Amino acid dipepetide frequency for Dyella choica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.812AlaAla: 14.812 ± 0.145
1.272AlaCys: 1.272 ± 0.032
6.11AlaAsp: 6.11 ± 0.066
5.91AlaGlu: 5.91 ± 0.089
3.835AlaPhe: 3.835 ± 0.053
9.828AlaGly: 9.828 ± 0.125
2.745AlaHis: 2.745 ± 0.05
5.482AlaIle: 5.482 ± 0.06
3.644AlaLys: 3.644 ± 0.07
13.792AlaLeu: 13.792 ± 0.122
3.353AlaMet: 3.353 ± 0.046
3.609AlaAsn: 3.609 ± 0.086
5.435AlaPro: 5.435 ± 0.068
5.601AlaGln: 5.601 ± 0.073
7.577AlaArg: 7.577 ± 0.091
7.241AlaSer: 7.241 ± 0.102
6.145AlaThr: 6.145 ± 0.109
8.13AlaVal: 8.13 ± 0.08
1.947AlaTrp: 1.947 ± 0.042
2.857AlaTyr: 2.857 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
1.051CysAla: 1.051 ± 0.03
0.126CysCys: 0.126 ± 0.009
0.49CysAsp: 0.49 ± 0.019
0.482CysGlu: 0.482 ± 0.018
0.315CysPhe: 0.315 ± 0.016
0.866CysGly: 0.866 ± 0.024
0.272CysHis: 0.272 ± 0.015
0.392CysIle: 0.392 ± 0.017
0.245CysLys: 0.245 ± 0.014
0.973CysLeu: 0.973 ± 0.027
0.219CysMet: 0.219 ± 0.012
0.264CysAsn: 0.264 ± 0.013
0.409CysPro: 0.409 ± 0.02
0.27CysGln: 0.27 ± 0.015
0.567CysArg: 0.567 ± 0.021
0.536CysSer: 0.536 ± 0.02
0.492CysThr: 0.492 ± 0.018
0.663CysVal: 0.663 ± 0.02
0.143CysTrp: 0.143 ± 0.009
0.246CysTyr: 0.246 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
7.017AspAla: 7.017 ± 0.087
0.467AspCys: 0.467 ± 0.016
2.92AspAsp: 2.92 ± 0.057
2.987AspGlu: 2.987 ± 0.049
2.048AspPhe: 2.048 ± 0.037
4.937AspGly: 4.937 ± 0.08
1.316AspHis: 1.316 ± 0.031
2.5AspIle: 2.5 ± 0.048
1.535AspLys: 1.535 ± 0.04
5.245AspLeu: 5.245 ± 0.056
1.157AspMet: 1.157 ± 0.029
1.51AspAsn: 1.51 ± 0.04
3.167AspPro: 3.167 ± 0.052
1.937AspGln: 1.937 ± 0.039
3.241AspArg: 3.241 ± 0.053
2.681AspSer: 2.681 ± 0.042
2.709AspThr: 2.709 ± 0.045
4.025AspVal: 4.025 ± 0.062
0.969AspTrp: 0.969 ± 0.03
1.73AspTyr: 1.73 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
6.032GluAla: 6.032 ± 0.084
0.397GluCys: 0.397 ± 0.018
2.157GluAsp: 2.157 ± 0.047
2.383GluGlu: 2.383 ± 0.053
1.502GluPhe: 1.502 ± 0.032
3.421GluGly: 3.421 ± 0.05
1.534GluHis: 1.534 ± 0.037
2.249GluIle: 2.249 ± 0.041
1.578GluLys: 1.578 ± 0.039
5.88GluLeu: 5.88 ± 0.085
1.027GluMet: 1.027 ± 0.028
1.333GluAsn: 1.333 ± 0.028
2.266GluPro: 2.266 ± 0.042
2.743GluGln: 2.743 ± 0.051
4.365GluArg: 4.365 ± 0.079
2.546GluSer: 2.546 ± 0.045
2.457GluThr: 2.457 ± 0.039
3.556GluVal: 3.556 ± 0.052
0.685GluTrp: 0.685 ± 0.023
