Amino acid dipepetide frequency for Acidithrix ferrooxidans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.228AlaAla: 8.228 ± 0.139	0.745AlaCys: 0.745 ± 0.031	3.899AlaAsp: 3.899 ± 0.067	4.19AlaGlu: 4.19 ± 0.076	3.498AlaPhe: 3.498 ± 0.075	6.692AlaGly: 6.692 ± 0.097	1.731AlaHis: 1.731 ± 0.043	7.526AlaIle: 7.526 ± 0.097	4.865AlaLys: 4.865 ± 0.079	10.515AlaLeu: 10.515 ± 0.118	2.4AlaMet: 2.4 ± 0.048	3.679AlaAsn: 3.679 ± 0.06	3.773AlaPro: 3.773 ± 0.076	3.21AlaGln: 3.21 ± 0.058	5.573AlaArg: 5.573 ± 0.083	7.551AlaSer: 7.551 ± 0.098	5.839AlaThr: 5.839 ± 0.095	5.959AlaVal: 5.959 ± 0.085	0.966AlaTrp: 0.966 ± 0.033	2.233AlaTyr: 2.233 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.737CysAla: 0.737 ± 0.027	0.106CysCys: 0.106 ± 0.01	0.7CysAsp: 0.7 ± 0.025	0.533CysGlu: 0.533 ± 0.026	0.311CysPhe: 0.311 ± 0.016	0.86CysGly: 0.86 ± 0.03	0.242CysHis: 0.242 ± 0.015	0.424CysIle: 0.424 ± 0.022	0.292CysLys: 0.292 ± 0.015	0.764CysLeu: 0.764 ± 0.025	0.139CysMet: 0.139 ± 0.012	0.296CysAsn: 0.296 ± 0.019	0.462CysPro: 0.462 ± 0.025	0.289CysGln: 0.289 ± 0.017	0.488CysArg: 0.488 ± 0.022	0.632CysSer: 0.632 ± 0.024	0.405CysThr: 0.405 ± 0.022	0.608CysVal: 0.608 ± 0.025	0.107CysTrp: 0.107 ± 0.011	0.301CysTyr: 0.301 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.42AspAla: 4.42 ± 0.077	0.434AspCys: 0.434 ± 0.026	2.85AspAsp: 2.85 ± 0.071	3.806AspGlu: 3.806 ± 0.07	2.362AspPhe: 2.362 ± 0.049	4.001AspGly: 4.001 ± 0.082	1.24AspHis: 1.24 ± 0.039	2.928AspIle: 2.928 ± 0.053	1.827AspLys: 1.827 ± 0.047	6.573AspLeu: 6.573 ± 0.086	0.894AspMet: 0.894 ± 0.035	1.543AspAsn: 1.543 ± 0.042	3.253AspPro: 3.253 ± 0.067	1.977AspGln: 1.977 ± 0.042	3.604AspArg: 3.604 ± 0.07	3.932AspSer: 3.932 ± 0.065	2.261AspThr: 2.261 ± 0.048	3.646AspVal: 3.646 ± 0.068	0.585AspTrp: 0.585 ± 0.025	1.435AspTyr: 1.435 ± 0.045	0.001AspXaa: 0.001 ± 0.001
Glu	5.58GluAla: 5.58 ± 0.089	0.429GluCys: 0.429 ± 0.024	2.601GluAsp: 2.601 ± 0.058	3.339GluGlu: 3.339 ± 0.07	2.106GluPhe: 2.106 ± 0.05	3.486GluGly: 3.486 ± 0.064	1.043GluHis: 1.043 ± 0.035	5.066GluIle: 5.066 ± 0.08	2.247GluLys: 2.247 ± 0.052	6.869GluLeu: 6.869 ± 0.096	1.507GluMet: 1.507 ± 0.037	1.827GluAsn: 1.827 ± 0.047	2.08GluPro: 2.08 ± 0.05	1.472GluGln: 1.472 ± 0.039	4.051GluArg: 4.051 ± 0.074	4.01GluSer: 4.01 ± 0.062	2.931GluThr: 2.931 ± 0.066	5.107GluVal: 5.107 ± 0.088	0.563GluTrp: 0.563 ± 0.026	1.204GluTyr: 1.204 ± 0.037	0.001GluXaa: 0.001 ± 0.001
Phe	3.519PheAla: 3.519 ± 0.053	0.396PheCys: 0.396 ± 0.02	2.765PheAsp: 2.765 ± 0.062	2.601PheGlu: 2.601 ± 0.056	1.514PhePhe: 1.514 ± 0.038	4.055PheGly: 4.055 ± 0.071	0.766PheHis: 0.766 ± 0.029	2.143PheIle: 2.143 ± 0.047	1.164PheLys: 1.164 ± 0.034	3.511PheLeu: 3.511 ± 0.069	0.742PheMet: 0.742 ± 0.032	1.233PheAsn: 1.233 ± 0.04	1.467PhePro: 1.467 ± 0.038	0.997PheGln: 0.997 ± 0.029	2.038PheArg: 2.038 ± 0.044	3.447PheSer: 3.447 ± 0.064	1.763PheThr: 1.763 ± 0.049	3.142PheVal: 3.142 ± 0.063	0.469PheTrp: 0.469 ± 0.023	1.052PheTyr: 1.052 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	7.437GlyAla: 7.437 ± 0.106	0.643GlyCys: 0.643 ± 0.028	4.311GlyAsp: 4.311 ± 0.072	4.235GlyGlu: 4.235 ± 0.075	3.427GlyPhe: 3.427 ± 0.055	6.402GlyGly: 6.402 ± 0.124	1.572GlyHis: 1.572 ± 0.045	5.415GlyIle: 5.415 ± 0.084	3.042GlyLys: 3.042 ± 0.056	7.624GlyLeu: 7.624 ± 0.099	1.709GlyMet: 1.709 ± 0.045	2.518GlyAsn: 2.518 ± 0.057	2.917GlyPro: 2.917 ± 0.063	2.339GlyGln: 2.339 ± 0.049	4.441GlyArg: 4.441 ± 0.072	6.251GlySer: 6.251 ± 0.094	4.237GlyThr: 4.237 ± 0.077	6.399GlyVal: 6.399 ± 0.073	1.101GlyTrp: 1.101 ± 0.037	2.539GlyTyr: 2.539 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.334HisAla: 1.334 ± 0.037	0.217HisCys: 0.217 ± 0.015	0.967HisAsp: 0.967 ± 0.035	0.997HisGlu: 0.997 ± 0.031	0.898HisPhe: 0.898 ± 0.034	1.649HisGly: 1.649 ± 0.044	0.546HisHis: 0.546 ± 0.025	1.074HisIle: 1.074 ± 0.032	0.747HisLys: 0.747 ± 0.028	2.444HisLeu: 2.444 ± 0.051	0.359HisMet: 0.359 ± 0.019	0.656HisAsn: 0.656 ± 0.024	1.183HisPro: 1.183 ± 0.032	0.689HisGln: 0.689 ± 0.029	1.451HisArg: 1.451 ± 0.037	1.529HisSer: 1.529 ± 0.039	0.785HisThr: 0.785 ± 0.028	1.108HisVal: 1.108 ± 0.036	0.26HisTrp: 0.26 ± 0.015	0.499HisTyr: 0.499 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	7.601IleAla: 7.601 ± 0.104	0.655IleCys: 0.655 ± 0.026	4.67IleAsp: 4.67 ± 0.079	4.755IleGlu: 4.755 ± 0.073	2.455IlePhe: 2.455 ± 0.053	5.454IleGly: 5.454 ± 0.073	1.156IleHis: 1.156 ± 0.038	3.371IleIle: 3.371 ± 0.065	2.369IleLys: 2.369 ± 0.053	5.632IleLeu: 5.632 ± 0.086	1.123IleMet: 1.123 ± 0.034	2.158IleAsn: 2.158 ± 0.05	2.991IlePro: 2.991 ± 0.063	1.68IleGln: 1.68 ± 0.037	3.382IleArg: 3.382 ± 0.071	5.869IleSer: 5.869 ± 0.078	3.758IleThr: 3.758 ± 0.067	5.104IleVal: 5.104 ± 0.07	0.692IleTrp: 0.692 ± 0.024	1.779IleTyr: 1.779 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.04LysAla: 