Amino acid dipepetide frequency for Aspergillus arachidicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.147AlaAla: 8.147 ± 0.051	1.135AlaCys: 1.135 ± 0.016	4.07AlaAsp: 4.07 ± 0.026	4.879AlaGlu: 4.879 ± 0.034	3.19AlaPhe: 3.19 ± 0.025	5.579AlaGly: 5.579 ± 0.035	1.779AlaHis: 1.779 ± 0.02	4.446AlaIle: 4.446 ± 0.03	3.731AlaLys: 3.731 ± 0.029	7.817AlaLeu: 7.817 ± 0.037	1.968AlaMet: 1.968 ± 0.017	2.862AlaAsn: 2.862 ± 0.025	4.323AlaPro: 4.323 ± 0.033	3.267AlaGln: 3.267 ± 0.024	4.641AlaArg: 4.641 ± 0.029	6.873AlaSer: 6.873 ± 0.036	5.138AlaThr: 5.138 ± 0.029	5.395AlaVal: 5.395 ± 0.035	1.191AlaTrp: 1.191 ± 0.016	2.265AlaTyr: 2.265 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	1.021CysAla: 1.021 ± 0.013	0.255CysCys: 0.255 ± 0.007	0.709CysAsp: 0.709 ± 0.013	0.627CysGlu: 0.627 ± 0.01	0.577CysPhe: 0.577 ± 0.009	0.942CysGly: 0.942 ± 0.014	0.357CysHis: 0.357 ± 0.008	0.767CysIle: 0.767 ± 0.012	0.502CysLys: 0.502 ± 0.01	1.4CysLeu: 1.4 ± 0.018	0.293CysMet: 0.293 ± 0.007	0.457CysAsn: 0.457 ± 0.008	0.696CysPro: 0.696 ± 0.015	0.498CysGln: 0.498 ± 0.009	0.803CysArg: 0.803 ± 0.013	0.99CysSer: 0.99 ± 0.014	0.734CysThr: 0.734 ± 0.013	0.86CysVal: 0.86 ± 0.014	0.214CysTrp: 0.214 ± 0.006	0.404CysTyr: 0.404 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.443AspAla: 4.443 ± 0.025	0.659AspCys: 0.659 ± 0.012	3.798AspAsp: 3.798 ± 0.034	4.133AspGlu: 4.133 ± 0.03	2.159AspPhe: 2.159 ± 0.021	3.939AspGly: 3.939 ± 0.027	1.299AspHis: 1.299 ± 0.015	3.317AspIle: 3.317 ± 0.028	2.291AspLys: 2.291 ± 0.02	5.184AspLeu: 5.184 ± 0.03	1.277AspMet: 1.277 ± 0.016	1.972AspAsn: 1.972 ± 0.02	3.348AspPro: 3.348 ± 0.026	1.964AspGln: 1.964 ± 0.017	3.06AspArg: 3.06 ± 0.023	4.133AspSer: 4.133 ± 0.028	3.053AspThr: 3.053 ± 0.022	3.66AspVal: 3.66 ± 0.024	0.905AspTrp: 0.905 ± 0.013	1.684AspTyr: 1.684 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	5.108GluAla: 5.108 ± 0.036	0.671GluCys: 0.671 ± 0.01	3.986GluAsp: 3.986 ± 0.031	5.203GluGlu: 5.203 ± 0.047	1.982GluPhe: 1.982 ± 0.02	3.647GluGly: 3.647 ± 0.028	1.426GluHis: 1.426 ± 0.02	3.105GluIle: 3.105 ± 0.021	3.586GluLys: 3.586 ± 0.031	5.266GluLeu: 5.266 ± 0.032	1.402GluMet: 1.402 ± 0.015	2.384GluAsn: 2.384 ± 0.021	2.761GluPro: 2.761 ± 0.042	2.507GluGln: 2.507 ± 0.025	3.823GluArg: 3.823 ± 0.031	4.39GluSer: 4.39 ± 0.031	3.511GluThr: 3.511 ± 0.028	3.554GluVal: 3.554 ± 0.022	0.898GluTrp: 0.898 ± 0.011	1.795GluTyr: 1.795 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	3.021PheAla: 3.021 ± 0.024	0.592PheCys: 0.592 ± 0.011	2.276PheAsp: 2.276 ± 0.02	2.112PheGlu: 2.112 ± 0.019	1.693PhePhe: 1.693 ± 0.02	2.857PheGly: 2.857 ± 0.023	0.989PheHis: 0.989 ± 0.012	1.976PheIle: 1.976 ± 0.02	1.455PheLys: 1.455 ± 0.016	3.72PheLeu: 3.72 ± 0.029	0.812PheMet: 0.812 ± 0.011	1.489PheAsn: 1.489 ± 0.014	2.04PhePro: 2.04 ± 0.021	1.503PheGln: 1.503 ± 0.017	2.0PheArg: 2.0 ± 0.019	3.078PheSer: 3.078 ± 0.023	2.254PheThr: 2.254 ± 0.02	2.447PheVal: 2.447 ± 0.023	0.681PheTrp: 0.681 ± 0.011	1.218PheTyr: 1.218 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.153GlyAla: 5.153 ± 0.035	0.939GlyCys: 0.939 ± 0.011	3.589GlyAsp: 3.589 ± 0.029	3.529GlyGlu: 3.529 ± 0.028	2.892GlyPhe: 2.892 ± 0.024	5.251GlyGly: 5.251 ± 0.043	1.728GlyHis: 1.728 ± 0.018	3.744GlyIle: 3.744 ± 0.029	3.281GlyLys: 3.281 ± 0.03	6.327GlyLeu: 6.327 ± 0.035	1.544GlyMet: 1.544 ± 0.017	2.581GlyAsn: 2.581 ± 0.022	3.265GlyPro: 3.265 ± 0.025	2.615GlyGln: 2.615 ± 0.023	3.911GlyArg: 3.911 ± 0.025	5.64GlySer: 5.64 ± 0.034	3.982GlyThr: 3.982 ± 0.029	4.514GlyVal: 4.514 ± 0.03	1.21GlyTrp: 1.21 ± 0.017	2.268GlyTyr: 2.268 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	1.838HisAla: 1.838 ± 0.016	0.367HisCys: 0.367 ± 0.008	1.354HisAsp: 1.354 ± 0.015	1.347HisGlu: 1.347 ± 0.015	0.952HisPhe: 0.952 ± 0.013	1.756HisGly: 1.756 ± 0.019	0.854HisHis: 0.854 ± 0.015	1.321HisIle: 1.321 ± 0.015	0.88HisLys: 0.88 ± 0.012	2.36HisLeu: 2.36 ± 0.023	0.503HisMet: 0.503 ± 0.009	0.878HisAsn: 0.878 ± 0.013	1.702HisPro: 1.702 ± 0.017	0.969HisGln: 0.969 ± 0.013	1.572HisArg: 1.572 ± 0.016	1.916HisSer: 1.916 ± 0.022	1.319HisThr: 1.319 ± 0.017	1.466HisVal: 1.466 ± 0.016	0.381HisTrp: 0.381 ± 0.009	0.746HisTyr: 0.746 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.381IleAla: 4.381 ± 0.031	0.831IleCys: 0.831 ± 0.011	2.919IleAsp: 2.919 ± 0.021	2.93IleGlu: 2.93 ± 0.022	2.13IlePhe: 2.13 ± 0.022	3.425IleGly: 3.425 ± 0.027	1.311IleHis: 1.311 ± 0.015	2.75IleIle: 2.75 ± 0.025	2.081IleLys: 2.081 ± 0.019	4.929IleLeu: 4.929 ± 0.035	1.066IleMet: 1.066 ± 0.013	1.893IleAsn: 1.893 ± 0.017	3.257IlePro: 3.257 ± 0.026	2.041IleGln: 2.041 ± 0.02	2.887IleArg: 2.887 ± 0.024	4.087IleSer: 4.087 ± 0.027	2.967IleThr: 2.967 ± 0.024	3.402IleVal: 3.402 ± 0.027	0.768IleTrp: 0.768 ± 0.011	1.594IleTyr: 1.594 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	3.951LysAla: 3.951 ± 0.027	0.533LysCys: 0.533 ± 0.01	2.759LysAsp: 2.759 ± 0.024	3.264LysGlu: 3.264 ± 0.032	1.402LysPhe: 1.402 ± 0.015	2.916LysGly: 2.916 ± 0.026	1.089LysHis: 1.089 ± 0.013	2.178LysIle: 2.178 ± 0.017	2.848LysLys: 2.848 ± 0.04	3.968LysLeu: 3.968 ± 0.029	0.917LysMet: 0.917 ± 0.012	1.714LysAsn: 1.714 ± 0.016	2.551LysPro: 2.551 ± 0.024	1.81LysGln: 1.81 ± 0.019	3.122LysArg: 3.122 ± 0.026	3.34LysSer: 3.34 ± 0.024	2.636LysThr: 2.636 ± 0.022	2.795LysVal: 2.795 ± 0.021	0.664LysTrp: 0.664 ± 0.01	1.391LysTyr: 1.391 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	7.823LeuAla: 7.823 ± 0.046	1.312LeuCys: 1.312 ± 0.017	5.255LeuAsp: 5.255 ± 0.037	5.637LeuGlu: 5.637 ± 0.039	3.538LeuPhe: 3.538 ± 0.028	6.176LeuGly: 6.176 ± 0.03	2.407LeuHis: 2.407 ± 0.024	4.274LeuIle: 4.274 ± 0.03	4.072LeuLys: 4.072 ± 0.029	8.89LeuLeu: 8.89 ± 0.06	1.869LeuMet: 1.869 ± 0.016	3.383LeuAsn: 3.383 ± 0.026	5.498LeuPro: 5.498 ± 0.035	3.987LeuGln: 3.987 ± 0.03	5.803LeuArg: 5.803 ± 0.034	7.722LeuSer: 7.722 ± 0.042	4.984LeuThr: 4.984 ± 0.029	5.716LeuVal: 5.716 ± 0.035	1.296LeuTrp: 1.296 ± 0.017	2.605LeuTyr: 2.605 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	2.118MetAla: 2.118 ± 0.02	0.281MetCys: 0.281 ± 0.006	1.22MetAsp: 1.22 ± 0.015	1.301MetGlu: 1.301 ± 0.015	0.75MetPhe: 0.75 ± 0.011	1.477MetGly: 1.477 ± 0.017	0.485MetHis: 0.485 ± 0.008	1.057MetIle: 1.057 ± 0.013	1.011MetLys: 1.011 ± 0.012	1.885MetLeu: 1.885 ± 0.018	0.546MetMet: 0.546 ± 0.01	0.826MetAsn: 0.826 ± 0.012	1.174MetPro: 1.174 ± 0.014	0.865MetGln: 0.865 ± 0.011	1.245MetArg: 1.245 ± 0.014	1.839MetSer: 1.839 ± 0.019	1.301MetThr: 1.301 ± 0.015	1.39MetVal: 1.39 ± 0.017	0.269MetTrp: 0.269 ± 0.008	0.551MetTyr: 0.551 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.108AsnAla: 3.108 ± 0.021	0.49AsnCys: 0.49 ± 0.008	2.002AsnAsp: 2.002 ± 0.023	2.087AsnGlu: 2.087 ± 0.017	1.385AsnPhe: 1.385 ± 0.017	2.989AsnGly: 2.989 ± 0.027	0.883AsnHis: 0.883 ± 0.013	2.216AsnIle: 2.216 ± 0.02	1.528AsnLys: 1.528 ± 0.017	3.333AsnLeu: 3.333 ± 0.025	0.881AsnMet: 0.881 ± 0.012	1.5AsnAsn: 1.5 ± 0.018	2.486AsnPro: 2.486 ± 0.018	1.359AsnGln: 1.359 ± 0.016	1.963AsnArg: 1.963 ± 0.017	2.746AsnSer: 2.746 ± 0.022	2.259AsnThr: 2.259 ± 0.02	2.417AsnVal: 2.417 ± 0.023	0.594AsnTrp: 0.594 ± 0.01	1.127AsnTyr: 1.127 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	4.688ProAla: 4.688 ± 0.04	0.556ProCys: 0.556 ± 0.01	3.221ProAsp: 3.221 ± 0.024	3.907ProGlu: 3.907 ± 0.041	2.12ProPhe: 2.12 ± 0.02	3.831ProGly: 3.831 ± 0.03	1.309ProHis: 1.309 ± 0.016	2.566ProIle: 2.566 ± 0.02	2.5ProLys: 2.5 ± 0.022	4.769ProLeu: 4.769 ± 0.03	1.052ProMet: 1.052 ± 0.013	2.184ProAsn: 2.184 ± 0.02	4.311ProPro: 4.311 ± 0.051	2.378ProGln: 2.378 ± 0.026	3.27ProArg: 3.27 ± 0.029	5.858ProSer: 5.858 ± 0.044	3.85ProThr: 3.85 ± 0.03	3.627ProVal: 3.627 ± 0.029	0.795ProTrp: 0.795 ± 0.01	1.571ProTyr: 1.571 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	3.317GlnAla: 3.317 ± 0.029	0.495GlnCys: 0.495 ± 0.009	2.086GlnAsp: 2.086 ± 0.019	2.477GlnGlu: 2.477 ± 0.023	1.35GlnPhe: 1.35 ± 0.014	2.509GlnGly: 2.509 ± 0.021	1.046GlnHis: 1.046 ± 0.016	1.971GlnIle: 1.971 ± 0.018	2.008GlnLys: 2.008 ± 0.02	3.604GlnLeu: 3.604 ± 0.025	0.878GlnMet: 0.878 ± 0.012	1.6GlnAsn: 1.6 ± 0.017	2.46GlnPro: 2.46 ± 0.027	2.244GlnGln: 2.244 ± 0.038	2.598GlnArg: 2.598 ± 0.022	3.2GlnSer: 3.2 ± 0.026	2.381GlnThr: 2.381 ± 0.022	2.257GlnVal: 2.257 ± 0.021	0.612GlnTrp: 0.612 ± 0.01	1.241GlnTyr: 1.241 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	4.433ArgAla: 4.433 ± 0.031	0.735ArgCys: 0.735 ± 0.012	3.301ArgAsp: 3.301 ± 0.028	3.732ArgGlu: 3.732 ± 0.033	2.221ArgPhe: 2.221 ± 0.02	3.534ArgGly: 3.534 ± 0.026	1.532ArgHis: 1.532 ± 0.017	2.95ArgIle: 2.95 ± 0.024	3.24ArgLys: 3.24 ± 0.024	5.643ArgLeu: 5.643 ± 0.035	1.273ArgMet: 1.273 ± 0.015	2.251ArgAsn: 2.251 ± 0.018	3.291ArgPro: 3.291 ± 0.031	2.577ArgGln: 2.577 ± 0.025	4.796ArgArg: 4.796 ± 0.037	4.656ArgSer: 4.656 ± 0.036	3.21ArgThr: 3.21 ± 0.024	3.456ArgVal: 3.456 ± 0.023	0.983ArgTrp: 0.983 ± 0.012	1.777ArgTyr: 1.777 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.42SerAla: 6.42 ± 0.038	0.955SerCys: 0.955 ± 0.016	4.301SerAsp: 4.301 ± 0.029	4.29SerGlu: 4.29 ± 0.029	3.158SerPhe: 3.158 ± 0.02	5.522SerGly: 5.522 ± 0.034	2.011SerHis: 2.011 ± 0.021	4.163SerIle: 4.163 ± 0.028	3.568SerLys: 3.568 ± 0.027	7.568SerLeu: 7.568 ± 0.04	1.697SerMet: 1.697 ± 0.017	3.058SerAsn: 3.058 ± 0.025	5.206SerPro: 5.206 ± 0.042	3.36SerGln: 3.36 ± 0.028	4.902SerArg: 4.902 ± 0.037	8.447SerSer: 8.447 ± 0.055	5.465SerThr: 5.465 ± 0.034	4.76SerVal: 4.76 ± 0.031	1.199SerTrp: 1.199 ± 0.016	2.195SerTyr: 2.195 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.09ThrAla: 5.09 ± 0.032	0.778ThrCys: 0.778 ± 0.013	2.962ThrAsp: 2.962 ± 0.025	3.23ThrGlu: 3.23 ± 0.023	2.309ThrPhe: 2.309 ± 0.017	4.27ThrGly: 4.27 ± 0.031	1.319ThrHis: 1.319 ± 0.013	3.224ThrIle: 3.224 ± 0.024	2.499ThrLys: 2.499 ± 0.021	5.396ThrLeu: 5.396 ± 0.031	1.226ThrMet: 1.226 ± 0.014	2.113ThrAsn: 2.113 ± 0.019	4.118ThrPro: 4.118 ± 0.035	2.115ThrGln: 2.115 ± 0.021	3.011ThrArg: 3.011 ± 0.023	5.199ThrSer: 5.199 ± 0.031	4.089ThrThr: 4.089 ± 0.033	3.979ThrVal: 3.979 ± 0.026	0.915ThrTrp: 0.915 ± 0.011	1.691ThrTyr: 1.691 ± 0.016	0.0ThrXaa: 0.0 ± 0.0
Val	5.217ValAla: 5.217 ± 0.031	0.883ValCys: 0.883 ± 0.012	3.813ValAsp: 3.813 ± 0.022	3.819ValGlu: 3.819 ± 0.026	2.57ValPhe: 2.57 ± 0.02	4.125ValGly: 4.125 ± 0.028	1.472ValHis: 1.472 ± 0.016	3.213ValIle: 3.213 ± 0.024	2.81ValLys: 2.81 ± 0.023	5.825ValLeu: 5.825 ± 0.033	1.343ValMet: 1.343 ± 0.017	2.341ValAsn: 2.341 ± 0.02	3.633ValPro: 3.633 ± 0.026	2.488ValGln: 2.488 ± 0.021	3.474ValArg: 3.474 ± 0.023	4.878ValSer: 4.878 ± 0.027	3.701ValThr: 3.701 ± 0.027	4.386ValVal: 4.386 ± 0.035	0.901ValTrp: 0.901 ± 0.013	1.878ValTyr: 1.878 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.165TrpAla: 1.165 ± 0.014	0.206TrpCys: 0.206 ± 0.006	0.944TrpAsp: 0.944 ± 0.014	0.882TrpGlu: 0.882 ± 0.012	0.564TrpPhe: 0.564 ± 0.01	0.984TrpGly: 0.984 ± 0.012	0.375TrpHis: 0.375 ± 0.008	0.829TrpIle: 0.829 ± 0.011	0.851TrpLys: 0.851 ± 0.011	1.46TrpLeu: 1.46 ± 0.017	0.384TrpMet: 0.384 ± 0.009	0.674TrpAsn: 0.674 ± 0.011	0.626TrpPro: 0.626 ± 0.01	0.586TrpGln: 0.586 ± 0.01	0.97TrpArg: 0.97 ± 0.012	1.097TrpSer: 1.097 ± 0.015	0.966TrpThr: 0.966 ± 0.013	0.936TrpVal: 0.936 ± 0.012	0.291TrpTrp: 0.291 ± 0.007	0.468TrpTyr: 0.468 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.253TyrAla: 2.253 ± 0.019	0.434TyrCys: 0.434 ± 0.008	1.709TyrAsp: 1.709 ± 0.017	1.621TyrGlu: 1.621 ± 0.017	1.271TyrPhe: 1.271 ± 0.014	2.232TyrGly: 2.232 ± 0.022	0.809TyrHis: 0.809 ± 0.013	1.583TyrIle: 1.583 ± 0.016	1.106TyrLys: 1.106 ± 0.015	2.902TyrLeu: 2.902 ± 0.025	0.661TyrMet: 0.661 ± 0.011	1.194TyrAsn: 1.194 ± 0.016	1.618TyrPro: 1.618 ± 0.019	1.201TyrGln: 1.201 ± 0.014	1.74TyrArg: 1.74 ± 0.017	2.159TyrSer: 2.159 ± 0.022	1.735TyrThr: 1.735 ± 0.018	1.752TyrVal: 1.752 ± 0.018	0.489TyrTrp: 0.489 ± 0.009	1.01TyrTyr: 1.01 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12090 proteins (6134843 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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