Amino acid dipepetide frequency for Granulicella rosea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.614AlaAla: 15.614 ± 0.173	0.999AlaCys: 0.999 ± 0.026	5.408AlaAsp: 5.408 ± 0.061	6.342AlaGlu: 6.342 ± 0.085	3.819AlaPhe: 3.819 ± 0.049	10.196AlaGly: 10.196 ± 0.131	2.296AlaHis: 2.296 ± 0.041	5.847AlaIle: 5.847 ± 0.072	4.285AlaLys: 4.285 ± 0.07	11.415AlaLeu: 11.415 ± 0.114	2.839AlaMet: 2.839 ± 0.042	3.733AlaAsn: 3.733 ± 0.054	6.127AlaPro: 6.127 ± 0.087	4.582AlaGln: 4.582 ± 0.071	6.131AlaArg: 6.131 ± 0.088	7.382AlaSer: 7.382 ± 0.096	7.672AlaThr: 7.672 ± 0.118	8.129AlaVal: 8.129 ± 0.095	1.409AlaTrp: 1.409 ± 0.034	2.791AlaTyr: 2.791 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.912CysAla: 0.912 ± 0.027	0.122CysCys: 0.122 ± 0.009	0.423CysAsp: 0.423 ± 0.017	0.396CysGlu: 0.396 ± 0.015	0.35CysPhe: 0.35 ± 0.015	0.897CysGly: 0.897 ± 0.029	0.193CysHis: 0.193 ± 0.015	0.419CysIle: 0.419 ± 0.017	0.24CysLys: 0.24 ± 0.014	0.811CysLeu: 0.811 ± 0.023	0.187CysMet: 0.187 ± 0.012	0.264CysAsn: 0.264 ± 0.013	0.47CysPro: 0.47 ± 0.026	0.216CysGln: 0.216 ± 0.011	0.473CysArg: 0.473 ± 0.018	0.583CysSer: 0.583 ± 0.019	0.572CysThr: 0.572 ± 0.022	0.634CysVal: 0.634 ± 0.021	0.114CysTrp: 0.114 ± 0.009	0.235CysTyr: 0.235 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	5.942AspAla: 5.942 ± 0.069	0.398AspCys: 0.398 ± 0.017	2.415AspAsp: 2.415 ± 0.046	2.928AspGlu: 2.928 ± 0.053	2.001AspPhe: 2.001 ± 0.036	4.607AspGly: 4.607 ± 0.072	1.138AspHis: 1.138 ± 0.03	2.262AspIle: 2.262 ± 0.041	1.711AspLys: 1.711 ± 0.036	5.125AspLeu: 5.125 ± 0.06	0.907AspMet: 0.907 ± 0.023	1.364AspAsn: 1.364 ± 0.032	3.222AspPro: 3.222 ± 0.051	1.69AspGln: 1.69 ± 0.039	3.252AspArg: 3.252 ± 0.051	2.675AspSer: 2.675 ± 0.042	2.698AspThr: 2.698 ± 0.043	3.433AspVal: 3.433 ± 0.059	0.809AspTrp: 0.809 ± 0.022	1.588AspTyr: 1.588 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	5.87GluAla: 5.87 ± 0.083	0.338GluCys: 0.338 ± 0.015	2.473GluAsp: 2.473 ± 0.044	2.852GluGlu: 2.852 ± 0.063	1.908GluPhe: 1.908 ± 0.041	3.484GluGly: 3.484 ± 0.056	1.296GluHis: 1.296 ± 0.03	3.017GluIle: 3.017 ± 0.058	2.155GluLys: 2.155 ± 0.042	5.519GluLeu: 5.519 ± 0.075	1.421GluMet: 1.421 ± 0.032	1.535GluAsn: 1.535 ± 0.031	2.458GluPro: 2.458 ± 0.056	2.295GluGln: 2.295 ± 0.047	3.849GluArg: 3.849 ± 0.055	2.834GluSer: 2.834 ± 0.048	3.066GluThr: 3.066 ± 0.047	3.391GluVal: 3.391 ± 0.056	0.677GluTrp: 0.677 ± 0.024	1.29GluTyr: 1.29 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.38PheAla: 4.38 ± 0.056	0.384PheCys: 0.384 ± 0.016	2.347PheAsp: 2.347 ± 0.039	1.962PheGlu: 1.962 ± 0.037	1.6PhePhe: 1.6 ± 0.038	3.471PheGly: 3.471 ± 0.054	0.917PheHis: 0.917 ± 0.026	1.424PheIle: 1.424 ± 0.03	1.079PheLys: 1.079 ± 0.028	3.442PheLeu: 3.442 ± 0.054	0.648PheMet: 0.648 ± 0.023	1.341PheAsn: 1.341 ± 0.039	1.694PhePro: 1.694 ± 0.036	1.218PheGln: 1.218 ± 0.029	2.027PheArg: 2.027 ± 0.04	2.535PheSer: 2.535 ± 0.046	2.645PheThr: 2.645 ± 0.048	2.587PheVal: 2.587 ± 0.046	0.495PheTrp: 0.495 ± 0.016	1.187PheTyr: 1.187 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	8.764GlyAla: 8.764 ± 0.128	0.903GlyCys: 0.903 ± 0.028	4.012GlyAsp: 4.012 ± 0.056	3.805GlyGlu: 3.805 ± 0.057	3.341GlyPhe: 3.341 ± 0.051	7.246GlyGly: 7.246 ± 0.108	1.805GlyHis: 1.805 ± 0.035	4.279GlyIle: 4.279 ± 0.054	3.537GlyLys: 3.537 ± 0.057	7.678GlyLeu: 7.678 ± 0.079	2.029GlyMet: 2.029 ± 0.038	2.901GlyAsn: 2.901 ± 0.063	3.283GlyPro: 3.283 ± 0.09	2.956GlyGln: 2.956 ± 0.046	4.519GlyArg: 4.519 ± 0.057	5.68GlySer: 5.68 ± 0.093	5.537GlyThr: 5.537 ± 0.099	6.329GlyVal: 6.329 ± 0.077	1.197GlyTrp: 1.197 ± 0.03	2.687GlyTyr: 2.687 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.451HisAla: 2.451 ± 0.042	0.192HisCys: 0.192 ± 0.01	1.164HisAsp: 1.164 ± 0.03	1.151HisGlu: 1.151 ± 0.034	0.919HisPhe: 0.919 ± 0.028	1.991HisGly: 1.991 ± 0.04	0.591HisHis: 0.591 ± 0.02	1.108HisIle: 1.108 ± 0.025	0.573HisLys: 0.573 ± 0.02	2.236HisLeu: 2.236 ± 0.04	0.487HisMet: 0.487 ± 0.019	0.625HisAsn: 0.625 ± 0.022	1.451HisPro: 1.451 ± 0.032	0.682HisGln: 0.682 ± 0.022	1.347HisArg: 1.347 ± 0.032	1.143HisSer: 1.143 ± 0.03	1.234HisThr: 1.234 ± 0.03	1.506HisVal: 1.506 ± 0.034	0.35HisTrp: 0.35 ± 0.014	0.627HisTyr: 0.627 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.577IleAla: 6.577 ± 0.082	0.422IleCys: 0.422 ± 0.018	3.033IleAsp: 3.033 ± 0.052	2.924IleGlu: 2.924 ± 0.049	1.825IlePhe: 1.825 ± 0.036	4.198IleGly: 4.198 ± 0.056	1.115IleHis: 1.115 ± 0.029	1.535IleIle: 1.535 ± 0.037	1.286IleLys: 1.286 ± 0.032	4.452IleLeu: 4.452 ± 0.061	0.688IleMet: 0.688 ± 0.025	1.446IleAsn: 1.446 ± 0.036	2.696IlePro: 2.696 ± 0.042	1.643IleGln: 1.643 ± 0.034	2.822IleArg: 2.822 ± 0.052	2.959IleSer: 2.959 ± 0.049	3.053IleThr: 3.053 ± 0.063	3.97IleVal: 3.97 ± 0.051	0.512IleTrp: 0.512 ± 0.021	1.323IleTyr: 1.323 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.798LysAla: 3.798 ± 0.06	0.171LysCys: 0.171 ± 0.011	1.885LysAsp: 1.885 ± 0.041	1.664LysGlu: 1.664 ± 0.039	1.058LysPhe: 1.058 ± 0.031	2.386LysGly: 2.386 ± 0.041	0.753LysHis: 0.753 ± 0.024	1.875LysIle: 1.875 ± 0.039	1.671LysLys: 1.671 ± 0.05	3.774LysLeu: 3.774 ± 0.053	0.962LysMet: 0.962 ± 0.029	1.21LysAsn: 1.21 ± 0.032	2.384LysPro: 2.384 ± 0.043	1.419LysGln: 1.419 ± 0.03	2.077LysArg: 2.077 ± 0.039	2.065LysSer: 2.065 ± 0.039	2.391LysThr: 2.391 ± 0.041	2.534LysVal: 2.534 ± 0.053	0.344LysTrp: 0.344 ± 0.016	0.933LysTyr: 0.933 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	12.345LeuAla: 12.345 ± 0.13	0.991LeuCys: 0.991 ± 0.024	5.166LeuAsp: 5.166 ± 0.071	4.997LeuGlu: 4.997 ± 0.078	3.49LeuPhe: 3.49 ± 0.053	7.481LeuGly: 7.481 ± 0.076	2.389LeuHis: 2.389 ± 0.043	4.427LeuIle: 4.427 ± 0.07	3.713LeuLys: 3.713 ± 0.061	10.361LeuLeu: 10.361 ± 0.134	1.996LeuMet: 1.996 ± 0.038	3.322LeuAsn: 3.322 ± 0.057	5.813LeuPro: 5.813 ± 0.072	3.379LeuGln: 3.379 ± 0.053	6.581LeuArg: 6.581 ± 0.101	6.399LeuSer: 6.399 ± 0.073	6.629LeuThr: 6.629 ± 0.08	6.309LeuVal: 6.309 ± 0.073	1.25LeuTrp: 1.25 ± 0.034	2.588LeuTyr: 2.588 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.433MetAla: 2.433 ± 0.042	0.14MetCys: 0.14 ± 0.01	0.981MetAsp: 0.981 ± 0.028	1.063MetGlu: 1.063 ± 0.028	0.605MetPhe: 0.605 ± 0.02	1.478MetGly: 1.478 ± 0.033	0.539MetHis: 0.539 ± 0.02	1.017MetIle: 1.017 ± 0.025	1.006MetLys: 1.006 ± 0.028	2.352MetLeu: 2.352 ± 0.043	0.53MetMet: 0.53 ± 0.02	0.829MetAsn: 0.829 ± 0.026	1.453MetPro: 1.453 ± 0.032	0.99MetGln: 0.99 ± 0.024	1.586MetArg: 1.586 ± 0.032	1.433MetSer: 1.433 ± 0.031	1.503MetThr: 1.503 ± 0.032	1.448MetVal: 1.448 ± 0.033	0.207MetTrp: 0.207 ± 0.013	0.449MetTyr: 0.449 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.598AsnAla: 3.598 ± 0.057	0.283AsnCys: 0.283 ± 0.013	1.536AsnAsp: 1.536 ± 0.035	1.438AsnGlu: 1.438 ± 0.033	1.362AsnPhe: 1.362 ± 0.034	3.136AsnGly: 3.136 ± 0.07	0.685AsnHis: 0.685 ± 0.023	1.665AsnIle: 1.665 ± 0.037	0.903AsnLys: 0.903 ± 0.023	3.368AsnLeu: 3.368 ± 0.056	0.599AsnMet: 0.599 ± 0.02	1.212AsnAsn: 1.212 ± 0.04	2.393AsnPro: 2.393 ± 0.05	1.161AsnGln: 1.161 ± 0.032	1.785AsnArg: 1.785 ± 0.031	2.016AsnSer: 2.016 ± 0.04	2.116AsnThr: 2.116 ± 0.048	2.461AsnVal: 2.461 ± 0.053	0.406AsnTrp: 0.406 ± 0.018	1.13AsnTyr: 1.13 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	7.19ProAla: 7.19 ± 0.091	0.366ProCys: 0.366 ± 0.015	2.965ProAsp: 2.965 ± 0.049	3.572ProGlu: 3.572 ± 0.059	1.905ProPhe: 1.905 ± 0.042	4.753ProGly: 4.753 ± 0.058	1.119ProHis: 1.119 ± 0.028	2.439ProIle: 2.439 ± 0.041	1.922ProLys: 1.922 ± 0.039	4.798ProLeu: 4.798 ± 0.057	1.134ProMet: 1.134 ± 0.026	1.826ProAsn: 1.826 ± 0.045	2.677ProPro: 2.677 ± 0.058	2.074ProGln: 2.074 ± 0.047	2.583ProArg: 2.583 ± 0.041	3.23ProSer: 3.23 ± 0.051	3.442ProThr: 3.442 ± 0.068	4.517ProVal: 4.517 ± 0.073	0.715ProTrp: 0.715 ± 0.023	1.505ProTyr: 1.505 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.251GlnAla: 4.251 ± 0.06	0.226GlnCys: 0.226 ± 0.013	1.55GlnAsp: 1.55 ± 0.028	1.594GlnGlu: 1.594 ± 0.035	1.368GlnPhe: 1.368 ± 0.034	2.618GlnGly: 2.618 ± 0.065	0.808GlnHis: 0.808 ± 0.023	1.963GlnIle: 1.963 ± 0.038	1.281GlnLys: 1.281 ± 0.032	3.422GlnLeu: 3.422 ± 0.05	1.053GlnMet: 1.053 ± 0.026	1.223GlnAsn: 1.223 ± 0.035	2.317GlnPro: 2.317 ± 0.04	1.974GlnGln: 1.974 ± 0.042	2.4GlnArg: 2.4 ± 0.043	2.191GlnSer: 2.191 ± 0.039	2.644GlnThr: 2.644 ± 0.051	2.579GlnVal: 2.579 ± 0.045	0.461GlnTrp: 0.461 ± 0.02	1.06GlnTyr: 1.06 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	5.765ArgAla: 5.765 ± 0.077	0.431ArgCys: 0.431 ± 0.015	2.934ArgAsp: 2.934 ± 0.046	3.565ArgGlu: 3.565 ± 0.069	2.431ArgPhe: 2.431 ± 0.045	3.786ArgGly: 3.786 ± 0.058	1.304ArgHis: 1.304 ± 0.031	3.371ArgIle: 3.371 ± 0.053	2.206ArgLys: 2.206 ± 0.037	6.22ArgLeu: 6.22 ± 0.087	1.741ArgMet: 1.741 ± 0.033	1.986ArgAsn: 1.986 ± 0.039	2.885ArgPro: 2.885 ± 0.06	2.252ArgGln: 2.252 ± 0.045	4.248ArgArg: 4.248 ± 0.067	3.466ArgSer: 3.466 ± 0.052	3.399ArgThr: 3.399 ± 0.047	4.124ArgVal: 4.124 ± 0.059	0.988ArgTrp: 0.988 ± 0.028	1.85ArgTyr: 1.85 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.961SerAla: 6.961 ± 0.078	0.558SerCys: 0.558 ± 0.028	2.781SerAsp: 2.781 ± 0.045	2.794SerGlu: 2.794 ± 0.042	2.693SerPhe: 2.693 ± 0.042	5.985SerGly: 5.985 ± 0.1	1.217SerHis: 1.217 ± 0.029	3.257SerIle: 3.257 ± 0.044	1.996SerLys: 1.996 ± 0.041	6.15SerLeu: 6.15 ± 0.071	1.235SerMet: 1.235 ± 0.028	2.185SerAsn: 2.185 ± 0.043	3.443SerPro: 3.443 ± 0.051	2.087SerGln: 2.087 ± 0.042	3.28SerArg: 3.28 ± 0.047	4.434SerSer: 4.434 ± 0.082	4.421SerThr: 4.421 ± 0.096	4.522SerVal: 4.522 ± 0.062	0.72SerTrp: 0.72 ± 0.021	1.811SerTyr: 1.811 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	7.613ThrAla: 7.613 ± 0.109	0.548ThrCys: 0.548 ± 0.022	2.915ThrAsp: 2.915 ± 0.047	2.708ThrGlu: 2.708 ± 0.046	2.381ThrPhe: 2.381 ± 0.049	6.34ThrGly: 6.34 ± 0.113	1.329ThrHis: 1.329 ± 0.032	3.398ThrIle: 3.398 ± 0.061	1.794ThrLys: 1.794 ± 0.04	7.069ThrLeu: 7.069 ± 0.085	1.184ThrMet: 1.184 ± 0.029	2.111ThrAsn: 2.111 ± 0.053	4.464ThrPro: 4.464 ± 0.072	2.219ThrGln: 2.219 ± 0.038	3.058ThrArg: 3.058 ± 0.044	4.082ThrSer: 4.082 ± 0.08	4.677ThrThr: 4.677 ± 0.106	5.347ThrVal: 5.347 ± 0.084	0.713ThrTrp: 0.713 ± 0.022	1.774ThrTyr: 1.774 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	8.471ValAla: 8.471 ± 0.092	0.659ValCys: 0.659 ± 0.021	4.062ValAsp: 4.062 ± 0.054	4.031ValGlu: 4.031 ± 0.056	2.635ValPhe: 2.635 ± 0.039	5.166ValGly: 5.166 ± 0.078	1.489ValHis: 1.489 ± 0.034	3.189ValIle: 3.189 ± 0.048	2.544ValLys: 2.544 ± 0.048	7.158ValLeu: 7.158 ± 0.077	1.464ValMet: 1.464 ± 0.028	2.553ValAsn: 2.553 ± 0.048	3.578ValPro: 3.578 ± 0.051	2.583ValGln: 2.583 ± 0.042	4.223ValArg: 4.223 ± 0.049	4.789ValSer: 4.789 ± 0.063	5.097ValThr: 5.097 ± 0.088	5.623ValVal: 5.623 ± 0.076	0.957ValTrp: 0.957 ± 0.03	2.0ValTyr: 2.0 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.089TrpAla: 1.089 ± 0.028	0.119TrpCys: 0.119 ± 0.009	0.57TrpAsp: 0.57 ± 0.019	0.563TrpGlu: 0.563 ± 0.021	0.515TrpPhe: 0.515 ± 0.02	0.865TrpGly: 0.865 ± 0.022	0.295TrpHis: 0.295 ± 0.015	0.729TrpIle: 0.729 ± 0.026	0.583TrpLys: 0.583 ± 0.023	1.395TrpLeu: 1.395 ± 0.033	0.416TrpMet: 0.416 ± 0.018	0.547TrpAsn: 0.547 ± 0.019	0.538TrpPro: 0.538 ± 0.018	0.621TrpGln: 0.621 ± 0.019	0.886TrpArg: 0.886 ± 0.027	0.872TrpSer: 0.872 ± 0.022	0.869TrpThr: 0.869 ± 0.028	0.891TrpVal: 0.891 ± 0.029	0.233TrpTrp: 0.233 ± 0.012	0.342TrpTyr: 0.342 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.991TyrAla: 2.991 ± 0.044	0.261TyrCys: 0.261 ± 0.013	1.547TyrAsp: 1.547 ± 0.033	1.379TyrGlu: 1.379 ± 0.035	1.177TyrPhe: 1.177 ± 0.03	2.405TyrGly: 2.405 ± 0.046	0.549TyrHis: 0.549 ± 0.02	1.257TyrIle: 1.257 ± 0.034	0.867TyrLys: 0.867 ± 0.029	2.883TyrLeu: 2.883 ± 0.048	0.52TyrMet: 0.52 ± 0.017	1.041TyrAsn: 1.041 ± 0.035	1.385TyrPro: 1.385 ± 0.034	0.944TyrGln: 0.944 ± 0.026	1.825TyrArg: 1.825 ± 0.036	1.762TyrSer: 1.762 ± 0.04	2.058TyrThr: 2.058 ± 0.049	1.938TyrVal: 1.938 ± 0.038	0.382TyrTrp: 0.382 ± 0.017	0.828TyrTyr: 0.828 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4295 proteins (1567266 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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