Amino acid dipepetide frequency for Alfalfa mosaic virus (strain 425 / isolate Leiden)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.568AlaAla: 6.568 ± 0.957
1.642AlaCys: 1.642 ± 0.314
4.926AlaAsp: 4.926 ± 1.549
3.284AlaGlu: 3.284 ± 0.389
2.463AlaPhe: 2.463 ± 0.806
6.568AlaGly: 6.568 ± 2.891
3.284AlaHis: 3.284 ± 0.806
5.747AlaIle: 5.747 ± 1.727
4.926AlaLys: 4.926 ± 2.079
6.568AlaLeu: 6.568 ± 1.43
1.232AlaMet: 1.232 ± 0.47
2.463AlaAsn: 2.463 ± 0.428
2.463AlaPro: 2.463 ± 1.446
3.284AlaGln: 3.284 ± 1.602
4.105AlaArg: 4.105 ± 0.904
4.105AlaSer: 4.105 ± 0.532
4.105AlaThr: 4.105 ± 1.382
4.105AlaVal: 4.105 ± 1.202
0.821AlaTrp: 0.821 ± 0.234
1.642AlaTyr: 1.642 ± 0.6
0.0AlaXaa: 0.0 ± 0.0
Cys
0.411CysAla: 0.411 ± 0.268
1.232CysCys: 1.232 ± 0.368
0.821CysAsp: 0.821 ± 0.537
0.0CysGlu: 0.0 ± 0.0
1.232CysPhe: 1.232 ± 0.805
0.411CysGly: 0.411 ± 0.268
0.821CysHis: 0.821 ± 0.234
0.411CysIle: 0.411 ± 0.543
0.411CysLys: 0.411 ± 0.344
2.874CysLeu: 2.874 ± 0.859
0.821CysMet: 0.821 ± 0.234
0.411CysAsn: 0.411 ± 0.268
0.411CysPro: 0.411 ± 0.268
0.411CysGln: 0.411 ± 0.268
1.642CysArg: 1.642 ± 0.468
2.053CysSer: 2.053 ± 0.854
1.232CysThr: 1.232 ± 0.567
1.642CysVal: 1.642 ± 0.377
0.0CysTrp: 0.0 ± 0.0
0.821CysTyr: 0.821 ± 0.688
0.0CysXaa: 0.0 ± 0.0
Asp
9.852AspAla: 9.852 ± 1.444
0.411AspCys: 0.411 ± 0.268
4.926AspAsp: 4.926 ± 0.856
4.926AspGlu: 4.926 ± 1.075
4.926AspPhe: 4.926 ± 0.841
3.284AspGly: 3.284 ± 1.798
1.642AspHis: 1.642 ± 0.913
2.463AspIle: 2.463 ± 1.533
4.926AspLys: 4.926 ± 1.404
5.747AspLeu: 5.747 ± 1.28
0.411AspMet: 0.411 ± 0.268
1.642AspAsn: 1.642 ± 0.468
4.105AspPro: 4.105 ± 1.395
1.232AspGln: 1.232 ± 0.368
1.232AspArg: 1.232 ± 0.366
4.516AspSer: 4.516 ± 1.775
1.642AspThr: 1.642 ± 0.742
4.516AspVal: 4.516 ± 0.267
0.411AspTrp: 0.411 ± 0.344
2.463AspTyr: 2.463 ± 0.736
0.0AspXaa: 0.0 ± 0.0
Glu
6.158GluAla: 6.158 ± 0.72
0.821GluCys: 0.821 ± 0.234
4.105GluAsp: 4.105 ± 1.329
3.284GluGlu: 3.284 ± 1.457
2.874GluPhe: 2.874 ± 1.481
2.874GluGly: 2.874 ± 0.64
0.0GluHis: 0.0 ± 0.0
4.516GluIle: 4.516 ± 0.811
3.284GluLys: 3.284 ± 0.848
6.158GluLeu: 6.158 ± 2.321
1.642GluMet: 1.642 ± 0.314
1.232GluAsn: 1.232 ± 0.792
2.463GluPro: 2.463 ± 0.771
0.411GluGln: 0.411 ± 0.268
4.926GluArg: 4.926 ± 0.749
2.874GluSer: 2.874 ± 0.429
2.874GluThr: 2.874 ± 0.959
4.926GluVal: 4.926 ± 0.344
1.232GluTrp: 1.232 ± 0.523
0.821GluTyr: 0.821 ± 0.688
0.0GluXaa: 0.0 ± 0.0
Phe
2.053PheAla: 2.053 ± 0.439
0.821PheCys: 0.821 ± 0.459
3.695PheAsp: 3.695 ± 0.921
1.642PheGlu: 1.642 ± 0.377
1.232PhePhe: 1.232 ± 1.031
2.463PheGly: 2.463 ± 0.428
1.232PheHis: 1.232 ± 0.752
4.105PheIle: 4.105 ± 0.532
1.642PheLys: 1.642 ± 0.542
4.926PheLeu: 4.926 ± 1.92
0.411PheMet: 0.411 ± 0.247
4.105PheAsn: 4.105 ± 1.866
2.874PhePro: 2.874 ± 1.123
2.874PheGln: 2.874 ± 0.956
2.053PheArg: 2.053 ± 0.542
4.926PheSer: 4.926 ± 0.749
2.463PheThr: 2.463 ± 0.421
4.926PheVal: 4.926 ± 0.749
0.0PheTrp: 0.0 ± 0.0
0.821PheTyr: 0.821 ± 0.537
0.0PheXaa: 0.0 ± 0.0
Gly
2.463GlyAla: 2.463 ± 1.373
1.642GlyCys: 1.642 ± 0.801
2.463GlyAsp: 2.463 ± 0.736
4.105GlyGlu: 4.105 ± 1.16
2.463GlyPhe: 2.463 ± 0.421
3.284GlyGly: 3.284 ± 0.578
0.821GlyHis: 0.821 ± 0.486
0.411GlyIle: 0.411 ± 0.344
6.568GlyLys: 6.568 ± 0.309
4.105GlyLeu: 4.105 ± 1.195
1.642GlyMet: 1.642 ± 1.243
2.874GlyAsn: 2.874 ± 0.587
4.105GlyPro: 4.105 ± 1.202
1.232GlyGln: 1.232 ± 0.386
3.284GlyArg: 3.284 ± 0.848
3.284GlySer: 3.284 ± 1.403
1.642GlyThr: 1.642 ± 1.039
4.516GlyVal: 4.516 ± 0.945
0.0GlyTrp: 0.0 ± 0.0
1.232GlyTyr: 1.232 ± 0.805
0.0GlyXaa: 0.0 ± 0.0
His
3.284HisAla: 3.284 ± 1.518
1.232HisCys: 1.232 ± 0.805
1.642HisAsp: 1.642 ± 0.913
0.821HisGlu: 0.821 ± 0.234
1.642HisPhe: 1.642 ± 0.468
1.232HisGly: 1.232 ± 0.919
2.463HisHis: 2.463 ± 0.601
0.0HisIle: 0.0 ± 0.0
0.821HisLys: 0.821 ± 0.537
1.232HisLeu: 1.232 ± 0.523
1.232HisMet: 1.232 ± 0.432
1.642HisAsn: 1.642 ± 0.6
0.821HisPro: 0.821 ± 0.537
0.821HisGln: 0.821 ± 0.234
1.642HisArg: 1.642 ± 0.468
4.105HisSer: 4.105 ± 0.765
1.232HisThr: 1.232 ± 0.805
1.232HisVal: 1.232 ± 1.031
0.0HisTrp: 0.0 ± 0.0
0.821HisTyr: 0.821 ± 0.537
0.0HisXaa: 0.0 ± 0.0
Ile
2.463IleAla: 2.463 ± 1.135
0.821IleCys: 0.821 ± 0.234
6.979IleAsp: 6.979 ± 1.48
2.053IleGlu: 2.053 ± 0.854
2.463IlePhe: 2.463 ± 0.601
2.463IleGly: 2.463 ± 0.265
1.232IleHis: 1.232 ± 0.805
2.874IleIle: 2.874 ± 0.769
2.463IleLys: 2.463 ± 1.142
7.389IleLeu: 7.389 ± 2.951
0.0IleMet: 0.0 ± 0.0
2.053IleAsn: 2.053 ± 0.439
6.568IlePro: 6.568 ± 1.254
1.642IleGln: 1.642 ± 0.468
2.874IleArg: 2.874 ± 0.769
3.284IleSer: 3.284 ± 1.254
4.516IleThr: 4.516 ± 1.084
2.874IleVal: 2.874 ± 0.956
0.411IleTrp: 0.411 ± 0.543
2.053IleTyr: 2.053 ± 0.472
0.0IleXaa: 0.0 ± 0.0
Lys
4.926LysAla: 4.926 ± 2.173
0.821LysCys: 0.821 ± 0.537
2.463LysAsp: 2.463 ± 0.946
2.463LysGlu: 2.463 ± 0.265
3.695LysPhe: 3.695 ± 1.207
4.516LysGly: 4.516 ± 1.549
2.463LysHis: 2.463 ± 0.654
4.105LysIle: 4.105 ± 0.532
4.926LysLys: 4.926 ± 0.749
5.747LysLeu: 5.747 ± 1.3
0.821LysMet: 0.821 ± 0.234
2.463LysAsn: 2.463 ± 0.428
4.516LysPro: 4.516 ± 1.389
2.053LysGln: 2.053 ± 0.962
2.053LysArg: 2.053 ± 0.542
4.516LysSer: 4.516 ± 1.412
4.516LysThr: 4.516 ± 1.541
3.695LysVal: 3.695 ± 1.048
0.0LysTrp: 0.0 ± 0.0
2.053LysTyr: 2.053 ± 0.555
0.0LysXaa: 0.0 ± 0.0
Leu
4.516LeuAla: 4.516 ± 0.638
2.463LeuCys: 2.463 ± 0.872
6.979LeuAsp: 6.979 ± 1.266
6.158LeuGlu: 6.158 ± 0.176
3.695LeuPhe: 3.695 ± 1.626
9.852LeuGly: 9.852 ± 1.239
1.642LeuHis: 1.642 ± 0.854
6.158LeuIle: 6.158 ± 1.102
8.621LeuLys: 8.621 ± 2.123
7.389LeuLeu: 7.389 ± 1.727
2.053LeuMet: 2.053 ± 1.192
3.284LeuAsn: 3.284 ± 1.333
4.926LeuPro: 4.926 ± 1.245
0.821LeuGln: 0.821 ± 0.537
4.926LeuArg: 4.926 ± 0.947
9.031LeuSer: 9.031 ± 1.144
5.337LeuThr: 5.337 ± 1.016
3.695LeuVal: 3.695 ± 1.907
0.411LeuTrp: 0.411 ± 0.344
3.695LeuTyr: 3.695 ± 0.719
0.0LeuXaa: 0.0 ± 0.0
Met
0.411MetAla: 0.411 ± 0.543
0.0MetCys: 0.0 ± 0.0
0.821MetAsp: 0.821 ± 0.234
0.411MetGlu: 0.411 ± 0.543
0.821MetPhe: 0.821 ± 0.688
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
0.411MetIle: 0.411 ± 0.344
0.821MetLys: 0.821 ± 0.537
4.105MetLeu: 4.105 ± 0.532
0.411MetMet: 0.411 ± 0.268
1.232MetAsn: 1.232 ± 0.386
2.053MetPro: 2.053 ± 0.826
0.821MetGln: 0.821 ± 0.919
0.411MetArg: 0.411 ± 0.268
2.463MetSer: 2.463 ± 0.946
1.642MetThr: 1.642 ± 1.375
1.642MetVal: 1.642 ± 0.801
0.411MetTrp: 0.411 ± 0.268
0.411MetTyr: 0.411 ± 0.543
0.0MetXaa: 0.0 ± 0.0
Asn
6.158AsnAla: 6.158 ± 0.728
0.821AsnCys: 0.821 ± 0.234
0.821AsnAsp: 0.821 ± 0.688
5.747AsnGlu: 5.747 ± 2.559
2.053AsnPhe: 2.053 ± 1.036
2.874AsnGly: 2.874 ± 0.886
0.821AsnHis: 0.821 ± 0.537
2.053AsnIle: 2.053 ± 0.439
1.232AsnLys: 1.232 ± 0.368
1.232AsnLeu: 1.232 ± 0.523
0.821AsnMet: 0.821 ± 0.586
0.411AsnAsn: 0.411 ± 0.344
2.463AsnPro: 2.463 ± 0.732
1.232AsnGln: 1.232 ± 0.783
2.053AsnArg: 2.053 ± 1.022
3.695AsnSer: 3.695 ± 0.55
3.695AsnThr: 3.695 ± 0.517
4.105AsnVal: 4.105 ± 1.469
0.411AsnTrp: 0.411 ± 0.344
1.232AsnTyr: 1.232 ± 0.366
0.0AsnXaa: 0.0 ± 0.0
Pro
