeu: 5.552 ± 0.064	1.861LysMet: 1.861 ± 0.036	2.502LysAsn: 2.502 ± 0.047	2.084LysPro: 2.084 ± 0.038	2.512LysGln: 2.512 ± 0.04	2.67LysArg: 2.67 ± 0.043	3.547LysSer: 3.547 ± 0.055	2.884LysThr: 2.884 ± 0.051	4.282LysVal: 4.282 ± 0.059	0.748LysTrp: 0.748 ± 0.022	2.082LysTyr: 2.082 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	6.777LeuAla: 6.777 ± 0.081	0.809LeuCys: 0.809 ± 0.023	5.32LeuAsp: 5.32 ± 0.069	6.109LeuGlu: 6.109 ± 0.08	4.476LeuPhe: 4.476 ± 0.061	6.529LeuGly: 6.529 ± 0.069	2.067LeuHis: 2.067 ± 0.043	7.452LeuIle: 7.452 ± 0.085	5.673LeuLys: 5.673 ± 0.063	10.211LeuLeu: 10.211 ± 0.108	2.784LeuMet: 2.784 ± 0.043	4.514LeuAsn: 4.514 ± 0.057	4.01LeuPro: 4.01 ± 0.06	3.979LeuGln: 3.979 ± 0.057	4.233LeuArg: 4.233 ± 0.051	7.579LeuSer: 7.579 ± 0.087	5.646LeuThr: 5.646 ± 0.065	6.237LeuVal: 6.237 ± 0.074	0.922LeuTrp: 0.922 ± 0.026	3.14LeuTyr: 3.14 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.061MetAla: 2.061 ± 0.041	0.17MetCys: 0.17 ± 0.01	1.706MetAsp: 1.706 ± 0.038	1.943MetGlu: 1.943 ± 0.039	1.116MetPhe: 1.116 ± 0.029	2.002MetGly: 2.002 ± 0.039	0.451MetHis: 0.451 ± 0.017	2.407MetIle: 2.407 ± 0.043	2.325MetLys: 2.325 ± 0.037	2.898MetLeu: 2.898 ± 0.043	1.052MetMet: 1.052 ± 0.032	1.828MetAsn: 1.828 ± 0.036	1.079MetPro: 1.079 ± 0.028	0.989MetGln: 0.989 ± 0.03	1.218MetArg: 1.218 ± 0.028	2.008MetSer: 2.008 ± 0.037	1.772MetThr: 1.772 ± 0.031	1.975MetVal: 1.975 ± 0.039	0.243MetTrp: 0.243 ± 0.013	0.819MetTyr: 0.819 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.921AsnAla: 2.921 ± 0.049	0.249AsnCys: 0.249 ± 0.014	2.316AsnAsp: 2.316 ± 0.042	3.019AsnGlu: 3.019 ± 0.05	1.623AsnPhe: 1.623 ± 0.037	3.459AsnGly: 3.459 ± 0.068	1.02AsnHis: 1.02 ± 0.025	3.496AsnIle: 3.496 ± 0.046	2.827AsnLys: 2.827 ± 0.048	3.861AsnLeu: 3.861 ± 0.054	1.317AsnMet: 1.317 ± 0.031	2.392AsnAsn: 2.392 ± 0.061	2.118AsnPro: 2.118 ± 0.036	1.787AsnGln: 1.787 ± 0.034	2.037AsnArg: 2.037 ± 0.041	2.716AsnSer: 2.716 ± 0.05	2.521AsnThr: 2.521 ± 0.045	3.159AsnVal: 3.159 ± 0.052	0.569AsnTrp: 0.569 ± 0.02	1.574AsnTyr: 1.574 ± 0.037	0.001AsnXaa: 0.001 ± 0.001
Pro	2.267ProAla: 2.267 ± 0.046	0.231ProCys: 0.231 ± 0.013	2.15ProAsp: 2.15 ± 0.036	2.895ProGlu: 2.895 ± 0.051	1.789ProPhe: 1.789 ± 0.036	2.277ProGly: 2.277 ± 0.046	0.803ProHis: 0.803 ± 0.024	2.866ProIle: 2.866 ± 0.05	1.818ProLys: 1.818 ± 0.035	3.649ProLeu: 3.649 ± 0.052	1.018ProMet: 1.018 ± 0.026	1.743ProAsn: 1.743 ± 0.039	0.931ProPro: 0.931 ± 0.029	1.333ProGln: 1.333 ± 0.031	1.212ProArg: 1.212 ± 0.028	2.506ProSer: 2.506 ± 0.044	2.204ProThr: 2.204 ± 0.043	2.81ProVal: 2.81 ± 0.044	0.461ProTrp: 0.461 ± 0.017	1.381ProTyr: 1.381 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	2.796GlnAla: 2.796 ± 0.044	0.223GlnCys: 0.223 ± 0.012	1.855GlnAsp: 1.855 ± 0.031	2.772GlnGlu: 2.772 ± 0.044	1.605GlnPhe: 1.605 ± 0.038	2.656GlnGly: 2.656 ± 0.043	0.853GlnHis: 0.853 ± 0.024	2.776GlnIle: 2.776 ± 0.043	2.074GlnLys: 2.074 ± 0.036	4.244GlnLeu: 4.244 ± 0.062	1.289GlnMet: 1.289 ± 0.03	1.45GlnAsn: 1.45 ± 0.037	1.33GlnPro: 1.33 ± 0.032	1.96GlnGln: 1.96 ± 0.041	1.765GlnArg: 1.765 ± 0.04	2.602GlnSer: 2.602 ± 0.046	1.874GlnThr: 1.874 ± 0.035	2.663GlnVal: 2.663 ± 0.047	0.529GlnTrp: 0.529 ± 0.02	1.492GlnTyr: 1.492 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.449ArgAla: 2.449 ± 0.039	0.298ArgCys: 0.298 ± 0.014	2.251ArgAsp: 2.251 ± 0.037	3.072ArgGlu: 3.072 ± 0.047	1.87ArgPhe: 1.87 ± 0.04	2.581ArgGly: 2.581 ± 0.048	0.913ArgHis: 0.913 ± 0.028	3.595ArgIle: 3.595 ± 0.054	2.762ArgLys: 2.762 ± 0.043	4.353ArgLeu: 4.353 ± 0.06	1.519ArgMet: 1.519 ± 0.033	2.168ArgAsn: 2.168 ± 0.034	1.384ArgPro: 1.384 ± 0.031	1.646ArgGln: 1.646 ± 0.031	2.155ArgArg: 2.155 ± 0.039	2.801ArgSer: 2.801 ± 0.045	2.444ArgThr: 2.444 ± 0.04	2.857ArgVal: 2.857 ± 0.043	0.561ArgTrp: 0.561 ± 0.02	1.747ArgTyr: 1.747 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	4.235SerAla: 4.235 ± 0.058	0.424SerCys: 0.424 ± 0.019	3.452SerAsp: 3.452 ± 0.053	4.194SerGlu: 4.194 ± 0.059	3.13SerPhe: 3.13 ± 0.049	5.126SerGly: 5.126 ± 0.069	1.376SerHis: 1.376 ± 0.031	5.513SerIle: 5.513 ± 0.074	3.862SerLys: 3.862 ± 0.053	6.812SerLeu: 6.812 ± 0.071	2.015SerMet: 2.015 ± 0.036	3.148SerAsn: 3.148 ± 0.055	2.344SerPro: 2.344 ± 0.038	2.389SerGln: 2.389 ± 0.04	2.784SerArg: 2.784 ± 0.044	5.047SerSer: 5.047 ± 0.076	3.802SerThr: 3.802 ± 0.047	4.815SerVal: 4.815 ± 0.072	0.813SerTrp: 0.813 ± 0.023	2.506SerTyr: 2.506 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	4.091ThrAla: 4.091 ± 0.07	0.369ThrCys: 0.369 ± 0.017	2.923ThrAsp: 2.923 ± 0.046	3.352ThrGlu: 3.352 ± 0.051	2.51ThrPhe: 2.51 ± 0.045	4.315ThrGly: 4.315 ± 0.065	1.087ThrHis: 1.087 ± 0.028	4.557ThrIle: 4.557 ± 0.059	2.941ThrLys: 2.941 ± 0.043	5.817ThrLeu: 5.817 ± 0.071	1.525ThrMet: 1.525 ± 0.032	2.536ThrAsn: 2.536 ± 0.045	2.468ThrPro: 2.468 ± 0.048	1.854ThrGln: 1.854 ± 0.04	2.143ThrArg: 2.143 ± 0.04	3.884ThrSer: 3.884 ± 0.053	3.527ThrThr: 3.527 ± 0.059	4.471ThrVal: 4.471 ± 0.073	0.666ThrTrp: 0.666 ± 0.021	2.06ThrTyr: 2.06 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	4.983ValAla: 4.983 ± 0.069	0.619ValCys: 0.619 ± 0.021	3.86ValAsp: 3.86 ± 0.052	4.499ValGlu: 4.499 ± 0.06	2.869ValPhe: 2.869 ± 0.048	4.762ValGly: 4.762 ± 0.066	1.424ValHis: 1.424 ± 0.033	5.848ValIle: 5.848 ± 0.063	4.083ValLys: 4.083 ± 0.058	6.897ValLeu: 6.897 ± 0.069	2.057ValMet: 2.057 ± 0.04	3.297ValAsn: 3.297 ± 0.052	2.665ValPro: 2.665 ± 0.047	2.563ValGln: 2.563 ± 0.042	2.872ValArg: 2.872 ± 0.045	5.122ValSer: 5.122 ± 0.069	4.628ValThr: 4.628 ± 0.08	5.313ValVal: 5.313 ± 0.066	0.793ValTrp: 0.793 ± 0.022	2.285ValTyr: 2.285 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.705TrpAla: 0.705 ± 0.021	0.082TrpCys: 0.082 ± 0.007	0.684TrpAsp: 0.684 ± 0.023	0.683TrpGlu: 0.683 ± 0.023	0.53TrpPhe: 0.53 ± 0.019	0.774TrpGly: 0.774 ± 0.022	0.231TrpHis: 0.231 ± 0.012	1.01TrpIle: 1.01 ± 0.026	0.702TrpLys: 0.702 ± 0.021	1.228TrpLeu: 1.228 ± 0.033	0.442TrpMet: 0.442 ± 0.019	0.725TrpAsn: 0.725 ± 0.022	0.294TrpPro: 0.294 ± 0.015	0.406TrpGln: 0.406 ± 0.018	0.496TrpArg: 0.496 ± 0.019	0.784TrpSer: 0.784 ± 0.027	0.612TrpThr: 0.612 ± 0.024	0.75TrpVal: 0.75 ± 0.024	0.178TrpTrp: 0.178 ± 0.01	0.39TrpTyr: 0.39 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.369TyrAla: 2.369 ± 0.045	0.312TyrCys: 0.312 ± 0.015	2.014TyrAsp: 2.014 ± 0.04	2.333TyrGlu: 2.333 ± 0.043	1.613TyrPhe: 1.613 ± 0.036	2.605TyrGly: 2.605 ± 0.045	0.772TyrHis: 0.772 ± 0.025	2.461TyrIle: 2.461 ± 0.035	1.95TyrLys: 1.95 ± 0.04	3.458TyrLeu: 3.458 ± 0.055	0.981TyrMet: 0.981 ± 0.028	1.641TyrAsn: 1.641 ± 0.037	1.458TyrPro: 1.458 ± 0.033	1.305TyrGln: 1.305 ± 0.032	1.802TyrArg: 1.802 ± 0.038	2.347TyrSer: 2.347 ± 0.044	2.02TyrThr: 2.02 ± 0.034	2.364TyrVal: 2.364 ± 0.047	0.413TyrTrp: 0.413 ± 0.016	1.421TyrTyr: 1.421 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4663 proteins (1491509 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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