Amino acid dipepetide frequency for Hepatospora eriocheir

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.076AlaAla: 1.076 ± 0.051
0.521AlaCys: 0.521 ± 0.03
1.307AlaAsp: 1.307 ± 0.044
1.453AlaGlu: 1.453 ± 0.057
1.552AlaPhe: 1.552 ± 0.046
1.007AlaGly: 1.007 ± 0.046
0.43AlaHis: 0.43 ± 0.029
2.62AlaIle: 2.62 ± 0.069
2.47AlaLys: 2.47 ± 0.066
2.656AlaLeu: 2.656 ± 0.068
0.539AlaMet: 0.539 ± 0.036
1.673AlaAsn: 1.673 ± 0.056
0.566AlaPro: 0.566 ± 0.038
0.585AlaGln: 0.585 ± 0.035
0.911AlaArg: 0.911 ± 0.045
1.74AlaSer: 1.74 ± 0.049
1.237AlaThr: 1.237 ± 0.046
1.721AlaVal: 1.721 ± 0.055
0.113AlaTrp: 0.113 ± 0.014
1.163AlaTyr: 1.163 ± 0.046
0.01AlaXaa: 0.01 ± 0.004
Cys
0.394CysAla: 0.394 ± 0.026
0.39CysCys: 0.39 ± 0.023
1.018CysAsp: 1.018 ± 0.047
1.111CysGlu: 1.111 ± 0.043
1.133CysPhe: 1.133 ± 0.047
0.829CysGly: 0.829 ± 0.039
0.233CysHis: 0.233 ± 0.021
1.536CysIle: 1.536 ± 0.049
1.852CysLys: 1.852 ± 0.049
1.863CysLeu: 1.863 ± 0.052
0.308CysMet: 0.308 ± 0.021
1.237CysAsn: 1.237 ± 0.047
0.419CysPro: 0.419 ± 0.028
0.338CysGln: 0.338 ± 0.024
0.526CysArg: 0.526 ± 0.025
1.163CysSer: 1.163 ± 0.046
0.65CysThr: 0.65 ± 0.033
0.966CysVal: 0.966 ± 0.043
0.097CysTrp: 0.097 ± 0.014
0.932CysTyr: 0.932 ± 0.043
0.013CysXaa: 0.013 ± 0.005
Asp
1.3AspAla: 1.3 ± 0.054
0.99AspCys: 0.99 ± 0.044
3.745AspAsp: 3.745 ± 0.096
4.774AspGlu: 4.774 ± 0.082
3.874AspPhe: 3.874 ± 0.085
1.954AspGly: 1.954 ± 0.07
0.843AspHis: 0.843 ± 0.039
5.271AspIle: 5.271 ± 0.101
6.243AspLys: 6.243 ± 0.125
6.175AspLeu: 6.175 ± 0.112
1.095AspMet: 1.095 ± 0.044
4.757AspAsn: 4.757 ± 0.091
1.214AspPro: 1.214 ± 0.047
1.488AspGln: 1.488 ± 0.048
1.769AspArg: 1.769 ± 0.059
4.067AspSer: 4.067 ± 0.082
2.126AspThr: 2.126 ± 0.06
3.182AspVal: 3.182 ± 0.079
0.301AspTrp: 0.301 ± 0.024
2.841AspTyr: 2.841 ± 0.066
0.043AspXaa: 0.043 ± 0.009
Glu
2.022GluAla: 2.022 ± 0.061
1.362GluCys: 1.362 ± 0.045
4.277GluAsp: 4.277 ± 0.095
6.372GluGlu: 6.372 ± 0.138
4.347GluPhe: 4.347 ± 0.095
2.084GluGly: 2.084 ± 0.06
0.942GluHis: 0.942 ± 0.038
7.897GluIle: 7.897 ± 0.12
