Amino acid dipepetide frequency for Salobo virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.808AlaAla: 5.808 ± 3.021
1.515AlaCys: 1.515 ± 0.438
1.768AlaAsp: 1.768 ± 0.415
4.04AlaGlu: 4.04 ± 1.09
1.768AlaPhe: 1.768 ± 0.634
4.545AlaGly: 4.545 ± 0.941
1.515AlaHis: 1.515 ± 0.846
3.03AlaIle: 3.03 ± 1.42
1.768AlaLys: 1.768 ± 0.814
5.051AlaLeu: 5.051 ± 0.572
3.535AlaMet: 3.535 ± 1.347
1.515AlaAsn: 1.515 ± 1.04
2.525AlaPro: 2.525 ± 0.507
0.505AlaGln: 0.505 ± 0.321
4.293AlaArg: 4.293 ± 0.648
5.303AlaSer: 5.303 ± 2.145
2.273AlaThr: 2.273 ± 0.826
4.04AlaVal: 4.04 ± 0.526
0.505AlaTrp: 0.505 ± 0.446
1.768AlaTyr: 1.768 ± 0.552
0.0AlaXaa: 0.0 ± 0.0
Cys
1.01CysAla: 1.01 ± 0.353
1.01CysCys: 1.01 ± 0.353
0.758CysAsp: 0.758 ± 0.219
0.758CysGlu: 0.758 ± 0.481
1.515CysPhe: 1.515 ± 0.824
0.758CysGly: 0.758 ± 0.668
1.01CysHis: 1.01 ± 0.562
1.263CysIle: 1.263 ± 0.704
1.768CysLys: 1.768 ± 0.481
1.768CysLeu: 1.768 ± 0.677
0.758CysMet: 0.758 ± 0.346
1.515CysAsn: 1.515 ± 0.692
1.515CysPro: 1.515 ± 0.564
1.768CysGln: 1.768 ± 0.732
0.505CysArg: 0.505 ± 0.152
4.293CysSer: 4.293 ± 1.382
1.263CysThr: 1.263 ± 0.486
1.515CysVal: 1.515 ± 1.337
0.0CysTrp: 0.0 ± 0.0
1.515CysTyr: 1.515 ± 0.692
0.0CysXaa: 0.0 ± 0.0
Asp
3.283AspAla: 3.283 ± 1.459
1.263AspCys: 1.263 ± 1.114
4.04AspAsp: 4.04 ± 1.494
4.798AspGlu: 4.798 ± 1.856
2.02AspPhe: 2.02 ± 1.262
3.03AspGly: 3.03 ± 0.572
1.515AspHis: 1.515 ± 0.564
2.02AspIle: 2.02 ± 1.387
3.535AspLys: 3.535 ± 1.129
4.293AspLeu: 4.293 ± 0.701
2.02AspMet: 2.02 ± 1.148
2.273AspAsn: 2.273 ± 0.301
2.02AspPro: 2.02 ± 0.553
2.273AspGln: 2.273 ± 0.483
2.02AspArg: 2.02 ± 0.553
4.798AspSer: 4.798 ± 1.443
3.03AspThr: 3.03 ± 0.893
2.273AspVal: 2.273 ± 0.44
1.263AspTrp: 1.263 ± 0.341
1.515AspTyr: 1.515 ± 0.322
0.0AspXaa: 0.0 ± 0.0
Glu
5.051GluAla: 5.051 ± 3.579
1.263GluCys: 1.263 ± 0.486
6.818GluAsp: 6.818 ± 1.26
6.818GluGlu: 6.818 ± 1.972
4.798GluPhe: 4.798 ± 0.686
4.545GluGly: 4.545 ± 1.057
0.253GluHis: 0.253 ± 0.16
4.798GluIle: 4.798 ± 0.52
3.535GluLys: 3.535 ± 0.461
7.071GluLeu: 7.071 ± 1.939
2.02GluMet: 2.02 ± 1.089
3.535GluAsn: 3.535 ± 1.106
1.768GluPro: 1.768 ± 0.814
0.505GluGln: 0.505 ± 0.152
3.283GluArg: 3.283 ± 0.662
5.051GluSer: 5.051 ± 0.537
3.03GluThr: 3.03 ± 0.876
6.061GluVal: 6.061 ± 0.863
0.253GluTrp: 0.253 ± 0.16
1.515GluTyr: 1.515 ± 0.474
0.0GluXaa: 0.0 ± 0.0
Phe
2.778PheAla: 2.778 ± 1.001
1.263PheCys: 1.263 ± 0.486
3.03PheAsp: 3.03 ± 3.301
1.768PheGlu: 1.768 ± 1.117
2.525PhePhe: 2.525 ± 1.289
1.01PheGly: 1.01 ± 0.641
0.505PheHis: 0.505 ± 0.321
3.283PheIle: 3.283 ± 0.633
2.525PheLys: 2.525 ± 1.604
3.535PheLeu: 3.535 ± 0.942
1.263PheMet: 1.263 ± 0.341
3.03PheAsn: 3.03 ± 0.898
2.525PhePro: 2.525 ± 2.014
0.505PheGln: 0.505 ± 0.446
2.02PheArg: 2.02 ± 0.707
4.293PheSer: 4.293 ± 0.822
3.283PheThr: 3.283 ± 0.713
3.283PheVal: 3.283 ± 0.328
0.758PheTrp: 0.758 ± 0.219
0.253PheTyr: 0.253 ± 0.712
0.0PheXaa: 0.0 ± 0.0
Gly
5.303GlyAla: 5.303 ± 1.17
1.263GlyCys: 1.263 ± 0.704
2.778GlyAsp: 2.778 ± 0.774
3.03GlyGlu: 3.03 ± 0.441
3.788GlyPhe: 3.788 ± 0.779
6.313GlyGly: 6.313 ± 1.52
1.263GlyHis: 1.263 ± 0.509
3.535GlyIle: 3.535 ± 0.771
5.303GlyLys: 5.303 ± 1.337
5.303GlyLeu: 5.303 ± 1.057
1.768GlyMet: 1.768 ± 0.411
3.03GlyAsn: 3.03 ± 0.824
2.02GlyPro: 2.02 ± 0.339
2.273GlyGln: 2.273 ± 1.094
2.525GlyArg: 2.525 ± 0.507
4.798GlySer: 4.798 ± 1.3
2.273GlyThr: 2.273 ± 0.428
4.293GlyVal: 4.293 ± 1.345
1.263GlyTrp: 1.263 ± 1.081
2.02GlyTyr: 2.02 ± 1.089
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
1.01HisCys: 1.01 ± 0.304
1.263HisAsp: 1.263 ± 0.341
0.253HisGlu: 0.253 ± 0.16
1.263HisPhe: 1.263 ± 0.5
2.778HisGly: 2.778 ± 0.916
0.0HisHis: 0.0 ± 0.0
1.263HisIle: 1.263 ± 0.502
2.02HisLys: 2.02 ± 1.089
1.768HisLeu: 1.768 ± 0.631
0.0HisMet: 0.0 ± 0.0
1.515HisAsn: 1.515 ± 0.418
1.263HisPro: 1.263 ± 0.771
1.263HisGln: 1.263 ± 0.486
1.263HisArg: 1.263 ± 0.509
1.01HisSer: 1.01 ± 0.304
1.263HisThr: 1.263 ± 0.341
1.263HisVal: 1.263 ± 0.502
0.0HisTrp: 0.0 ± 0.0
1.768HisTyr: 1.768 ± 0.565
0.0HisXaa: 0.0 ± 0.0
Ile
3.03IleAla: 3.03 ± 0.934
1.01IleCys: 1.01 ± 0.304
2.525IleAsp: 2.525 ± 0.958
4.293IleGlu: 4.293 ± 1.045
2.273IlePhe: 2.273 ± 0.657
5.556IleGly: 5.556 ± 2.088
1.263IleHis: 1.263 ± 0.802
3.788IleIle: 3.788 ± 1.073
4.04IleLys: 4.04 ± 1.216
4.545IleLeu: 4.545 ± 0.757
1.515IleMet: 1.515 ± 0.438
2.778IleAsn: 2.778 ± 0.646
2.778IlePro: 2.778 ± 1.81
3.283IleGln: 3.283 ± 0.99
3.03IleArg: 3.03 ± 1.117
4.798IleSer: 4.798 ± 1.373
2.273IleThr: 2.273 ± 0.44
4.293IleVal: 4.293 ± 1.675
1.01IleTrp: 1.01 ± 0.353
1.263IleTyr: 1.263 ± 0.341
0.0IleXaa: 0.0 ± 0.0
Lys
3.03LysAla: 3.03 ± 0.572
3.283LysCys: 3.283 ± 1.905
3.283LysAsp: 3.283 ± 0.493
5.808LysGlu: 5.808 ± 0.56
2.273LysPhe: 2.273 ± 1.13
3.03LysGly: 3.03 ± 0.825
1.515LysHis: 1.515 ± 0.536
4.293LysIle: 4.293 ± 1.815
4.798LysLys: 4.798 ± 1.321
3.283LysLeu: 3.283 ± 0.925
4.293LysMet: 4.293 ± 0.872
2.02LysAsn: 2.02 ± 0.397
5.051LysPro: 5.051 ± 1.166
2.02LysGln: 2.02 ± 0.608
2.273LysArg: 2.273 ± 0.779
4.798LysSer: 4.798 ± 1.721
4.545LysThr: 4.545 ± 1.252
4.293LysVal: 4.293 ± 0.822
1.768LysTrp: 1.768 ± 0.389
1.768LysTyr: 1.768 ± 0.565
0.0LysXaa: 0.0 ± 0.0
Leu
4.293LeuAla: 4.293 ± 0.923
2.273LeuCys: 2.273 ± 0.609
5.051LeuAsp: 5.051 ± 0.852
7.828LeuGlu: 7.828 ± 1.798
3.788LeuPhe: 3.788 ± 1.622
4.545LeuGly: 4.545 ± 0.654
2.273LeuHis: 2.273 ± 0.609
5.303LeuIle: 5.303 ± 2.835
6.313LeuLys: 6.313 ± 1.328
5.808LeuLeu: 5.808 ± 1.01
3.535LeuMet: 3.535 ± 0.91
3.03LeuAsn: 3.03 ± 0.441
1.768LeuPro: 1.768 ± 0.634
2.778LeuGln: 2.778 ± 0.916
5.808LeuArg: 5.808 ± 1.076
9.343LeuSer: 9.343 ± 2.519
3.03LeuThr: 3.03 ± 0.389
5.051LeuVal: 5.051 ± 0.572
0.0LeuTrp: 0.0 ± 0.0
1.263LeuTyr: 1.263 ± 0.509
0.0LeuXaa: 0.0 ± 0.0
Met
1.768MetAla: 1.768 ± 0.376
0.0MetCys: 0.0 ± 0.0
2.273MetAsp: 2.273 ± 0.483
2.273MetGlu: 2.273 ± 0.509
1.01MetPhe: 1.01 ± 0.353
1.768MetGly: 1.768 ± 0.481
1.263MetHis: 1.263 ± 0.638
1.768MetIle: 1.768 ± 0.732
2.02MetLys: 2.02 ± 0.553
4.04MetLeu: 4.04 ± 2.121
1.768MetMet: 1.768 ± 1.046
2.273MetAsn: 2.273 ± 2.536
0.758MetPro: 0.758 ± 0.596
1.515MetGln: 1.515 ± 0.322
1.01MetArg: 1.01 ± 0.353
2.778MetSer: 2.778 ± 0.925
1.768MetThr: 1.768 ± 0.696
4.04MetVal: 4.04 ± 0.527
0.505MetTrp: 0.505 ± 0.152
0.505MetTyr: 0.505 ± 0.321
0.0MetXaa: 0.0 ± 0.0
Asn
2.273AsnAla: 2.273 ± 0.301
0.758AsnCys: 0.758 ± 0.219
0.758AsnAsp: 0.758 ± 0.481
3.788AsnGlu: 3.788 ± 2.39
2.273AsnPhe: 2.273 ± 1.163
2.778AsnGly: 2.778 ± 0.329
0.758AsnHis: 0.758 ± 0.219
1.515AsnIle: 1.515 ± 0.418
4.04AsnLys: 4.04 ± 0.931
4.04AsnLeu: 4.04 ± 1.494
1.263AsnMet: 1.263 ± 0.5
2.778AsnAsn: 2.778 ± 0.459
3.283AsnPro: 3.283 ± 0.992
0.758AsnGln: 0.758 ± 0.346
3.03AsnArg: 3.03 ± 0.976
2.02AsnSer: 2.02 ± 0.339
1.768AsnThr: 1.768 ± 0.437
2.273AsnVal: 2.273 ± 0.661
0.0AsnTrp: 0.0 ± 0.0
1.768AsnTyr: 1.768 ± 0.935
0.0AsnXaa: 0.0 ± 0.0
Pro
1.768ProAla: 1.768 ± 0.415
0.758ProCys: 0.758 ± 0.864
4.04ProAsp: 4.04 ± 0.68
4.293ProGlu: 4.293 ± 1.416
1.263ProPhe: 1.263 ± 0.704
2.778ProGly: 2.778 ± 1.251
0.0ProHis: 0.0 ± 0.0
2.525ProIle: 2.525 ± 0.683
3.03ProLys: 3.03 ± 0.825
3.788ProLeu: 3.788 ± 1.013
1.515ProMet: 1.515 ± 0.322
1.263ProAsn: 1.263 ± 0.687
1.263ProPro: 1.263 ± 0.782
1.263ProGln: 1.263 ± 0.502
2.02ProArg: 2.02 ± 1.153
3.535ProSer: 3.535 ± 0.622
2.273ProThr: 2.273 ± 1.122
3.535ProVal: 3.535 ± 1.583
1.263ProTrp: 1.263 ± 0.723
1.263ProTyr: 1.263 ± 0.786
0.0ProXaa: 0.0 ± 0.0
Gln
2.525GlnAla: 2.525 ± 0.876
1.01GlnCys: 1.01 ± 0.562
1.01GlnAsp: 1.01 ± 0.353
1.263GlnGlu: 1.263 ± 0.341
0.758GlnPhe: 0.758 ± 0.331
2.273GlnGly: 2.273 ± 0.615
1.515GlnHis: 1.515 ± 0.438
2.778GlnIle: 2.778 ± 0.916
2.525GlnLys: 2.525 ± 0.507
1.515GlnLeu: 1.515 ± 1.186
0.505GlnMet: 0.505 ± 0.152
1.01GlnAsn: 1.01 ± 0.353
1.515GlnPro: 1.515 ± 0.664
1.01GlnGln: 1.01 ± 0.515
0.758GlnArg: 0.758 ± 0.481
2.273GlnSer: 2.273 ± 0.657
3.03GlnThr: 3.03 ± 1.407
2.02GlnVal: 2.02 ± 0.424
0.253GlnTrp: 0.253 ± 0.16
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
3.535ArgAla: 3.535 ± 0.125
1.01ArgCys: 1.01 ± 0.562
2.02ArgAsp: 2.02 ± 0.949
2.778ArgGlu: 2.778 ± 0.276
0.505ArgPhe: 0.505 ± 0.321
2.02ArgGly: 2.02 ± 0.901
1.515ArgHis: 1.515 ± 0.456
4.293ArgIle: 4.293 ± 0.417
4.04ArgLys: 4.04 ± 0.882
4.545ArgLeu: 4.545 ± 1.044
1.768ArgMet: 1.768 ± 1.117
1.515ArgAsn: 1.515 ± 0.438
3.03ArgPro: 3.03 ± 0.82
1.01ArgGln: 1.01 ± 0.665
2.778ArgArg: 2.778 ± 0.646
4.545ArgSer: 4.545 ± 1.413
3.283ArgThr: 3.283 ± 0.662
5.051ArgVal: 5.051 ± 1.228
1.263ArgTrp: 1.263 ± 0.509
1.01ArgTyr: 1.01 ± 0.353
0.0ArgXaa: 0.0 ± 0.0
Ser
4.293SerAla: 4.293 ± 1.1
2.273SerCys: 2.273 ± 1.669
5.303SerAsp: 5.303 ± 1.168
7.071SerGlu: 7.071 ± 1.492
3.535SerPhe: 3.535 ± 0.951
6.313SerGly: 6.313 ± 1.674
2.02SerHis: 2.02 ± 0.608
5.051SerIle: 5.051 ± 1.52
5.303SerLys: 5.303 ± 1.909
8.081SerLeu: 8.081 ± 1.495
1.768SerMet: 1.768 ± 0.481
2.273SerAsn: 2.273 ± 0.509
3.535SerPro: 3.535 ± 0.941
2.525SerGln: 2.525 ± 0.625
5.051SerArg: 5.051 ± 1.434
11.616SerSer: 11.616 ± 3.32
4.545SerThr: 4.545 ± 0.239
4.04SerVal: 4.04 ± 0.205
1.515SerTrp: 1.515 ± 1.192
2.02SerTyr: 2.02 ± 0.553
0.0SerXaa: 0.0 ± 0.0
Thr
1.515ThrAla: 1.515 ± 0.456
2.02ThrCys: 2.02 ± 1.232
2.273ThrAsp: 2.273 ± 0.44
3.535ThrGlu: 3.535 ± 0.771
3.535ThrPhe: 3.535 ± 0.557
2.778ThrGly: 2.778 ± 0.929
1.01ThrHis: 1.01 ± 0.353
3.535ThrIle: 3.535 ± 1.226
3.283ThrLys: 3.283 ± 0.72
5.556ThrLeu: 5.556 ± 1.344
1.263ThrMet: 1.263 ± 0.687
1.768ThrAsn: 1.768 ± 0.389
3.283ThrPro: 3.283 ± 0.539
0.758ThrGln: 0.758 ± 0.481
2.778ThrArg: 2.778 ± 0.332
3.03ThrSer: 3.03 ± 1.058
4.293ThrThr: 4.293 ± 0.137
4.293ThrVal: 4.293 ± 0.767
0.505ThrTrp: 0.505 ± 0.693
1.515ThrTyr: 1.515 ± 2.198
0.0ThrXaa: 0.0 ± 0.0
Val
4.04ValAla: 4.04 ± 1.09
1.768ValCys: 1.768 ± 0.481
3.788ValAsp: 3.788 ± 1.09
5.051ValGlu: 5.051 ± 0.696
3.03ValPhe: 3.03 ± 0.8
5.051ValGly: 5.051 ± 1.253
2.525ValHis: 2.525 ± 0.583
3.788ValIle: 3.788 ± 0.056
4.798ValLys: 4.798 ± 0.571
5.556ValLeu: 5.556 ± 0.65
3.03ValMet: 3.03 ± 0.598
2.778ValAsn: 2.778 ± 0.648
1.515ValPro: 1.515 ± 0.657
2.02ValGln: 2.02 ± 0.493
4.545ValArg: 4.545 ± 0.968
6.818ValSer: 6.818 ± 1.282
2.525ValThr: 2.525 ± 0.507
5.556ValVal: 5.556 ± 1.18
0.253ValTrp: 0.253 ± 0.16
2.273ValTyr: 2.273 ± 0.626
0.0ValXaa: 0.0 ± 0.0
Trp
1.01TrpAla: 1.01 ± 0.353
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.505TrpGlu: 0.505 ± 0.321
0.505TrpPhe: 0.505 ± 0.659
1.01TrpGly: 1.01 ± 0.53
0.0TrpHis: 0.0 ± 0.0
0.758TrpIle: 0.758 ± 0.596
1.01TrpLys: 1.01 ± 0.791
1.01TrpLeu: 1.01 ± 0.304
0.505TrpMet: 0.505 ± 0.152
0.758TrpAsn: 0.758 ± 0.346
0.505TrpPro: 0.505 ± 0.659
0.505TrpGln: 0.505 ± 0.152
0.505TrpArg: 0.505 ± 0.152
0.505TrpSer: 0.505 ± 0.152
1.515TrpThr: 1.515 ± 0.474
1.768TrpVal: 1.768 ± 0.68
0.253TrpTrp: 0.253 ± 0.16
0.253TrpTyr: 0.253 ± 0.16
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.758TyrAla: 0.758 ± 0.828
1.515TyrCys: 1.515 ± 0.792
0.505TyrAsp: 0.505 ± 0.321
2.02TyrGlu: 2.02 ± 0.553
1.01TyrPhe: 1.01 ± 0.641
1.515TyrGly: 1.515 ± 0.641
0.505TyrHis: 0.505 ± 0.321
0.758TyrIle: 0.758 ± 0.219
1.768TyrLys: 1.768 ± 0.481
2.525TyrLeu: 2.525 ± 0.986
0.758TyrMet: 0.758 ± 0.219
1.263TyrAsn: 1.263 ± 0.509
1.515TyrPro: 1.515 ± 1.412
1.01TyrGln: 1.01 ± 0.428
2.02TyrArg: 2.02 ± 1.844
2.525TyrSer: 2.525 ± 0.913
1.263TyrThr: 1.263 ± 0.509
1.768TyrVal: 1.768 ± 1.123
0.253TyrTrp: 0.253 ± 0.223
0.758TyrTyr: 0.758 ± 0.596
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (3961 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski