Amino acid dipepetide frequency for Thalassospira sp. HJ

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.292AlaAla: 12.292 ± 0.155	1.06AlaCys: 1.06 ± 0.03	6.569AlaAsp: 6.569 ± 0.078	6.922AlaGlu: 6.922 ± 0.092	4.157AlaPhe: 4.157 ± 0.07	8.833AlaGly: 8.833 ± 0.181	1.95AlaHis: 1.95 ± 0.043	6.432AlaIle: 6.432 ± 0.088	4.987AlaLys: 4.987 ± 0.075	10.781AlaLeu: 10.781 ± 0.112	3.415AlaMet: 3.415 ± 0.061	3.397AlaAsn: 3.397 ± 0.058	4.299AlaPro: 4.299 ± 0.074	3.496AlaGln: 3.496 ± 0.054	6.279AlaArg: 6.279 ± 0.091	5.831AlaSer: 5.831 ± 0.076	5.347AlaThr: 5.347 ± 0.069	7.614AlaVal: 7.614 ± 0.088	1.152AlaTrp: 1.152 ± 0.033	2.369AlaTyr: 2.369 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.029CysAla: 1.029 ± 0.032	0.124CysCys: 0.124 ± 0.011	0.698CysAsp: 0.698 ± 0.027	0.539CysGlu: 0.539 ± 0.02	0.39CysPhe: 0.39 ± 0.016	0.946CysGly: 0.946 ± 0.031	0.293CysHis: 0.293 ± 0.015	0.469CysIle: 0.469 ± 0.023	0.338CysLys: 0.338 ± 0.016	0.859CysLeu: 0.859 ± 0.029	0.213CysMet: 0.213 ± 0.013	0.265CysAsn: 0.265 ± 0.015	0.47CysPro: 0.47 ± 0.021	0.285CysGln: 0.285 ± 0.015	0.535CysArg: 0.535 ± 0.022	0.477CysSer: 0.477 ± 0.021	0.43CysThr: 0.43 ± 0.019	0.654CysVal: 0.654 ± 0.026	0.126CysTrp: 0.126 ± 0.012	0.241CysTyr: 0.241 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.779AspAla: 6.779 ± 0.087	0.593AspCys: 0.593 ± 0.028	4.288AspAsp: 4.288 ± 0.158	4.146AspGlu: 4.146 ± 0.067	2.551AspPhe: 2.551 ± 0.046	5.7AspGly: 5.7 ± 0.156	1.603AspHis: 1.603 ± 0.039	4.19AspIle: 4.19 ± 0.065	2.146AspLys: 2.146 ± 0.043	6.511AspLeu: 6.511 ± 0.08	1.767AspMet: 1.767 ± 0.036	1.783AspAsn: 1.783 ± 0.047	3.297AspPro: 3.297 ± 0.058	2.42AspGln: 2.42 ± 0.035	3.816AspArg: 3.816 ± 0.066	2.525AspSer: 2.525 ± 0.062	3.002AspThr: 3.002 ± 0.214	4.87AspVal: 4.87 ± 0.086	1.002AspTrp: 1.002 ± 0.029	1.671AspTyr: 1.671 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	6.393GluAla: 6.393 ± 0.076	0.463GluCys: 0.463 ± 0.021	3.69GluAsp: 3.69 ± 0.056	3.993GluGlu: 3.993 ± 0.073	2.142GluPhe: 2.142 ± 0.043	4.246GluGly: 4.246 ± 0.097	1.287GluHis: 1.287 ± 0.039	4.302GluIle: 4.302 ± 0.066	3.196GluLys: 3.196 ± 0.053	5.927GluLeu: 5.927 ± 0.081	1.884GluMet: 1.884 ± 0.042	2.577GluAsn: 2.577 ± 0.049	2.314GluPro: 2.314 ± 0.054	2.337GluGln: 2.337 ± 0.05	3.962GluArg: 3.962 ± 0.059	2.631GluSer: 2.631 ± 0.048	3.923GluThr: 3.923 ± 0.057	4.123GluVal: 4.123 ± 0.063	0.677GluTrp: 0.677 ± 0.025	1.298GluTyr: 