7.373GluLys: 7.373 ± 0.125
7.067GluLeu: 7.067 ± 0.12
1.982GluMet: 1.982 ± 0.054
6.791GluAsn: 6.791 ± 0.116
1.205GluPro: 1.205 ± 0.041
1.463GluGln: 1.463 ± 0.052
2.513GluArg: 2.513 ± 0.067
5.18GluSer: 5.18 ± 0.105
3.279GluThr: 3.279 ± 0.072
3.726GluVal: 3.726 ± 0.082
0.347GluTrp: 0.347 ± 0.024
3.606GluTyr: 3.606 ± 0.086
0.037GluXaa: 0.037 ± 0.008
Phe
1.28PheAla: 1.28 ± 0.044
0.986PheCys: 0.986 ± 0.039
3.673PheAsp: 3.673 ± 0.085
3.566PheGlu: 3.566 ± 0.082
3.103PhePhe: 3.103 ± 0.09
1.853PheGly: 1.853 ± 0.056
0.757PheHis: 0.757 ± 0.036
7.086PheIle: 7.086 ± 0.122
6.831PheLys: 6.831 ± 0.103
5.76PheLeu: 5.76 ± 0.11
1.275PheMet: 1.275 ± 0.051
6.078PheAsn: 6.078 ± 0.107
1.203PhePro: 1.203 ± 0.038
1.112PheGln: 1.112 ± 0.043
1.643PheArg: 1.643 ± 0.057
3.926PheSer: 3.926 ± 0.09
2.865PheThr: 2.865 ± 0.07
2.879PheVal: 2.879 ± 0.073
0.253PheTrp: 0.253 ± 0.022
3.6PheTyr: 3.6 ± 0.071
0.038PheXaa: 0.038 ± 0.008
Gly
0.998GlyAla: 0.998 ± 0.047
0.792GlyCys: 0.792 ± 0.039
1.748GlyAsp: 1.748 ± 0.062
2.022GlyGlu: 2.022 ± 0.059
1.978GlyPhe: 1.978 ± 0.061
1.458GlyGly: 1.458 ± 0.059
0.604GlyHis: 0.604 ± 0.031
3.377GlyIle: 3.377 ± 0.083
3.273GlyLys: 3.273 ± 0.086
3.227GlyLeu: 3.227 ± 0.066
0.849GlyMet: 0.849 ± 0.05
2.154GlyAsn: 2.154 ± 0.062
0.645GlyPro: 0.645 ± 0.039
0.682GlyGln: 0.682 ± 0.033
1.332GlyArg: 1.332 ± 0.051
2.416GlySer: 2.416 ± 0.079
1.554GlyThr: 1.554 ± 0.058
2.123GlyVal: 2.123 ± 0.057
0.204GlyTrp: 0.204 ± 0.017
1.633GlyTyr: 1.633 ± 0.051
0.022GlyXaa: 0.022 ± 0.006
His
0.384HisAla: 0.384 ± 0.028
0.303HisCys: 0.303 ± 0.02
0.671HisAsp: 0.671 ± 0.035
0.798HisGlu: 0.798 ± 0.034
0.947HisPhe: 0.947 ± 0.037
0.556HisGly: 0.556 ± 0.034
0.335HisHis: 0.335 ± 0.03
1.241HisIle: 1.241 ± 0.046
1.423HisLys: 1.423 ± 0.053
1.718HisLeu: 1.718 ± 0.051
0.268HisMet: 0.268 ± 0.021
1.09HisAsn: 1.09 ± 0.037
0.507HisPro: 0.507 ± 0.026
0.416HisGln: 0.416 ± 0.025
0.585HisArg: 0.585 ± 0.029
1.141HisSer: 1.141 ± 0.039
0.698HisThr: 0.698 ± 0.036
0.821HisVal: 0.821 ± 0.037
0.092HisTrp: 0.092 ± 0.012
0.728HisTyr: 0.728 ± 0.035
0.003HisXaa: 0.003 ± 0.002
Ile
2.534IleAla: 2.534 ± 0.061
1.707IleCys: 1.707 ± 0.052
6.565IleAsp: 6.565 ± 0.105
8.087IleGlu: 8.087 ± 0.142
5.65IlePhe: 5.65 ± 0.12
3.155IleGly: 3.155 ± 0.073
1.48IleHis: 1.48 ± 0.051
9.178IleIle: 9.178 ± 0.167
12.077IleLys: 12.077 ± 0.148
9.768IleLeu: 9.768 ± 0.138
1.782IleMet: 1.782 ± 0.062
9.107IleAsn: 9.107 ± 0.135
2.416IlePro: 2.416 ± 0.06
2.449IleGln: 2.449 ± 0.067
3.286IleArg: 3.286 ± 0.073
6.908IleSer: 6.908 ± 0.1
4.672IleThr: 4.672 ± 0.097
4.736IleVal: 4.736 ± 0.101
0.435IleTrp: 0.435 ± 0.026
4.379IleTyr: 4.379 ± 0.097
0.054IleXaa: 0.054 ± 0.01
Lys
2.65LysAla: 2.65 ± 0.069
1.59LysCys: 1.59 ± 0.053
6.143LysAsp: 6.143 ± 0.114
9.857LysGlu: 9.857 ± 0.161
5.542LysPhe: 5.542 ± 0.091
3.192LysGly: 3.192 ± 0.076
1.703LysHis: 1.703 ± 0.058
11.272LysIle: 11.272 ± 0.152
10.786LysLys: 10.786 ± 0.186
10.241LysLeu: 10.241 ± 0.149
2.762LysMet: 2.762 ± 0.077
9.523LysAsn: 9.523 ± 0.143
2.111LysPro: 2.111 ± 0.053
2.797LysGln: 2.797 ± 0.072
3.917LysArg: 3.917 ± 0.089
7.392LysSer: 7.392 ± 0.147
5.062LysThr: 5.062 ± 0.09
5.493LysVal: 5.493 ± 0.099
0.475LysTrp: 0.475 ± 0.031
5.106LysTyr: 5.106 ± 0.1
0.054LysXaa: 0.054 ± 0.009
Leu
2.693LeuAla: 2.693 ± 0.064
1.638LeuCys: 1.638 ± 0.054
5.066LeuAsp: 5.066 ± 0.087
6.728LeuGlu: 6.728 ± 0.12
6.109LeuPhe: 6.109 ± 0.11
3.024LeuGly: 3.024 ± 0.075
1.278LeuHis: 1.278 ± 0.045
10.997LeuIle: 10.997 ± 0.176
11.773LeuLys: 11.773 ± 0.142
10.259LeuLeu: 10.259 ± 0.183
1.965LeuMet: 1.965 ± 0.06
9.304LeuAsn: 9.304 ± 0.124
2.221LeuPro: 2.221 ± 0.061
2.043LeuGln: 2.043 ± 0.066
3.34LeuArg: 3.34 ± 0.062
7.118LeuSer: 7.118 ± 0.119
4.788LeuThr: 4.788 ± 0.094
4.957LeuVal: 4.957 ± 0.088
0.403LeuTrp: 0.403 ± 0.027
4.124LeuTyr: 4.124 ± 0.091
0.064LeuXaa: 0.064 ± 0.01
Met
0.706MetAla: 0.706 ± 0.033
0.33MetCys: 0.33 ± 0.023
0.848MetAsp: 0.848 ± 0.039
1.256MetGlu: 1.256 ± 0.048
1.45MetPhe: 1.45 ± 0.055
0.817MetGly: 0.817 ± 0.042
0.249MetHis: 0.249 ± 0.021
2.655MetIle: 2.655 ± 0.083
2.527MetLys: 2.527 ± 0.069
2.011MetLeu: 2.011 ± 0.058
0.492MetMet: 0.492 ± 0.043
2.13MetAsn: 2.13 ± 0.074
0.462MetPro: 0.462 ± 0.031
0.39MetGln: 0.39 ± 0.028
0.763MetArg: 0.763 ± 0.033
1.433MetSer: 1.433 ± 0.054
1.025MetThr: 1.025 ± 0.04
1.1MetVal: 1.1 ± 0.041
0.083MetTrp: 0.083 ± 0.011
0.776MetTyr: 0.776 ± 0.036
0.008MetXaa: 0.008 ± 0.004
Asn
1.622AsnAla: 1.622 ± 0.051
1.316AsnCys: 1.316 ± 0.046
5.729AsnAsp: 5.729 ± 0.097
7.099AsnGlu: 7.099 ± 0.138
4.973AsnPhe: 4.973 ± 0.088
2.462AsnGly: 2.462 ± 0.068
1.27AsnHis: 1.27 ± 0.049
8.179AsnIle: 8.179 ± 0.149
9.301AsnLys: 9.301 ± 0.167
8.957AsnLeu: 8.957 ± 0.13
1.842AsnMet: 1.842 ± 0.064
8.786AsnAsn: 8.786 ± 0.192
1.998AsnPro: 1.998 ± 0.076
2.817AsnGln: 2.817 ± 0.083
2.811AsnArg: 2.811 ± 0.073
6.165AsnSer: 6.165 ± 0.107
3.831AsnThr: 3.831 ± 0.091
4.076AsnVal: 4.076 ± 0.09
0.378AsnTrp: 0.378 ± 0.028
4.122AsnTyr: 4.122 ± 0.085
0.056AsnXaa: 0.056 ± 0.009
Pro
0.559ProAla: 0.559 ± 0.035
0.341ProCys: 0.341 ± 0.024
1.149ProAsp: 1.149 ± 0.05
1.584ProGlu: 1.584 ± 0.053
1.552ProPhe: 1.552 ± 0.049
0.749ProGly: 0.749 ± 0.043
0.325ProHis: 0.325 ± 0.021
2.223ProIle: 2.223 ± 0.068
2.057ProLys: 2.057 ± 0.062
2.121ProLeu: 2.121 ± 0.062
0.41ProMet: 0.41 ± 0.026
1.629ProAsn: 1.629 ± 0.059
0.602ProPro: 0.602 ± 0.04
0.545ProGln: 0.545 ± 0.031
0.674ProArg: 0.674 ± 0.037
1.716ProSer: 1.716 ± 0.058
1.123ProThr: 1.123 ± 0.047
1.385ProVal: 1.385 ± 0.05
0.15ProTrp: 0.15 ± 0.017
0.931ProTyr: 0.931 ± 0.044
0.008ProXaa: 0.008 ± 0.003
Gln
0.69GlnAla: 0.69 ± 0.037
0.376GlnCys: 0.376 ± 0.023
1.045GlnAsp: 1.045 ± 0.046
1.638GlnGlu: 1.638 ± 0.058
1.396GlnPhe: 1.396 ± 0.046
0.771GlnGly: 0.771 ± 0.048
0.352GlnHis: 0.352 ± 0.024
2.601GlnIle: 2.601 ± 0.06
2.338GlnLys: 2.338 ± 0.071
2.5GlnLeu: 2.5 ± 0.066
0.709GlnMet: 0.709 ± 0.035
2.072GlnAsn: 2.072 ± 0.063
0.652GlnPro: 0.652 ± 0.044
0.743GlnGln: 0.743 ± 0.048
0.98GlnArg: 0.98 ± 0.041
1.761GlnSer: 1.761 ± 0.054
1.213GlnThr: 1.213 ± 0.048
1.15GlnVal: 1.15 ± 0.041
0.104GlnTrp: 0.104 ± 0.014
0.991GlnTyr: 0.991 ± 0.043
0.006GlnXaa: 0.006 ± 0.003
Arg
0.926ArgAla: 0.926 ± 0.041
