Amino acid dipepetide frequency for Hanseniaspora uvarum (Yeast) (Kloeckera apiculata)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.808AlaAla: 2.808 ± 0.064	0.544AlaCys: 0.544 ± 0.016	2.441AlaAsp: 2.441 ± 0.038	2.853AlaGlu: 2.853 ± 0.053	1.974AlaPhe: 1.974 ± 0.033	2.174AlaGly: 2.174 ± 0.042	0.735AlaHis: 0.735 ± 0.02	3.191AlaIle: 3.191 ± 0.049	3.676AlaLys: 3.676 ± 0.051	4.302AlaLeu: 4.302 ± 0.049	1.0AlaMet: 1.0 ± 0.022	2.85AlaAsn: 2.85 ± 0.037	1.476AlaPro: 1.476 ± 0.041	1.411AlaGln: 1.411 ± 0.033	1.34AlaArg: 1.34 ± 0.03	3.688AlaSer: 3.688 ± 0.059	2.527AlaThr: 2.527 ± 0.053	2.604AlaVal: 2.604 ± 0.044	0.326AlaTrp: 0.326 ± 0.015	1.49AlaTyr: 1.49 ± 0.029	0.188AlaXaa: 0.188 ± 0.01
Cys	0.436CysAla: 0.436 ± 0.015	0.252CysCys: 0.252 ± 0.011	0.623CysAsp: 0.623 ± 0.02	0.577CysGlu: 0.577 ± 0.016	0.668CysPhe: 0.668 ± 0.016	0.673CysGly: 0.673 ± 0.019	0.217CysHis: 0.217 ± 0.011	0.999CysIle: 0.999 ± 0.021	0.9CysLys: 0.9 ± 0.023	1.269CysLeu: 1.269 ± 0.025	0.262CysMet: 0.262 ± 0.01	0.653CysAsn: 0.653 ± 0.021	0.357CysPro: 0.357 ± 0.013	0.362CysGln: 0.362 ± 0.013	0.331CysArg: 0.331 ± 0.013	0.847CysSer: 0.847 ± 0.021	0.516CysThr: 0.516 ± 0.019	0.641CysVal: 0.641 ± 0.018	0.118CysTrp: 0.118 ± 0.008	0.488CysTyr: 0.488 ± 0.016	0.039CysXaa: 0.039 ± 0.004
Asp	2.514AspAla: 2.514 ± 0.042	0.697AspCys: 0.697 ± 0.02	4.843AspAsp: 4.843 ± 0.076	5.402AspGlu: 5.402 ± 0.075	3.443AspPhe: 3.443 ± 0.046	2.419AspGly: 2.419 ± 0.033	1.059AspHis: 1.059 ± 0.023	5.375AspIle: 5.375 ± 0.061	4.559AspLys: 4.559 ± 0.048	6.427AspLeu: 6.427 ± 0.057	1.41AspMet: 1.41 ± 0.029	4.231AspAsn: 4.231 ± 0.046	1.968AspPro: 1.968 ± 0.034	1.778AspGln: 1.778 ± 0.03	1.553AspArg: 1.553 ± 0.03	4.826AspSer: 4.826 ± 0.054	3.013AspThr: 3.013 ± 0.04	3.501AspVal: 3.501 ± 0.039	0.52AspTrp: 0.52 ± 0.016	2.767AspTyr: 2.767 ± 0.038	0.386AspXaa: 0.386 ± 0.016
Glu	2.908GluAla: 2.908 ± 0.048	0.583GluCys: 0.583 ± 0.018	5.048GluAsp: 5.048 ± 0.07	6.473GluGlu: 6.473 ± 0.102	3.139GluPhe: 3.139 ± 0.045	2.33GluGly: 2.33 ± 0.037	1.258GluHis: 1.258 ± 0.027	5.16GluIle: 5.16 ± 0.054	6.28GluLys: 6.28 ± 0.07	6.317GluLeu: 6.317 ± 0.068	1.496GluMet: 1.496 ± 0.029	5.876GluAsn: 5.876 ± 0.062	1.648GluPro: 1.648 ± 0.033	2.651GluGln: 2.651 ± 0.036	2.094GluArg: 2.094 ± 0.035	4.893GluSer: 4.893 ± 0.057	3.738GluThr: 3.738 ± 0.054	3.538GluVal: 3.538 ± 0.051	0.537GluTrp: 0.537 ± 0.016	2.952GluTyr: 2.952 ± 0.038	0.406GluXaa: 0.406 ± 0.018
Phe	2.048PheAla: 2.048 ± 0.034	0.484PheCys: 0.484 ± 0.017	3.412PheAsp: 3.412 ± 0.035	3.442PheGlu: 3.442 ± 0.046	2.343PhePhe: 2.343 ± 0.043	2.605PheGly: 2.605 ± 0.055	0.796PheHis: 0.796 ± 0.02	3.657PheIle: 3.657 ± 0.05	4.422PheLys: 4.422 ± 0.053	4.446PheLeu: 4.446 ± 0.048	1.045PheMet: 1.045 ± 0.024	3.707PheAsn: 3.707 ± 0.046	1.32PhePro: 1.32 ± 0.027	1.68PheGln: 1.68 ± 0.029	1.19PheArg: 1.19 ± 0.025	3.573PheSer: 3.573 ± 0.047	2.453PheThr: 2.453 ± 0.035	2.839PheVal: 2.839 ± 0.04	0.441PheTrp: 0.441 ± 0.014	1.884PheTyr: 1.884 ± 0.034	0.22PheXaa: 0.22 ± 0.012
Gly	1.956GlyAla: 1.956 ± 0.045	0.684GlyCys: 0.684 ± 0.02	2.399GlyAsp: 2.399 ± 0.036	2.369GlyGlu: 2.369 ± 0.039	2.458GlyPhe: 2.458 ± 0.04	2.498GlyGly: 2.498 ± 0.055	0.862GlyHis: 0.862 ± 0.024	3.363GlyIle: 3.363 ± 0.043	3.495GlyLys: 3.495 ± 0.046	4.269GlyLeu: 4.269 ± 0.052	0.986GlyMet: 0.986 ± 0.024	2.946GlyAsn: 2.946 ± 0.04	1.077GlyPro: 1.077 ± 0.027	1.257GlyGln: 1.257 ± 0.039	1.474GlyArg: 1.474 ± 0.031	3.834GlySer: 3.834 ± 0.058	2.396GlyThr: 2.396 ± 0.048	2.557GlyVal: 2.557 ± 0.047	0.426GlyTrp: 0.426 ± 0.014	1.845GlyTyr: 1.845 ± 0.038	0.162GlyXaa: 0.162 ± 0.009
His	0.695HisAla: 0.695 ± 0.02	0.258HisCys: 0.258 ± 0.012	0.985HisAsp: 0.985 ± 0.02	1.092HisGlu: 1.092 ± 0.021	0.93HisPhe: 0.93 ± 0.022	0.846HisGly: 0.846 ± 0.022	0.438HisHis: 0.438 ± 0.015	1.367HisIle: 1.367 ± 0.028	1.425HisLys: 1.425 ± 0.027	1.909HisLeu: 1.909 ± 0.033	0.391HisMet: 0.391 ± 0.015	1.231HisAsn: 1.231 ± 0.031	0.741HisPro: 0.741 ± 0.018	0.694HisGln: 0.694 ± 0.02	0.661HisArg: 0.661 ± 0.016	1.452HisSer: 1.452 ± 0.03	0.902HisThr: 0.902 ± 0.019	0.924HisVal: 0.924 ± 0.023	0.175HisTrp: 0.175 ± 0.01	0.777HisTyr: 0.777 ± 0.019	0.091HisXaa: 0.091 ± 0.007
Ile	3.194IleAla: 3.194 ± 0.048	0.88IleCys: 0.88 ± 0.022	5.141IleAsp: 5.141 ± 0.053	5.086IleGlu: 5.086 ± 0.057	3.5IlePhe: 3.5 ± 0.042	3.05IleGly: 3.05 ± 0.041	1.317IleHis: 1.317 ± 0.028	5.455IleIle: 5.455 ± 0.068	6.789IleLys: 6.789 ± 0.063	7.122IleLeu: 7.122 ± 0.074	1.523IleMet: 1.523 ± 0.027	6.047IleAsn: 6.047 ± 0.066	3.019IlePro: 3.019 ± 0.042	2.731IleGln: 2.731 ± 0.037	2.134IleArg: 2.134 ± 0.033	6.141IleSer: 6.141 ± 0.063	4.102IleThr: 4.102 ± 0.055	3.937IleVal: 3.937 ± 0.047	0.585IleTrp: 0.585 ± 0.019	2.636IleTyr: 2.636 ± 0.041	0.359IleXaa: 0.359 ± 0.017
Lys	3.716LysAla: 3.716 ± 0.057	0.842LysCys: 0.842 ± 0.023	5.261LysAsp: 5.261 ± 0.051	6.573LysGlu: 6.573 ± 0.073	3.923LysPhe: 3.923 ± 0.049	2.946LysGly: 2.946 ± 0.042	1.819LysHis: 1.819 ± 0.033	6.59LysIle: 6.59 ± 0.064	9.331LysLys: 9.331 ± 0.107	8.3LysLeu: 8.3 ± 0.081	1.969LysMet: 1.969 ± 0.031	7.289LysAsn: 7.289 ± 0.075	2.964LysPro: 2.964 ± 0.044	3.815LysGln: 3.815 ± 0.053	3.346LysArg: 3.346 ± 0.046	6.469LysSer: 6.469 ± 0.07	5.147LysThr: 5.147 ± 0.051	4.398LysVal: 4.398 ± 0.049	0.705LysTrp: 0.705 ± 0.018	3.673LysTyr: 3.673 ± 0.045	0.492LysXaa: 0.492 ± 0.019
Leu	4.216LeuAla: 4.216 ± 0.056	1.04LeuCys: 1.04 ± 0.024	5.778LeuAsp: 5.778 ± 0.058	6.306LeuGlu: 6.306 ± 0.069	4.234LeuPhe: 4.234 ± 0.056	3.985LeuGly: 3.985 ± 0.058	1.645LeuHis: 1.645 ± 0.03	6.931LeuIle: 6.931 ± 0.075	9.877LeuLys: 9.877 ± 0.091	9.304LeuLeu: 9.304 ± 0.093	2.052LeuMet: 2.052 ± 0.033	7.852LeuAsn: 7.852 ± 0.078	3.725LeuPro: 3.725 ± 0.045	3.925LeuGln: 3.925 ± 0.049	3.06LeuArg: 3.06 ± 0.039	8.013LeuSer: 8.013 ± 0.066	5.089LeuThr: 5.089 ± 0.059	4.716LeuVal: 4.716 ± 0.049	0.686LeuTrp: 0.686 ± 0.019	3.287LeuTyr: 3.287 ± 0.041	0.383LeuXaa: 0.383 ± 0.017
Met	1.053MetAla: 1.053 ± 0.022	0.245MetCys: 0.245 ± 0.01	1.321MetAsp: 1.321 ± 0.026	1.266MetGlu: 1.266 ± 0.025	1.053MetPhe: 1.053 ± 0.022	0.935MetGly: 0.935 ± 0.026	0.326MetHis: 0.326 ± 0.013	1.578MetIle: 1.578 ± 0.032	1.975MetLys: 1.975 ± 0.032	1.794MetLeu: 1.794 ± 0.03	0.563MetMet: 0.563 ± 0.017	1.948MetAsn: 1.948 ± 0.036	0.682MetPro: 0.682 ± 0.02	0.672MetGln: 0.672 ± 0.022	0.648MetArg: 0.648 ± 0.018	2.109MetSer: 2.109 ± 0.035	1.127MetThr: 1.127 ± 0.023	1.04MetVal: 1.04 ± 0.02	0.144MetTrp: 0.144 ± 0.008	0.689MetTyr: 0.689 ± 0.019	0.093MetXaa: 0.093 ± 0.006
Asn	2.908AsnAla: 2.908 ± 0.045	0.763AsnCys: 0.763 ± 0.021	5.132AsnAsp: 5.132 ± 0.054	5.401AsnGlu: 5.401 ± 0.059	3.46AsnPhe: 3.46 ± 0.046	3.383AsnGly: 3.383 ± 0.046	1.366AsnHis: 1.366 ± 0.029	6.051AsnIle: 6.051 ± 0.068	7.275AsnLys: 7.275 ± 0.084	6.855AsnLeu: 6.855 ± 0.063	1.575AsnMet: 1.575 ± 0.025	7.16AsnAsn: 7.16 ± 0.089	2.37AsnPro: 2.37 ± 0.037	2.687AsnGln: 2.687 ± 0.04	2.009AsnArg: 2.009 ± 0.033	6.542AsnSer: 6.542 ± 0.081	4.386AsnThr: 4.386 ± 0.057	3.949AsnVal: 3.949 ± 0.038	0.632AsnTrp: 0.632 ± 0.019	2.799AsnTyr: 2.799 ± 0.041	0.506AsnXaa: 0.506 ± 0.019
Pro	1.533ProAla: 1.533 ± 0.036	0.278ProCys: 0.278 ± 0.012	1.712ProAsp: 1.712 ± 0.029	2.595ProGlu: 2.595 ± 0.038	1.621ProPhe: 1.621 ± 0.032	1.34ProGly: 1.34 ± 0.031	0.581ProHis: 0.581 ± 0.017	2.582ProIle: 2.582 ± 0.038	2.859ProLys: 2.859 ± 0.041	3.264ProLeu: 3.264 ± 0.038	0.667ProMet: 0.667 ± 0.02	2.216ProAsn: 2.216 ± 0.037	1.327ProPro: 1.327 ± 0.048	1.285ProGln: 1.285 ± 0.031	0.971ProArg: 0.971 ± 0.025	2.876ProSer: 2.876 ± 0.044	2.021ProThr: 2.021 ± 0.036	2.175ProVal: 2.175 ± 0.034	0.312ProTrp: 0.312 ± 0.015	1.215ProTyr: 1.215 ± 0.024	0.176ProXaa: 0.176 ± 0.01
Gln	1.512GlnAla: 1.512 ± 0.034	0.366GlnCys: 0.366 ± 0.014	1.964GlnAsp: 1.964 ± 0.03	2.492GlnGlu: 2.492 ± 0.037	1.763GlnPhe: 1.763 ± 0.03	1.371GlnGly: 1.371 ± 0.027	0.726GlnHis: 0.726 ± 0.02	2.586GlnIle: 2.586 ± 0.038	3.197GlnLys: 3.197 ± 0.046	3.597GlnLeu: 3.597 ± 0.048	0.854GlnMet: 0.854 ± 0.025	2.762GlnAsn: 2.762 ± 0.04	1.295GlnPro: 1.295 ± 0.036	2.41GlnGln: 2.41 ± 0.075	1.402GlnArg: 1.402 ± 0.029	2.788GlnSer: 2.788 ± 0.035	1.866GlnThr: 1.866 ± 0.036	1.795GlnVal: 1.795 ± 0.031	0.289GlnTrp: 0.289 ± 0.01	1.509GlnTyr: 1.509 ± 0.029	0.193GlnXaa: 0.193 ± 0.01
Arg	1.382ArgAla: 1.382 ± 0.027	0.365ArgCys: 0.365 ± 0.014	1.738ArgAsp: 1.738 ± 0.03	1.906ArgGlu: 1.906 ± 0.033	1.596ArgPhe: 1.596 ± 0.028	1.364ArgGly: 1.364 ± 0.036	0.643ArgHis: 0.643 ± 0.019	2.194ArgIle: 2.194 ± 0.038	2.822ArgLys: 2.822 ± 0.042	3.136ArgLeu: 3.136 ± 0.038	0.672ArgMet: 0.672 ± 0.018	2.123ArgAsn: 2.123 ± 0.035	0.937ArgPro: 0.937 ± 0.02	1.234ArgGln: 1.234 ± 0.025	1.498ArgArg: 1.498 ± 0.035	2.427ArgSer: 2.427 ± 0.04	1.517ArgThr: 1.517 ± 0.028	1.589ArgVal: 1.589 ± 0.03	0.262ArgTrp: 0.262 ± 0.012	1.29ArgTyr: 1.29 ± 0.025	0.104ArgXaa: 0.104 ± 0.007
Ser	3.467SerAla: 3.467 ± 0.053	0.871SerCys: 0.871 ± 0.023	4.816SerAsp: 4.816 ± 0.055	4.948SerGlu: 4.948 ± 0.056	4.034SerPhe: 4.034 ± 0.054	3.721SerGly: 3.721 ± 0.052	1.373SerHis: 1.373 ± 0.027	6.369SerIle: 6.369 ± 0.063	7.094SerLys: 7.094 ± 0.069	8.122SerLeu: 8.122 ± 0.076	1.659SerMet: 1.659 ± 0.031	6.557SerAsn: 6.557 ± 0.074	2.659SerPro: 2.659 ± 0.048	2.73SerGln: 2.73 ± 0.044	2.48SerArg: 2.48 ± 0.046	8.726SerSer: 8.726 ± 0.164	5.117SerThr: 5.117 ± 0.114	4.303SerVal: 4.303 ± 0.061	0.623SerTrp: 0.623 ± 0.015	2.964SerTyr: 2.964 ± 0.043	0.462SerXaa: 0.462 ± 0.017
Thr	2.589ThrAla: 2.589 ± 0.046	0.634ThrCys: 0.634 ± 0.017	3.047ThrAsp: 3.047 ± 0.04	3.313ThrGlu: 3.313 ± 0.046	2.684ThrPhe: 2.684 ± 0.04	2.889ThrGly: 2.889 ± 0.063	0.955ThrHis: 0.955 ± 0.023	3.972ThrIle: 3.972 ± 0.057	4.572ThrLys: 4.572 ± 0.055	5.161ThrLeu: 5.161 ± 0.056	0.947ThrMet: 0.947 ± 0.02	3.987ThrAsn: 3.987 ± 0.05	2.399ThrPro: 2.399 ± 0.046	1.734ThrGln: 1.734 ± 0.033	1.562ThrArg: 1.562 ± 0.029	5.234ThrSer: 5.234 ± 0.113	3.749ThrThr: 3.749 ± 0.109	3.075ThrVal: 3.075 ± 0.056	0.447ThrTrp: 0.447 ± 0.016	1.994ThrTyr: 1.994 ± 0.047	0.289ThrXaa: 0.289 ± 0.013
Val	2.597ValAla: 2.597 ± 0.05	0.708ValCys: 0.708 ± 0.017	3.618ValAsp: 3.618 ± 0.046	3.749ValGlu: 3.749 ± 0.046	2.652ValPhe: 2.652 ± 0.035	2.365ValGly: 2.365 ± 0.041	0.902ValHis: 0.902 ± 0.022	3.843ValIle: 3.843 ± 0.044	4.26ValLys: 4.26 ± 0.056	5.438ValLeu: 5.438 ± 0.058	1.091ValMet: 1.091 ± 0.026	3.692ValAsn: 3.692 ± 0.042	2.047ValPro: 2.047 ± 0.036	1.681ValGln: 1.681 ± 0.031	1.412ValArg: 1.412 ± 0.027	4.543ValSer: 4.543 ± 0.064	2.801ValThr: 2.801 ± 0.052	3.316ValVal: 3.316 ± 0.057	0.463ValTrp: 0.463 ± 0.017	2.138ValTyr: 2.138 ± 0.039	0.222ValXaa: 0.222 ± 0.012
Trp	0.376TrpAla: 0.376 ± 0.013	0.167TrpCys: 0.167 ± 0.008	0.524TrpAsp: 0.524 ± 0.016	0.512TrpGlu: 0.512 ± 0.017	0.449TrpPhe: 0.449 ± 0.015	0.391TrpGly: 0.391 ± 0.015	0.136TrpHis: 0.136 ± 0.009	0.579TrpIle: 0.579 ± 0.018	0.76TrpLys: 0.76 ± 0.019	0.753TrpLeu: 0.753 ± 0.022	0.196TrpMet: 0.196 ± 0.01	0.601TrpAsn: 0.601 ± 0.016	0.212TrpPro: 0.212 ± 0.01	0.255TrpGln: 0.255 ± 0.01	0.342TrpArg: 0.342 ± 0.013	0.634TrpSer: 0.634 ± 0.02	0.454TrpThr: 0.454 ± 0.024	0.441TrpVal: 0.441 ± 0.016	0.101TrpTrp: 0.101 ± 0.008	0.309TrpTyr: 0.309 ± 0.014	0.023TrpXaa: 0.023 ± 0.003
Tyr	1.507TyrAla: 1.507 ± 0.033	0.531TyrCys: 0.531 ± 0.016	2.526TyrAsp: 2.526 ± 0.037	2.552TyrGlu: 2.552 ± 0.037	1.835TyrPhe: 1.835 ± 0.034	1.858TyrGly: 1.858 ± 0.029	0.756TyrHis: 0.756 ± 0.02	2.596TyrIle: 2.596 ± 0.041	3.482TyrLys: 3.482 ± 0.045	3.891TyrLeu: 3.891 ± 0.049	0.807TyrMet: 0.807 ± 0.019	2.972TyrAsn: 2.972 ± 0.047	1.245TyrPro: 1.245 ± 0.027	1.569TyrGln: 1.569 ± 0.034	1.173TyrArg: 1.173 ± 0.023	3.001TyrSer: 3.001 ± 0.052	2.041TyrThr: 2.041 ± 0.032	1.981TyrVal: 1.981 ± 0.037	0.397TyrTrp: 0.397 ± 0.018	1.775TyrTyr: 1.775 ± 0.041	0.148TyrXaa: 0.148 ± 0.011
Xaa	0.185XaaAla: 0.185 ± 0.009	0.034XaaCys: 0.034 ± 0.004	0.363XaaAsp: 0.363 ± 0.016	0.419XaaGlu: 0.419 ± 0.018	0.25XaaPhe: 0.25 ± 0.013	0.175XaaGly: 0.175 ± 0.01	0.075XaaHis: 0.075 ± 0.006	0.309XaaIle: 0.309 ± 0.014	0.515XaaLys: 0.515 ± 0.018	0.426XaaLeu: 0.426 ± 0.016	0.091XaaMet: 0.091 ± 0.007	0.512XaaAsn: 0.512 ± 0.02	0.143XaaPro: 0.143 ± 0.01	0.175XaaGln: 0.175 ± 0.01	0.117XaaArg: 0.117 ± 0.009	0.48XaaSer: 0.48 ± 0.019	0.27XaaThr: 0.27 ± 0.014	0.22XaaVal: 0.22 ± 0.01	0.025XaaTrp: 0.025 ± 0.003	0.16XaaTyr: 0.16 ± 0.01	0.152XaaXaa: 0.152 ± 0.014

Statistics based on 4059 proteins (2125948 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---