Amino acid dipepetide frequency for Treponema bryantii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.888AlaAla: 6.888 ± 0.116	1.017AlaCys: 1.017 ± 0.034	4.603AlaAsp: 4.603 ± 0.069	5.469AlaGlu: 5.469 ± 0.093	3.217AlaPhe: 3.217 ± 0.059	5.537AlaGly: 5.537 ± 0.082	1.038AlaHis: 1.038 ± 0.032	4.927AlaIle: 4.927 ± 0.07	4.857AlaLys: 4.857 ± 0.075	6.41AlaLeu: 6.41 ± 0.091	1.855AlaMet: 1.855 ± 0.048	2.949AlaAsn: 2.949 ± 0.058	2.137AlaPro: 2.137 ± 0.049	2.264AlaGln: 2.264 ± 0.049	2.71AlaArg: 2.71 ± 0.06	4.231AlaSer: 4.231 ± 0.08	3.275AlaThr: 3.275 ± 0.077	5.354AlaVal: 5.354 ± 0.082	0.679AlaTrp: 0.679 ± 0.024	2.483AlaTyr: 2.483 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	1.007CysAla: 1.007 ± 0.032	0.267CysCys: 0.267 ± 0.018	0.864CysAsp: 0.864 ± 0.027	0.85CysGlu: 0.85 ± 0.033	0.735CysPhe: 0.735 ± 0.027	1.352CysGly: 1.352 ± 0.046	0.236CysHis: 0.236 ± 0.017	1.074CysIle: 1.074 ± 0.031	0.871CysLys: 0.871 ± 0.034	1.082CysLeu: 1.082 ± 0.035	0.334CysMet: 0.334 ± 0.019	0.68CysAsn: 0.68 ± 0.025	0.58CysPro: 0.58 ± 0.028	0.354CysGln: 0.354 ± 0.017	0.582CysArg: 0.582 ± 0.024	0.997CysSer: 0.997 ± 0.033	0.762CysThr: 0.762 ± 0.029	0.879CysVal: 0.879 ± 0.032	0.147CysTrp: 0.147 ± 0.012	0.588CysTyr: 0.588 ± 0.029	0.0CysXaa: 0.0 ± 0.0
Asp	3.972AspAla: 3.972 ± 0.07	0.846AspCys: 0.846 ± 0.03	3.372AspAsp: 3.372 ± 0.081	4.543AspGlu: 4.543 ± 0.085	3.595AspPhe: 3.595 ± 0.065	4.418AspGly: 4.418 ± 0.075	0.637AspHis: 0.637 ± 0.027	4.451AspIle: 4.451 ± 0.074	4.25AspLys: 4.25 ± 0.071	4.329AspLeu: 4.329 ± 0.068	1.391AspMet: 1.391 ± 0.036	2.944AspAsn: 2.944 ± 0.071	1.739AspPro: 1.739 ± 0.045	1.124AspGln: 1.124 ± 0.032	1.937AspArg: 1.937 ± 0.044	4.013AspSer: 4.013 ± 0.074	3.106AspThr: 3.106 ± 0.075	3.569AspVal: 3.569 ± 0.062	0.766AspTrp: 0.766 ± 0.026	2.769AspTyr: 2.769 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	4.917GluAla: 4.917 ± 0.084	0.773GluCys: 0.773 ± 0.031	3.72GluAsp: 3.72 ± 0.065	5.519GluGlu: 5.519 ± 0.094	2.949GluPhe: 2.949 ± 0.058	3.912GluGly: 3.912 ± 0.055	1.092GluHis: 1.092 ± 0.029	5.607GluIle: 5.607 ± 0.083	6.702GluLys: 6.702 ± 0.107	6.449GluLeu: 6.449 ± 0.085	1.799GluMet: 1.799 ± 0.05	4.793GluAsn: 4.793 ± 0.086	1.989GluPro: 1.989 ± 0.051	2.3GluGln: 2.3 ± 0.052	2.738GluArg: 2.738 ± 0.06	3.643GluSer: 3.643 ± 0.056	3.828GluThr: 3.828 ± 0.066	3.929GluVal: 3.929 ± 0.066	0.738GluTrp: 0.738 ± 0.026	2.974GluTyr: 2.974 ± 0.07	0.0GluXaa: 0.0 ± 0.0
Phe	3.46PheAla: 3.46 ± 0.063	0.87PheCys: 0.87 ± 0.033	3.118PheAsp: 3.118 ± 0.057	3.183PheGlu: 3.183 ± 0.062	2.507PhePhe: 2.507 ± 0.062	3.225PheGly: 3.225 ± 0.064	0.731PheHis: 0.731 ± 0.026	3.908PheIle: 3.908 ± 0.084	2.881PheLys: 2.881 ± 0.054	3.876PheLeu: 3.876 ± 0.075	1.192PheMet: 1.192 ± 0.034	2.342PheAsn: 2.342 ± 0.058	1.651PhePro: 1.651 ± 0.041	1.113PheGln: 1.113 ± 0.035	1.681PheArg: 1.681 ± 0.046	3.84PheSer: 3.84 ± 0.076	3.131PheThr: 3.131 ± 0.06	3.178PheVal: 3.178 ± 0.06	0.511PheTrp: 0.511 ± 0.023	2.11PheTyr: 2.11 ± 0.054	0.0PheXaa: 0.0 ± 0.0
Gly	4.387GlyAla: 4.387 ± 0.076	1.111GlyCys: 1.111 ± 0.041	3.488GlyAsp: 3.488 ± 0.06	4.066GlyGlu: 4.066 ± 0.065	3.491GlyPhe: 3.491 ± 0.065	4.366GlyGly: 4.366 ± 0.087	1.099GlyHis: 1.099 ± 0.036	5.473GlyIle: 5.473 ± 0.081	5.334GlyLys: 5.334 ± 0.077	5.564GlyLeu: 5.564 ± 0.078	1.763GlyMet: 1.763 ± 0.046	3.452GlyAsn: 3.452 ± 0.098	1.368GlyPro: 1.368 ± 0.04	1.748GlyGln: 1.748 ± 0.055	2.523GlyArg: 2.523 ± 0.055	4.063GlySer: 4.063 ± 0.069	4.173GlyThr: 4.173 ± 0.097	4.209GlyVal: 4.209 ± 0.069	0.875GlyTrp: 0.875 ± 0.029	2.893GlyTyr: 2.893 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	0.924HisAla: 0.924 ± 0.028	0.242HisCys: 0.242 ± 0.016	0.829HisAsp: 0.829 ± 0.029	0.974HisGlu: 0.974 ± 0.03	0.873HisPhe: 0.873 ± 0.029	1.126HisGly: 1.126 ± 0.037	0.348HisHis: 0.348 ± 0.022	1.233HisIle: 1.233 ± 0.036	0.996HisLys: 0.996 ± 0.033	1.331HisLeu: 1.331 ± 0.04	0.291HisMet: 0.291 ± 0.018	0.838HisAsn: 0.838 ± 0.029	0.77HisPro: 0.77 ± 0.032	0.424HisGln: 0.424 ± 0.019	0.604HisArg: 0.604 ± 0.026	0.991HisSer: 0.991 ± 0.033	0.882HisThr: 0.882 ± 0.034	0.867HisVal: 0.867 ± 0.033	0.174HisTrp: 0.174 ± 0.013	0.647HisTyr: 0.647 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.484IleAla: 5.484 ± 0.081	1.256IleCys: 1.256 ± 0.037	4.457IleAsp: 4.457 ± 0.067	5.147IleGlu: 5.147 ± 0.07	3.51IlePhe: 3.51 ± 0.076	4.415IleGly: 4.415 ± 0.078	1.201IleHis: 1.201 ± 0.031	6.137IleIle: 6.137 ± 0.098	5.766IleLys: 5.766 ± 0.067	6.832IleLeu: 6.832 ± 0.097	1.71IleMet: 1.71 ± 0.053	3.88IleAsn: 3.88 ± 0.072	3.411IlePro: 3.411 ± 0.056	2.386IleGln: 2.386 ± 0.052	3.041IleArg: 3.041 ± 0.057	5.951IleSer: 5.951 ± 0.091	5.056IleThr: 5.056 ± 0.086	4.574IleVal: 4.574 ± 0.072	0.644IleTrp: 0.644 ± 0.026	2.861IleTyr: 2.861 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	5.324LysAla: 5.324 ± 0.082	0.739LysCys: 0.739 ± 0.031	4.452LysAsp: 4.452 ± 0.072	5.668LysGlu: 5.668 ± 0.081	2.664LysPhe: 2.664 ± 0.05	4.009LysGly: 4.009 ± 0.071	1.026LysHis: 1.026 ± 0.032	6.167LysIle: 6.167 ± 0.065	7.033LysLys: 7.033 ± 0.109	6.492LysLeu: 6.492 ± 0.074	2.112LysMet: 2.112 ± 0.042	4.895LysAsn: 4.895 ± 0.084	2.369LysPro: 2.369 ± 0.051	2.348LysGln: 2.348 ± 0.054	2.63LysArg: 2.63 ± 0.053	4.242LysSer: 4.242 ± 0.056	4.675LysThr: 4.675 ± 0.067	4.3LysVal: 4.3 ± 0.064	0.722LysTrp: 0.722 ± 0.028	3.1LysTyr: 3.1 ± 0.059	0.0LysXaa: 0.0 ± 0.0
Leu	6.093LeuAla: 6.093 ± 0.091	1.472LeuCys: 1.472 ± 0.044	4.746LeuAsp: 4.746 ± 0.067	5.806LeuGlu: 5.806 ± 0.082	4.518LeuPhe: 4.518 ± 0.073	5.323LeuGly: 5.323 ± 0.09	1.353LeuHis: 1.353 ± 0.038	6.551LeuIle: 6.551 ± 0.088	6.55LeuLys: 6.55 ± 0.074	7.723LeuLeu: 7.723 ± 0.108	2.136LeuMet: 2.136 ± 0.05	4.492LeuAsn: 4.492 ± 0.064	3.612LeuPro: 3.612 ± 0.057	2.532LeuGln: 2.532 ± 0.053	3.41LeuArg: 3.41 ± 0.065	6.62LeuSer: 6.62 ± 0.105	4.975LeuThr: 4.975 ± 0.086	4.947LeuVal: 4.947 ± 0.084	0.775LeuTrp: 0.775 ± 0.027	3.513LeuTyr: 3.513 ± 0.067	0.0LeuXaa: 0.0 ± 0.0
Met	1.905MetAla: 1.905 ± 0.045	0.323MetCys: 0.323 ± 0.02	1.289MetAsp: 1.289 ± 0.033	1.629MetGlu: 1.629 ± 0.044	1.057MetPhe: 1.057 ± 0.042	1.452MetGly: 1.452 ± 0.045	0.423MetHis: 0.423 ± 0.024	1.853MetIle: 1.853 ± 0.043	2.374MetLys: 2.374 ± 0.052	2.051MetLeu: 2.051 ± 0.043	0.642MetMet: 0.642 ± 0.028	1.511MetAsn: 1.511 ± 0.04	0.981MetPro: 0.981 ± 0.03	0.866MetGln: 0.866 ± 0.028	0.876MetArg: 0.876 ± 0.032	1.58MetSer: 1.58 ± 0.038	1.476MetThr: 1.476 ± 0.042	1.255MetVal: 1.255 ± 0.035	0.161MetTrp: 0.161 ± 0.011	0.787MetTyr: 0.787 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.606AsnAla: 3.606 ± 0.064	0.777AsnCys: 0.777 ± 0.03	2.753AsnAsp: 2.753 ± 0.063	3.448AsnGlu: 3.448 ± 0.067	2.403AsnPhe: 2.403 ± 0.056	4.0AsnGly: 4.0 ± 0.092	0.861AsnHis: 0.861 ± 0.028	4.098AsnIle: 4.098 ± 0.072	3.687AsnLys: 3.687 ± 0.067	4.591AsnLeu: 4.591 ± 0.07	1.277AsnMet: 1.277 ± 0.036	2.889AsnAsn: 2.889 ± 0.084	2.447AsnPro: 2.447 ± 0.045	1.776AsnGln: 1.776 ± 0.044	1.982AsnArg: 1.982 ± 0.045	3.384AsnSer: 3.384 ± 0.082	2.806AsnThr: 2.806 ± 0.072	3.065AsnVal: 3.065 ± 0.06	0.708AsnTrp: 0.708 ± 0.026	2.275AsnTyr: 2.275 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	2.763ProAla: 2.763 ± 0.06	0.431ProCys: 0.431 ± 0.02	2.519ProAsp: 2.519 ± 0.058	3.475ProGlu: 3.475 ± 0.075	1.722ProPhe: 1.722 ± 0.041	2.164ProGly: 2.164 ± 0.061	0.56ProHis: 0.56 ± 0.02	1.929ProIle: 1.929 ± 0.043	2.016ProLys: 2.016 ± 0.05	2.974ProLeu: 2.974 ± 0.054	0.714ProMet: 0.714 ± 0.025	1.333ProAsn: 1.333 ± 0.039	0.85ProPro: 0.85 ± 0.032	1.172ProGln: 1.172 ± 0.031	1.014ProArg: 1.014 ± 0.036	2.176ProSer: 2.176 ± 0.048	1.514ProThr: 1.514 ± 0.041	3.248ProVal: 3.248 ± 0.06	0.34ProTrp: 0.34 ± 0.018	1.467ProTyr: 1.467 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.001GlnAla: 2.001 ± 0.054	0.3GlnCys: 0.3 ± 0.017	1.37GlnAsp: 1.37 ± 0.034	1.835GlnGlu: 1.835 ± 0.052	1.383GlnPhe: 1.383 ± 0.04	1.596GlnGly: 1.596 ± 0.04	0.456GlnHis: 0.456 ± 0.023	2.658GlnIle: 2.658 ± 0.054	2.813GlnLys: 2.813 ± 0.054	2.705GlnLeu: 2.705 ± 0.054	0.863GlnMet: 0.863 ± 0.033	2.014GlnAsn: 2.014 ± 0.045	0.862GlnPro: 0.862 ± 0.029	1.097GlnGln: 1.097 ± 0.035	1.151GlnArg: 1.151 ± 0.038	1.739GlnSer: 1.739 ± 0.047	1.827GlnThr: 1.827 ± 0.041	1.539GlnVal: 1.539 ± 0.039	0.314GlnTrp: 0.314 ± 0.018	1.215GlnTyr: 1.215 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.537ArgAla: 2.537 ± 0.06	0.518ArgCys: 0.518 ± 0.022	1.991ArgAsp: 1.991 ± 0.043	2.585ArgGlu: 2.585 ± 0.057	1.841ArgPhe: 1.841 ± 0.037	2.254ArgGly: 2.254 ± 0.052	0.606ArgHis: 0.606 ± 0.025	3.215ArgIle: 3.215 ± 0.056	2.856ArgLys: 2.856 ± 0.063	3.407ArgLeu: 3.407 ± 0.062	1.046ArgMet: 1.046 ± 0.036	2.09ArgAsn: 2.09 ± 0.051	1.171ArgPro: 1.171 ± 0.04	1.2ArgGln: 1.2 ± 0.033	1.712ArgArg: 1.712 ± 0.049	2.01ArgSer: 2.01 ± 0.048	2.08ArgThr: 2.08 ± 0.045	2.158ArgVal: 2.158 ± 0.047	0.399ArgTrp: 0.399 ± 0.021	1.544ArgTyr: 1.544 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	4.593SerAla: 4.593 ± 0.075	0.88SerCys: 0.88 ± 0.03	4.102SerAsp: 4.102 ± 0.077	4.722SerGlu: 4.722 ± 0.071	3.535SerPhe: 3.535 ± 0.063	5.129SerGly: 5.129 ± 0.106	0.995SerHis: 0.995 ± 0.033	5.124SerIle: 5.124 ± 0.086	4.372SerLys: 4.372 ± 0.067	5.929SerLeu: 5.929 ± 0.092	1.529SerMet: 1.529 ± 0.044	3.007SerAsn: 3.007 ± 0.072	1.938SerPro: 1.938 ± 0.046	1.935SerGln: 1.935 ± 0.043	2.433SerArg: 2.433 ± 0.048	4.478SerSer: 4.478 ± 0.113	3.255SerThr: 3.255 ± 0.084	4.707SerVal: 4.707 ± 0.074	0.736SerTrp: 0.736 ± 0.031	2.691SerTyr: 2.691 ± 0.06	0.001SerXaa: 0.001 ± 0.001
Thr	4.576ThrAla: 4.576 ± 0.092	0.624ThrCys: 0.624 ± 0.023	3.547ThrAsp: 3.547 ± 0.079	3.939ThrGlu: 3.939 ± 0.078	2.575ThrPhe: 2.575 ± 0.058	4.402ThrGly: 4.402 ± 0.084	0.818ThrHis: 0.818 ± 0.031	4.459ThrIle: 4.459 ± 0.095	3.555ThrLys: 3.555 ± 0.064	5.003ThrLeu: 5.003 ± 0.079	1.158ThrMet: 1.158 ± 0.036	2.565ThrAsn: 2.565 ± 0.065	2.296ThrPro: 2.296 ± 0.053	1.622ThrGln: 1.622 ± 0.04	1.791ThrArg: 1.791 ± 0.044	3.772ThrSer: 3.772 ± 0.081	3.188ThrThr: 3.188 ± 0.1	4.317ThrVal: 4.317 ± 0.076	0.575ThrTrp: 0.575 ± 0.027	2.216ThrTyr: 2.216 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	4.291ValAla: 4.291 ± 0.079	1.04ValCys: 1.04 ± 0.034	3.278ValAsp: 3.278 ± 0.069	4.117ValGlu: 4.117 ± 0.07	3.212ValPhe: 3.212 ± 0.054	3.362ValGly: 3.362 ± 0.069	0.993ValHis: 0.993 ± 0.035	5.134ValIle: 5.134 ± 0.076	4.299ValLys: 4.299 ± 0.071	5.922ValLeu: 5.922 ± 0.083	1.559ValMet: 1.559 ± 0.045	3.02ValAsn: 3.02 ± 0.064	2.548ValPro: 2.548 ± 0.052	1.939ValGln: 1.939 ± 0.043	2.487ValArg: 2.487 ± 0.05	4.678ValSer: 4.678 ± 0.078	3.836ValThr: 3.836 ± 0.083	4.134ValVal: 4.134 ± 0.075	0.615ValTrp: 0.615 ± 0.025	2.641ValTyr: 2.641 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	0.644TrpAla: 0.644 ± 0.026	0.162TrpCys: 0.162 ± 0.014	0.586TrpAsp: 0.586 ± 0.024	0.709TrpGlu: 0.709 ± 0.029	0.55TrpPhe: 0.55 ± 0.024	0.725TrpGly: 0.725 ± 0.03	0.211TrpHis: 0.211 ± 0.015	0.701TrpIle: 0.701 ± 0.029	0.825TrpLys: 0.825 ± 0.027	0.898TrpLeu: 0.898 ± 0.027	0.244TrpMet: 0.244 ± 0.014	0.753TrpAsn: 0.753 ± 0.029	0.256TrpPro: 0.256 ± 0.017	0.406TrpGln: 0.406 ± 0.021	0.365TrpArg: 0.365 ± 0.019	0.643TrpSer: 0.643 ± 0.027	0.614TrpThr: 0.614 ± 0.03	0.502TrpVal: 0.502 ± 0.023	0.171TrpTrp: 0.171 ± 0.015	0.557TrpTyr: 0.557 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.528TyrAla: 2.528 ± 0.055	0.589TyrCys: 0.589 ± 0.026	2.686TyrAsp: 2.686 ± 0.072	2.687TyrGlu: 2.687 ± 0.053	2.169TyrPhe: 2.169 ± 0.05	2.678TyrGly: 2.678 ± 0.06	0.681TyrHis: 0.681 ± 0.027	3.018TyrIle: 3.018 ± 0.063	2.93TyrLys: 2.93 ± 0.06	3.582TyrLeu: 3.582 ± 0.066	0.874TyrMet: 0.874 ± 0.026	2.385TyrAsn: 2.385 ± 0.055	1.41TyrPro: 1.41 ± 0.034	1.133TyrGln: 1.133 ± 0.035	1.555TyrArg: 1.555 ± 0.037	3.037TyrSer: 3.037 ± 0.073	2.537TyrThr: 2.537 ± 0.056	2.377TyrVal: 2.377 ± 0.041	0.472TyrTrp: 0.472 ± 0.023	1.866TyrTyr: 1.866 ± 0.059	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.003

Statistics based on 3051 proteins (1068725 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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