0.569ArgCys: 0.569 ± 0.028
1.675ArgAsp: 1.675 ± 0.045
2.393ArgGlu: 2.393 ± 0.06
1.971ArgPhe: 1.971 ± 0.053
1.195ArgGly: 1.195 ± 0.047
0.585ArgHis: 0.585 ± 0.035
3.369ArgIle: 3.369 ± 0.079
3.606ArgLys: 3.606 ± 0.087
3.157ArgLeu: 3.157 ± 0.067
0.878ArgMet: 0.878 ± 0.033
2.902ArgAsn: 2.902 ± 0.076
0.687ArgPro: 0.687 ± 0.034
0.931ArgGln: 0.931 ± 0.044
1.504ArgArg: 1.504 ± 0.067
2.108ArgSer: 2.108 ± 0.062
1.444ArgThr: 1.444 ± 0.046
1.848ArgVal: 1.848 ± 0.054
0.14ArgTrp: 0.14 ± 0.016
1.496ArgTyr: 1.496 ± 0.049
0.01ArgXaa: 0.01 ± 0.004
Ser
1.676SerAla: 1.676 ± 0.062
1.074SerCys: 1.074 ± 0.042
4.392SerAsp: 4.392 ± 0.093
4.828SerGlu: 4.828 ± 0.089
4.414SerPhe: 4.414 ± 0.091
2.427SerGly: 2.427 ± 0.07
0.977SerHis: 0.977 ± 0.042
7.112SerIle: 7.112 ± 0.116
7.638SerLys: 7.638 ± 0.128
7.442SerLeu: 7.442 ± 0.133
1.367SerMet: 1.367 ± 0.043
6.224SerAsn: 6.224 ± 0.114
1.337SerPro: 1.337 ± 0.05
1.66SerGln: 1.66 ± 0.05
2.124SerArg: 2.124 ± 0.058
5.284SerSer: 5.284 ± 0.13
3.15SerThr: 3.15 ± 0.077
3.606SerVal: 3.606 ± 0.083
0.279SerTrp: 0.279 ± 0.023
3.131SerTyr: 3.131 ± 0.074
0.04SerXaa: 0.04 ± 0.008
Thr
1.329ThrAla: 1.329 ± 0.054
0.711ThrCys: 0.711 ± 0.032
2.785ThrAsp: 2.785 ± 0.077
3.131ThrGlu: 3.131 ± 0.068
2.667ThrPhe: 2.667 ± 0.06
1.86ThrGly: 1.86 ± 0.056
0.728ThrHis: 0.728 ± 0.033
4.476ThrIle: 4.476 ± 0.086
4.605ThrLys: 4.605 ± 0.081
4.186ThrLeu: 4.186 ± 0.082
0.782ThrMet: 0.782 ± 0.038
3.749ThrAsn: 3.749 ± 0.089
1.3ThrPro: 1.3 ± 0.052
1.135ThrGln: 1.135 ± 0.046
1.493ThrArg: 1.493 ± 0.046
3.332ThrSer: 3.332 ± 0.076
2.526ThrThr: 2.526 ± 0.094
2.704ThrVal: 2.704 ± 0.075
0.201ThrTrp: 0.201 ± 0.016
1.791ThrTyr: 1.791 ± 0.057
0.022ThrXaa: 0.022 ± 0.006
Val
1.369ValAla: 1.369 ± 0.058
1.036ValCys: 1.036 ± 0.041
3.238ValAsp: 3.238 ± 0.076
3.595ValGlu: 3.595 ± 0.086
3.399ValPhe: 3.399 ± 0.081
1.947ValGly: 1.947 ± 0.071
0.746ValHis: 0.746 ± 0.038
5.192ValIle: 5.192 ± 0.089
5.588ValLys: 5.588 ± 0.093
4.992ValLeu: 4.992 ± 0.1
1.063ValMet: 1.063 ± 0.042
4.411ValAsn: 4.411 ± 0.092
1.184ValPro: 1.184 ± 0.05
1.082ValGln: 1.082 ± 0.043
1.479ValArg: 1.479 ± 0.051
3.722ValSer: 3.722 ± 0.085
2.191ValThr: 2.191 ± 0.066
3.077ValVal: 3.077 ± 0.079
0.263ValTrp: 0.263 ± 0.022
2.507ValTyr: 2.507 ± 0.063
0.032ValXaa: 0.032 ± 0.008
Trp
0.127TrpAla: 0.127 ± 0.013
0.104TrpCys: 0.104 ± 0.014
0.276TrpAsp: 0.276 ± 0.022
0.21TrpGlu: 0.21 ± 0.018
0.336TrpPhe: 0.336 ± 0.022
0.201TrpGly: 0.201 ± 0.017
0.081TrpHis: 0.081 ± 0.012
0.44TrpIle: 0.44 ± 0.026
0.456TrpLys: 0.456 ± 0.03
0.413TrpLeu: 0.413 ± 0.027
0.127TrpMet: 0.127 ± 0.014
0.362TrpAsn: 0.362 ± 0.024
0.105TrpPro: 0.105 ± 0.016
0.076TrpGln: 0.076 ± 0.01
0.188TrpArg: 0.188 ± 0.016
0.325TrpSer: 0.325 ± 0.023
0.202TrpThr: 0.202 ± 0.02
0.269TrpVal: 0.269 ± 0.021
0.027TrpTrp: 0.027 ± 0.007
0.241TrpTyr: 0.241 ± 0.019
0.002TrpXaa: 0.002 ± 0.002
Tyr
1.009TyrAla: 1.009 ± 0.043
0.86TyrCys: 0.86 ± 0.038
2.695TyrAsp: 2.695 ± 0.071
3.346TyrGlu: 3.346 ± 0.084
3.332TyrPhe: 3.332 ± 0.087
1.536TyrGly: 1.536 ± 0.047
0.797TyrHis: 0.797 ± 0.035
3.651TyrIle: 3.651 ± 0.083
5.4TyrLys: 5.4 ± 0.104
5.329TyrLeu: 5.329 ± 0.108
0.934TyrMet: 0.934 ± 0.038
3.778TyrAsn: 3.778 ± 0.076
0.99TyrPro: 0.99 ± 0.043
1.318TyrGln: 1.318 ± 0.052
1.531TyrArg: 1.531 ± 0.052
3.252TyrSer: 3.252 ± 0.077
1.853TyrThr: 1.853 ± 0.058
2.253TyrVal: 2.253 ± 0.059
0.223TyrTrp: 0.223 ± 0.019
2.562TyrTyr: 2.562 ± 0.067
0.029TyrXaa: 0.029 ± 0.007
Xaa
0.006XaaAla: 0.006 ± 0.003
0.01XaaCys: 0.01 ± 0.004
0.008XaaAsp: 0.008 ± 0.003
0.024XaaGlu: 0.024 ± 0.007
0.043XaaPhe: 0.043 ± 0.008
0.013XaaGly: 0.013 ± 0.004
0.01XaaHis: 0.01 ± 0.004
0.053XaaIle: 0.053 ± 0.008
0.051XaaLys: 0.051 ± 0.009
0.051XaaLeu: 0.051 ± 0.008
0.081XaaMet: 0.081 ± 0.013
0.035XaaAsn: 0.035 ± 0.008
0.008XaaPro: 0.008 ± 0.004
0.019XaaGln: 0.019 ± 0.005
0.024XaaArg: 0.024 ± 0.006
0.032XaaSer: 0.032 ± 0.007
0.025XaaThr: 0.025 ± 0.007
0.04XaaVal: 0.04 ± 0.008
0.0XaaTrp: 0.0 ± 0.0
0.018XaaTyr: 0.018 ± 0.005
1.936XaaXaa: 1.936 ± 0.146
Statistics based on 2687 proteins (627558 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski