Amino acid dipepetide frequency for Phytomonas sp. isolate Hart1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.015AlaAla: 7.015 ± 0.079	1.253AlaCys: 1.253 ± 0.025	3.124AlaAsp: 3.124 ± 0.035	4.751AlaGlu: 4.751 ± 0.05	2.87AlaPhe: 2.87 ± 0.033	3.78AlaGly: 3.78 ± 0.05	1.903AlaHis: 1.903 ± 0.026	3.632AlaIle: 3.632 ± 0.037	3.56AlaLys: 3.56 ± 0.043	8.038AlaLeu: 8.038 ± 0.064	1.948AlaMet: 1.948 ± 0.025	2.707AlaAsn: 2.707 ± 0.033	3.341AlaPro: 3.341 ± 0.039	2.706AlaGln: 2.706 ± 0.032	4.449AlaArg: 4.449 ± 0.045	6.031AlaSer: 6.031 ± 0.06	3.861AlaThr: 3.861 ± 0.038	4.995AlaVal: 4.995 ± 0.044	0.763AlaTrp: 0.763 ± 0.017	1.857AlaTyr: 1.857 ± 0.027	0.006AlaXaa: 0.006 ± 0.001
Cys	1.414CysAla: 1.414 ± 0.023	0.458CysCys: 0.458 ± 0.014	0.926CysAsp: 0.926 ± 0.019	1.141CysGlu: 1.141 ± 0.018	0.88CysPhe: 0.88 ± 0.019	1.431CysGly: 1.431 ± 0.026	0.462CysHis: 0.462 ± 0.013	1.084CysIle: 1.084 ± 0.021	0.748CysLys: 0.748 ± 0.016	1.781CysLeu: 1.781 ± 0.024	0.453CysMet: 0.453 ± 0.012	0.709CysAsn: 0.709 ± 0.018	0.874CysPro: 0.874 ± 0.023	0.585CysGln: 0.585 ± 0.015	1.147CysArg: 1.147 ± 0.02	1.488CysSer: 1.488 ± 0.023	1.091CysThr: 1.091 ± 0.024	1.477CysVal: 1.477 ± 0.029	0.201CysTrp: 0.201 ± 0.008	0.515CysTyr: 0.515 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.147AspAla: 4.147 ± 0.041	0.841AspCys: 0.841 ± 0.017	3.249AspAsp: 3.249 ± 0.038	3.855AspGlu: 3.855 ± 0.043	2.199AspPhe: 2.199 ± 0.029	3.263AspGly: 3.263 ± 0.038	1.191AspHis: 1.191 ± 0.022	2.812AspIle: 2.812 ± 0.032	2.282AspLys: 2.282 ± 0.031	4.881AspLeu: 4.881 ± 0.051	1.081AspMet: 1.081 ± 0.021	2.028AspAsn: 2.028 ± 0.03	2.873AspPro: 2.873 ± 0.031	1.396AspGln: 1.396 ± 0.023	2.698AspArg: 2.698 ± 0.034	3.893AspSer: 3.893 ± 0.04	2.683AspThr: 2.683 ± 0.033	3.444AspVal: 3.444 ± 0.034	0.514AspTrp: 0.514 ± 0.014	1.414AspTyr: 1.414 ± 0.022	0.002AspXaa: 0.002 ± 0.001
Glu	5.557GluAla: 5.557 ± 0.053	1.051GluCys: 1.051 ± 0.019	3.858GluAsp: 3.858 ± 0.042	5.967GluGlu: 5.967 ± 0.072	2.026GluPhe: 2.026 ± 0.025	4.249GluGly: 4.249 ± 0.045	1.429GluHis: 1.429 ± 0.023	3.127GluIle: 3.127 ± 0.036	4.279GluLys: 4.279 ± 0.052	6.266GluLeu: 6.266 ± 0.059	1.72GluMet: 1.72 ± 0.023	2.932GluAsn: 2.932 ± 0.037	2.213GluPro: 2.213 ± 0.031	2.248GluGln: 2.248 ± 0.033	4.464GluArg: 4.464 ± 0.055	4.473GluSer: 4.473 ± 0.045	3.176GluThr: 3.176 ± 0.03	4.554GluVal: 4.554 ± 0.044	0.746GluTrp: 0.746 ± 0.017	1.641GluTyr: 1.641 ± 0.026	0.003GluXaa: 0.003 ± 0.001
Phe	2.557PheAla: 2.557 ± 0.03	0.845PheCys: 0.845 ± 0.018	2.104PheAsp: 2.104 ± 0.032	2.122PheGlu: 2.122 ± 0.029	2.102PhePhe: 2.102 ± 0.038	2.102PheGly: 2.102 ± 0.03	1.185PheHis: 1.185 ± 0.021	2.254PheIle: 2.254 ± 0.034	1.61PheLys: 1.61 ± 0.024	4.206PheLeu: 4.206 ± 0.046	0.972PheMet: 0.972 ± 0.021	1.64PheAsn: 1.64 ± 0.025	2.114PhePro: 2.114 ± 0.026	1.402PheGln: 1.402 ± 0.024	2.158PheArg: 2.158 ± 0.031	3.918PheSer: 3.918 ± 0.045	2.372PheThr: 2.372 ± 0.031	2.559PheVal: 2.559 ± 0.033	0.425PheTrp: 0.425 ± 0.012	1.353PheTyr: 1.353 ± 0.023	0.001PheXaa: 0.001 ± 0.001
Gly	4.077GlyAla: 4.077 ± 0.046	1.139GlyCys: 1.139 ± 0.018	3.152GlyAsp: 3.152 ± 0.033	3.809GlyGlu: 3.809 ± 0.043	2.337GlyPhe: 2.337 ± 0.035	4.754GlyGly: 4.754 ± 0.059	1.333GlyHis: 1.333 ± 0.024	3.051GlyIle: 3.051 ± 0.035	3.237GlyLys: 3.237 ± 0.036	5.161GlyLeu: 5.161 ± 0.048	1.495GlyMet: 1.495 ± 0.023	2.503GlyAsn: 2.503 ± 0.038	2.339GlyPro: 2.339 ± 0.035	1.591GlyGln: 1.591 ± 0.029	3.426GlyArg: 3.426 ± 0.039	4.631GlySer: 4.631 ± 0.053	2.985GlyThr: 2.985 ± 0.032	4.284GlyVal: 4.284 ± 0.044	0.649GlyTrp: 0.649 ± 0.015	1.574GlyTyr: 1.574 ± 0.026	0.007GlyXaa: 0.007 ± 0.002
His	1.981HisAla: 1.981 ± 0.028	0.535HisCys: 0.535 ± 0.015	1.254HisAsp: 1.254 ± 0.022	1.581HisGlu: 1.581 ± 0.024	1.189HisPhe: 1.189 ± 0.021	1.493HisGly: 1.493 ± 0.023	1.088HisHis: 1.088 ± 0.024	1.37HisIle: 1.37 ± 0.023	1.121HisLys: 1.121 ± 0.019	2.788HisLeu: 2.788 ± 0.029	0.507HisMet: 0.507 ± 0.014	1.111HisAsn: 1.111 ± 0.021	1.746HisPro: 1.746 ± 0.027	1.099HisGln: 1.099 ± 0.022	1.861HisArg: 1.861 ± 0.027	2.208HisSer: 2.208 ± 0.029	1.57HisThr: 1.57 ± 0.027	1.595HisVal: 1.595 ± 0.024	0.308HisTrp: 0.308 ± 0.01	0.88HisTyr: 0.88 ± 0.017	0.002HisXaa: 0.002 ± 0.001
Ile	3.681IleAla: 3.681 ± 0.036	0.988IleCys: 0.988 ± 0.022	2.656IleAsp: 2.656 ± 0.032	3.129IleGlu: 3.129 ± 0.038	2.255IlePhe: 2.255 ± 0.031	2.59IleGly: 2.59 ± 0.033	1.454IleHis: 1.454 ± 0.023	2.551IleIle: 2.551 ± 0.035	2.369IleLys: 2.369 ± 0.032	5.016IleLeu: 5.016 ± 0.047	1.058IleMet: 1.058 ± 0.022	2.102IleAsn: 2.102 ± 0.028	3.036IlePro: 3.036 ± 0.034	2.151IleGln: 2.151 ± 0.032	2.891IleArg: 2.891 ± 0.03	4.288IleSer: 4.288 ± 0.046	2.893IleThr: 2.893 ± 0.035	2.981IleVal: 2.981 ± 0.031	0.454IleTrp: 0.454 ± 0.014	1.457IleTyr: 1.457 ± 0.023	0.001IleXaa: 0.001 ± 0.001
Lys	3.67LysAla: 3.67 ± 0.04	0.821LysCys: 0.821 ± 0.021	2.865LysAsp: 2.865 ± 0.035	4.097LysGlu: 4.097 ± 0.052	1.413LysPhe: 1.413 ± 0.022	3.189LysGly: 3.189 ± 0.035	1.24LysHis: 1.24 ± 0.02	2.397LysIle: 2.397 ± 0.032	3.727LysLys: 3.727 ± 0.054	4.448LysLeu: 4.448 ± 0.047	1.321LysMet: 1.321 ± 0.024	2.382LysAsn: 2.382 ± 0.033	2.21LysPro: 2.21 ± 0.032	1.917LysGln: 1.917 ± 0.029	3.506LysArg: 3.506 ± 0.043	3.636LysSer: 3.636 ± 0.038	2.802LysThr: 2.802 ± 0.034	2.945LysVal: 2.945 ± 0.03	0.5LysTrp: 0.5 ± 0.012	1.378LysTyr: 1.378 ± 0.025	0.002LysXaa: 0.002 ± 0.001
Leu	6.585LeuAla: 6.585 ± 0.051	2.141LeuCys: 2.141 ± 0.03	4.783LeuAsp: 4.783 ± 0.04	6.329LeuGlu: 6.329 ± 0.065	4.063LeuPhe: 4.063 ± 0.041	4.889LeuGly: 4.889 ± 0.043	3.127LeuHis: 3.127 ± 0.035	4.399LeuIle: 4.399 ± 0.046	5.099LeuLys: 5.099 ± 0.05	10.516LeuLeu: 10.516 ± 0.091	2.299LeuMet: 2.299 ± 0.03	4.151LeuAsn: 4.151 ± 0.039	5.444LeuPro: 5.444 ± 0.051	4.547LeuGln: 4.547 ± 0.047	7.326LeuArg: 7.326 ± 0.052	8.886LeuSer: 8.886 ± 0.066	5.214LeuThr: 5.214 ± 0.053	5.533LeuVal: 5.533 ± 0.048	1.167LeuTrp: 1.167 ± 0.021	2.855LeuTyr: 2.855 ± 0.032	0.004LeuXaa: 0.004 ± 0.001
Met	1.714MetAla: 1.714 ± 0.027	0.439MetCys: 0.439 ± 0.012	1.363MetAsp: 1.363 ± 0.019	1.763MetGlu: 1.763 ± 0.029	0.772MetPhe: 0.772 ± 0.019	1.365MetGly: 1.365 ± 0.022	0.637MetHis: 0.637 ± 0.016	1.104MetIle: 1.104 ± 0.02	1.226MetLys: 1.226 ± 0.021	2.388MetLeu: 2.388 ± 0.033	0.625MetMet: 0.625 ± 0.014	1.107MetAsn: 1.107 ± 0.019	1.192MetPro: 1.192 ± 0.022	1.027MetGln: 1.027 ± 0.02	1.701MetArg: 1.701 ± 0.022	1.766MetSer: 1.766 ± 0.022	1.216MetThr: 1.216 ± 0.021	1.427MetVal: 1.427 ± 0.024	0.288MetTrp: 0.288 ± 0.009	0.564MetTyr: 0.564 ± 0.014	0.001MetXaa: 0.001 ± 0.001
Asn	3.208AsnAla: 3.208 ± 0.031	0.721AsnCys: 0.721 ± 0.016	2.298AsnAsp: 2.298 ± 0.031	2.81AsnGlu: 2.81 ± 0.034	1.695AsnPhe: 1.695 ± 0.026	2.48AsnGly: 2.48 ± 0.032	1.139AsnHis: 1.139 ± 0.02	2.467AsnIle: 2.467 ± 0.037	2.042AsnLys: 2.042 ± 0.031	3.767AsnLeu: 3.767 ± 0.045	0.959AsnMet: 0.959 ± 0.018	2.073AsnAsn: 2.073 ± 0.034	2.499AsnPro: 2.499 ± 0.027	1.367AsnGln: 1.367 ± 0.025	2.311AsnArg: 2.311 ± 0.03	3.642AsnSer: 3.642 ± 0.044	2.638AsnThr: 2.638 ± 0.032	2.531AsnVal: 2.531 ± 0.031	0.378AsnTrp: 0.378 ± 0.013	1.253AsnTyr: 1.253 ± 0.023	0.001AsnXaa: 0.001 ± 0.001
Pro	3.211ProAla: 3.211 ± 0.043	0.871ProCys: 0.871 ± 0.02	2.261ProAsp: 2.261 ± 0.029	2.869ProGlu: 2.869 ± 0.036	2.298ProPhe: 2.298 ± 0.026	2.535ProGly: 2.535 ± 0.04	1.572ProHis: 1.572 ± 0.021	2.501ProIle: 2.501 ± 0.033	2.295ProLys: 2.295 ± 0.029	5.185ProLeu: 5.185 ± 0.044	1.029ProMet: 1.029 ± 0.017	2.346ProAsn: 2.346 ± 0.033	3.944ProPro: 3.944 ± 0.051	2.098ProGln: 2.098 ± 0.033	2.989ProArg: 2.989 ± 0.041	5.312ProSer: 5.312 ± 0.054	3.306ProThr: 3.306 ± 0.041	2.77ProVal: 2.77 ± 0.032	0.504ProTrp: 0.504 ± 0.013	1.412ProTyr: 1.412 ± 0.025	0.002ProXaa: 0.002 ± 0.001
Gln	2.495GlnAla: 2.495 ± 0.028	0.725GlnCys: 0.725 ± 0.014	1.698GlnAsp: 1.698 ± 0.028	2.456GlnGlu: 2.456 ± 0.034	1.171GlnPhe: 1.171 ± 0.02	1.943GlnGly: 1.943 ± 0.026	1.197GlnHis: 1.197 ± 0.023	1.761GlnIle: 1.761 ± 0.024	2.23GlnLys: 2.23 ± 0.033	4.029GlnLeu: 4.029 ± 0.043	0.917GlnMet: 0.917 ± 0.02	1.664GlnAsn: 1.664 ± 0.031	1.724GlnPro: 1.724 ± 0.034	2.07GlnGln: 2.07 ± 0.044	3.168GlnArg: 3.168 ± 0.035	2.735GlnSer: 2.735 ± 0.033	2.174GlnThr: 2.174 ± 0.028	2.029GlnVal: 2.029 ± 0.026	0.465GlnTrp: 0.465 ± 0.014	1.054GlnTyr: 1.054 ± 0.018	0.003GlnXaa: 0.003 ± 0.001
Arg	4.546ArgAla: 4.546 ± 0.049	1.358ArgCys: 1.358 ± 0.023	3.025ArgAsp: 3.025 ± 0.033	4.421ArgGlu: 4.421 ± 0.05	2.377ArgPhe: 2.377 ± 0.031	3.796ArgGly: 3.796 ± 0.042	1.835ArgHis: 1.835 ± 0.027	3.176ArgIle: 3.176 ± 0.032	3.252ArgLys: 3.252 ± 0.036	6.474ArgLeu: 6.474 ± 0.052	1.54ArgMet: 1.54 ± 0.022	2.512ArgAsn: 2.512 ± 0.032	2.752ArgPro: 2.752 ± 0.034	2.781ArgGln: 2.781 ± 0.033	5.402ArgArg: 5.402 ± 0.068	4.621ArgSer: 4.621 ± 0.041	3.174ArgThr: 3.174 ± 0.033	4.079ArgVal: 4.079 ± 0.043	0.88ArgTrp: 0.88 ± 0.02	1.914ArgTyr: 1.914 ± 0.024	0.004ArgXaa: 0.004 ± 0.001
Ser	5.618SerAla: 5.618 ± 0.053	1.531SerCys: 1.531 ± 0.024	3.999SerAsp: 3.999 ± 0.042	4.779SerGlu: 4.779 ± 0.048	3.723SerPhe: 3.723 ± 0.039	4.68SerGly: 4.68 ± 0.043	2.187SerHis: 2.187 ± 0.031	4.341SerIle: 4.341 ± 0.046	4.008SerLys: 4.008 ± 0.045	8.229SerLeu: 8.229 ± 0.055	1.95SerMet: 1.95 ± 0.024	3.669SerAsn: 3.669 ± 0.041	4.848SerPro: 4.848 ± 0.05	2.867SerGln: 2.867 ± 0.036	4.667SerArg: 4.667 ± 0.048	9.19SerSer: 9.19 ± 0.098	5.476SerThr: 5.476 ± 0.056	4.949SerVal: 4.949 ± 0.053	0.813SerTrp: 0.813 ± 0.018	2.073SerTyr: 2.073 ± 0.025	0.006SerXaa: 0.006 ± 0.001
Thr	4.173ThrAla: 4.173 ± 0.043	0.902ThrCys: 0.902 ± 0.023	2.527ThrAsp: 2.527 ± 0.032	3.252ThrGlu: 3.252 ± 0.035	2.206ThrPhe: 2.206 ± 0.029	2.985ThrGly: 2.985 ± 0.039	1.524ThrHis: 1.524 ± 0.024	2.861ThrIle: 2.861 ± 0.033	2.678ThrLys: 2.678 ± 0.028	5.633ThrLeu: 5.633 ± 0.039	1.314ThrMet: 1.314 ± 0.022	2.44ThrAsn: 2.44 ± 0.035	3.478ThrPro: 3.478 ± 0.042	2.094ThrGln: 2.094 ± 0.026	3.022ThrArg: 3.022 ± 0.035	5.079ThrSer: 5.079 ± 0.049	3.942ThrThr: 3.942 ± 0.041	3.25ThrVal: 3.25 ± 0.033	0.51ThrTrp: 0.51 ± 0.012	1.357ThrTyr: 1.357 ± 0.022	0.004ThrXaa: 0.004 ± 0.001
Val	4.33ValAla: 4.33 ± 0.046	1.374ValCys: 1.374 ± 0.024	3.538ValAsp: 3.538 ± 0.035	4.539ValGlu: 4.539 ± 0.047	2.654ValPhe: 2.654 ± 0.032	3.654ValGly: 3.654 ± 0.042	1.648ValHis: 1.648 ± 0.023	3.012ValIle: 3.012 ± 0.033	2.95ValLys: 2.95 ± 0.036	6.7ValLeu: 6.7 ± 0.059	1.535ValMet: 1.535 ± 0.023	2.484ValAsn: 2.484 ± 0.03	3.028ValPro: 3.028 ± 0.036	2.345ValGln: 2.345 ± 0.028	4.001ValArg: 4.001 ± 0.043	5.005ValSer: 5.005 ± 0.05	2.522ValThr: 2.522 ± 0.029	4.818ValVal: 4.818 ± 0.051	0.773ValTrp: 0.773 ± 0.017	1.799ValTyr: 1.799 ± 0.028	0.006ValXaa: 0.006 ± 0.001
Trp	0.698TrpAla: 0.698 ± 0.017	0.279TrpCys: 0.279 ± 0.01	0.591TrpAsp: 0.591 ± 0.016	0.683TrpGlu: 0.683 ± 0.017	0.39TrpPhe: 0.39 ± 0.012	0.694TrpGly: 0.694 ± 0.017	0.251TrpHis: 0.251 ± 0.009	0.567TrpIle: 0.567 ± 0.014	0.615TrpLys: 0.615 ± 0.014	1.005TrpLeu: 1.005 ± 0.02	0.347TrpMet: 0.347 ± 0.012	0.506TrpAsn: 0.506 ± 0.012	0.376TrpPro: 0.376 ± 0.011	0.387TrpGln: 0.387 ± 0.011	0.893TrpArg: 0.893 ± 0.018	0.788TrpSer: 0.788 ± 0.016	0.505TrpThr: 0.505 ± 0.013	0.721TrpVal: 0.721 ± 0.017	0.195TrpTrp: 0.195 ± 0.009	0.345TrpTyr: 0.345 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.909TyrAla: 1.909 ± 0.032	0.591TyrCys: 0.591 ± 0.014	1.478TyrAsp: 1.478 ± 0.024	1.623TyrGlu: 1.623 ± 0.026	1.38TyrPhe: 1.38 ± 0.022	1.654TyrGly: 1.654 ± 0.027	0.882TyrHis: 0.882 ± 0.017	1.533TyrIle: 1.533 ± 0.026	1.138TyrLys: 1.138 ± 0.022	2.84TyrLeu: 2.84 ± 0.038	0.611TyrMet: 0.611 ± 0.013	1.211TyrAsn: 1.211 ± 0.023	1.272TyrPro: 1.272 ± 0.021	1.028TyrGln: 1.028 ± 0.02	1.835TyrArg: 1.835 ± 0.028	2.006TyrSer: 2.006 ± 0.03	1.631TyrThr: 1.631 ± 0.024	1.772TyrVal: 1.772 ± 0.026	0.303TyrTrp: 0.303 ± 0.009	1.074TyrTyr: 1.074 ± 0.021	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.004XaaAla: 0.004 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.002XaaAsp: 0.002 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.002XaaPhe: 0.002 ± 0.001	0.008XaaGly: 0.008 ± 0.002	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.001XaaLys: 0.001 ± 0.001	0.006XaaLeu: 0.006 ± 0.001	0.002XaaMet: 0.002 ± 0.001	0.002XaaAsn: 0.002 ± 0.001	0.005XaaPro: 0.005 ± 0.001	0.002XaaGln: 0.002 ± 0.001	0.006XaaArg: 0.006 ± 0.001	0.006XaaSer: 0.006 ± 0.001	0.003XaaThr: 0.003 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	8.062XaaXaa: 8.062 ± 0.972

Statistics based on 6442 proteins (2938716 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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