1.298 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.34PheAla: 4.34 ± 0.074	0.485PheCys: 0.485 ± 0.019	3.12PheAsp: 3.12 ± 0.059	2.458PheGlu: 2.458 ± 0.045	1.519PhePhe: 1.519 ± 0.037	3.903PheGly: 3.903 ± 0.061	0.737PheHis: 0.737 ± 0.026	2.084PheIle: 2.084 ± 0.046	1.365PheLys: 1.365 ± 0.033	3.412PheLeu: 3.412 ± 0.063	0.973PheMet: 0.973 ± 0.026	1.275PheAsn: 1.275 ± 0.038	1.536PhePro: 1.536 ± 0.039	0.992PheGln: 0.992 ± 0.033	1.954PheArg: 1.954 ± 0.039	2.365PheSer: 2.365 ± 0.05	2.042PheThr: 2.042 ± 0.04	3.049PheVal: 3.049 ± 0.058	0.595PheTrp: 0.595 ± 0.025	1.038PheTyr: 1.038 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	7.994GlyAla: 7.994 ± 0.159	0.845GlyCys: 0.845 ± 0.028	5.043GlyAsp: 5.043 ± 0.234	4.783GlyGlu: 4.783 ± 0.095	3.619GlyPhe: 3.619 ± 0.064	6.854GlyGly: 6.854 ± 0.239	1.823GlyHis: 1.823 ± 0.046	5.052GlyIle: 5.052 ± 0.078	4.075GlyLys: 4.075 ± 0.065	8.135GlyLeu: 8.135 ± 0.101	2.58GlyMet: 2.58 ± 0.052	2.756GlyAsn: 2.756 ± 0.159	2.895GlyPro: 2.895 ± 0.055	2.801GlyGln: 2.801 ± 0.049	4.584GlyArg: 4.584 ± 0.068	4.525GlySer: 4.525 ± 0.115	4.443GlyThr: 4.443 ± 0.087	6.175GlyVal: 6.175 ± 0.083	1.212GlyTrp: 1.212 ± 0.036	2.381GlyTyr: 2.381 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.063HisAla: 2.063 ± 0.047	0.267HisCys: 0.267 ± 0.014	1.455HisAsp: 1.455 ± 0.042	1.125HisGlu: 1.125 ± 0.032	0.902HisPhe: 0.902 ± 0.03	1.82HisGly: 1.82 ± 0.048	0.608HisHis: 0.608 ± 0.027	1.141HisIle: 1.141 ± 0.033	0.711HisLys: 0.711 ± 0.025	2.052HisLeu: 2.052 ± 0.048	0.554HisMet: 0.554 ± 0.022	0.639HisAsn: 0.639 ± 0.023	1.292HisPro: 1.292 ± 0.038	0.724HisGln: 0.724 ± 0.026	1.187HisArg: 1.187 ± 0.03	1.013HisSer: 1.013 ± 0.032	0.906HisThr: 0.906 ± 0.032	1.454HisVal: 1.454 ± 0.039	0.293HisTrp: 0.293 ± 0.016	0.574HisTyr: 0.574 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.451IleAla: 7.451 ± 0.096	0.655IleCys: 0.655 ± 0.026	4.313IleAsp: 4.313 ± 0.074	4.241IleGlu: 4.241 ± 0.065	2.037IlePhe: 2.037 ± 0.044	5.361IleGly: 5.361 ± 0.073	1.054IleHis: 1.054 ± 0.03	3.072IleIle: 3.072 ± 0.056	2.34IleLys: 2.34 ± 0.054	5.119IleLeu: 5.119 ± 0.086	1.307IleMet: 1.307 ± 0.037	2.078IleAsn: 2.078 ± 0.046	2.611IlePro: 2.611 ± 0.051	1.317IleGln: 1.317 ± 0.029	3.192IleArg: 3.192 ± 0.049	3.895IleSer: 3.895 ± 0.056	3.513IleThr: 3.513 ± 0.058	4.225IleVal: 4.225 ± 0.061	0.668IleTrp: 0.668 ± 0.025	1.366IleTyr: 1.366 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.41LysAla: 4.41 ± 0.079	0.274LysCys: 0.274 ± 0.016	2.309LysAsp: 2.309 ± 0.048	2.158LysGlu: 2.158 ± 0.054	1.372LysPhe: 1.372 ± 0.034	2.957LysGly: 2.957 ± 0.058	0.83LysHis: 0.83 ± 0.028	2.402LysIle: 2.402 ± 0.046	1.986LysLys: 1.986 ± 0.049	4.332LysLeu: 4.332 ± 0.079	1.181LysMet: 1.181 ± 0.038	1.341LysAsn: 1.341 ± 0.031	2.263LysPro: 2.263 ± 0.053	1.393LysGln: 1.393 ± 0.035	2.806LysArg: 2.806 ± 0.053	2.596LysSer: 2.596 ± 0.053	2.506LysThr: 2.506 ± 0.048	2.892LysVal: 2.892 ± 0.058	0.487LysTrp: 0.487 ± 0.02	0.947LysTyr: 0.947 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	10.939LeuAla: 10.939 ± 0.117	0.982LeuCys: 0.982 ± 0.03	6.071LeuAsp: 6.071 ± 0.088	5.666LeuGlu: 5.666 ± 0.072	3.865LeuPhe: 3.865 ± 0.072	8.007LeuGly: 8.007 ± 0.092	1.836LeuHis: 1.836 ± 0.043	5.854LeuIle: 5.854 ± 0.084	3.823LeuLys: 3.823 ± 0.061	8.629LeuLeu: 8.629 ± 0.12	2.609LeuMet: 2.609 ± 0.056	3.001LeuAsn: 3.001 ± 0.047	4.928LeuPro: 4.928 ± 0.08	2.709LeuGln: 2.709 ± 0.052	6.098LeuArg: 6.098 ± 0.088	6.578LeuSer: 6.578 ± 0.084	5.259LeuThr: 5.259 ± 0.069	6.742LeuVal: 6.742 ± 0.084	1.01LeuTrp: 1.01 ± 0.036	2.157LeuTyr: 2.157 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.263MetAla: 3.263 ± 0.056	0.241MetCys: 0.241 ± 0.013	1.327MetAsp: 1.327 ± 0.037	1.327MetGlu: 1.327 ± 0.031	0.97MetPhe: 0.97 ± 0.031	2.032MetGly: 2.032 ± 0.046	0.472MetHis: 0.472 ± 0.021	1.806MetIle: 1.806 ± 0.043	1.19MetLys: 1.19 ± 0.031	2.767MetLeu: 2.767 ± 0.054	0.846MetMet: 0.846 ± 0.028	0.952MetAsn: 0.952 ± 0.029	1.5MetPro: 1.5 ± 0.037	0.903MetGln: 0.903 ± 0.029	1.714MetArg: 1.714 ± 0.04	1.978MetSer: 1.978 ± 0.036	2.009MetThr: 2.009 ± 0.038	2.072MetVal: 2.072 ± 0.05	0.232MetTrp: 0.232 ± 0.013	0.427MetTyr: 0.427 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.612AsnAla: 3.612 ± 0.056	0.317AsnCys: 0.317 ± 0.015	2.134AsnAsp: 2.134 ± 0.145	1.715AsnGlu: 1.715 ± 0.045	1.228AsnPhe: 1.228 ± 0.037	2.873AsnGly: 2.873 ± 0.064	0.668AsnHis: 0.668 ± 0.023	1.978AsnIle: 1.978 ± 0.04	1.078AsnLys: 1.078 ± 0.032	3.213AsnLeu: 3.213 ± 0.049	0.905AsnMet: 0.905 ± 0.031	1.032AsnAsn: 1.032 ± 0.033	2.05AsnPro: 2.05 ± 0.042	1.008AsnGln: 1.008 ± 0.032	2.045AsnArg: 2.045 ± 0.045	1.633AsnSer: 1.633 ± 0.04	1.62AsnThr: 1.62 ± 0.043	2.402AsnVal: 2.402 ± 0.058	0.532AsnTrp: 0.532 ± 0.02	0.829AsnTyr: 0.829 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	4.633ProAla: 4.633 ± 0.074	0.314ProCys: 0.314 ± 0.018	3.729ProAsp: 3.729 ± 0.066	3.785ProGlu: 3.785 ± 0.074	1.875ProPhe: 1.875 ± 0.041	3.696ProGly: 3.696 ± 0.067	0.982ProHis: 0.982 ± 0.03	2.395ProIle: 2.395 ± 0.051	2.012ProLys: 2.012 ± 0.043	3.926ProLeu: 3.926 ± 0.062	1.179ProMet: 1.179 ± 0.031	1.501ProAsn: 1.501 ± 0.036	1.621ProPro: 1.621 ± 0.047	1.398ProGln: 1.398 ± 0.033	2.074ProArg: 2.074 ± 0.044	2.43ProSer: 2.43 ± 0.043	2.369ProThr: 2.369 ± 0.049	3.865ProVal: 3.865 ± 0.061	0.577ProTrp: 0.577 ± 0.021	1.12ProTyr: 1.12 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.441GlnAla: 3.441 ± 0.058	0.214GlnCys: 0.214 ± 0.013	1.686GlnAsp: 1.686 ± 0.039	1.728GlnGlu: 1.728 ± 0.04	1.171GlnPhe: 1.171 ± 0.028	2.27GlnGly: 2.27 ± 0.043	0.655GlnHis: 0.655 ± 0.028	2.191GlnIle: 2.191 ± 0.045	1.434GlnLys: 1.434 ± 0.039	2.884GlnLeu: 2.884 ± 0.052	0.98GlnMet: 0.98 ± 0.029	1.242GlnAsn: 1.242 ± 0.03	1.403GlnPro: 1.403 ± 0.04	1.199GlnGln: 1.199 ± 0.038	1.98GlnArg: 1.98 ± 0.047	2.093GlnSer: 2.093 ± 0.045	1.944GlnThr: 1.944 ± 0.043	2.215GlnVal: 2.215 ± 0.041	0.375GlnTrp: 0.375 ± 0.016	0.766GlnTyr: 0.766 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	5.81ArgAla: 5.81 ± 0.078	0.469ArgCys: 0.469 ± 0.022	4.175ArgAsp: 4.175 ± 0.073	3.867ArgGlu: 3.867 ± 0.066	2.523ArgPhe: 2.523 ± 0.055	3.858ArgGly: 3.858 ± 0.067	1.405ArgHis: 1.405 ± 0.034	3.602ArgIle: 3.602 ± 0.057	2.761ArgLys: 2.761 ± 0.053	6.05ArgLeu: 6.05 ± 0.104	1.656ArgMet: 1.656 ± 0.036	2.096ArgAsn: 2.096 ± 0.041	2.5ArgPro: 2.5 ± 0.049	2.113ArgGln: 2.113 ± 0.042	3.666ArgArg: 3.666 ± 0.07	3.016ArgSer: 3.016 ± 0.059	2.701ArgThr: 2.701 ± 0.047	3.961ArgVal: 3.961 ± 0.072	0.674ArgTrp: 0.674 ± 0.023	1.616ArgTyr: 1.616 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.875SerAla: 5.875 ± 0.075	0.459SerCys: 0.459 ± 0.02	3.83SerAsp: 3.83 ± 0.072	3.472SerGlu: 3.472 ± 0.066	2.448SerPhe: 2.448 ± 0.045	5.54SerGly: 5.54 ± 0.138	1.234SerHis: 1.234 ± 0.033	3.095SerIle: 3.095 ± 0.057	2.048SerLys: 2.048 ± 0.043	5.3SerLeu: 5.3 ± 0.071	1.607SerMet: 1.607 ± 0.043	1.812SerAsn: 1.812 ± 0.045	2.519SerPro: 2.519 ± 0.05	1.815SerGln: 1.815 ± 0.036	3.102SerArg: 3.102 ± 0.062	3.335SerSer: 3.335 ± 0.071	2.827SerThr: 2.827 ± 0.054	4.176SerVal: 4.176 ± 0.062	0.712SerTrp: 0.712 ± 0.025	1.489SerTyr: 1.489 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.613ThrAla: 5.613 ± 0.078	0.445ThrCys: 0.445 ± 0.022	3.381ThrAsp: 3.381 ± 0.067	3.012ThrGlu: 3.012 ± 0.057	2.038ThrPhe: 2.038 ± 0.042	5.05ThrGly: 5.05 ± 0.123	1.092ThrHis: 1.092 ± 0.033	3.116ThrIle: 3.116 ± 0.07	1.951ThrLys: 1.951 ± 0.044	5.554ThrLeu: 5.554 ± 0.118	1.279ThrMet: 1.279 ± 0.037	1.721ThrAsn: 1.721 ± 0.035	2.975ThrPro: 2.975 ± 0.068	1.515ThrGln: 1.515 ± 0.039	2.972ThrArg: 2.972 ± 0.059	3.036ThrSer: 3.036 ± 0.057	2.947ThrThr: 2.947 ± 0.055	4.332ThrVal: 4.332 ± 0.066	0.564ThrTrp: 0.564 ± 0.023	1.309ThrTyr: 1.309 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	7.85ValAla: 7.85 ± 0.102	0.745ValCys: 0.745 ± 0.026	4.447ValAsp: 4.447 ± 0.065	4.401ValGlu: 4.401 ± 0.066	2.87ValPhe: 2.87 ± 0.055	5.612ValGly: 5.612 ± 0.089	1.326ValHis: 1.326 ± 0.032	4.828ValIle: 4.828 ± 0.082	2.733ValLys: 2.733 ± 0.055	7.291ValLeu: 7.291 ± 0.098	2.192ValMet: 2.192 ± 0.046	2.238ValAsn: 2.238 ± 0.051	3.357ValPro: 3.357 ± 0.059	1.912ValGln: 1.912 ± 0.045	4.006ValArg: 4.006 ± 0.055	4.697ValSer: 4.697 ± 0.066	4.44ValThr: 4.44 ± 0.058	5.547ValVal: 5.547 ± 0.088	0.839ValTrp: 0.839 ± 0.028	1.568ValTyr: 1.568 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.016TrpAla: 1.016 ± 0.03	0.131TrpCys: 0.131 ± 0.011	0.688TrpAsp: 0.688 ± 0.028	0.598TrpGlu: 0.598 ± 0.021	0.52TrpPhe: 0.52 ± 0.022	0.817TrpGly: 0.817 ± 0.03	0.331TrpHis: 0.331 ± 0.017	0.634TrpIle: 0.634 ± 0.026	0.495TrpLys: 0.495 ± 0.021	1.566TrpLeu: 1.566 ± 0.043	0.392TrpMet: 0.392 ± 0.021	0.451TrpAsn: 0.451 ± 0.019	0.548TrpPro: 0.548 ± 0.027	0.686TrpGln: 0.686 ± 0.024	0.902TrpArg: 0.902 ± 0.028	0.698TrpSer: 0.698 ± 0.025	0.56TrpThr: 0.56 ± 0.023	0.801TrpVal: 0.801 ± 0.026	0.187TrpTrp: 0.187 ± 0.013	0.288TrpTyr: 0.288 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.381TyrAla: 2.381 ± 0.048	0.299TyrCys: 0.299 ± 0.017	1.704TyrAsp: 1.704 ± 0.043	1.429TyrGlu: 1.429 ± 0.034	1.045TyrPhe: 1.045 ± 0.03	2.205TyrGly: 2.205 ± 0.044	0.59TyrHis: 0.59 ± 0.024	1.174TyrIle: 1.174 ± 0.036	0.774TyrLys: 0.774 ± 0.028	2.454TyrLeu: 2.454 ± 0.052	0.511TyrMet: 0.511 ± 0.018	0.715TyrAsn: 0.715 ± 0.028	1.101TyrPro: 1.101 ± 0.033	0.846TyrGln: 0.846 ± 0.025	1.643TyrArg: 1.643 ± 0.036	1.345TyrSer: 1.345 ± 0.032	1.113TyrThr: 1.113 ± 0.035	1.734TyrVal: 1.734 ± 0.042	0.395TyrTrp: 0.395 ± 0.019	0.76TyrTyr: 0.76 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3669 proteins (1179098 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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