Amino acid dipepetide frequency for Curtobacterium sp. Leaf183

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.924AlaAla: 20.924 ± 0.238	0.618AlaCys: 0.618 ± 0.024	8.83AlaAsp: 8.83 ± 0.11	6.906AlaGlu: 6.906 ± 0.099	4.042AlaPhe: 4.042 ± 0.068	12.168AlaGly: 12.168 ± 0.124	2.39AlaHis: 2.39 ± 0.053	5.09AlaIle: 5.09 ± 0.075	2.689AlaLys: 2.689 ± 0.059	13.689AlaLeu: 13.689 ± 0.138	2.816AlaMet: 2.816 ± 0.049	2.289AlaAsn: 2.289 ± 0.047	6.497AlaPro: 6.497 ± 0.135	3.633AlaGln: 3.633 ± 0.068	8.973AlaArg: 8.973 ± 0.104	7.633AlaSer: 7.633 ± 0.097	8.641AlaThr: 8.641 ± 0.106	13.54AlaVal: 13.54 ± 0.144	2.017AlaTrp: 2.017 ± 0.053	2.198AlaTyr: 2.198 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.599CysAla: 0.599 ± 0.024	0.042CysCys: 0.042 ± 0.006	0.267CysAsp: 0.267 ± 0.017	0.201CysGlu: 0.201 ± 0.014	0.139CysPhe: 0.139 ± 0.013	0.47CysGly: 0.47 ± 0.023	0.104CysHis: 0.104 ± 0.01	0.162CysIle: 0.162 ± 0.013	0.047CysLys: 0.047 ± 0.006	0.394CysLeu: 0.394 ± 0.018	0.073CysMet: 0.073 ± 0.008	0.092CysAsn: 0.092 ± 0.011	0.244CysPro: 0.244 ± 0.018	0.097CysGln: 0.097 ± 0.01	0.276CysArg: 0.276 ± 0.018	0.355CysSer: 0.355 ± 0.017	0.311CysThr: 0.311 ± 0.018	0.432CysVal: 0.432 ± 0.019	0.075CysTrp: 0.075 ± 0.009	0.088CysTyr: 0.088 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	9.591AspAla: 9.591 ± 0.123	0.246AspCys: 0.246 ± 0.016	5.207AspAsp: 5.207 ± 0.085	4.179AspGlu: 4.179 ± 0.074	1.678AspPhe: 1.678 ± 0.04	6.713AspGly: 6.713 ± 0.086	1.522AspHis: 1.522 ± 0.04	1.92AspIle: 1.92 ± 0.045	0.978AspLys: 0.978 ± 0.035	6.553AspLeu: 6.553 ± 0.082	0.863AspMet: 0.863 ± 0.03	0.822AspAsn: 0.822 ± 0.034	4.414AspPro: 4.414 ± 0.067	2.106AspGln: 2.106 ± 0.049	5.384AspArg: 5.384 ± 0.075	2.506AspSer: 2.506 ± 0.049	3.664AspThr: 3.664 ± 0.069	6.758AspVal: 6.758 ± 0.082	1.015AspTrp: 1.015 ± 0.032	1.033AspTyr: 1.033 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	5.633GluAla: 5.633 ± 0.087	0.186GluCys: 0.186 ± 0.014	2.716GluAsp: 2.716 ± 0.06	1.944GluGlu: 1.944 ± 0.053	1.452GluPhe: 1.452 ± 0.042	3.142GluGly: 3.142 ± 0.063	1.671GluHis: 1.671 ± 0.048	1.916GluIle: 1.916 ± 0.05	0.926GluLys: 0.926 ± 0.032	5.516GluLeu: 5.516 ± 0.089	0.728GluMet: 0.728 ± 0.029	0.835GluAsn: 0.835 ± 0.031	2.896GluPro: 2.896 ± 0.059	2.286GluGln: 2.286 ± 0.057	5.127GluArg: 5.127 ± 0.082	2.596GluSer: 2.596 ± 0.056	2.678GluThr: 2.678 ± 0.058	4.178GluVal: 4.178 ± 0.077	0.67GluTrp: 0.67 ± 0.027	1.068GluTyr: 1.068 ± 0.035	0.002GluXaa: 0.002 ± 0.001
Phe	4.046PheAla: 4.046 ± 0.065	0.188PheCys: 0.188 ± 0.012	2.333PheAsp: 2.333 ± 0.054	1.403PheGlu: 1.403 ± 0.045	1.002PhePhe: 1.002 ± 0.041	3.335PheGly: 3.335 ± 0.069	0.55PheHis: 0.55 ± 0.027	1.009PheIle: 1.009 ± 0.035	0.387PheLys: 0.387 ± 0.021	2.799PheLeu: 2.799 ± 0.062	0.424PheMet: 0.424 ± 0.022	0.563PheAsn: 0.563 ± 0.024	1.489PhePro: 1.489 ± 0.043	0.82PheGln: 0.82 ± 0.031	2.026PheArg: 2.026 ± 0.052	1.647PheSer: 1.647 ± 0.04	2.095PheThr: 2.095 ± 0.05	3.147PheVal: 3.147 ± 0.069	0.506PheTrp: 0.506 ± 0.024	0.528PheTyr: 0.528 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	11.075GlyAla: 11.075 ± 0.125	0.501GlyCys: 0.501 ± 0.024	5.308GlyAsp: 5.308 ± 0.075	3.863GlyGlu: 3.863 ± 0.067	3.262GlyPhe: 3.262 ± 0.067	7.735GlyGly: 7.735 ± 0.109	1.973GlyHis: 1.973 ± 0.046	4.515GlyIle: 4.515 ± 0.071	2.157GlyLys: 2.157 ± 0.057	8.678GlyLeu: 8.678 ± 0.105	1.806GlyMet: 1.806 ± 0.043	1.78GlyAsn: 1.78 ± 0.045	4.121GlyPro: 4.121 ± 0.067	2.661GlyGln: 2.661 ± 0.057	6.513GlyArg: 6.513 ± 0.085	6.173GlySer: 6.173 ± 0.102	6.738GlyThr: 6.738 ± 0.103	8.469GlyVal: 8.469 ± 0.097	1.584GlyTrp: 1.584 ± 0.036	2.081GlyTyr: 2.081 ± 0.044	0.001GlyXaa: 0.001 ± 0.001
His	2.516HisAla: 2.516 ± 0.051	0.112HisCys: 0.112 ± 0.01	1.691HisAsp: 1.691 ± 0.048	1.181HisGlu: 1.181 ± 0.041	0.514HisPhe: 0.514 ± 0.021	2.264HisGly: 2.264 ± 0.056	0.583HisHis: 0.583 ± 0.029	0.578HisIle: 0.578 ± 0.021	0.23HisLys: 0.23 ± 0.014	1.937HisLeu: 1.937 ± 0.049	0.33HisMet: 0.33 ± 0.017	0.301HisAsn: 0.301 ± 0.018	1.434HisPro: 1.434 ± 0.035	0.575HisGln: 0.575 ± 0.026	1.825HisArg: 1.825 ± 0.041	0.793HisSer: 0.793 ± 0.025	1.099HisThr: 1.099 ± 0.031	2.061HisVal: 2.061 ± 0.05	0.323HisTrp: 0.323 ± 0.018	0.35HisTyr: 0.35 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	6.328IleAla: 6.328 ± 0.091	0.202IleCys: 0.202 ± 0.014	3.072IleAsp: 3.072 ± 0.056	2.198IleGlu: 2.198 ± 0.057	0.658IlePhe: 0.658 ± 0.031	4.552IleGly: 4.552 ± 0.082	0.561IleHis: 0.561 ± 0.028	1.25IleIle: 1.25 ± 0.042	0.696IleLys: 0.696 ± 0.032	2.598IleLeu: 2.598 ± 0.061	0.461IleMet: 0.461 ± 0.024	0.72IleAsn: 0.72 ± 0.027	1.919IlePro: 1.919 ± 0.054	0.862IleGln: 0.862 ± 0.034	2.492IleArg: 2.492 ± 0.048	1.804IleSer: 1.804 ± 0.045	2.634IleThr: 2.634 ± 0.049	4.144IleVal: 4.144 ± 0.066	0.417IleTrp: 0.417 ± 0.021	0.507IleTyr: 0.507 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	2.242LysAla: 2.242 ± 0.053	0.056LysCys: 0.056 ± 0.008	1.215LysAsp: 1.215 ± 0.04	0.767LysGlu: 0.767 ± 0.031	0.427LysPhe: 0.427 ± 0.021	1.498LysGly: 1.498 ± 0.044	0.456LysHis: 0.456 ± 0.021	0.747LysIle: 0.747 ± 0.03	0.672LysLys: 0.672 ± 0.037	1.628LysLeu: 1.628 ± 0.042	0.334LysMet: 0.334 ± 0.02	0.477LysAsn: 0.477 ± 0.027	1.112LysPro: 1.112 ± 0.035	0.797LysGln: 0.797 ± 0.034	1.402LysArg: 1.402 ± 0.038	1.115LysSer: 1.115 ± 0.038	1.243LysThr: 1.243 ± 0.033	1.587LysVal: 1.587 ± 0.045	0.232LysTrp: 0.232 ± 0.015	0.444LysTyr: 0.444 ± 0.023	0.001LysXaa: 0.001 ± 0.001
Leu	13.628LeuAla: 13.628 ± 0.124	0.398LeuCys: 0.398 ± 0.019	6.928LeuAsp: 6.928 ± 0.102	4.501LeuGlu: 4.501 ± 0.072	2.773LeuPhe: 2.773 ± 0.06	9.342LeuGly: 9.342 ± 0.111	1.92LeuHis: 1.92 ± 0.049	3.018LeuIle: 3.018 ± 0.069	1.414LeuLys: 1.414 ± 0.037	9.403LeuLeu: 9.403 ± 0.12	1.333LeuMet: 1.333 ± 0.042	1.472LeuAsn: 1.472 ± 0.038	5.451LeuPro: 5.451 ± 0.083	2.715LeuGln: 2.715 ± 0.051	7.366LeuArg: 7.366 ± 0.095	5.018LeuSer: 5.018 ± 0.071	6.113LeuThr: 6.113 ± 0.092	10.719LeuVal: 10.719 ± 0.136	1.213LeuTrp: 1.213 ± 0.036	1.489LeuTyr: 1.489 ± 0.038	0.001LeuXaa: 0.001 ± 0.001
Met	2.086MetAla: 2.086 ± 0.043	0.074MetCys: 0.074 ± 0.008	0.824MetAsp: 0.824 ± 0.028	0.569MetGlu: 0.569 ± 0.027	0.449MetPhe: 0.449 ± 0.019	1.188MetGly: 1.188 ± 0.036	0.408MetHis: 0.408 ± 0.02	0.651MetIle: 0.651 ± 0.028	0.301MetLys: 0.301 ± 0.018	1.719MetLeu: 1.719 ± 0.045	0.238MetMet: 0.238 ± 0.016	0.403MetAsn: 0.403 ± 0.022	1.127MetPro: 1.127 ± 0.03	0.553MetGln: 0.553 ± 0.025	1.383MetArg: 1.383 ± 0.037	1.337MetSer: 1.337 ± 0.032	1.859MetThr: 1.859 ± 0.042	1.438MetVal: 1.438 ± 0.036	0.193MetTrp: 0.193 ± 0.015	0.28MetTyr: 0.28 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.389AsnAla: 2.389 ± 0.048	0.097AsnCys: 0.097 ± 0.01	1.233AsnAsp: 1.233 ± 0.036	0.813AsnGlu: 0.813 ± 0.031	0.476AsnPhe: 0.476 ± 0.025	1.925AsnGly: 1.925 ± 0.051	0.38AsnHis: 0.38 ± 0.021	0.628AsnIle: 0.628 ± 0.028	0.357AsnLys: 0.357 ± 0.019	1.55AsnLeu: 1.55 ± 0.045	0.288AsnMet: 0.288 ± 0.018	0.402AsnAsn: 0.402 ± 0.019	1.277AsnPro: 1.277 ± 0.039	0.58AsnGln: 0.58 ± 0.029	1.185AsnArg: 1.185 ± 0.035	0.848AsnSer: 0.848 ± 0.032	1.178AsnThr: 1.178 ± 0.037	1.63AsnVal: 1.63 ± 0.039	0.285AsnTrp: 0.285 ± 0.018	0.454AsnTyr: 0.454 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.258ProAla: 7.258 ± 0.111	0.172ProCys: 0.172 ± 0.012	4.372ProAsp: 4.372 ± 0.065	3.268ProGlu: 3.268 ± 0.048	1.784ProPhe: 1.784 ± 0.042	5.013ProGly: 5.013 ± 0.076	1.055ProHis: 1.055 ± 0.033	1.861ProIle: 1.861 ± 0.047	1.064ProLys: 1.064 ± 0.041	4.46ProLeu: 4.46 ± 0.074	0.912ProMet: 0.912 ± 0.032	0.959ProAsn: 0.959 ± 0.032	2.011ProPro: 2.011 ± 0.052	1.456ProGln: 1.456 ± 0.043	3.184ProArg: 3.184 ± 0.054	3.534ProSer: 3.534 ± 0.065	4.033ProThr: 4.033 ± 0.069	5.545ProVal: 5.545 ± 0.076	0.894ProTrp: 0.894 ± 0.029	0.991ProTyr: 0.991 ± 0.036	0.001ProXaa: 0.001 ± 0.001
Gln	3.872GlnAla: 3.872 ± 0.068	0.097GlnCys: 0.097 ± 0.009	1.791GlnAsp: 1.791 ± 0.041	1.212GlnGlu: 1.212 ± 0.037	0.841GlnPhe: 0.841 ± 0.029	2.269GlnGly: 2.269 ± 0.048	0.806GlnHis: 0.806 ± 0.029	1.224GlnIle: 1.224 ± 0.034	0.573GlnLys: 0.573 ± 0.027	3.052GlnLeu: 3.052 ± 0.06	0.439GlnMet: 0.439 ± 0.02	0.612GlnAsn: 0.612 ± 0.029	1.598GlnPro: 1.598 ± 0.041	1.584GlnGln: 1.584 ± 0.052	2.54GlnArg: 2.54 ± 0.054	1.608GlnSer: 1.608 ± 0.045	1.668GlnThr: 1.668 ± 0.04	2.87GlnVal: 2.87 ± 0.048	0.43GlnTrp: 0.43 ± 0.021	0.745GlnTyr: 0.745 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	9.513ArgAla: 9.513 ± 0.14	0.287ArgCys: 0.287 ± 0.019	4.53ArgAsp: 4.53 ± 0.071	3.454ArgGlu: 3.454 ± 0.066	2.441ArgPhe: 2.441 ± 0.05	5.514ArgGly: 5.514 ± 0.075	1.564ArgHis: 1.564 ± 0.042	3.305ArgIle: 3.305 ± 0.048	1.294ArgLys: 1.294 ± 0.035	6.931ArgLeu: 6.931 ± 0.091	1.705ArgMet: 1.705 ± 0.042	1.279ArgAsn: 1.279 ± 0.035	3.831ArgPro: 3.831 ± 0.065	2.248ArgGln: 2.248 ± 0.047	6.672ArgArg: 6.672 ± 0.103	4.536ArgSer: 4.536 ± 0.065	5.002ArgThr: 5.002 ± 0.07	6.607ArgVal: 6.607 ± 0.084	1.309ArgTrp: 1.309 ± 0.035	1.523ArgTyr: 1.523 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	7.523SerAla: 7.523 ± 0.101	0.244SerCys: 0.244 ± 0.017	3.518SerAsp: 3.518 ± 0.067	2.36SerGlu: 2.36 ± 0.059	1.84SerPhe: 1.84 ± 0.048	6.242SerGly: 6.242 ± 0.089	0.976SerHis: 0.976 ± 0.028	2.295SerIle: 2.295 ± 0.047	1.149SerLys: 1.149 ± 0.042	4.925SerLeu: 4.925 ± 0.071	1.191SerMet: 1.191 ± 0.033	1.122SerAsn: 1.122 ± 0.037	2.794SerPro: 2.794 ± 0.044	1.362SerGln: 1.362 ± 0.043	3.57SerArg: 3.57 ± 0.065	3.687SerSer: 3.687 ± 0.079	4.205SerThr: 4.205 ± 0.079	5.267SerVal: 5.267 ± 0.081	0.948SerTrp: 0.948 ± 0.031	1.102SerTyr: 1.102 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	9.172ThrAla: 9.172 ± 0.117	0.285ThrCys: 0.285 ± 0.019	4.32ThrAsp: 4.32 ± 0.057	3.005ThrGlu: 3.005 ± 0.06	1.982ThrPhe: 1.982 ± 0.046	6.634ThrGly: 6.634 ± 0.094	1.133ThrHis: 1.133 ± 0.033	2.916ThrIle: 2.916 ± 0.055	1.345ThrLys: 1.345 ± 0.039	6.099ThrLeu: 6.099 ± 0.082	1.118ThrMet: 1.118 ± 0.035	1.397ThrAsn: 1.397 ± 0.04	4.334ThrPro: 4.334 ± 0.081	1.533ThrGln: 1.533 ± 0.038	3.9ThrArg: 3.9 ± 0.068	3.773ThrSer: 3.773 ± 0.064	5.128ThrThr: 5.128 ± 0.083	7.041ThrVal: 7.041 ± 0.103	1.059ThrTrp: 1.059 ± 0.035	1.282ThrTyr: 1.282 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	13.275ValAla: 13.275 ± 0.152	0.446ValCys: 0.446 ± 0.022	6.796ValAsp: 6.796 ± 0.083	4.804ValGlu: 4.804 ± 0.078	3.275ValPhe: 3.275 ± 0.063	8.005ValGly: 8.005 ± 0.106	2.022ValHis: 2.022 ± 0.043	3.855ValIle: 3.855 ± 0.072	1.506ValLys: 1.506 ± 0.043	10.787ValLeu: 10.787 ± 0.116	1.506ValMet: 1.506 ± 0.038	1.663ValAsn: 1.663 ± 0.045	5.613ValPro: 5.613 ± 0.084	2.752ValGln: 2.752 ± 0.054	7.027ValArg: 7.027 ± 0.09	5.282ValSer: 5.282 ± 0.077	6.953ValThr: 6.953 ± 0.103	11.957ValVal: 11.957 ± 0.169	1.207ValTrp: 1.207 ± 0.039	1.583ValTyr: 1.583 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.632TrpAla: 1.632 ± 0.044	0.104TrpCys: 0.104 ± 0.012	0.853TrpAsp: 0.853 ± 0.032	0.571TrpGlu: 0.571 ± 0.023	0.62TrpPhe: 0.62 ± 0.021	1.095TrpGly: 1.095 ± 0.034	0.344TrpHis: 0.344 ± 0.019	0.624TrpIle: 0.624 ± 0.023	0.318TrpLys: 0.318 ± 0.019	1.62TrpLeu: 1.62 ± 0.045	0.283TrpMet: 0.283 ± 0.017	0.39TrpAsn: 0.39 ± 0.021	0.734TrpPro: 0.734 ± 0.029	0.59TrpGln: 0.59 ± 0.022	1.204TrpArg: 1.204 ± 0.035	1.071TrpSer: 1.071 ± 0.034	1.065TrpThr: 1.065 ± 0.037	1.264TrpVal: 1.264 ± 0.038	0.387TrpTrp: 0.387 ± 0.02	0.308TrpTyr: 0.308 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.279TyrAla: 2.279 ± 0.047	0.113TyrCys: 0.113 ± 0.01	1.349TyrAsp: 1.349 ± 0.041	0.964TyrGlu: 0.964 ± 0.032	0.638TyrPhe: 0.638 ± 0.026	1.887TyrGly: 1.887 ± 0.054	0.277TyrHis: 0.277 ± 0.017	0.512TyrIle: 0.512 ± 0.026	0.347TyrLys: 0.347 ± 0.02	1.877TyrLeu: 1.877 ± 0.05	0.227TyrMet: 0.227 ± 0.016	0.397TyrAsn: 0.397 ± 0.023	0.934TyrPro: 0.934 ± 0.029	0.621TyrGln: 0.621 ± 0.026	1.501TyrArg: 1.501 ± 0.037	1.008TyrSer: 1.008 ± 0.029	1.147TyrThr: 1.147 ± 0.04	1.66TyrVal: 1.66 ± 0.039	0.315TyrTrp: 0.315 ± 0.017	0.412TyrTyr: 0.412 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.005XaaXaa: 0.005 ± 0.002

Statistics based on 3232 proteins (1037927 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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