4.04 ± 0.07	0.272LysCys: 0.272 ± 0.017	2.149LysAsp: 2.149 ± 0.05	2.682LysGlu: 2.682 ± 0.058	1.302LysPhe: 1.302 ± 0.033	2.846LysGly: 2.846 ± 0.058	0.587LysHis: 0.587 ± 0.024	2.814LysIle: 2.814 ± 0.059	1.798LysLys: 1.798 ± 0.055	3.781LysLeu: 3.781 ± 0.077	1.004LysMet: 1.004 ± 0.033	1.43LysAsn: 1.43 ± 0.04	1.638LysPro: 1.638 ± 0.041	0.989LysGln: 0.989 ± 0.031	2.689LysArg: 2.689 ± 0.054	3.084LysSer: 3.084 ± 0.055	2.424LysThr: 2.424 ± 0.057	3.639LysVal: 3.639 ± 0.064	0.533LysTrp: 0.533 ± 0.023	1.023LysTyr: 1.023 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	10.922LeuAla: 10.922 ± 0.115	0.982LeuCys: 0.982 ± 0.032	6.035LeuAsp: 6.035 ± 0.094	6.528LeuGlu: 6.528 ± 0.103	3.649LeuPhe: 3.649 ± 0.068	9.022LeuGly: 9.022 ± 0.111	1.811LeuHis: 1.811 ± 0.044	6.469LeuIle: 6.469 ± 0.089	3.548LeuLys: 3.548 ± 0.065	9.538LeuLeu: 9.538 ± 0.114	1.928LeuMet: 1.928 ± 0.039	3.415LeuAsn: 3.415 ± 0.058	4.383LeuPro: 4.383 ± 0.064	2.319LeuGln: 2.319 ± 0.059	6.102LeuArg: 6.102 ± 0.086	8.891LeuSer: 8.891 ± 0.107	5.156LeuThr: 5.156 ± 0.076	7.928LeuVal: 7.928 ± 0.089	1.027LeuTrp: 1.027 ± 0.034	2.357LeuTyr: 2.357 ± 0.05	0.001LeuXaa: 0.001 ± 0.001
Met	2.697MetAla: 2.697 ± 0.055	0.145MetCys: 0.145 ± 0.013	1.141MetAsp: 1.141 ± 0.032	1.213MetGlu: 1.213 ± 0.038	0.48MetPhe: 0.48 ± 0.023	1.606MetGly: 1.606 ± 0.047	0.386MetHis: 0.386 ± 0.02	1.326MetIle: 1.326 ± 0.043	0.862MetLys: 0.862 ± 0.028	1.769MetLeu: 1.769 ± 0.044	0.46MetMet: 0.46 ± 0.025	0.856MetAsn: 0.856 ± 0.03	0.92MetPro: 0.92 ± 0.031	0.565MetGln: 0.565 ± 0.02	1.342MetArg: 1.342 ± 0.045	1.575MetSer: 1.575 ± 0.041	1.526MetThr: 1.526 ± 0.036	1.932MetVal: 1.932 ± 0.044	0.177MetTrp: 0.177 ± 0.016	0.312MetTyr: 0.312 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.205AsnAla: 3.205 ± 0.063	0.373AsnCys: 0.373 ± 0.02	1.813AsnAsp: 1.813 ± 0.043	1.983AsnGlu: 1.983 ± 0.056	1.466AsnPhe: 1.466 ± 0.043	2.817AsnGly: 2.817 ± 0.059	0.82AsnHis: 0.82 ± 0.029	1.75AsnIle: 1.75 ± 0.048	1.289AsnLys: 1.289 ± 0.039	3.854AsnLeu: 3.854 ± 0.066	0.652AsnMet: 0.652 ± 0.027	1.195AsnAsn: 1.195 ± 0.042	2.274AsnPro: 2.274 ± 0.054	1.412AsnGln: 1.412 ± 0.039	2.071AsnArg: 2.071 ± 0.046	2.975AsnSer: 2.975 ± 0.068	1.648AsnThr: 1.648 ± 0.037	2.215AsnVal: 2.215 ± 0.043	0.512AsnTrp: 0.512 ± 0.024	1.082AsnTyr: 1.082 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	3.314ProAla: 3.314 ± 0.069	0.264ProCys: 0.264 ± 0.018	2.285ProAsp: 2.285 ± 0.046	2.452ProGlu: 2.452 ± 0.053	1.713ProPhe: 1.713 ± 0.043	3.343ProGly: 3.343 ± 0.062	0.825ProHis: 0.825 ± 0.027	3.165ProIle: 3.165 ± 0.062	2.407ProLys: 2.407 ± 0.055	4.32ProLeu: 4.32 ± 0.067	1.035ProMet: 1.035 ± 0.03	2.073ProAsn: 2.073 ± 0.05	1.891ProPro: 1.891 ± 0.053	1.417ProGln: 1.417 ± 0.039	2.373ProArg: 2.373 ± 0.056	4.122ProSer: 4.122 ± 0.072	3.083ProThr: 3.083 ± 0.076	2.828ProVal: 2.828 ± 0.057	0.548ProTrp: 0.548 ± 0.024	1.23ProTyr: 1.23 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.847GlnAla: 2.847 ± 0.053	0.255GlnCys: 0.255 ± 0.016	1.307GlnAsp: 1.307 ± 0.037	1.717GlnGlu: 1.717 ± 0.044	1.018GlnPhe: 1.018 ± 0.03	2.351GlnGly: 2.351 ± 0.048	0.444GlnHis: 0.444 ± 0.021	2.459GlnIle: 2.459 ± 0.052	1.271GlnLys: 1.271 ± 0.036	3.265GlnLeu: 3.265 ± 0.069	0.778GlnMet: 0.778 ± 0.028	1.161GlnAsn: 1.161 ± 0.033	1.157GlnPro: 1.157 ± 0.033	0.833GlnGln: 0.833 ± 0.037	2.079GlnArg: 2.079 ± 0.053	2.334GlnSer: 2.334 ± 0.051	1.515GlnThr: 1.515 ± 0.039	2.334GlnVal: 2.334 ± 0.047	0.353GlnTrp: 0.353 ± 0.021	0.74GlnTyr: 0.74 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	5.174ArgAla: 5.174 ± 0.069	0.575ArgCys: 0.575 ± 0.024	3.235ArgAsp: 3.235 ± 0.062	3.33ArgGlu: 3.33 ± 0.064	2.635ArgPhe: 2.635 ± 0.052	3.972ArgGly: 3.972 ± 0.068	1.308ArgHis: 1.308 ± 0.046	4.09ArgIle: 4.09 ± 0.065	2.341ArgLys: 2.341 ± 0.051	6.139ArgLeu: 6.139 ± 0.094	1.295ArgMet: 1.295 ± 0.04	2.126ArgAsn: 2.126 ± 0.047	2.451ArgPro: 2.451 ± 0.055	2.09ArgGln: 2.09 ± 0.047	4.678ArgArg: 4.678 ± 0.098	5.081ArgSer: 5.081 ± 0.078	2.787ArgThr: 2.787 ± 0.056	4.195ArgVal: 4.195 ± 0.075	0.828ArgTrp: 0.828 ± 0.033	1.818ArgTyr: 1.818 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.754SerAla: 6.754 ± 0.099	0.675SerCys: 0.675 ± 0.027	4.292SerAsp: 4.292 ± 0.072	4.126SerGlu: 4.126 ± 0.07	3.228SerPhe: 3.228 ± 0.061	6.712SerGly: 6.712 ± 0.102	1.737SerHis: 1.737 ± 0.043	5.493SerIle: 5.493 ± 0.074	4.055SerLys: 4.055 ± 0.067	8.037SerLeu: 8.037 ± 0.109	1.965SerMet: 1.965 ± 0.046	3.404SerAsn: 3.404 ± 0.068	3.807SerPro: 3.807 ± 0.073	3.026SerGln: 3.026 ± 0.055	4.561SerArg: 4.561 ± 0.078	7.197SerSer: 7.197 ± 0.125	4.667SerThr: 4.667 ± 0.078	5.253SerVal: 5.253 ± 0.082	0.95SerTrp: 0.95 ± 0.031	2.242SerTyr: 2.242 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	4.301ThrAla: 4.301 ± 0.075	0.474ThrCys: 0.474 ± 0.026	2.208ThrAsp: 2.208 ± 0.048	2.404ThrGlu: 2.404 ± 0.052	2.329ThrPhe: 2.329 ± 0.05	3.944ThrGly: 3.944 ± 0.078	1.065ThrHis: 1.065 ± 0.032	3.929ThrIle: 3.929 ± 0.066	2.752ThrLys: 2.752 ± 0.056	5.73ThrLeu: 5.73 ± 0.075	1.161ThrMet: 1.161 ± 0.032	2.262ThrAsn: 2.262 ± 0.055	3.083ThrPro: 3.083 ± 0.07	1.762ThrGln: 1.762 ± 0.046	2.637ThrArg: 2.637 ± 0.059	4.878ThrSer: 4.878 ± 0.086	4.167ThrThr: 4.167 ± 0.114	3.686ThrVal: 3.686 ± 0.076	0.644ThrTrp: 0.644 ± 0.025	1.524ThrTyr: 1.524 ± 0.04	0.001ThrXaa: 0.001 ± 0.001
Val	8.221ValAla: 8.221 ± 0.095	0.619ValCys: 0.619 ± 0.025	4.436ValAsp: 4.436 ± 0.075	4.502ValGlu: 4.502 ± 0.073	2.704ValPhe: 2.704 ± 0.057	6.195ValGly: 6.195 ± 0.092	1.245ValHis: 1.245 ± 0.039	5.193ValIle: 5.193 ± 0.082	2.47ValLys: 2.47 ± 0.049	7.14ValLeu: 7.14 ± 0.092	1.369ValMet: 1.369 ± 0.039	2.323ValAsn: 2.323 ± 0.052	3.292ValPro: 3.292 ± 0.059	1.723ValGln: 1.723 ± 0.044	3.929ValArg: 3.929 ± 0.064	5.734ValSer: 5.734 ± 0.081	4.438ValThr: 4.438 ± 0.071	7.124ValVal: 7.124 ± 0.104	0.621ValTrp: 0.621 ± 0.027	1.512ValTyr: 1.512 ± 0.04	0.001ValXaa: 0.001 ± 0.001
Trp	0.864TrpAla: 0.864 ± 0.031	0.133TrpCys: 0.133 ± 0.011	0.49TrpAsp: 0.49 ± 0.02	0.574TrpGlu: 0.574 ± 0.023	0.475TrpPhe: 0.475 ± 0.024	0.739TrpGly: 0.739 ± 0.026	0.274TrpHis: 0.274 ± 0.018	0.827TrpIle: 0.827 ± 0.028	0.48TrpLys: 0.48 ± 0.021	1.347TrpLeu: 1.347 ± 0.042	0.342TrpMet: 0.342 ± 0.016	0.51TrpAsn: 0.51 ± 0.022	0.471TrpPro: 0.471 ± 0.021	0.406TrpGln: 0.406 ± 0.021	0.845TrpArg: 0.845 ± 0.027	0.94TrpSer: 0.94 ± 0.033	0.55TrpThr: 0.55 ± 0.023	0.809TrpVal: 0.809 ± 0.029	0.203TrpTrp: 0.203 ± 0.016	0.267TrpTyr: 0.267 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.876TyrAla: 1.876 ± 0.051	0.306TyrCys: 0.306 ± 0.016	1.417TyrAsp: 1.417 ± 0.044	1.552TyrGlu: 1.552 ± 0.048	1.213TyrPhe: 1.213 ± 0.034	2.413TyrGly: 2.413 ± 0.057	0.595TyrHis: 0.595 ± 0.027	1.193TyrIle: 1.193 ± 0.034	0.898TyrLys: 0.898 ± 0.034	3.159TyrLeu: 3.159 ± 0.064	0.426TyrMet: 0.426 ± 0.021	0.74TyrAsn: 0.74 ± 0.031	1.194TyrPro: 1.194 ± 0.035	1.022TyrGln: 1.022 ± 0.033	1.815TyrArg: 1.815 ± 0.038	2.148TyrSer: 2.148 ± 0.048	1.002TyrThr: 1.002 ± 0.038	1.773TyrVal: 1.773 ± 0.041	0.406TyrTrp: 0.406 ± 0.027	0.663TyrTyr: 0.663 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.002XaaPhe: 0.002 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3548 proteins (982248 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---