2.053ProAla: 2.053 ± 0.831
1.232ProCys: 1.232 ± 0.523
2.874ProAsp: 2.874 ± 0.92
4.105ProGlu: 4.105 ± 0.41
0.821ProPhe: 0.821 ± 0.234
0.821ProGly: 0.821 ± 0.537
1.642ProHis: 1.642 ± 0.377
4.105ProIle: 4.105 ± 0.532
3.284ProLys: 3.284 ± 1.585
6.158ProLeu: 6.158 ± 1.357
1.232ProMet: 1.232 ± 0.366
4.105ProAsn: 4.105 ± 1.123
0.411ProPro: 0.411 ± 0.459
0.411ProGln: 0.411 ± 0.459
3.284ProArg: 3.284 ± 1.429
4.926ProSer: 4.926 ± 1.288
4.926ProThr: 4.926 ± 1.354
5.747ProVal: 5.747 ± 0.955
0.0ProTrp: 0.0 ± 0.0
0.411ProTyr: 0.411 ± 0.344
0.0ProXaa: 0.0 ± 0.0
Gln
1.642GlnAla: 1.642 ± 0.314
0.411GlnCys: 0.411 ± 0.344
1.232GlnAsp: 1.232 ± 0.368
2.463GlnGlu: 2.463 ± 1.15
0.821GlnPhe: 0.821 ± 0.537
0.821GlnGly: 0.821 ± 0.537
0.411GlnHis: 0.411 ± 0.268
1.642GlnIle: 1.642 ± 0.314
2.463GlnLys: 2.463 ± 1.284
2.053GlnLeu: 2.053 ± 1.304
0.411GlnMet: 0.411 ± 0.268
2.463GlnAsn: 2.463 ± 1.265
0.821GlnPro: 0.821 ± 0.52
0.411GlnGln: 0.411 ± 0.268
1.232GlnArg: 1.232 ± 0.386
3.284GlnSer: 3.284 ± 0.806
1.642GlnThr: 1.642 ± 0.377
0.411GlnVal: 0.411 ± 0.268
0.411GlnTrp: 0.411 ± 0.268
0.411GlnTyr: 0.411 ± 0.268
0.0GlnXaa: 0.0 ± 0.0
Arg
4.926ArgAla: 4.926 ± 0.609
1.642ArgCys: 1.642 ± 0.468
4.105ArgAsp: 4.105 ± 0.72
1.232ArgGlu: 1.232 ± 0.523
2.463ArgPhe: 2.463 ± 1.036
0.411ArgGly: 0.411 ± 0.543
2.463ArgHis: 2.463 ± 0.428
3.284ArgIle: 3.284 ± 0.343
4.926ArgLys: 4.926 ± 0.609
4.105ArgLeu: 4.105 ± 0.585
1.642ArgMet: 1.642 ± 1.168
1.232ArgAsn: 1.232 ± 0.368
1.232ArgPro: 1.232 ± 0.523
0.411ArgGln: 0.411 ± 0.268
3.695ArgArg: 3.695 ± 0.992
6.158ArgSer: 6.158 ± 1.79
2.874ArgThr: 2.874 ± 0.902
2.874ArgVal: 2.874 ± 0.959
0.821ArgTrp: 0.821 ± 0.537
0.821ArgTyr: 0.821 ± 0.586
0.0ArgXaa: 0.0 ± 0.0
Ser
4.105SerAla: 4.105 ± 1.923
0.821SerCys: 0.821 ± 0.537
5.337SerAsp: 5.337 ± 1.029
4.516SerGlu: 4.516 ± 1.775
4.926SerPhe: 4.926 ± 1.226
4.105SerGly: 4.105 ± 1.123
2.874SerHis: 2.874 ± 1.015
5.747SerIle: 5.747 ± 1.423
4.105SerLys: 4.105 ± 1.937
9.852SerLeu: 9.852 ± 1.782
0.821SerMet: 0.821 ± 0.486
3.284SerAsn: 3.284 ± 0.648
4.926SerPro: 4.926 ± 0.53
2.053SerGln: 2.053 ± 0.755
3.695SerArg: 3.695 ± 0.513
10.673SerSer: 10.673 ± 3.251
3.695SerThr: 3.695 ± 1.17
4.516SerVal: 4.516 ± 1.42
0.411SerTrp: 0.411 ± 0.344
4.105SerTyr: 4.105 ± 0.226
0.0SerXaa: 0.0 ± 0.0
Thr
2.053ThrAla: 2.053 ± 0.542
0.411ThrCys: 0.411 ± 0.268
4.105ThrAsp: 4.105 ± 1.149
3.284ThrGlu: 3.284 ± 0.305
2.463ThrPhe: 2.463 ± 0.769
2.874ThrGly: 2.874 ± 0.251
1.232ThrHis: 1.232 ± 0.595
4.926ThrIle: 4.926 ± 0.344
2.053ThrLys: 2.053 ± 0.472
5.747ThrLeu: 5.747 ± 1.318
1.232ThrMet: 1.232 ± 0.368
3.695ThrAsn: 3.695 ± 1.349
2.053ThrPro: 2.053 ± 0.755
2.463ThrGln: 2.463 ± 0.771
1.642ThrArg: 1.642 ± 0.314
3.695ThrSer: 3.695 ± 1.104
4.926ThrThr: 4.926 ± 0.344
3.695ThrVal: 3.695 ± 0.517
0.821ThrTrp: 0.821 ± 0.537
2.874ThrTyr: 2.874 ± 0.429
0.0ThrXaa: 0.0 ± 0.0
Val
5.747ValAla: 5.747 ± 0.924
0.0ValCys: 0.0 ± 0.0
5.337ValAsp: 5.337 ± 1.043
4.105ValGlu: 4.105 ± 1.012
5.337ValPhe: 5.337 ± 0.991
3.284ValGly: 3.284 ± 1.173
2.053ValHis: 2.053 ± 1.022
2.874ValIle: 2.874 ± 0.956
4.105ValLys: 4.105 ± 0.771
5.747ValLeu: 5.747 ± 2.05
1.232ValMet: 1.232 ± 0.368
3.284ValAsn: 3.284 ± 1.708
3.695ValPro: 3.695 ± 0.719
0.411ValGln: 0.411 ± 0.344
3.695ValArg: 3.695 ± 0.714
4.105ValSer: 4.105 ± 1.244
2.874ValThr: 2.874 ± 1.015
4.516ValVal: 4.516 ± 0.605
1.232ValTrp: 1.232 ± 0.878
2.874ValTyr: 2.874 ± 0.959
0.0ValXaa: 0.0 ± 0.0
Trp
0.821TrpAla: 0.821 ± 0.234
0.0TrpCys: 0.0 ± 0.0
0.411TrpAsp: 0.411 ± 0.268
0.821TrpGlu: 0.821 ± 0.486
0.411TrpPhe: 0.411 ± 0.344
0.0TrpGly: 0.0 ± 0.0
0.411TrpHis: 0.411 ± 0.268
0.411TrpIle: 0.411 ± 0.344
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
0.411TrpMet: 0.411 ± 0.344
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.821TrpGln: 0.821 ± 0.52
0.411TrpArg: 0.411 ± 0.268
0.0TrpSer: 0.0 ± 0.0
0.411TrpThr: 0.411 ± 0.268
1.232TrpVal: 1.232 ± 0.366
0.0TrpTrp: 0.0 ± 0.0
1.232TrpTyr: 1.232 ± 0.368
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.695TyrAla: 3.695 ± 1.024
0.821TyrCys: 0.821 ± 0.537
1.232TyrAsp: 1.232 ± 1.031
2.053TyrGlu: 2.053 ± 0.334
2.463TyrPhe: 2.463 ± 0.736
0.0TyrGly: 0.0 ± 0.0
0.821TyrHis: 0.821 ± 0.234
1.232TyrIle: 1.232 ± 0.368
1.232TyrLys: 1.232 ± 0.523
4.516TyrLeu: 4.516 ± 0.811
0.411TyrMet: 0.411 ± 0.543
2.053TyrAsn: 2.053 ± 1.342
1.642TyrPro: 1.642 ± 0.972
1.642TyrGln: 1.642 ± 0.468
2.463TyrArg: 2.463 ± 0.428
2.874TyrSer: 2.874 ± 0.556
0.0TyrThr: 0.0 ± 0.0
1.642TyrVal: 1.642 ± 0.314
0.0TyrTrp: 0.0 ± 0.0
1.232TyrTyr: 1.232 ± 0.805
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (2437 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski