Amino acid dipepetide frequency for Hydrogenophaga sp. IBVHS1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.147AlaAla: 16.147 ± 0.15
1.295AlaCys: 1.295 ± 0.03
6.068AlaAsp: 6.068 ± 0.065
6.472AlaGlu: 6.472 ± 0.081
4.207AlaPhe: 4.207 ± 0.064
10.301AlaGly: 10.301 ± 0.1
2.842AlaHis: 2.842 ± 0.048
5.02AlaIle: 5.02 ± 0.064
3.426AlaLys: 3.426 ± 0.064
14.984AlaLeu: 14.984 ± 0.149
3.765AlaMet: 3.765 ± 0.054
2.759AlaAsn: 2.759 ± 0.053
6.185AlaPro: 6.185 ± 0.081
5.654AlaGln: 5.654 ± 0.068
8.932AlaArg: 8.932 ± 0.095
7.041AlaSer: 7.041 ± 0.069
6.138AlaThr: 6.138 ± 0.073
9.094AlaVal: 9.094 ± 0.091
2.092AlaTrp: 2.092 ± 0.043
2.423AlaTyr: 2.423 ± 0.039
0.0AlaXaa: 0.0 ± 0.0
Cys
1.192CysAla: 1.192 ± 0.032
0.108CysCys: 0.108 ± 0.009
0.54CysAsp: 0.54 ± 0.02
0.554CysGlu: 0.554 ± 0.02
0.317CysPhe: 0.317 ± 0.016
0.948CysGly: 0.948 ± 0.029
0.286CysHis: 0.286 ± 0.016
0.4CysIle: 0.4 ± 0.017
0.228CysLys: 0.228 ± 0.012
0.855CysLeu: 0.855 ± 0.026
0.22CysMet: 0.22 ± 0.013
0.25CysAsn: 0.25 ± 0.014
0.5CysPro: 0.5 ± 0.018
0.273CysGln: 0.273 ± 0.013
0.554CysArg: 0.554 ± 0.022
0.514CysSer: 0.514 ± 0.021
0.503CysThr: 0.503 ± 0.022
0.772CysVal: 0.772 ± 0.025
0.124CysTrp: 0.124 ± 0.009
0.182CysTyr: 0.182 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
6.746AspAla: 6.746 ± 0.078
0.415AspCys: 0.415 ± 0.018
2.483AspAsp: 2.483 ± 0.045
3.05AspGlu: 3.05 ± 0.052
1.963AspPhe: 1.963 ± 0.041
4.273AspGly: 4.273 ± 0.068
1.21AspHis: 1.21 ± 0.029
2.309AspIle: 2.309 ± 0.04
1.559AspLys: 1.559 ± 0.037
5.304AspLeu: 5.304 ± 0.078
1.291AspMet: 1.291 ± 0.03
1.159AspAsn: 1.159 ± 0.029
2.859AspPro: 2.859 ± 0.044
1.632AspGln: 1.632 ± 0.031
3.362AspArg: 3.362 ± 0.057
2.111AspSer: 2.111 ± 0.036
2.545AspThr: 2.545 ± 0.044
4.073AspVal: 4.073 ± 0.057
0.933AspTrp: 0.933 ± 0.029
1.17AspTyr: 1.17 ± 0.03
0.0AspXaa: 0.0 ± 0.0
Glu
6.847GluAla: 6.847 ± 0.089
0.421GluCys: 0.421 ± 0.019
2.284GluAsp: 2.284 ± 0.043
2.477GluGlu: 2.477 ± 0.048
1.813GluPhe: 1.813 ± 0.036
3.967GluGly: 3.967 ± 0.061
1.436GluHis: 1.436 ± 0.034
2.467GluIle: 2.467 ± 0.044
1.972GluLys: 1.972 ± 0.048
6.037GluLeu: 6.037 ± 0.081
1.334GluMet: 1.334 ± 0.028
1.259GluAsn: 1.259 ± 0.032
2.7GluPro: 2.7 ± 0.047
2.508GluGln: 2.508 ± 0.047
4.776GluArg: 4.776 ± 0.069
2.625GluSer: 2.625 ± 0.046
2.568GluThr: 2.568 ± 0.04
4.24GluVal: 4.24 ± 0.062
0.763GluTrp: 0.763 ± 0.025
0.962GluTyr: 0.962 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
4.093PheAla: 4.093 ± 0.052
0.442PheCys: 0.442 ± 0.019
2.445PheAsp: 2.445 ± 0.047
2.217PheGlu: 2.217 ± 0.041
1.401PhePhe: 1.401 ± 0.035
3.339PheGly: 3.339 ± 0.061
0.829PheHis: 0.829 ± 0.022
1.501PheIle: 1.501 ± 0.039
1.197PheLys: 1.197 ± 0.032
3.205PheLeu: 3.205 ± 0.047
0.888PheMet: 0.888 ± 0.028
1.155PheAsn: 1.155 ± 0.03
1.499PhePro: 1.499 ± 0.031
1.085PheGln: 1.085 ± 0.027
1.847PheArg: 1.847 ± 0.037
2.182PheSer: 2.182 ± 0.046
1.993PheThr: 1.993 ± 0.039
2.833PheVal: 2.833 ± 0.046
0.536PheTrp: 0.536 ± 0.022
0.877PheTyr: 0.877 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
9.195GlyAla: 9.195 ± 0.104
0.882GlyCys: 0.882 ± 0.025
3.803GlyAsp: 3.803 ± 0.063
4.601GlyGlu: 4.601 ± 0.064
3.411GlyPhe: 3.411 ± 0.053
6.978GlyGly: 6.978 ± 0.11
2.096GlyHis: 2.096 ± 0.043
3.922GlyIle: 3.922 ± 0.061
3.065GlyLys: 3.065 ± 0.051
9.383GlyLeu: 9.383 ± 0.094
2.545GlyMet: 2.545 ± 0.044
2.119GlyAsn: 2.119 ± 0.042
3.223GlyPro: 3.223 ± 0.054
3.452GlyGln: 3.452 ± 0.052
5.345GlyArg: 5.345 ± 0.06
4.602GlySer: 4.602 ± 0.061
4.359GlyThr: 4.359 ± 0.058
6.968GlyVal: 6.968 ± 0.077
1.542GlyTrp: 1.542 ± 0.038
2.159GlyTyr: 2.159 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
3.019HisAla: 3.019 ± 0.054
0.297HisCys: 0.297 ± 0.015
1.12HisAsp: 1.12 ± 0.031
1.218HisGlu: 1.218 ± 0.031
0.931HisPhe: 0.931 ± 0.024
2.275HisGly: 2.275 ± 0.049
0.759HisHis: 0.759 ± 0.026
1.003HisIle: 1.003 ± 0.024
0.627HisLys: 0.627 ± 0.022
2.478HisLeu: 2.478 ± 0.042
0.568HisMet: 0.568 ± 0.019
0.53HisAsn: 0.53 ± 0.021
1.594HisPro: 1.594 ± 0.036
0.845HisGln: 0.845 ± 0.026
1.599HisArg: 1.599 ± 0.038
1.09HisSer: 1.09 ± 0.028
1.226HisThr: 1.226 ± 0.031
1.662HisVal: 1.662 ± 0.038
0.469HisTrp: 0.469 ± 0.02
0.577HisTyr: 0.577 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
5.635IleAla: 5.635 ± 0.068
0.432IleCys: 0.432 ± 0.019
2.89IleAsp: 2.89 ± 0.048
3.069IleGlu: 3.069 ± 0.054
1.282IlePhe: 1.282 ± 0.036
4.077IleGly: 4.077 ± 0.07
0.882IleHis: 0.882 ± 0.026
1.399IleIle: 1.399 ± 0.037
1.457IleLys: 1.457 ± 0.036
3.126IleLeu: 3.126 ± 0.05
0.783IleMet: 0.783 ± 0.026
1.392IleAsn: 1.392 ± 0.035
1.996IlePro: 1.996 ± 0.042
1.341IleGln: 1.341 ± 0.031
2.469IleArg: 2.469 ± 0.043
2.345IleSer: 2.345 ± 0.043
2.541IleThr: 2.541 ± 0.044
3.422IleVal: 3.422 ± 0.054
0.53IleTrp: 0.53 ± 0.022
0.947IleTyr: 0.947 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
4.059LysAla: 4.059 ± 0.065
0.152LysCys: 0.152 ± 0.01
1.634LysAsp: 1.634 ± 0.036
1.481LysGlu: 1.481 ± 0.038
0.904LysPhe: 0.904 ± 0.025
2.544LysGly: 2.544 ± 0.049
0.668LysHis: 0.668 ± 0.021
1.302LysIle: 1.302 ± 0.033
1.35LysLys: 1.35 ± 0.041
3.346LysLeu: 3.346 ± 0.052
0.785LysMet: 0.785 ± 0.027
0.922LysAsn: 0.922 ± 0.034
2.097LysPro: 2.097 ± 0.032
1.108LysGln: 1.108 ± 0.034
2.156LysArg: 2.156 ± 0.043
1.744LysSer: 1.744 ± 0.039
1.937LysThr: 1.937 ± 0.041
2.494LysVal: 2.494 ± 0.059
0.34LysTrp: 0.34 ± 0.014
0.622LysTyr: 0.622 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
14.683LeuAla: 14.683 ± 0.12
1.092LeuCys: 1.092 ± 0.031
5.737LeuAsp: 5.737 ± 0.069
5.29LeuGlu: 5.29 ± 0.076
3.476LeuPhe: 3.476 ± 0.06
9.069LeuGly: 9.069 ± 0.107
2.543LeuHis: 2.543 ± 0.05
4.412LeuIle: 4.412 ± 0.056
3.706LeuLys: 3.706 ± 0.052
11.626LeuLeu: 11.626 ± 0.126
2.869LeuMet: 2.869 ± 0.045
2.874LeuAsn: 2.874 ± 0.046
6.256LeuPro: 6.256 ± 0.069
4.45LeuGln: 4.45 ± 0.061
7.805LeuArg: 7.805 ± 0.097
6.276LeuSer: 6.276 ± 0.078
5.452LeuThr: 5.452 ± 0.064
8.255LeuVal: 8.255 ± 0.096
1.474LeuTrp: 1.474 ± 0.034
1.944LeuTyr: 1.944 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
3.397MetAla: 3.397 ± 0.052
0.198MetCys: 0.198 ± 0.014
1.242MetAsp: 1.242 ± 0.033
1.159MetGlu: 1.159 ± 0.031
0.768MetPhe: 0.768 ± 0.024
2.259MetGly: 2.259 ± 0.041
0.557MetHis: 0.557 ± 0.019
0.988MetIle: 0.988 ± 0.029
1.172MetLys: 1.172 ± 0.036
2.817MetLeu: 2.817 ± 0.052
0.619MetMet: 0.619 ± 0.024
0.998MetAsn: 0.998 ± 0.025
1.55MetPro: 1.55 ± 0.041
1.058MetGln: 1.058 ± 0.029
1.761MetArg: 1.761 ± 0.034
1.713MetSer: 1.713 ± 0.034
1.539MetThr: 1.539 ± 0.036
1.971MetVal: 1.971 ± 0.04
0.251MetTrp: 0.251 ± 0.013
0.384MetTyr: 0.384 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.352AsnAla: 3.352 ± 0.044
0.251AsnCys: 0.251 ± 0.015
1.324AsnAsp: 1.324 ± 0.032
1.291AsnGlu: 1.291 ± 0.034
0.9AsnPhe: 0.9 ± 0.03
2.185AsnGly: 2.185 ± 0.04
0.555AsnHis: 0.555 ± 0.024
1.158AsnIle: 1.158 ± 0.029
0.722AsnLys: 0.722 ± 0.026
2.635AsnLeu: 2.635 ± 0.044
0.573AsnMet: 0.573 ± 0.022
0.741AsnAsn: 0.741 ± 0.024
1.906AsnPro: 1.906 ± 0.032
0.962AsnGln: 0.962 ± 0.028
1.643AsnArg: 1.643 ± 0.04
1.162AsnSer: 1.162 ± 0.032
1.454AsnThr: 1.454 ± 0.028
1.884AsnVal: 1.884 ± 0.041
0.46AsnTrp: 0.46 ± 0.02
0.603AsnTyr: 0.603 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
7.016ProAla: 7.016 ± 0.086
0.36ProCys: 0.36 ± 0.018
3.066ProAsp: 3.066 ± 0.046
3.436ProGlu: 3.436 ± 0.058
1.889ProPhe: 1.889 ± 0.039
4.821ProGly: 4.821 ± 0.073
1.233ProHis: 1.233 ± 0.033
1.875ProIle: 1.875 ± 0.039
1.492ProLys: 1.492 ± 0.034
5.444ProLeu: 5.444 ± 0.068
1.542ProMet: 1.542 ± 0.029
1.275ProAsn: 1.275 ± 0.033
2.719ProPro: 2.719 ± 0.058
2.065ProGln: 2.065 ± 0.034
3.082ProArg: 3.082 ± 0.047
2.864ProSer: 2.864 ± 0.046
2.756ProThr: 2.756 ± 0.041
4.523ProVal: 4.523 ± 0.069
0.869ProTrp: 0.869 ± 0.024
1.076ProTyr: 1.076 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
5.633GlnAla: 5.633 ± 0.067
0.276GlnCys: 0.276 ± 0.014
1.572GlnAsp: 1.572 ± 0.039
1.582GlnGlu: 1.582 ± 0.035
1.185GlnPhe: 1.185 ± 0.03
3.263GlnGly: 3.263 ± 0.049
0.989GlnHis: 0.989 ± 0.027
1.726GlnIle: 1.726 ± 0.032
1.215GlnLys: 1.215 ± 0.031
4.163GlnLeu: 4.163 ± 0.06
1.046GlnMet: 1.046 ± 0.027
0.862GlnAsn: 0.862 ± 0.023
2.282GlnPro: 2.282 ± 0.037
1.766GlnGln: 1.766 ± 0.042
3.768GlnArg: 3.768 ± 0.07
2.006GlnSer: 2.006 ± 0.034
2.097GlnThr: 2.097 ± 0.04
2.997GlnVal: 2.997 ± 0.039
0.713GlnTrp: 0.713 ± 0.023
0.71GlnTyr: 0.71 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
7.753ArgAla: 7.753 ± 0.092
0.642ArgCys: 0.642 ± 0.026
3.474ArgAsp: 3.474 ± 0.06
4.497ArgGlu: 4.497 ± 0.067
2.842ArgPhe: 2.842 ± 0.047
4.543ArgGly: 4.543 ± 0.063
1.928ArgHis: 1.928 ± 0.036
3.284ArgIle: 3.284 ± 0.049
2.064ArgLys: 2.064 ± 0.039
8.075ArgLeu: 8.075 ± 0.094
1.941ArgMet: 1.941 ± 0.036
1.739ArgAsn: 1.739 ± 0.035
3.279ArgPro: 3.279 ± 0.058
2.992ArgGln: 2.992 ± 0.046
4.881ArgArg: 4.881 ± 0.066
3.66ArgSer: 3.66 ± 0.057
3.305ArgThr: 3.305 ± 0.051
5.367ArgVal: 5.367 ± 0.064
1.229ArgTrp: 1.229 ± 0.035
1.675ArgTyr: 1.675 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
6.535SerAla: 6.535 ± 0.078
0.418SerCys: 0.418 ± 0.02
2.598SerAsp: 2.598 ± 0.041
2.695SerGlu: 2.695 ± 0.047
2.05SerPhe: 2.05 ± 0.044
5.172SerGly: 5.172 ± 0.06
1.25SerHis: 1.25 ± 0.034
2.221SerIle: 2.221 ± 0.043
1.512SerLys: 1.512 ± 0.038
5.967SerLeu: 5.967 ± 0.069
1.462SerMet: 1.462 ± 0.033
1.34SerAsn: 1.34 ± 0.029
3.01SerPro: 3.01 ± 0.04
1.969SerGln: 1.969 ± 0.042
3.658SerArg: 3.658 ± 0.051
3.016SerSer: 3.016 ± 0.055
2.997SerThr: 2.997 ± 0.046
4.21SerVal: 4.21 ± 0.057
0.716SerTrp: 0.716 ± 0.024
1.176SerTyr: 1.176 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
5.976ThrAla: 5.976 ± 0.08
0.457ThrCys: 0.457 ± 0.021
2.453ThrAsp: 2.453 ± 0.042
2.583ThrGlu: 2.583 ± 0.048
1.814ThrPhe: 1.814 ± 0.038
4.782ThrGly: 4.782 ± 0.065
1.278ThrHis: 1.278 ± 0.033
2.027ThrIle: 2.027 ± 0.038
1.208ThrLys: 1.208 ± 0.031
6.571ThrLeu: 6.571 ± 0.071
1.169ThrMet: 1.169 ± 0.032
1.159ThrAsn: 1.159 ± 0.033
3.701ThrPro: 3.701 ± 0.061
2.003ThrGln: 2.003 ± 0.037
3.386ThrArg: 3.386 ± 0.054
2.745ThrSer: 2.745 ± 0.046
2.978ThrThr: 2.978 ± 0.045
4.234ThrVal: 4.234 ± 0.057
0.746ThrTrp: 0.746 ± 0.026
1.029ThrTyr: 1.029 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
9.627ValAla: 9.627 ± 0.091
0.768ValCys: 0.768 ± 0.024
3.991ValAsp: 3.991 ± 0.058
4.118ValGlu: 4.118 ± 0.062
2.95ValPhe: 2.95 ± 0.046
5.885ValGly: 5.885 ± 0.071
1.719ValHis: 1.719 ± 0.032
3.549ValIle: 3.549 ± 0.052
2.565ValLys: 2.565 ± 0.052
8.785ValLeu: 8.785 ± 0.095
2.117ValMet: 2.117 ± 0.043
2.218ValAsn: 2.218 ± 0.043
4.157ValPro: 4.157 ± 0.06
3.073ValGln: 3.073 ± 0.046
5.27ValArg: 5.27 ± 0.069
4.306ValSer: 4.306 ± 0.055
3.974ValThr: 3.974 ± 0.051
6.784ValVal: 6.784 ± 0.087
1.143ValTrp: 1.143 ± 0.029
1.521ValTyr: 1.521 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
1.512TrpAla: 1.512 ± 0.038
0.19TrpCys: 0.19 ± 0.011
0.645TrpAsp: 0.645 ± 0.024
0.577TrpGlu: 0.577 ± 0.022
0.569TrpPhe: 0.569 ± 0.023
1.053TrpGly: 1.053 ± 0.031
0.382TrpHis: 0.382 ± 0.02
0.67TrpIle: 0.67 ± 0.022
0.488TrpLys: 0.488 ± 0.021
2.193TrpLeu: 2.193 ± 0.053
0.463TrpMet: 0.463 ± 0.019
0.448TrpAsn: 0.448 ± 0.019
0.859TrpPro: 0.859 ± 0.028
0.786TrpGln: 0.786 ± 0.024
1.331TrpArg: 1.331 ± 0.033
0.866TrpSer: 0.866 ± 0.024
0.754TrpThr: 0.754 ± 0.024
1.194TrpVal: 1.194 ± 0.034
0.366TrpTrp: 0.366 ± 0.019
0.301TrpTyr: 0.301 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.428TyrAla: 2.428 ± 0.044
0.226TyrCys: 0.226 ± 0.012
1.077TyrAsp: 1.077 ± 0.026
1.09TyrGlu: 1.09 ± 0.028
0.889TyrPhe: 0.889 ± 0.031
1.917TyrGly: 1.917 ± 0.035
0.447TyrHis: 0.447 ± 0.021
0.781TyrIle: 0.781 ± 0.021
0.619TyrLys: 0.619 ± 0.022
2.297TyrLeu: 2.297 ± 0.047
0.421TyrMet: 0.421 ± 0.017
0.557TyrAsn: 0.557 ± 0.02
1.032TyrPro: 1.032 ± 0.03
0.83TyrGln: 0.83 ± 0.027
1.548TyrArg: 1.548 ± 0.037
1.104TyrSer: 1.104 ± 0.029
1.182TyrThr: 1.182 ± 0.033
1.545TyrVal: 1.545 ± 0.036
0.35TyrTrp: 0.35 ± 0.016
0.514TyrTyr: 0.514 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4193 proteins (1365467 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski