Amino acid dipepetide frequency for Alteromonas phage vB_AmeM_PT11-V22

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.913AlaAla: 3.913 ± 0.584
0.761AlaCys: 0.761 ± 0.169
3.55AlaAsp: 3.55 ± 0.449
4.021AlaGlu: 4.021 ± 0.373
2.572AlaPhe: 2.572 ± 0.364
3.985AlaGly: 3.985 ± 0.548
0.833AlaHis: 0.833 ± 0.15
3.333AlaIle: 3.333 ± 0.378
4.021AlaLys: 4.021 ± 0.438
4.818AlaLeu: 4.818 ± 0.398
1.413AlaMet: 1.413 ± 0.217
3.369AlaAsn: 3.369 ± 0.731
1.051AlaPro: 1.051 ± 0.206
2.282AlaGln: 2.282 ± 0.284
2.21AlaArg: 2.21 ± 0.31
4.42AlaSer: 4.42 ± 0.675
4.311AlaThr: 4.311 ± 0.477
3.804AlaVal: 3.804 ± 0.442
0.507AlaTrp: 0.507 ± 0.141
2.681AlaTyr: 2.681 ± 0.279
0.0AlaXaa: 0.0 ± 0.0
Cys
0.58CysAla: 0.58 ± 0.15
0.145CysCys: 0.145 ± 0.062
0.942CysAsp: 0.942 ± 0.21
0.978CysGlu: 0.978 ± 0.199
0.616CysPhe: 0.616 ± 0.159
1.087CysGly: 1.087 ± 0.213
0.399CysHis: 0.399 ± 0.129
0.942CysIle: 0.942 ± 0.158
1.051CysLys: 1.051 ± 0.26
1.087CysLeu: 1.087 ± 0.19
0.217CysMet: 0.217 ± 0.092
0.616CysAsn: 0.616 ± 0.177
0.435CysPro: 0.435 ± 0.115
0.29CysGln: 0.29 ± 0.109
0.58CysArg: 0.58 ± 0.149
0.869CysSer: 0.869 ± 0.198
0.58CysThr: 0.58 ± 0.167
1.196CysVal: 1.196 ± 0.244
0.145CysTrp: 0.145 ± 0.068
0.543CysTyr: 0.543 ± 0.157
0.0CysXaa: 0.0 ± 0.0
Asp
2.971AspAla: 2.971 ± 0.346
1.014AspCys: 1.014 ± 0.192
3.985AspAsp: 3.985 ± 0.467
5.253AspGlu: 5.253 ± 0.486
3.405AspPhe: 3.405 ± 0.365
4.13AspGly: 4.13 ± 0.435
0.978AspHis: 0.978 ± 0.212
4.71AspIle: 4.71 ± 0.427
5.615AspLys: 5.615 ± 0.483
5.76AspLeu: 5.76 ± 0.59
1.956AspMet: 1.956 ± 0.329
4.673AspAsn: 4.673 ± 0.468
1.92AspPro: 1.92 ± 0.296
1.956AspGln: 1.956 ± 0.253
1.993AspArg: 1.993 ± 0.271
4.166AspSer: 4.166 ± 0.425
4.384AspThr: 4.384 ± 0.356
4.384AspVal: 4.384 ± 0.414
1.159AspTrp: 1.159 ± 0.192
2.826AspTyr: 2.826 ± 0.268
0.0AspXaa: 0.0 ± 0.0
Glu
4.855GluAla: 4.855 ± 0.469
0.906GluCys: 0.906 ± 0.177
5.978GluAsp: 5.978 ± 0.586
8.695GluGlu: 8.695 ± 0.815
2.79GluPhe: 2.79 ± 0.321
5.833GluGly: 5.833 ± 0.399
1.848GluHis: 1.848 ± 0.28
5.941GluIle: 5.941 ± 0.674
5.144GluLys: 5.144 ± 0.474
7.934GluLeu: 7.934 ± 0.726
2.608GluMet: 2.608 ± 0.302
3.731GluAsn: 3.731 ± 0.385
1.993GluPro: 1.993 ± 0.32
2.717GluGln: 2.717 ± 0.333
3.405GluArg: 3.405 ± 0.387
3.985GluSer: 3.985 ± 0.377
3.297GluThr: 3.297 ± 0.351
5.724GluVal: 5.724 ± 0.552
1.232GluTrp: 1.232 ± 0.234
3.587GluTyr: 3.587 ± 0.423
0.0GluXaa: 0.0 ± 0.0
Phe
1.956PheAla: 1.956 ± 0.266
0.543PheCys: 0.543 ± 0.145
2.464PheAsp: 2.464 ± 0.298
3.188PheGlu: 3.188 ± 0.292
1.848PhePhe: 1.848 ± 0.24
2.464PheGly: 2.464 ± 0.322
1.014PheHis: 1.014 ± 0.222
2.753PheIle: 2.753 ± 0.286
3.369PheLys: 3.369 ± 0.389
2.681PheLeu: 2.681 ± 0.327
1.014PheMet: 1.014 ± 0.172
2.391PheAsn: 2.391 ± 0.315
1.666PhePro: 1.666 ± 0.222
1.159PheGln: 1.159 ± 0.201
1.449PheArg: 1.449 ± 0.219
3.405PheSer: 3.405 ± 0.39
2.934PheThr: 2.934 ± 0.334
2.608PheVal: 2.608 ± 0.374
0.652PheTrp: 0.652 ± 0.138
1.92PheTyr: 1.92 ± 0.282
0.0PheXaa: 0.0 ± 0.0
Gly
3.949GlyAla: 3.949 ± 0.482
0.761GlyCys: 0.761 ± 0.192
4.021GlyAsp: 4.021 ± 0.461
4.166GlyGlu: 4.166 ± 0.349
3.188GlyPhe: 3.188 ± 0.298
5.072GlyGly: 5.072 ± 0.412
1.377GlyHis: 1.377 ± 0.238
4.42GlyIle: 4.42 ± 0.43
4.818GlyLys: 4.818 ± 0.462
5.108GlyLeu: 5.108 ± 0.463
1.848GlyMet: 1.848 ± 0.25
4.166GlyAsn: 4.166 ± 0.531
0.036GlyPro: 0.036 ± 0.035
1.848GlyGln: 1.848 ± 0.263
2.427GlyArg: 2.427 ± 0.282
4.565GlySer: 4.565 ± 0.486
4.746GlyThr: 4.746 ± 0.855
5.144GlyVal: 5.144 ± 0.554
1.014GlyTrp: 1.014 ± 0.189
2.971GlyTyr: 2.971 ± 0.321
0.0GlyXaa: 0.0 ± 0.0
His
0.906HisAla: 0.906 ± 0.166
0.399HisCys: 0.399 ± 0.115
1.014HisAsp: 1.014 ± 0.194
0.978HisGlu: 0.978 ± 0.199
0.797HisPhe: 0.797 ± 0.181
1.413HisGly: 1.413 ± 0.231
0.254HisHis: 0.254 ± 0.106
1.522HisIle: 1.522 ± 0.276
1.558HisLys: 1.558 ± 0.239
1.558HisLeu: 1.558 ± 0.24
0.435HisMet: 0.435 ± 0.127
1.123HisAsn: 1.123 ± 0.19
1.087HisPro: 1.087 ± 0.225
0.29HisGln: 0.29 ± 0.109
0.725HisArg: 0.725 ± 0.178
1.522HisSer: 1.522 ± 0.242
1.413HisThr: 1.413 ± 0.243
0.869HisVal: 0.869 ± 0.181
0.254HisTrp: 0.254 ± 0.097
0.833HisTyr: 0.833 ± 0.187
0.0HisXaa: 0.0 ± 0.0
Ile
4.166IleAla: 4.166 ± 0.549
0.869IleCys: 0.869 ± 0.214
5.543IleAsp: 5.543 ± 0.45
5.652IleGlu: 5.652 ± 0.528
1.775IlePhe: 1.775 ± 0.258
2.717IleGly: 2.717 ± 0.31
1.377IleHis: 1.377 ± 0.213
3.261IleIle: 3.261 ± 0.33
5.326IleLys: 5.326 ± 0.423
4.058IleLeu: 4.058 ± 0.37
1.558IleMet: 1.558 ± 0.282
3.333IleAsn: 3.333 ± 0.4
2.21IlePro: 2.21 ± 0.249
1.594IleGln: 1.594 ± 0.257
2.282IleArg: 2.282 ± 0.259
3.623IleSer: 3.623 ± 0.374
5.905IleThr: 5.905 ± 1.089
4.746IleVal: 4.746 ± 0.424
0.471IleTrp: 0.471 ± 0.121
1.993IleTyr: 1.993 ± 0.294
0.0IleXaa: 0.0 ± 0.0
Lys
5.108LysAla: 5.108 ± 0.415
0.869LysCys: 0.869 ± 0.194
4.891LysAsp: 4.891 ± 0.55
7.499LysGlu: 7.499 ± 0.703
3.152LysPhe: 3.152 ± 0.335
5.326LysGly: 5.326 ± 0.498
1.413LysHis: 1.413 ± 0.266
4.094LysIle: 4.094 ± 0.467
5.326LysLys: 5.326 ± 0.571
6.086LysLeu: 6.086 ± 0.521
2.101LysMet: 2.101 ± 0.308
3.152LysAsn: 3.152 ± 0.354
2.282LysPro: 2.282 ± 0.388
2.536LysGln: 2.536 ± 0.336
3.514LysArg: 3.514 ± 0.347
4.456LysSer: 4.456 ± 0.528
3.695LysThr: 3.695 ± 0.456
5.181LysVal: 5.181 ± 0.59
0.978LysTrp: 0.978 ± 0.201
3.079LysTyr: 3.079 ± 0.367
0.0LysXaa: 0.0 ± 0.0
Leu
4.999LeuAla: 4.999 ± 0.464
0.797LeuCys: 0.797 ± 0.189
6.05LeuAsp: 6.05 ± 0.533
7.028LeuGlu: 7.028 ± 0.584
2.898LeuPhe: 2.898 ± 0.345
5.796LeuGly: 5.796 ± 0.49
1.522LeuHis: 1.522 ± 0.248
4.239LeuIle: 4.239 ± 0.322
5.579LeuLys: 5.579 ± 0.551
5.833LeuLeu: 5.833 ± 0.633
1.884LeuMet: 1.884 ± 0.261
5.072LeuAsn: 5.072 ± 0.511
2.898LeuPro: 2.898 ± 0.302
3.587LeuGln: 3.587 ± 0.404
3.84LeuArg: 3.84 ± 0.367
5.579LeuSer: 5.579 ± 0.422
5.072LeuThr: 5.072 ± 0.49
5.072LeuVal: 5.072 ± 0.39
0.906LeuTrp: 0.906 ± 0.182
3.043LeuTyr: 3.043 ± 0.348
0.0LeuXaa: 0.0 ± 0.0
Met
1.413MetAla: 1.413 ± 0.208
0.362MetCys: 0.362 ± 0.121
1.413MetAsp: 1.413 ± 0.204
1.993MetGlu: 1.993 ± 0.284
1.268MetPhe: 1.268 ± 0.202
1.087MetGly: 1.087 ± 0.205
0.652MetHis: 0.652 ± 0.146
1.703MetIle: 1.703 ± 0.246
2.572MetLys: 2.572 ± 0.276
1.594MetLeu: 1.594 ± 0.265
0.58MetMet: 0.58 ± 0.179
1.087MetAsn: 1.087 ± 0.231
0.58MetPro: 0.58 ± 0.137
0.833MetGln: 0.833 ± 0.172
0.869MetArg: 0.869 ± 0.196
2.572MetSer: 2.572 ± 0.331
1.522MetThr: 1.522 ± 0.261
1.558MetVal: 1.558 ± 0.214
0.362MetTrp: 0.362 ± 0.12
0.906MetTyr: 0.906 ± 0.174
0.0MetXaa: 0.0 ± 0.0
Asn
3.913AsnAla: 3.913 ± 0.509
0.435AsnCys: 0.435 ± 0.11
3.043AsnAsp: 3.043 ± 0.368
4.347AsnGlu: 4.347 ± 0.485
2.79AsnPhe: 2.79 ± 0.328
3.333AsnGly: 3.333 ± 0.436
0.906AsnHis: 0.906 ± 0.192
3.333AsnIle: 3.333 ± 0.386
4.311AsnLys: 4.311 ± 0.427
4.492AsnLeu: 4.492 ± 0.507
1.196AsnMet: 1.196 ± 0.21
3.405AsnAsn: 3.405 ± 0.368
2.101AsnPro: 2.101 ± 0.276
1.63AsnGln: 1.63 ± 0.211
1.666AsnArg: 1.666 ± 0.271
3.695AsnSer: 3.695 ± 0.59
4.13AsnThr: 4.13 ± 0.628
3.261AsnVal: 3.261 ± 0.301
0.507AsnTrp: 0.507 ± 0.128
2.065AsnTyr: 2.065 ± 0.303
0.0AsnXaa: 0.0 ± 0.0
Pro
2.029ProAla: 2.029 ± 0.269
0.688ProCys: 0.688 ± 0.173
2.79ProAsp: 2.79 ± 0.344
2.971ProGlu: 2.971 ± 0.352
1.268ProPhe: 1.268 ± 0.232
0.036ProGly: 0.036 ± 0.039
0.616ProHis: 0.616 ± 0.137
1.666ProIle: 1.666 ± 0.237
2.137ProLys: 2.137 ± 0.384
2.427ProLeu: 2.427 ± 0.278
0.326ProMet: 0.326 ± 0.104
1.703ProAsn: 1.703 ± 0.276
1.087ProPro: 1.087 ± 0.235
0.978ProGln: 0.978 ± 0.172
0.906ProArg: 0.906 ± 0.198
2.065ProSer: 2.065 ± 0.313
1.956ProThr: 1.956 ± 0.352
1.92ProVal: 1.92 ± 0.265
0.399ProTrp: 0.399 ± 0.117
1.485ProTyr: 1.485 ± 0.242
0.0ProXaa: 0.0 ± 0.0
Gln
2.065GlnAla: 2.065 ± 0.313
0.471GlnCys: 0.471 ± 0.125
1.956GlnAsp: 1.956 ± 0.244
2.572GlnGlu: 2.572 ± 0.298
1.159GlnPhe: 1.159 ± 0.226
2.572GlnGly: 2.572 ± 0.309
0.543GlnHis: 0.543 ± 0.156
2.065GlnIle: 2.065 ± 0.286
2.21GlnLys: 2.21 ± 0.289
2.826GlnLeu: 2.826 ± 0.365
0.942GlnMet: 0.942 ± 0.18
1.522GlnAsn: 1.522 ± 0.307
0.833GlnPro: 0.833 ± 0.189
1.666GlnGln: 1.666 ± 0.303
1.594GlnArg: 1.594 ± 0.274
2.137GlnSer: 2.137 ± 0.258
2.065GlnThr: 2.065 ± 0.318
2.5GlnVal: 2.5 ± 0.293
0.507GlnTrp: 0.507 ± 0.14
1.087GlnTyr: 1.087 ± 0.22
0.0GlnXaa: 0.0 ± 0.0
Arg
1.34ArgAla: 1.34 ± 0.195
0.471ArgCys: 0.471 ± 0.118
2.246ArgAsp: 2.246 ± 0.263
4.058ArgGlu: 4.058 ± 0.372
1.051ArgPhe: 1.051 ± 0.223
2.971ArgGly: 2.971 ± 0.413
0.688ArgHis: 0.688 ± 0.162
2.681ArgIle: 2.681 ± 0.313
3.623ArgLys: 3.623 ± 0.426
3.478ArgLeu: 3.478 ± 0.4
1.413ArgMet: 1.413 ± 0.248
1.848ArgAsn: 1.848 ± 0.301
0.978ArgPro: 0.978 ± 0.2
1.666ArgGln: 1.666 ± 0.244
1.848ArgArg: 1.848 ± 0.256
2.101ArgSer: 2.101 ± 0.265
1.63ArgThr: 1.63 ± 0.261
3.297ArgVal: 3.297 ± 0.294
0.399ArgTrp: 0.399 ± 0.133
1.485ArgTyr: 1.485 ± 0.238
0.0ArgXaa: 0.0 ± 0.0
Ser
3.188SerAla: 3.188 ± 0.526
0.869SerCys: 0.869 ± 0.201
4.637SerAsp: 4.637 ± 0.391
4.384SerGlu: 4.384 ± 0.38
2.934SerPhe: 2.934 ± 0.304
5.253SerGly: 5.253 ± 0.792
1.377SerHis: 1.377 ± 0.242
3.55SerIle: 3.55 ± 0.442
5.181SerLys: 5.181 ± 0.567
5.615SerLeu: 5.615 ± 0.428
1.196SerMet: 1.196 ± 0.24
3.731SerAsn: 3.731 ± 0.455
2.029SerPro: 2.029 ± 0.292
1.993SerGln: 1.993 ± 0.323
2.862SerArg: 2.862 ± 0.31
3.876SerSer: 3.876 ± 0.433
3.333SerThr: 3.333 ± 0.339
4.999SerVal: 4.999 ± 0.66
1.196SerTrp: 1.196 ± 0.226
2.898SerTyr: 2.898 ± 0.362
0.0SerXaa: 0.0 ± 0.0
Thr
3.949ThrAla: 3.949 ± 0.681
0.688ThrCys: 0.688 ± 0.183
3.876ThrAsp: 3.876 ± 0.409
4.275ThrGlu: 4.275 ± 0.38
2.898ThrPhe: 2.898 ± 0.331
4.601ThrGly: 4.601 ± 0.657
1.087ThrHis: 1.087 ± 0.227
4.891ThrIle: 4.891 ± 0.935
3.985ThrLys: 3.985 ± 0.308
6.086ThrLeu: 6.086 ± 0.803
1.196ThrMet: 1.196 ± 0.21
2.645ThrAsn: 2.645 ± 0.367
2.572ThrPro: 2.572 ± 0.309
2.282ThrGln: 2.282 ± 0.269
2.065ThrArg: 2.065 ± 0.251
3.84ThrSer: 3.84 ± 0.552
4.202ThrThr: 4.202 ± 0.648
4.456ThrVal: 4.456 ± 0.514
0.978ThrTrp: 0.978 ± 0.166
3.043ThrTyr: 3.043 ± 0.348
0.0ThrXaa: 0.0 ± 0.0
Val
4.239ValAla: 4.239 ± 0.52
1.123ValCys: 1.123 ± 0.231
4.347ValAsp: 4.347 ± 0.465
5.724ValGlu: 5.724 ± 0.567
2.645ValPhe: 2.645 ± 0.298
4.818ValGly: 4.818 ± 0.472
1.34ValHis: 1.34 ± 0.238
4.202ValIle: 4.202 ± 0.404
4.746ValLys: 4.746 ± 0.403
5.217ValLeu: 5.217 ± 0.46
1.377ValMet: 1.377 ± 0.224
3.876ValAsn: 3.876 ± 0.469
2.029ValPro: 2.029 ± 0.266
2.608ValGln: 2.608 ± 0.281
3.007ValArg: 3.007 ± 0.314
4.855ValSer: 4.855 ± 0.426
5.144ValThr: 5.144 ± 0.577
5.144ValVal: 5.144 ± 0.483
0.688ValTrp: 0.688 ± 0.144
2.174ValTyr: 2.174 ± 0.289
0.0ValXaa: 0.0 ± 0.0
Trp
0.688TrpAla: 0.688 ± 0.152
0.399TrpCys: 0.399 ± 0.126
0.869TrpAsp: 0.869 ± 0.173
1.304TrpGlu: 1.304 ± 0.247
0.797TrpPhe: 0.797 ± 0.161
0.942TrpGly: 0.942 ± 0.198
0.145TrpHis: 0.145 ± 0.092
0.471TrpIle: 0.471 ± 0.124
0.978TrpLys: 0.978 ± 0.199
1.159TrpLeu: 1.159 ± 0.239
0.362TrpMet: 0.362 ± 0.117
0.797TrpAsn: 0.797 ± 0.183
0.362TrpPro: 0.362 ± 0.105
0.326TrpGln: 0.326 ± 0.124
0.507TrpArg: 0.507 ± 0.119
1.087TrpSer: 1.087 ± 0.194
0.399TrpThr: 0.399 ± 0.134
0.725TrpVal: 0.725 ± 0.139
0.254TrpTrp: 0.254 ± 0.127
0.797TrpTyr: 0.797 ± 0.158
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.63TyrAla: 1.63 ± 0.248
0.725TyrCys: 0.725 ± 0.171
3.623TyrAsp: 3.623 ± 0.335
3.116TyrGlu: 3.116 ± 0.428
1.63TyrPhe: 1.63 ± 0.265
2.21TyrGly: 2.21 ± 0.311
0.58TyrHis: 0.58 ± 0.187
2.681TyrIle: 2.681 ± 0.331
3.224TyrLys: 3.224 ± 0.371
3.876TyrLeu: 3.876 ± 0.354
1.268TyrMet: 1.268 ± 0.23
2.319TyrAsn: 2.319 ± 0.27
1.304TyrPro: 1.304 ± 0.217
1.051TyrGln: 1.051 ± 0.194
1.522TyrArg: 1.522 ± 0.268
2.282TyrSer: 2.282 ± 0.314
2.898TyrThr: 2.898 ± 0.295
2.717TyrVal: 2.717 ± 0.366
0.761TyrTrp: 0.761 ± 0.186
2.137TyrTyr: 2.137 ± 0.326
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 156 proteins (27604 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski