Amino acid dipepetide frequency for Human papillomavirus 151

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.912AlaAla: 3.912 ± 1.248
1.174AlaCys: 1.174 ± 0.549
4.304AlaAsp: 4.304 ± 1.16
2.739AlaGlu: 2.739 ± 0.83
1.565AlaPhe: 1.565 ± 0.496
1.956AlaGly: 1.956 ± 1.042
0.391AlaHis: 0.391 ± 0.282
1.956AlaIle: 1.956 ± 0.973
3.912AlaLys: 3.912 ± 1.823
3.521AlaLeu: 3.521 ± 0.817
1.174AlaMet: 1.174 ± 0.677
1.565AlaAsn: 1.565 ± 0.584
3.13AlaPro: 3.13 ± 0.894
3.13AlaGln: 3.13 ± 0.901
5.869AlaArg: 5.869 ± 1.557
6.651AlaSer: 6.651 ± 0.619
4.304AlaThr: 4.304 ± 1.234
1.956AlaVal: 1.956 ± 0.871
0.391AlaTrp: 0.391 ± 0.282
1.956AlaTyr: 1.956 ± 0.895
0.0AlaXaa: 0.0 ± 0.0
Cys
1.174CysAla: 1.174 ± 0.549
1.565CysCys: 1.565 ± 0.915
0.782CysAsp: 0.782 ± 0.861
0.782CysGlu: 0.782 ± 0.36
1.174CysPhe: 1.174 ± 0.379
0.391CysGly: 0.391 ± 0.43
0.0CysHis: 0.0 ± 0.0
0.782CysIle: 0.782 ± 0.36
1.956CysLys: 1.956 ± 0.737
1.956CysLeu: 1.956 ± 0.648
0.391CysMet: 0.391 ± 0.539
1.174CysAsn: 1.174 ± 0.8
1.565CysPro: 1.565 ± 0.755
1.174CysGln: 1.174 ± 0.654
1.174CysArg: 1.174 ± 0.669
2.347CysSer: 2.347 ± 1.307
0.782CysThr: 0.782 ± 0.565
0.0CysVal: 0.0 ± 0.0
0.391CysTrp: 0.391 ± 0.282
0.782CysTyr: 0.782 ± 0.403
0.0CysXaa: 0.0 ± 0.0
Asp
5.477AspAla: 5.477 ± 1.431
0.391AspCys: 0.391 ± 0.351
3.912AspAsp: 3.912 ± 1.553
2.347AspGlu: 2.347 ± 0.577
1.565AspPhe: 1.565 ± 0.75
2.739AspGly: 2.739 ± 0.98
1.174AspHis: 1.174 ± 0.573
4.695AspIle: 4.695 ± 1.191
3.912AspLys: 3.912 ± 1.376
5.869AspLeu: 5.869 ± 1.146
2.739AspMet: 2.739 ± 1.187
1.956AspAsn: 1.956 ± 0.78
4.695AspPro: 4.695 ± 1.652
1.956AspGln: 1.956 ± 0.787
3.912AspArg: 3.912 ± 1.142
4.695AspSer: 4.695 ± 1.24
3.912AspThr: 3.912 ± 0.606
3.13AspVal: 3.13 ± 1.141
0.782AspTrp: 0.782 ± 0.387
2.347AspTyr: 2.347 ± 0.774
0.0AspXaa: 0.0 ± 0.0
Glu
1.956GluAla: 1.956 ± 1.012
1.565GluCys: 1.565 ± 1.13
4.304GluAsp: 4.304 ± 0.837
7.825GluGlu: 7.825 ± 2.963
1.565GluPhe: 1.565 ± 0.612
4.695GluGly: 4.695 ± 1.287
0.782GluHis: 0.782 ± 0.387
3.13GluIle: 3.13 ± 1.401
3.13GluLys: 3.13 ± 1.032
5.869GluLeu: 5.869 ± 1.903
0.782GluMet: 0.782 ± 0.459
3.521GluAsn: 3.521 ± 0.8
3.521GluPro: 3.521 ± 1.272
3.521GluGln: 3.521 ± 1.048
3.912GluArg: 3.912 ± 1.382
4.304GluSer: 4.304 ± 1.709
5.086GluThr: 5.086 ± 2.124
5.477GluVal: 5.477 ± 1.284
0.391GluTrp: 0.391 ± 0.351
1.956GluTyr: 1.956 ± 1.024
0.0GluXaa: 0.0 ± 0.0
Phe
1.565PheAla: 1.565 ± 0.5
0.782PheCys: 0.782 ± 0.567
4.304PheAsp: 4.304 ± 0.483
4.304PheGlu: 4.304 ± 1.831
1.174PhePhe: 1.174 ± 0.379
1.565PheGly: 1.565 ± 0.627
0.782PheHis: 0.782 ± 0.454
1.956PheIle: 1.956 ± 0.737
1.956PheLys: 1.956 ± 1.149
3.521PheLeu: 3.521 ± 1.229
0.782PheMet: 0.782 ± 0.457
1.565PheAsn: 1.565 ± 0.999
3.521PhePro: 3.521 ± 1.065
2.739PheGln: 2.739 ± 0.509
1.956PheArg: 1.956 ± 0.53
2.347PheSer: 2.347 ± 0.947
1.565PheThr: 1.565 ± 0.645
1.956PheVal: 1.956 ± 0.949
1.565PheTrp: 1.565 ± 0.719
1.174PheTyr: 1.174 ± 0.443
0.0PheXaa: 0.0 ± 0.0
Gly
3.521GlyAla: 3.521 ± 1.274
1.956GlyCys: 1.956 ± 0.571
3.13GlyAsp: 3.13 ± 0.719
4.304GlyGlu: 4.304 ± 1.416
0.782GlyPhe: 0.782 ± 0.716
6.651GlyGly: 6.651 ± 2.449
3.912GlyHis: 3.912 ± 0.618
1.956GlyIle: 1.956 ± 0.662
3.13GlyLys: 3.13 ± 0.742
3.521GlyLeu: 3.521 ± 0.8
0.0GlyMet: 0.0 ± 0.0
1.956GlyAsn: 1.956 ± 0.495
4.695GlyPro: 4.695 ± 2.182
3.13GlyGln: 3.13 ± 0.533
5.086GlyArg: 5.086 ± 1.796
3.13GlySer: 3.13 ± 0.819
3.13GlyThr: 3.13 ± 0.826
5.086GlyVal: 5.086 ± 0.895
0.391GlyTrp: 0.391 ± 0.282
1.565GlyTyr: 1.565 ± 0.652
0.0GlyXaa: 0.0 ± 0.0
His
1.174HisAla: 1.174 ± 0.401
1.174HisCys: 1.174 ± 0.654
1.565HisAsp: 1.565 ± 0.999
1.174HisGlu: 1.174 ± 0.756
0.782HisPhe: 0.782 ± 0.387
1.565HisGly: 1.565 ± 0.535
1.565HisHis: 1.565 ± 0.899
1.174HisIle: 1.174 ± 0.69
1.565HisLys: 1.565 ± 0.688
0.0HisLeu: 0.0 ± 0.0
0.0HisMet: 0.0 ± 0.0
1.565HisAsn: 1.565 ± 0.627
1.956HisPro: 1.956 ± 0.849
0.782HisGln: 0.782 ± 0.428
0.391HisArg: 0.391 ± 0.282
1.565HisSer: 1.565 ± 0.675
0.782HisThr: 0.782 ± 0.422
2.347HisVal: 2.347 ± 0.759
1.565HisTrp: 1.565 ± 0.666
0.391HisTyr: 0.391 ± 0.43
0.0HisXaa: 0.0 ± 0.0
Ile
1.565IleAla: 1.565 ± 0.584
0.782IleCys: 0.782 ± 0.567
2.739IleAsp: 2.739 ± 1.176
5.086IleGlu: 5.086 ± 2.642
1.565IlePhe: 1.565 ± 0.471
3.912IleGly: 3.912 ± 1.285
1.956IleHis: 1.956 ± 0.713
4.304IleIle: 4.304 ± 1.159
1.174IleLys: 1.174 ± 0.61
4.304IleLeu: 4.304 ± 0.823
1.565IleMet: 1.565 ± 0.582
1.174IleAsn: 1.174 ± 0.379
2.347IlePro: 2.347 ± 1.343
2.347IleGln: 2.347 ± 0.994
2.347IleArg: 2.347 ± 0.932
5.869IleSer: 5.869 ± 0.699
0.391IleThr: 0.391 ± 0.282
3.912IleVal: 3.912 ± 1.128
1.174IleTrp: 1.174 ± 0.68
2.347IleTyr: 2.347 ± 0.572
0.0IleXaa: 0.0 ± 0.0
Lys
3.521LysAla: 3.521 ± 0.664
0.782LysCys: 0.782 ± 0.403
3.13LysAsp: 3.13 ± 1.878
1.956LysGlu: 1.956 ± 1.012
3.912LysPhe: 3.912 ± 1.111
2.739LysGly: 2.739 ± 0.637
1.565LysHis: 1.565 ± 0.748
3.13LysIle: 3.13 ± 0.855
2.347LysLys: 2.347 ± 1.243
5.869LysLeu: 5.869 ± 1.561
0.391LysMet: 0.391 ± 0.358
1.174LysAsn: 1.174 ± 0.549
1.174LysPro: 1.174 ± 1.053
1.565LysGln: 1.565 ± 0.702
5.477LysArg: 5.477 ± 0.555
4.695LysSer: 4.695 ± 1.561
1.956LysThr: 1.956 ± 0.65
1.565LysVal: 1.565 ± 0.471
0.391LysTrp: 0.391 ± 0.539
2.347LysTyr: 2.347 ± 0.757
0.0LysXaa: 0.0 ± 0.0
Leu
4.304LeuAla: 4.304 ± 0.932
2.739LeuCys: 2.739 ± 1.112
4.695LeuAsp: 4.695 ± 1.035
8.607LeuGlu: 8.607 ± 0.891
3.521LeuPhe: 3.521 ± 1.095
4.695LeuGly: 4.695 ± 1.427
2.347LeuHis: 2.347 ± 0.942
4.304LeuIle: 4.304 ± 1.472
4.695LeuLys: 4.695 ± 1.422
9.781LeuLeu: 9.781 ± 2.478
1.956LeuMet: 1.956 ± 0.729
2.347LeuAsn: 2.347 ± 0.371
4.695LeuPro: 4.695 ± 1.673
6.26LeuGln: 6.26 ± 1.888
3.521LeuArg: 3.521 ± 0.833
6.26LeuSer: 6.26 ± 0.955
6.651LeuThr: 6.651 ± 0.989
3.912LeuVal: 3.912 ± 1.078
1.174LeuTrp: 1.174 ± 0.66
1.174LeuTyr: 1.174 ± 0.424
0.0LeuXaa: 0.0 ± 0.0
Met
0.782MetAla: 0.782 ± 0.463
0.0MetCys: 0.0 ± 0.0
1.174MetAsp: 1.174 ± 0.424
0.782MetGlu: 0.782 ± 0.702
1.174MetPhe: 1.174 ± 0.66
0.782MetGly: 0.782 ± 0.454
0.0MetHis: 0.0 ± 0.0
1.565MetIle: 1.565 ± 0.954
1.565MetLys: 1.565 ± 0.884
1.565MetLeu: 1.565 ± 1.102
0.391MetMet: 0.391 ± 0.539
1.565MetAsn: 1.565 ± 0.719
0.0MetPro: 0.0 ± 0.0
1.174MetGln: 1.174 ± 1.172
1.956MetArg: 1.956 ± 0.6
2.739MetSer: 2.739 ± 1.012
1.565MetThr: 1.565 ± 0.999
1.174MetVal: 1.174 ± 0.519
0.391MetTrp: 0.391 ± 0.539
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.565AsnAla: 1.565 ± 0.627
0.391AsnCys: 0.391 ± 0.282
1.565AsnAsp: 1.565 ± 0.605
1.565AsnGlu: 1.565 ± 0.533
2.347AsnPhe: 2.347 ± 0.74
2.739AsnGly: 2.739 ± 0.904
0.782AsnHis: 0.782 ± 0.36
2.739AsnIle: 2.739 ± 1.036
2.739AsnLys: 2.739 ± 1.212
0.391AsnLeu: 0.391 ± 0.388
0.0AsnMet: 0.0 ± 0.0
1.565AsnAsn: 1.565 ± 0.999
3.13AsnPro: 3.13 ± 1.081
1.174AsnGln: 1.174 ± 0.865
1.956AsnArg: 1.956 ± 0.597
3.13AsnSer: 3.13 ± 1.123
2.739AsnThr: 2.739 ± 1.2
2.739AsnVal: 2.739 ± 0.642
0.391AsnTrp: 0.391 ± 0.358
0.782AsnTyr: 0.782 ± 0.36
0.0AsnXaa: 0.0 ± 0.0
Pro
4.695ProAla: 4.695 ± 0.92
1.174ProCys: 1.174 ± 0.549
5.086ProAsp: 5.086 ± 1.255
3.912ProGlu: 3.912 ± 1.6
2.347ProPhe: 2.347 ± 0.832
2.347ProGly: 2.347 ± 1.208
0.391ProHis: 0.391 ± 0.539
2.347ProIle: 2.347 ± 1.034
2.739ProLys: 2.739 ± 0.642
7.433ProLeu: 7.433 ± 1.054
0.782ProMet: 0.782 ± 0.387
1.565ProAsn: 1.565 ± 0.605
8.607ProPro: 8.607 ± 3.009
1.565ProGln: 1.565 ± 1.559
1.956ProArg: 1.956 ± 0.669
4.695ProSer: 4.695 ± 2.283
6.651ProThr: 6.651 ± 3.141
4.695ProVal: 4.695 ± 1.205
0.391ProTrp: 0.391 ± 0.351
1.174ProTyr: 1.174 ± 0.521
0.0ProXaa: 0.0 ± 0.0
Gln
1.565GlnAla: 1.565 ± 0.961
0.782GlnCys: 0.782 ± 0.36
1.956GlnAsp: 1.956 ± 0.466
3.912GlnGlu: 3.912 ± 0.673
3.521GlnPhe: 3.521 ± 1.1
2.347GlnGly: 2.347 ± 0.877
1.174GlnHis: 1.174 ± 0.73
2.347GlnIle: 2.347 ± 0.493
1.174GlnLys: 1.174 ± 0.665
6.651GlnLeu: 6.651 ± 1.5
2.739GlnMet: 2.739 ± 1.055
2.347GlnAsn: 2.347 ± 0.861
1.956GlnPro: 1.956 ± 0.808
4.304GlnGln: 4.304 ± 1.566
4.304GlnArg: 4.304 ± 1.462
2.347GlnSer: 2.347 ± 0.814
2.347GlnThr: 2.347 ± 0.77
1.956GlnVal: 1.956 ± 0.576
0.391GlnTrp: 0.391 ± 0.282
2.739GlnTyr: 2.739 ± 1.007
0.0GlnXaa: 0.0 ± 0.0
Arg
5.086ArgAla: 5.086 ± 1.212
1.565ArgCys: 1.565 ± 0.961
3.13ArgAsp: 3.13 ± 1.004
4.695ArgGlu: 4.695 ± 0.629
2.739ArgPhe: 2.739 ± 0.766
3.13ArgGly: 3.13 ± 1.13
2.347ArgHis: 2.347 ± 0.746
1.956ArgIle: 1.956 ± 0.495
4.304ArgLys: 4.304 ± 0.851
5.869ArgLeu: 5.869 ± 1.16
1.174ArgMet: 1.174 ± 0.574
1.565ArgAsn: 1.565 ± 0.729
2.739ArgPro: 2.739 ± 1.31
3.912ArgGln: 3.912 ± 1.962
7.042ArgArg: 7.042 ± 1.938
7.042ArgSer: 7.042 ± 3.45
3.521ArgThr: 3.521 ± 0.694
2.739ArgVal: 2.739 ± 1.778
0.782ArgTrp: 0.782 ± 0.581
2.347ArgTyr: 2.347 ± 0.974
0.0ArgXaa: 0.0 ± 0.0
Ser
3.912SerAla: 3.912 ± 0.682
0.782SerCys: 0.782 ± 0.517
5.086SerAsp: 5.086 ± 1.147
3.13SerGlu: 3.13 ± 1.185
3.521SerPhe: 3.521 ± 0.8
7.433SerGly: 7.433 ± 1.08
0.391SerHis: 0.391 ± 0.282
3.912SerIle: 3.912 ± 0.722
3.912SerLys: 3.912 ± 1.028
9.39SerLeu: 9.39 ± 0.612
1.956SerMet: 1.956 ± 1.311
3.13SerAsn: 3.13 ± 0.696
5.086SerPro: 5.086 ± 1.459
2.739SerGln: 2.739 ± 0.631
5.869SerArg: 5.869 ± 1.995
3.521SerSer: 3.521 ± 0.964
5.086SerThr: 5.086 ± 2.673
3.912SerVal: 3.912 ± 1.492
0.782SerTrp: 0.782 ± 0.428
1.956SerTyr: 1.956 ± 0.943
0.0SerXaa: 0.0 ± 0.0
Thr
1.956ThrAla: 1.956 ± 0.677
1.174ThrCys: 1.174 ± 0.424
7.042ThrAsp: 7.042 ± 1.264
3.521ThrGlu: 3.521 ± 0.716
3.13ThrPhe: 3.13 ± 0.661
3.13ThrGly: 3.13 ± 0.728
0.782ThrHis: 0.782 ± 0.422
3.13ThrIle: 3.13 ± 2.112
1.565ThrLys: 1.565 ± 0.686
4.304ThrLeu: 4.304 ± 1.391
1.174ThrMet: 1.174 ± 0.522
0.782ThrAsn: 0.782 ± 0.403
6.651ThrPro: 6.651 ± 2.479
3.521ThrGln: 3.521 ± 0.847
3.13ThrArg: 3.13 ± 1.165
5.086ThrSer: 5.086 ± 1.69
1.956ThrThr: 1.956 ± 0.954
6.26ThrVal: 6.26 ± 1.507
0.782ThrTrp: 0.782 ± 0.702
1.956ThrTyr: 1.956 ± 0.601
0.0ThrXaa: 0.0 ± 0.0
Val
3.13ValAla: 3.13 ± 0.739
0.782ValCys: 0.782 ± 0.36
3.13ValAsp: 3.13 ± 0.393
5.086ValGlu: 5.086 ± 1.339
2.739ValPhe: 2.739 ± 0.99
5.477ValGly: 5.477 ± 0.822
1.565ValHis: 1.565 ± 0.29
2.347ValIle: 2.347 ± 0.927
1.174ValLys: 1.174 ± 0.521
2.347ValLeu: 2.347 ± 1.354
0.782ValMet: 0.782 ± 0.428
1.956ValAsn: 1.956 ± 0.495
3.521ValPro: 3.521 ± 1.041
3.13ValGln: 3.13 ± 1.218
5.086ValArg: 5.086 ± 1.236
4.304ValSer: 4.304 ± 0.997
5.086ValThr: 5.086 ± 2.209
2.739ValVal: 2.739 ± 1.202
0.782ValTrp: 0.782 ± 0.403
3.521ValTyr: 3.521 ± 0.551
0.0ValXaa: 0.0 ± 0.0
Trp
1.565TrpAla: 1.565 ± 0.533
0.0TrpCys: 0.0 ± 0.0
0.391TrpAsp: 0.391 ± 0.358
0.782TrpGlu: 0.782 ± 0.644
0.391TrpPhe: 0.391 ± 0.282
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.782TrpIle: 0.782 ± 0.565
1.174TrpLys: 1.174 ± 0.726
1.956TrpLeu: 1.956 ± 0.646
0.391TrpMet: 0.391 ± 0.539
0.782TrpAsn: 0.782 ± 0.716
0.0TrpPro: 0.0 ± 0.0
1.174TrpGln: 1.174 ± 0.538
0.391TrpArg: 0.391 ± 0.539
0.782TrpSer: 0.782 ± 0.702
1.956TrpThr: 1.956 ± 0.884
0.782TrpVal: 0.782 ± 0.428
0.0TrpTrp: 0.0 ± 0.0
0.391TrpTyr: 0.391 ± 0.282
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.13TyrAla: 3.13 ± 1.046
0.782TyrCys: 0.782 ± 0.568
0.782TyrAsp: 0.782 ± 0.36
0.782TyrGlu: 0.782 ± 0.428
1.565TyrPhe: 1.565 ± 0.6
2.739TyrGly: 2.739 ± 0.78
1.174TyrHis: 1.174 ± 0.536
2.347TyrIle: 2.347 ± 0.577
1.565TyrLys: 1.565 ± 0.777
3.521TyrLeu: 3.521 ± 1.041
0.782TyrMet: 0.782 ± 0.403
1.174TyrAsn: 1.174 ± 0.576
1.565TyrPro: 1.565 ± 0.627
1.565TyrGln: 1.565 ± 0.708
2.347TyrArg: 2.347 ± 0.962
0.391TyrSer: 0.391 ± 0.358
1.565TyrThr: 1.565 ± 0.494
2.347TyrVal: 2.347 ± 0.693
0.782TyrTrp: 0.782 ± 0.644
3.521TyrTyr: 3.521 ± 1.075
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (2557 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski