Amino acid dipepetide frequency for Pseudonocardia autotrophica (Amycolata autotrophica) (Nocardia autotrophica)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.506AlaAla: 23.506 ± 0.18	1.05AlaCys: 1.05 ± 0.023	9.199AlaAsp: 9.199 ± 0.08	8.756AlaGlu: 8.756 ± 0.073	3.29AlaPhe: 3.29 ± 0.044	15.98AlaGly: 15.98 ± 0.109	2.775AlaHis: 2.775 ± 0.038	3.996AlaIle: 3.996 ± 0.051	1.607AlaLys: 1.607 ± 0.037	14.448AlaLeu: 14.448 ± 0.101	2.423AlaMet: 2.423 ± 0.034	1.706AlaAsn: 1.706 ± 0.037	7.724AlaPro: 7.724 ± 0.088	3.325AlaGln: 3.325 ± 0.045	11.189AlaArg: 11.189 ± 0.081	5.416AlaSer: 5.416 ± 0.066	7.685AlaThr: 7.685 ± 0.075	13.527AlaVal: 13.527 ± 0.104	1.721AlaTrp: 1.721 ± 0.031	1.989AlaTyr: 1.989 ± 0.029	0.0AlaXaa: 0.0 ± 0.0
Cys	1.078CysAla: 1.078 ± 0.024	0.103CysCys: 0.103 ± 0.007	0.477CysAsp: 0.477 ± 0.014	0.366CysGlu: 0.366 ± 0.014	0.191CysPhe: 0.191 ± 0.009	0.977CysGly: 0.977 ± 0.025	0.169CysHis: 0.169 ± 0.008	0.172CysIle: 0.172 ± 0.008	0.067CysLys: 0.067 ± 0.005	0.635CysLeu: 0.635 ± 0.017	0.111CysMet: 0.111 ± 0.007	0.115CysAsn: 0.115 ± 0.008	0.519CysPro: 0.519 ± 0.019	0.122CysGln: 0.122 ± 0.007	0.665CysArg: 0.665 ± 0.019	0.458CysSer: 0.458 ± 0.016	0.505CysThr: 0.505 ± 0.019	0.599CysVal: 0.599 ± 0.017	0.121CysTrp: 0.121 ± 0.008	0.137CysTyr: 0.137 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	8.447AspAla: 8.447 ± 0.081	0.379AspCys: 0.379 ± 0.014	4.567AspAsp: 4.567 ± 0.054	3.98AspGlu: 3.98 ± 0.048	1.245AspPhe: 1.245 ± 0.024	7.158AspGly: 7.158 ± 0.06	1.385AspHis: 1.385 ± 0.03	1.615AspIle: 1.615 ± 0.026	0.624AspLys: 0.624 ± 0.02	6.611AspLeu: 6.611 ± 0.065	0.769AspMet: 0.769 ± 0.018	0.724AspAsn: 0.724 ± 0.017	5.726AspPro: 5.726 ± 0.06	1.407AspGln: 1.407 ± 0.026	6.19AspArg: 6.19 ± 0.059	2.221AspSer: 2.221 ± 0.034	3.335AspThr: 3.335 ± 0.042	5.405AspVal: 5.405 ± 0.059	0.841AspTrp: 0.841 ± 0.022	0.979AspTyr: 0.979 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	6.048GluAla: 6.048 ± 0.057	0.318GluCys: 0.318 ± 0.011	2.216GluAsp: 2.216 ± 0.036	2.393GluGlu: 2.393 ± 0.036	1.553GluPhe: 1.553 ± 0.028	3.334GluGly: 3.334 ± 0.047	1.746GluHis: 1.746 ± 0.032	2.597GluIle: 2.597 ± 0.038	0.945GluLys: 0.945 ± 0.025	7.408GluLeu: 7.408 ± 0.079	0.85GluMet: 0.85 ± 0.02	0.903GluAsn: 0.903 ± 0.021	3.799GluPro: 3.799 ± 0.049	2.56GluGln: 2.56 ± 0.04	5.605GluArg: 5.605 ± 0.058	2.406GluSer: 2.406 ± 0.031	2.665GluThr: 2.665 ± 0.037	4.436GluVal: 4.436 ± 0.043	0.715GluTrp: 0.715 ± 0.017	0.907GluTyr: 0.907 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.649PheAla: 3.649 ± 0.042	0.274PheCys: 0.274 ± 0.011	1.996PheAsp: 1.996 ± 0.036	1.193PheGlu: 1.193 ± 0.024	0.736PhePhe: 0.736 ± 0.021	3.178PheGly: 3.178 ± 0.042	0.59PheHis: 0.59 ± 0.019	0.551PheIle: 0.551 ± 0.017	0.26PheLys: 0.26 ± 0.011	2.494PheLeu: 2.494 ± 0.037	0.311PheMet: 0.311 ± 0.012	0.391PheAsn: 0.391 ± 0.016	1.316PhePro: 1.316 ± 0.026	0.482PheGln: 0.482 ± 0.016	1.831PheArg: 1.831 ± 0.028	1.301PheSer: 1.301 ± 0.027	1.761PheThr: 1.761 ± 0.03	2.37PheVal: 2.37 ± 0.039	0.395PheTrp: 0.395 ± 0.015	0.499PheTyr: 0.499 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	12.542GlyAla: 12.542 ± 0.098	0.864GlyCys: 0.864 ± 0.02	5.53GlyAsp: 5.53 ± 0.054	5.118GlyGlu: 5.118 ± 0.058	2.969GlyPhe: 2.969 ± 0.042	9.412GlyGly: 9.412 ± 0.097	2.23GlyHis: 2.23 ± 0.036	3.933GlyIle: 3.933 ± 0.048	1.445GlyLys: 1.445 ± 0.033	9.979GlyLeu: 9.979 ± 0.077	2.148GlyMet: 2.148 ± 0.036	1.513GlyAsn: 1.513 ± 0.029	6.567GlyPro: 6.567 ± 0.08	2.323GlyGln: 2.323 ± 0.038	8.753GlyArg: 8.753 ± 0.077	5.828GlySer: 5.828 ± 0.074	6.782GlyThr: 6.782 ± 0.065	8.203GlyVal: 8.203 ± 0.064	1.797GlyTrp: 1.797 ± 0.029	2.271GlyTyr: 2.271 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.605HisAla: 2.605 ± 0.038	0.186HisCys: 0.186 ± 0.01	1.592HisAsp: 1.592 ± 0.029	1.138HisGlu: 1.138 ± 0.025	0.488HisPhe: 0.488 ± 0.016	2.484HisGly: 2.484 ± 0.037	0.661HisHis: 0.661 ± 0.019	0.536HisIle: 0.536 ± 0.018	0.2HisLys: 0.2 ± 0.009	2.283HisLeu: 2.283 ± 0.034	0.298HisMet: 0.298 ± 0.013	0.322HisAsn: 0.322 ± 0.011	1.848HisPro: 1.848 ± 0.033	0.519HisGln: 0.519 ± 0.016	2.321HisArg: 2.321 ± 0.037	0.975HisSer: 0.975 ± 0.021	1.154HisThr: 1.154 ± 0.026	1.747HisVal: 1.747 ± 0.031	0.332HisTrp: 0.332 ± 0.012	0.436HisTyr: 0.436 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	5.377IleAla: 5.377 ± 0.052	0.27IleCys: 0.27 ± 0.012	2.546IleAsp: 2.546 ± 0.033	2.023IleGlu: 2.023 ± 0.03	0.625IlePhe: 0.625 ± 0.019	4.191IleGly: 4.191 ± 0.05	0.508IleHis: 0.508 ± 0.015	0.8IleIle: 0.8 ± 0.017	0.416IleLys: 0.416 ± 0.015	2.241IleLeu: 2.241 ± 0.037	0.425IleMet: 0.425 ± 0.015	0.588IleAsn: 0.588 ± 0.016	1.819IlePro: 1.819 ± 0.032	0.552IleGln: 0.552 ± 0.018	2.404IleArg: 2.404 ± 0.036	1.655IleSer: 1.655 ± 0.029	2.235IleThr: 2.235 ± 0.04	3.163IleVal: 3.163 ± 0.042	0.373IleTrp: 0.373 ± 0.014	0.517IleTyr: 0.517 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	1.57LysAla: 1.57 ± 0.035	0.059LysCys: 0.059 ± 0.005	0.655LysAsp: 0.655 ± 0.02	0.603LysGlu: 0.603 ± 0.021	0.291LysPhe: 0.291 ± 0.012	0.957LysGly: 0.957 ± 0.024	0.285LysHis: 0.285 ± 0.012	0.632LysIle: 0.632 ± 0.022	0.345LysLys: 0.345 ± 0.018	1.328LysLeu: 1.328 ± 0.03	0.225LysMet: 0.225 ± 0.011	0.255LysAsn: 0.255 ± 0.012	0.764LysPro: 0.764 ± 0.024	0.43LysGln: 0.43 ± 0.015	0.974LysArg: 0.974 ± 0.023	0.629LysSer: 0.629 ± 0.019	0.733LysThr: 0.733 ± 0.021	1.145LysVal: 1.145 ± 0.028	0.156LysTrp: 0.156 ± 0.01	0.235LysTyr: 0.235 ± 0.01	0.0LysXaa: 0.0 ± 0.0
Leu	15.981LeuAla: 15.981 ± 0.104	0.765LeuCys: 0.765 ± 0.018	7.392LeuAsp: 7.392 ± 0.065	4.407LeuGlu: 4.407 ± 0.049	2.553LeuPhe: 2.553 ± 0.039	9.912LeuGly: 9.912 ± 0.08	2.328LeuHis: 2.328 ± 0.034	3.127LeuIle: 3.127 ± 0.047	1.013LeuLys: 1.013 ± 0.022	11.632LeuLeu: 11.632 ± 0.116	1.411LeuMet: 1.411 ± 0.026	1.402LeuAsn: 1.402 ± 0.028	6.407LeuPro: 6.407 ± 0.062	2.135LeuGln: 2.135 ± 0.033	8.982LeuArg: 8.982 ± 0.079	4.903LeuSer: 4.903 ± 0.051	6.311LeuThr: 6.311 ± 0.057	10.06LeuVal: 10.06 ± 0.081	1.144LeuTrp: 1.144 ± 0.023	1.51LeuTyr: 1.51 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.073MetAla: 2.073 ± 0.033	0.13MetCys: 0.13 ± 0.008	0.717MetAsp: 0.717 ± 0.022	0.588MetGlu: 0.588 ± 0.016	0.477MetPhe: 0.477 ± 0.016	1.162MetGly: 1.162 ± 0.025	0.348MetHis: 0.348 ± 0.013	0.769MetIle: 0.769 ± 0.019	0.281MetLys: 0.281 ± 0.011	1.814MetLeu: 1.814 ± 0.028	0.266MetMet: 0.266 ± 0.012	0.38MetAsn: 0.38 ± 0.012	1.059MetPro: 1.059 ± 0.023	0.442MetGln: 0.442 ± 0.016	1.336MetArg: 1.336 ± 0.023	1.366MetSer: 1.366 ± 0.024	1.653MetThr: 1.653 ± 0.028	1.306MetVal: 1.306 ± 0.024	0.196MetTrp: 0.196 ± 0.008	0.236MetTyr: 0.236 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	1.907AsnAla: 1.907 ± 0.033	0.129AsnCys: 0.129 ± 0.009	0.848AsnAsp: 0.848 ± 0.02	0.635AsnGlu: 0.635 ± 0.02	0.4AsnPhe: 0.4 ± 0.015	1.516AsnGly: 1.516 ± 0.032	0.33AsnHis: 0.33 ± 0.012	0.525AsnIle: 0.525 ± 0.016	0.22AsnLys: 0.22 ± 0.01	1.481AsnLeu: 1.481 ± 0.025	0.239AsnMet: 0.239 ± 0.011	0.318AsnAsn: 0.318 ± 0.014	1.261AsnPro: 1.261 ± 0.024	0.398AsnGln: 0.398 ± 0.014	1.219AsnArg: 1.219 ± 0.026	0.748AsnSer: 0.748 ± 0.019	0.895AsnThr: 0.895 ± 0.022	1.221AsnVal: 1.221 ± 0.024	0.219AsnTrp: 0.219 ± 0.011	0.326AsnTyr: 0.326 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	10.046ProAla: 10.046 ± 0.096	0.352ProCys: 0.352 ± 0.014	5.507ProAsp: 5.507 ± 0.059	4.353ProGlu: 4.353 ± 0.057	1.493ProPhe: 1.493 ± 0.028	7.882ProGly: 7.882 ± 0.089	1.319ProHis: 1.319 ± 0.029	1.624ProIle: 1.624 ± 0.031	0.711ProLys: 0.711 ± 0.02	5.204ProLeu: 5.204 ± 0.05	1.055ProMet: 1.055 ± 0.023	0.82ProAsn: 0.82 ± 0.021	3.911ProPro: 3.911 ± 0.066	1.596ProGln: 1.596 ± 0.033	4.271ProArg: 4.271 ± 0.053	3.119ProSer: 3.119 ± 0.048	3.369ProThr: 3.369 ± 0.043	6.311ProVal: 6.311 ± 0.063	0.892ProTrp: 0.892 ± 0.018	0.97ProTyr: 0.97 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.302GlnAla: 3.302 ± 0.05	0.156GlnCys: 0.156 ± 0.01	1.227GlnAsp: 1.227 ± 0.024	1.17GlnGlu: 1.17 ± 0.024	0.601GlnPhe: 0.601 ± 0.018	1.847GlnGly: 1.847 ± 0.035	0.59GlnHis: 0.59 ± 0.016	1.043GlnIle: 1.043 ± 0.023	0.358GlnLys: 0.358 ± 0.015	2.806GlnLeu: 2.806 ± 0.036	0.415GlnMet: 0.415 ± 0.014	0.443GlnAsn: 0.443 ± 0.016	1.483GlnPro: 1.483 ± 0.03	1.074GlnGln: 1.074 ± 0.033	2.402GlnArg: 2.402 ± 0.041	1.035GlnSer: 1.035 ± 0.023	1.137GlnThr: 1.137 ± 0.023	2.493GlnVal: 2.493 ± 0.038	0.361GlnTrp: 0.361 ± 0.013	0.463GlnTyr: 0.463 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	11.06ArgAla: 11.06 ± 0.1	0.674ArgCys: 0.674 ± 0.023	4.967ArgAsp: 4.967 ± 0.054	4.741ArgGlu: 4.741 ± 0.052	2.508ArgPhe: 2.508 ± 0.036	6.219ArgGly: 6.219 ± 0.057	2.05ArgHis: 2.05 ± 0.03	3.745ArgIle: 3.745 ± 0.046	1.084ArgLys: 1.084 ± 0.026	8.523ArgLeu: 8.523 ± 0.07	1.972ArgMet: 1.972 ± 0.028	1.362ArgAsn: 1.362 ± 0.024	5.604ArgPro: 5.604 ± 0.069	1.882ArgGln: 1.882 ± 0.029	8.631ArgArg: 8.631 ± 0.102	4.912ArgSer: 4.912 ± 0.057	5.612ArgThr: 5.612 ± 0.052	6.501ArgVal: 6.501 ± 0.063	1.508ArgTrp: 1.508 ± 0.028	1.807ArgTyr: 1.807 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.608SerAla: 6.608 ± 0.065	0.409SerCys: 0.409 ± 0.016	2.772SerAsp: 2.772 ± 0.043	2.307SerGlu: 2.307 ± 0.037	1.391SerPhe: 1.391 ± 0.025	6.195SerGly: 6.195 ± 0.071	0.829SerHis: 0.829 ± 0.02	1.532SerIle: 1.532 ± 0.027	0.62SerLys: 0.62 ± 0.019	4.172SerLeu: 4.172 ± 0.052	1.095SerMet: 1.095 ± 0.021	0.734SerAsn: 0.734 ± 0.019	3.146SerPro: 3.146 ± 0.041	1.024SerGln: 1.024 ± 0.023	3.797SerArg: 3.797 ± 0.042	2.755SerSer: 2.755 ± 0.053	3.268SerThr: 3.268 ± 0.038	4.202SerVal: 4.202 ± 0.047	0.853SerTrp: 0.853 ± 0.023	0.943SerTyr: 0.943 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	8.915ThrAla: 8.915 ± 0.071	0.434ThrCys: 0.434 ± 0.014	3.782ThrAsp: 3.782 ± 0.045	3.228ThrGlu: 3.228 ± 0.04	1.477ThrPhe: 1.477 ± 0.026	7.484ThrGly: 7.484 ± 0.065	1.157ThrHis: 1.157 ± 0.026	1.914ThrIle: 1.914 ± 0.028	0.663ThrLys: 0.663 ± 0.019	5.476ThrLeu: 5.476 ± 0.051	0.957ThrMet: 0.957 ± 0.021	0.82ThrAsn: 0.82 ± 0.02	4.14ThrPro: 4.14 ± 0.046	1.054ThrGln: 1.054 ± 0.021	4.216ThrArg: 4.216 ± 0.047	2.914ThrSer: 2.914 ± 0.036	3.846ThrThr: 3.846 ± 0.045	6.451ThrVal: 6.451 ± 0.058	0.859ThrTrp: 0.859 ± 0.02	0.951ThrTyr: 0.951 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	12.749ValAla: 12.749 ± 0.095	0.733ValCys: 0.733 ± 0.018	5.735ValAsp: 5.735 ± 0.049	4.904ValGlu: 4.904 ± 0.053	2.304ValPhe: 2.304 ± 0.039	7.533ValGly: 7.533 ± 0.065	2.136ValHis: 2.136 ± 0.039	2.705ValIle: 2.705 ± 0.037	0.983ValLys: 0.983 ± 0.025	11.107ValLeu: 11.107 ± 0.097	1.18ValMet: 1.18 ± 0.025	1.43ValAsn: 1.43 ± 0.027	5.892ValPro: 5.892 ± 0.055	2.143ValGln: 2.143 ± 0.03	7.6ValArg: 7.6 ± 0.065	4.212ValSer: 4.212 ± 0.048	5.801ValThr: 5.801 ± 0.053	9.644ValVal: 9.644 ± 0.095	1.032ValTrp: 1.032 ± 0.024	1.337ValTyr: 1.337 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.688TrpAla: 1.688 ± 0.027	0.144TrpCys: 0.144 ± 0.009	0.75TrpAsp: 0.75 ± 0.019	0.652TrpGlu: 0.652 ± 0.017	0.503TrpPhe: 0.503 ± 0.016	0.989TrpGly: 0.989 ± 0.023	0.333TrpHis: 0.333 ± 0.012	0.546TrpIle: 0.546 ± 0.018	0.201TrpLys: 0.201 ± 0.01	1.68TrpLeu: 1.68 ± 0.03	0.265TrpMet: 0.265 ± 0.01	0.318TrpAsn: 0.318 ± 0.014	0.799TrpPro: 0.799 ± 0.022	0.467TrpGln: 0.467 ± 0.013	1.231TrpArg: 1.231 ± 0.027	0.958TrpSer: 0.958 ± 0.023	0.993TrpThr: 0.993 ± 0.023	1.0TrpVal: 1.0 ± 0.023	0.338TrpTrp: 0.338 ± 0.013	0.264TrpTyr: 0.264 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.162TyrAla: 2.162 ± 0.03	0.161TyrCys: 0.161 ± 0.009	1.133TyrAsp: 1.133 ± 0.024	0.849TyrGlu: 0.849 ± 0.023	0.484TyrPhe: 0.484 ± 0.016	1.796TyrGly: 1.796 ± 0.033	0.355TyrHis: 0.355 ± 0.013	0.367TyrIle: 0.367 ± 0.013	0.231TyrLys: 0.231 ± 0.011	2.051TyrLeu: 2.051 ± 0.034	0.185TyrMet: 0.185 ± 0.011	0.292TyrAsn: 0.292 ± 0.011	1.018TyrPro: 1.018 ± 0.024	0.47TyrGln: 0.47 ± 0.014	1.744TyrArg: 1.744 ± 0.032	0.842TyrSer: 0.842 ± 0.022	0.997TyrThr: 0.997 ± 0.023	1.377TyrVal: 1.377 ± 0.024	0.266TyrTrp: 0.266 ± 0.013	0.35TyrTyr: 0.35 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6859 proteins (2184090 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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