1.128GluTyr: 1.128 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
4.07PheAla: 4.07 ± 0.058
0.317PheCys: 0.317 ± 0.016
2.424PheAsp: 2.424 ± 0.043
1.866PheGlu: 1.866 ± 0.038
1.227PhePhe: 1.227 ± 0.032
3.284PheGly: 3.284 ± 0.051
0.866PheHis: 0.866 ± 0.024
1.341PheIle: 1.341 ± 0.03
0.988PheLys: 0.988 ± 0.027
2.949PheLeu: 2.949 ± 0.052
0.726PheMet: 0.726 ± 0.022
1.288PheAsn: 1.288 ± 0.037
1.501PhePro: 1.501 ± 0.033
1.134PheGln: 1.134 ± 0.031
1.996PheArg: 1.996 ± 0.04
2.175PheSer: 2.175 ± 0.038
1.92PheThr: 1.92 ± 0.041
2.608PheVal: 2.608 ± 0.046
0.485PheTrp: 0.485 ± 0.018
0.953PheTyr: 0.953 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
8.268GlyAla: 8.268 ± 0.121
0.837GlyCys: 0.837 ± 0.028
4.242GlyAsp: 4.242 ± 0.06
4.265GlyGlu: 4.265 ± 0.06
3.153GlyPhe: 3.153 ± 0.051
6.918GlyGly: 6.918 ± 0.149
2.187GlyHis: 2.187 ± 0.037
4.001GlyIle: 4.001 ± 0.064
3.222GlyLys: 3.222 ± 0.049
8.158GlyLeu: 8.158 ± 0.071
2.304GlyMet: 2.304 ± 0.046
3.035GlyAsn: 3.035 ± 0.124
2.878GlyPro: 2.878 ± 0.043
3.397GlyGln: 3.397 ± 0.066
5.057GlyArg: 5.057 ± 0.066
5.481GlySer: 5.481 ± 0.14
4.811GlyThr: 4.811 ± 0.14
6.215GlyVal: 6.215 ± 0.066
1.487GlyTrp: 1.487 ± 0.036
2.673GlyTyr: 2.673 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
3.267HisAla: 3.267 ± 0.052
0.286HisCys: 0.286 ± 0.015
1.454HisAsp: 1.454 ± 0.032
1.337HisGlu: 1.337 ± 0.034
1.01HisPhe: 1.01 ± 0.027
2.445HisGly: 2.445 ± 0.049
0.713HisHis: 0.713 ± 0.023
0.984HisIle: 0.984 ± 0.025
0.581HisLys: 0.581 ± 0.021
2.465HisLeu: 2.465 ± 0.052
0.581HisMet: 0.581 ± 0.021
0.586HisAsn: 0.586 ± 0.018
1.585HisPro: 1.585 ± 0.035
0.87HisGln: 0.87 ± 0.027
1.706HisArg: 1.706 ± 0.035
1.258HisSer: 1.258 ± 0.03
1.165HisThr: 1.165 ± 0.028
1.906HisVal: 1.906 ± 0.037
0.485HisTrp: 0.485 ± 0.017
0.806HisTyr: 0.806 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.21IleAla: 6.21 ± 0.078
0.42IleCys: 0.42 ± 0.018
3.264IleAsp: 3.264 ± 0.049
2.827IleGlu: 2.827 ± 0.05
1.249IlePhe: 1.249 ± 0.03
4.324IleGly: 4.324 ± 0.055
1.004IleHis: 1.004 ± 0.025
1.495IleIle: 1.495 ± 0.035
1.271IleLys: 1.271 ± 0.033
3.256IleLeu: 3.256 ± 0.055
0.655IleMet: 0.655 ± 0.021
1.593IleAsn: 1.593 ± 0.041
2.103IlePro: 2.103 ± 0.04
1.409IleGln: 1.409 ± 0.032
2.668IleArg: 2.668 ± 0.047
2.723IleSer: 2.723 ± 0.055
2.707IleThr: 2.707 ± 0.064
3.451IleVal: 3.451 ± 0.057
0.492IleTrp: 0.492 ± 0.017
1.163IleTyr: 1.163 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
3.509LysAla: 3.509 ± 0.071
0.16LysCys: 0.16 ± 0.01
1.484LysAsp: 1.484 ± 0.034
1.318LysGlu: 1.318 ± 0.036
0.84LysPhe: 0.84 ± 0.028
2.119LysGly: 2.119 ± 0.045
0.831LysHis: 0.831 ± 0.021
1.204LysIle: 1.204 ± 0.03
0.998LysLys: 0.998 ± 0.035
3.554LysLeu: 3.554 ± 0.049
0.583LysMet: 0.583 ± 0.024
0.818LysAsn: 0.818 ± 0.026
2.074LysPro: 2.074 ± 0.041
1.532LysGln: 1.532 ± 0.038
2.072LysArg: 2.072 ± 0.039
1.657LysSer: 1.657 ± 0.032
1.603LysThr: 1.603 ± 0.031
2.216LysVal: 2.216 ± 0.043
0.336LysTrp: 0.336 ± 0.015
0.66LysTyr: 0.66 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
13.916LeuAla: 13.916 ± 0.125
1.014LeuCys: 1.014 ± 0.024
6.208LeuAsp: 6.208 ± 0.074
5.052LeuGlu: 5.052 ± 0.082
3.558LeuPhe: 3.558 ± 0.058
8.53LeuGly: 8.53 ± 0.08
2.759LeuHis: 2.759 ± 0.049
4.503LeuIle: 4.503 ± 0.067
3.366LeuLys: 3.366 ± 0.05
11.578LeuLeu: 11.578 ± 0.143
2.17LeuMet: 2.17 ± 0.046
3.037LeuAsn: 3.037 ± 0.058
6.354LeuPro: 6.354 ± 0.081
4.207LeuGln: 4.207 ± 0.059
7.809LeuArg: 7.809 ± 0.094
6.944LeuSer: 6.944 ± 0.079
5.534LeuThr: 5.534 ± 0.096
7.293LeuVal: 7.293 ± 0.087
1.355LeuTrp: 1.355 ± 0.035
2.393LeuTyr: 2.393 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
2.743MetAla: 2.743 ± 0.05
0.162MetCys: 0.162 ± 0.011
1.068MetAsp: 1.068 ± 0.026
0.965MetGlu: 0.965 ± 0.025
0.62MetPhe: 0.62 ± 0.022
1.504MetGly: 1.504 ± 0.034
0.655MetHis: 0.655 ± 0.02
0.928MetIle: 0.928 ± 0.024
0.834MetLys: 0.834 ± 0.023
2.71MetLeu: 2.71 ± 0.052
0.488MetMet: 0.488 ± 0.019
0.802MetAsn: 0.802 ± 0.021
1.525MetPro: 1.525 ± 0.034
1.143MetGln: 1.143 ± 0.031
1.704MetArg: 1.704 ± 0.034
1.604MetSer: 1.604 ± 0.036
1.357MetThr: 1.357 ± 0.029
1.527MetVal: 1.527 ± 0.035
0.227MetTrp: 0.227 ± 0.013
0.447MetTyr: 0.447 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.842AsnAla: 3.842 ± 0.085
0.236AsnCys: 0.236 ± 0.013
1.681AsnAsp: 1.681 ± 0.032
1.374AsnGlu: 1.374 ± 0.028
1.071AsnPhe: 1.071 ± 0.032
3.242AsnGly: 3.242 ± 0.119
0.679AsnHis: 0.679 ± 0.022
1.327AsnIle: 1.327 ± 0.04
0.741AsnLys: 0.741 ± 0.023
3.044AsnLeu: 3.044 ± 0.056
0.57AsnMet: 0.57 ± 0.02
1.151AsnAsn: 1.151 ± 0.049
1.926AsnPro: 1.926 ± 0.037
1.19AsnGln: 1.19 ± 0.033
1.743AsnArg: 1.743 ± 0.036
1.811AsnSer: 1.811 ± 0.065
1.749AsnThr: 1.749 ± 0.065
2.364AsnVal: 2.364 ± 0.06
0.5AsnTrp: 0.5 ± 0.019
0.969AsnTyr: 0.969 ± 0.04
0.0AsnXaa: 0.0 ± 0.0
Pro
6.443ProAla: 6.443 ± 0.088
0.373ProCys: 0.373 ± 0.017
3.183ProAsp: 3.183 ± 0.053
2.845ProGlu: 2.845 ± 0.05
1.736ProPhe: 1.736 ± 0.035
4.516ProGly: 4.516 ± 0.063
1.193ProHis: 1.193 ± 0.029
2.114ProIle: 2.114 ± 0.037
1.418ProLys: 1.418 ± 0.036
5.314ProLeu: 5.314 ± 0.073
1.314ProMet: 1.314 ± 0.031
1.607ProAsn: 1.607 ± 0.039
2.767ProPro: 2.767 ± 0.062
2.155ProGln: 2.155 ± 0.038
2.762ProArg: 2.762 ± 0.049
3.278ProSer: 3.278 ± 0.064
2.598ProThr: 2.598 ± 0.055
3.977ProVal: 3.977 ± 0.054
0.828ProTrp: 0.828 ± 0.023
1.389ProTyr: 1.389 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
5.576GlnAla: 5.576 ± 0.083
0.306GlnCys: 0.306 ± 0.013
1.758GlnAsp: 1.758 ± 0.036
1.609GlnGlu: 1.609 ± 0.035
1.289GlnPhe: 1.289 ± 0.03
3.184GlnGly: 3.184 ± 0.051
1.168GlnHis: 1.168 ± 0.031
1.851GlnIle: 1.851 ± 0.038
1.022GlnLys: 1.022 ± 0.03
4.851GlnLeu: 4.851 ± 0.06
0.971GlnMet: 0.971 ± 0.026
1.122GlnAsn: 1.122 ± 0.028
2.428GlnPro: 2.428 ± 0.043
2.452GlnGln: 2.452 ± 0.053
3.452GlnArg: 3.452 ± 0.065
2.348GlnSer: 2.348 ± 0.042
2.064GlnThr: 2.064 ± 0.052
3.139GlnVal: 3.139 ± 0.053
0.677GlnTrp: 0.677 ± 0.023
1.046GlnTyr: 1.046 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
6.811ArgAla: 6.811 ± 0.099
0.609ArgCys: 0.609 ± 0.022
3.511ArgAsp: 3.511 ± 0.058
3.961ArgGlu: 3.961 ± 0.061
2.596ArgPhe: 2.596 ± 0.043
4.276ArgGly: 4.276 ± 0.062
2.047ArgHis: 2.047 ± 0.04
3.467ArgIle: 3.467 ± 0.049
2.13ArgLys: 2.13 ± 0.045
7.71ArgLeu: 7.71 ± 0.11
1.782ArgMet: 1.782 ± 0.036
1.916ArgAsn: 1.916 ± 0.037
2.902ArgPro: 2.902 ± 0.05
2.881ArgGln: 2.881 ± 0.056
4.923ArgArg: 4.923 ± 0.088
3.734ArgSer: 3.734 ± 0.046
3.076ArgThr: 3.076 ± 0.045
4.689ArgVal: 4.689 ± 0.055
1.187ArgTrp: 1.187 ± 0.03
2.132ArgTyr: 2.132 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
6.751SerAla: 6.751 ± 0.089
0.516SerCys: 0.516 ± 0.02
2.927SerAsp: 2.927 ± 0.047
2.584SerGlu: 2.584 ± 0.046
2.276SerPhe: 2.276 ± 0.039
5.887SerGly: 5.887 ± 0.157
1.459SerHis: 1.459 ± 0.031
2.787SerIle: 2.787 ± 0.056
1.669SerLys: 1.669 ± 0.039
6.581SerLeu: 6.581 ± 0.082
1.457SerMet: 1.457 ± 0.038
2.069SerAsn: 2.069 ± 0.065
3.091SerPro: 3.091 ± 0.053
2.314SerGln: 2.314 ± 0.042
3.518SerArg: 3.518 ± 0.049
4.168SerSer: 4.168 ± 0.088
3.555SerThr: 3.555 ± 0.101
4.355SerVal: 4.355 ± 0.065
0.948SerTrp: 0.948 ± 0.028
1.825SerTyr: 1.825 ± 0.052
0.0SerXaa: 0.0 ± 0.0
Thr
6.011ThrAla: 6.011 ± 0.104
0.425ThrCys: 0.425 ± 0.016
2.737ThrAsp: 2.737 ± 0.058
2.082ThrGlu: 2.082 ± 0.037
1.723ThrPhe: 1.723 ± 0.04
4.803ThrGly: 4.803 ± 0.111
1.331ThrHis: 1.331 ± 0.03
2.397ThrIle: 2.397 ± 0.059
1.187ThrLys: 1.187 ± 0.033
6.517ThrLeu: 6.517 ± 0.125
1.029ThrMet: 1.029 ± 0.026
1.523ThrAsn: 1.523 ± 0.053
3.572ThrPro: 3.572 ± 0.07
2.267ThrGln: 2.267 ± 0.052
3.205ThrArg: 3.205 ± 0.044
3.266ThrSer: 3.266 ± 0.086
3.208ThrThr: 3.208 ± 0.155
4.206ThrVal: 4.206 ± 0.081
0.763ThrTrp: 0.763 ± 0.021
1.706ThrTyr: 1.706 ± 0.097
0.0ThrXaa: 0.0 ± 0.0
Val
8.632ValAla: 8.632 ± 0.087
0.684ValCys: 0.684 ± 0.019
4.189ValAsp: 4.189 ± 0.054
3.659ValGlu: 3.659 ± 0.059
2.453ValPhe: 2.453 ± 0.049
5.212ValGly: 5.212 ± 0.072
1.7ValHis: 1.7 ± 0.035
3.615ValIle: 3.615 ± 0.051
2.032ValLys: 2.032 ± 0.041
8.038ValLeu: 8.038 ± 0.087
1.712ValMet: 1.712 ± 0.034
2.37ValAsn: 2.37 ± 0.054
3.724ValPro: 3.724 ± 0.052
2.817ValGln: 2.817 ± 0.048
4.65ValArg: 4.65 ± 0.07
4.69ValSer: 4.69 ± 0.07
4.384ValThr: 4.384 ± 0.106
5.612ValVal: 5.612 ± 0.076
0.952ValTrp: 0.952 ± 0.024
1.81ValTyr: 1.81 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
1.166TrpAla: 1.166 ± 0.03
0.16TrpCys: 0.16 ± 0.009
0.631TrpAsp: 0.631 ± 0.02
0.527TrpGlu: 0.527 ± 0.02
0.577TrpPhe: 0.577 ± 0.021
0.94TrpGly: 0.94 ± 0.025
0.459TrpHis: 0.459 ± 0.018
0.734TrpIle: 0.734 ± 0.024
0.457TrpLys: 0.457 ± 0.016
2.177TrpLeu: 2.177 ± 0.044
0.449TrpMet: 0.449 ± 0.019
0.579TrpAsn: 0.579 ± 0.02
0.764TrpPro: 0.764 ± 0.024
0.845TrpGln: 0.845 ± 0.025
1.248TrpArg: 1.248 ± 0.034
1.0TrpSer: 1.0 ± 0.02
0.823TrpThr: 0.823 ± 0.025
1.001TrpVal: 1.001 ± 0.026
0.292TrpTrp: 0.292 ± 0.014
0.395TrpTyr: 0.395 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.198TyrAla: 3.198 ± 0.051
0.255TyrCys: 0.255 ± 0.013
1.657TyrAsp: 1.657 ± 0.089
1.208TyrGlu: 1.208 ± 0.033
1.039TyrPhe: 1.039 ± 0.027
2.353TyrGly: 2.353 ± 0.047
0.574TyrHis: 0.574 ± 0.017
0.914TyrIle: 0.914 ± 0.022
0.652TyrLys: 0.652 ± 0.022
2.795TyrLeu: 2.795 ± 0.044
0.466TyrMet: 0.466 ± 0.018
0.995TyrAsn: 0.995 ± 0.043
1.336TyrPro: 1.336 ± 0.03
1.147TyrGln: 1.147 ± 0.028
2.076TyrArg: 2.076 ± 0.04
1.595TyrSer: 1.595 ± 0.047
1.599TyrThr: 1.599 ± 0.063
2.002TyrVal: 2.002 ± 0.039
0.467TyrTrp: 0.467 ± 0.02
0.828TyrTyr: 0.828 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4604 proteins (1582698 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski