Amino acid dipepetide frequency for Monosporascus ibericus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.92AlaAla: 10.92 ± 0.079	1.08AlaCys: 1.08 ± 0.017	4.872AlaAsp: 4.872 ± 0.027	5.847AlaGlu: 5.847 ± 0.04	3.179AlaPhe: 3.179 ± 0.025	6.582AlaGly: 6.582 ± 0.043	1.854AlaHis: 1.854 ± 0.019	4.031AlaIle: 4.031 ± 0.032	4.142AlaLys: 4.142 ± 0.035	7.997AlaLeu: 7.997 ± 0.041	2.04AlaMet: 2.04 ± 0.019	3.043AlaAsn: 3.043 ± 0.026	5.184AlaPro: 5.184 ± 0.044	3.455AlaGln: 3.455 ± 0.029	5.754AlaArg: 5.754 ± 0.036	7.452AlaSer: 7.452 ± 0.041	5.565AlaThr: 5.565 ± 0.038	5.937AlaVal: 5.937 ± 0.039	1.204AlaTrp: 1.204 ± 0.017	2.276AlaTyr: 2.276 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	0.951CysAla: 0.951 ± 0.014	0.22CysCys: 0.22 ± 0.008	0.656CysAsp: 0.656 ± 0.013	0.605CysGlu: 0.605 ± 0.011	0.502CysPhe: 0.502 ± 0.011	0.963CysGly: 0.963 ± 0.016	0.303CysHis: 0.303 ± 0.008	0.637CysIle: 0.637 ± 0.01	0.455CysLys: 0.455 ± 0.011	1.142CysLeu: 1.142 ± 0.015	0.239CysMet: 0.239 ± 0.007	0.401CysAsn: 0.401 ± 0.008	0.627CysPro: 0.627 ± 0.012	0.411CysGln: 0.411 ± 0.008	0.771CysArg: 0.771 ± 0.013	0.836CysSer: 0.836 ± 0.014	0.619CysThr: 0.619 ± 0.011	0.759CysVal: 0.759 ± 0.014	0.193CysTrp: 0.193 ± 0.006	0.345CysTyr: 0.345 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.316AspAla: 5.316 ± 0.033	0.612AspCys: 0.612 ± 0.012	4.701AspAsp: 4.701 ± 0.056	4.758AspGlu: 4.758 ± 0.042	2.205AspPhe: 2.205 ± 0.022	4.627AspGly: 4.627 ± 0.032	1.219AspHis: 1.219 ± 0.016	2.961AspIle: 2.961 ± 0.026	2.337AspLys: 2.337 ± 0.025	5.045AspLeu: 5.045 ± 0.032	1.285AspMet: 1.285 ± 0.017	1.891AspAsn: 1.891 ± 0.022	3.593AspPro: 3.593 ± 0.025	1.807AspGln: 1.807 ± 0.019	3.38AspArg: 3.38 ± 0.03	4.022AspSer: 4.022 ± 0.032	2.845AspThr: 2.845 ± 0.025	3.932AspVal: 3.932 ± 0.034	0.915AspTrp: 0.915 ± 0.014	1.647AspTyr: 1.647 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	6.022GluAla: 6.022 ± 0.043	0.643GluCys: 0.643 ± 0.01	4.473GluAsp: 4.473 ± 0.036	5.626GluGlu: 5.626 ± 0.056	1.992GluPhe: 1.992 ± 0.018	4.139GluGly: 4.139 ± 0.029	1.411GluHis: 1.411 ± 0.016	2.9GluIle: 2.9 ± 0.024	3.61GluLys: 3.61 ± 0.034	5.391GluLeu: 5.391 ± 0.041	1.431GluMet: 1.431 ± 0.018	2.303GluAsn: 2.303 ± 0.021	3.069GluPro: 3.069 ± 0.031	2.477GluGln: 2.477 ± 0.025	4.272GluArg: 4.272 ± 0.036	4.192GluSer: 4.192 ± 0.031	3.52GluThr: 3.52 ± 0.028	3.735GluVal: 3.735 ± 0.028	0.913GluTrp: 0.913 ± 0.014	1.653GluTyr: 1.653 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.093PheAla: 3.093 ± 0.025	0.516PheCys: 0.516 ± 0.01	2.232PheAsp: 2.232 ± 0.023	2.208PheGlu: 2.208 ± 0.021	1.475PhePhe: 1.475 ± 0.018	2.844PheGly: 2.844 ± 0.029	0.834PheHis: 0.834 ± 0.013	1.57PheIle: 1.57 ± 0.018	1.428PheLys: 1.428 ± 0.017	3.206PheLeu: 3.206 ± 0.029	0.742PheMet: 0.742 ± 0.012	1.309PheAsn: 1.309 ± 0.017	1.861PhePro: 1.861 ± 0.021	1.27PheGln: 1.27 ± 0.015	2.071PheArg: 2.071 ± 0.02	2.715PheSer: 2.715 ± 0.023	1.975PheThr: 1.975 ± 0.021	2.35PheVal: 2.35 ± 0.023	0.604PheTrp: 0.604 ± 0.01	1.049PheTyr: 1.049 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	6.197GlyAla: 6.197 ± 0.044	0.884GlyCys: 0.884 ± 0.014	4.231GlyAsp: 4.231 ± 0.032	4.032GlyGlu: 4.032 ± 0.027	2.791GlyPhe: 2.791 ± 0.025	6.856GlyGly: 6.856 ± 0.067	1.817GlyHis: 1.817 ± 0.025	3.397GlyIle: 3.397 ± 0.029	3.434GlyLys: 3.434 ± 0.033	6.137GlyLeu: 6.137 ± 0.041	1.568GlyMet: 1.568 ± 0.02	2.677GlyAsn: 2.677 ± 0.027	3.769GlyPro: 3.769 ± 0.038	2.547GlyGln: 2.547 ± 0.024	4.802GlyArg: 4.802 ± 0.035	5.96GlySer: 5.96 ± 0.04	4.109GlyThr: 4.109 ± 0.031	4.616GlyVal: 4.616 ± 0.038	1.186GlyTrp: 1.186 ± 0.017	2.14GlyTyr: 2.14 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	1.906HisAla: 1.906 ± 0.024	0.301HisCys: 0.301 ± 0.008	1.29HisAsp: 1.29 ± 0.016	1.358HisGlu: 1.358 ± 0.017	0.857HisPhe: 0.857 ± 0.012	1.808HisGly: 1.808 ± 0.018	0.885HisHis: 0.885 ± 0.02	1.108HisIle: 1.108 ± 0.016	0.863HisLys: 0.863 ± 0.012	2.083HisLeu: 2.083 ± 0.023	0.499HisMet: 0.499 ± 0.01	0.802HisAsn: 0.802 ± 0.013	1.665HisPro: 1.665 ± 0.021	0.977HisGln: 0.977 ± 0.015	1.588HisArg: 1.588 ± 0.02	1.684HisSer: 1.684 ± 0.02	1.129HisThr: 1.129 ± 0.014	1.452HisVal: 1.452 ± 0.018	0.334HisTrp: 0.334 ± 0.008	0.685HisTyr: 0.685 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	3.929IleAla: 3.929 ± 0.032	0.672IleCys: 0.672 ± 0.013	2.711IleAsp: 2.711 ± 0.023	2.734IleGlu: 2.734 ± 0.023	1.744IlePhe: 1.744 ± 0.021	2.956IleGly: 2.956 ± 0.028	1.058IleHis: 1.058 ± 0.014	2.152IleIle: 2.152 ± 0.022	1.98IleLys: 1.98 ± 0.022	4.082IleLeu: 4.082 ± 0.032	0.926IleMet: 0.926 ± 0.013	1.619IleAsn: 1.619 ± 0.019	2.816IlePro: 2.816 ± 0.025	1.701IleGln: 1.701 ± 0.02	2.845IleArg: 2.845 ± 0.022	3.354IleSer: 3.354 ± 0.028	2.599IleThr: 2.599 ± 0.024	2.931IleVal: 2.931 ± 0.028	0.681IleTrp: 0.681 ± 0.012	1.289IleTyr: 1.289 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	4.314LysAla: 4.314 ± 0.037	0.432LysCys: 0.432 ± 0.01	2.678LysAsp: 2.678 ± 0.029	3.264LysGlu: 3.264 ± 0.032	1.362LysPhe: 1.362 ± 0.017	3.045LysGly: 3.045 ± 0.032	1.036LysHis: 1.036 ± 0.013	2.01LysIle: 2.01 ± 0.022	3.172LysLys: 3.172 ± 0.045	3.926LysLeu: 3.926 ± 0.03	0.943LysMet: 0.943 ± 0.014	1.583LysAsn: 1.583 ± 0.02	2.742LysPro: 2.742 ± 0.03	1.766LysGln: 1.766 ± 0.02	3.378LysArg: 3.378 ± 0.033	3.198LysSer: 3.198 ± 0.029	2.691LysThr: 2.691 ± 0.027	2.749LysVal: 2.749 ± 0.027	0.634LysTrp: 0.634 ± 0.011	1.283LysTyr: 1.283 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	8.163LeuAla: 8.163 ± 0.044	1.119LeuCys: 1.119 ± 0.017	5.18LeuAsp: 5.18 ± 0.033	5.584LeuGlu: 5.584 ± 0.04	3.092LeuPhe: 3.092 ± 0.029	6.077LeuGly: 6.077 ± 0.044	2.04LeuHis: 2.04 ± 0.02	3.533LeuIle: 3.533 ± 0.027	4.012LeuLys: 4.012 ± 0.032	8.185LeuLeu: 8.185 ± 0.059	1.743LeuMet: 1.743 ± 0.02	2.951LeuAsn: 2.951 ± 0.022	5.394LeuPro: 5.394 ± 0.037	3.579LeuGln: 3.579 ± 0.032	6.148LeuArg: 6.148 ± 0.039	6.835LeuSer: 6.835 ± 0.046	4.57LeuThr: 4.57 ± 0.03	5.437LeuVal: 5.437 ± 0.042	1.207LeuTrp: 1.207 ± 0.02	2.251LeuTyr: 2.251 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	2.28MetAla: 2.28 ± 0.021	0.228MetCys: 0.228 ± 0.006	1.224MetAsp: 1.224 ± 0.015	1.258MetGlu: 1.258 ± 0.016	0.691MetPhe: 0.691 ± 0.011	1.426MetGly: 1.426 ± 0.019	0.478MetHis: 0.478 ± 0.009	0.89MetIle: 0.89 ± 0.015	0.938MetLys: 0.938 ± 0.013	1.811MetLeu: 1.811 ± 0.019	0.562MetMet: 0.562 ± 0.01	0.745MetAsn: 0.745 ± 0.012	1.299MetPro: 1.299 ± 0.019	0.816MetGln: 0.816 ± 0.013	1.369MetArg: 1.369 ± 0.017	1.735MetSer: 1.735 ± 0.018	1.276MetThr: 1.276 ± 0.016	1.317MetVal: 1.317 ± 0.018	0.263MetTrp: 0.263 ± 0.008	0.5MetTyr: 0.5 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.201AsnAla: 3.201 ± 0.026	0.421AsnCys: 0.421 ± 0.011	1.905AsnAsp: 1.905 ± 0.019	1.949AsnGlu: 1.949 ± 0.022	1.276AsnPhe: 1.276 ± 0.017	3.086AsnGly: 3.086 ± 0.031	0.819AsnHis: 0.819 ± 0.012	1.796AsnIle: 1.796 ± 0.021	1.454AsnLys: 1.454 ± 0.019	3.041AsnLeu: 3.041 ± 0.025	0.785AsnMet: 0.785 ± 0.014	1.488AsnAsn: 1.488 ± 0.023	2.443AsnPro: 2.443 ± 0.022	1.237AsnGln: 1.237 ± 0.018	2.009AsnArg: 2.009 ± 0.017	2.594AsnSer: 2.594 ± 0.025	1.999AsnThr: 1.999 ± 0.021	2.183AsnVal: 2.183 ± 0.024	0.537AsnTrp: 0.537 ± 0.01	1.001AsnTyr: 1.001 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.715ProAla: 5.715 ± 0.041	0.502ProCys: 0.502 ± 0.01	3.478ProAsp: 3.478 ± 0.028	4.117ProGlu: 4.117 ± 0.034	1.962ProPhe: 1.962 ± 0.02	4.454ProGly: 4.454 ± 0.043	1.324ProHis: 1.324 ± 0.018	2.295ProIle: 2.295 ± 0.021	2.603ProLys: 2.603 ± 0.028	4.782ProLeu: 4.782 ± 0.031	1.074ProMet: 1.074 ± 0.016	2.167ProAsn: 2.167 ± 0.021	5.625ProPro: 5.625 ± 0.072	2.513ProGln: 2.513 ± 0.031	3.814ProArg: 3.814 ± 0.036	5.874ProSer: 5.874 ± 0.05	3.988ProThr: 3.988 ± 0.036	3.634ProVal: 3.634 ± 0.032	0.758ProTrp: 0.758 ± 0.013	1.516ProTyr: 1.516 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.495GlnAla: 3.495 ± 0.03	0.41GlnCys: 0.41 ± 0.009	2.043GlnAsp: 2.043 ± 0.019	2.352GlnGlu: 2.352 ± 0.025	1.214GlnPhe: 1.214 ± 0.015	2.477GlnGly: 2.477 ± 0.023	1.066GlnHis: 1.066 ± 0.017	1.681GlnIle: 1.681 ± 0.019	1.863GlnLys: 1.863 ± 0.02	3.306GlnLeu: 3.306 ± 0.029	0.84GlnMet: 0.84 ± 0.013	1.392GlnAsn: 1.392 ± 0.018	2.614GlnPro: 2.614 ± 0.032	2.58GlnGln: 2.58 ± 0.05	2.693GlnArg: 2.693 ± 0.024	2.829GlnSer: 2.829 ± 0.024	2.144GlnThr: 2.144 ± 0.022	2.12GlnVal: 2.12 ± 0.026	0.538GlnTrp: 0.538 ± 0.011	1.094GlnTyr: 1.094 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	5.447ArgAla: 5.447 ± 0.036	0.745ArgCys: 0.745 ± 0.013	3.925ArgAsp: 3.925 ± 0.037	4.242ArgGlu: 4.242 ± 0.038	2.205ArgPhe: 2.205 ± 0.024	4.36ArgGly: 4.36 ± 0.035	1.714ArgHis: 1.714 ± 0.022	2.898ArgIle: 2.898 ± 0.023	3.4ArgLys: 3.4 ± 0.031	5.895ArgLeu: 5.895 ± 0.041	1.376ArgMet: 1.376 ± 0.016	2.351ArgAsn: 2.351 ± 0.022	3.948ArgPro: 3.948 ± 0.038	2.764ArgGln: 2.764 ± 0.025	5.882ArgArg: 5.882 ± 0.055	4.858ArgSer: 4.858 ± 0.043	3.449ArgThr: 3.449 ± 0.027	3.625ArgVal: 3.625 ± 0.029	1.0ArgTrp: 1.0 ± 0.014	1.712ArgTyr: 1.712 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.848SerAla: 6.848 ± 0.037	0.799SerCys: 0.799 ± 0.013	4.097SerAsp: 4.097 ± 0.035	4.16SerGlu: 4.16 ± 0.025	2.765SerPhe: 2.765 ± 0.025	5.82SerGly: 5.82 ± 0.038	1.802SerHis: 1.802 ± 0.019	3.447SerIle: 3.447 ± 0.025	3.407SerLys: 3.407 ± 0.031	6.664SerLeu: 6.664 ± 0.048	1.638SerMet: 1.638 ± 0.018	2.74SerAsn: 2.74 ± 0.024	5.448SerPro: 5.448 ± 0.05	3.057SerGln: 3.057 ± 0.028	5.16SerArg: 5.16 ± 0.042	8.334SerSer: 8.334 ± 0.073	5.113SerThr: 5.113 ± 0.043	4.422SerVal: 4.422 ± 0.033	1.091SerTrp: 1.091 ± 0.015	2.03SerTyr: 2.03 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.476ThrAla: 5.476 ± 0.036	0.713ThrCys: 0.713 ± 0.011	2.789ThrAsp: 2.789 ± 0.026	3.166ThrGlu: 3.166 ± 0.029	2.039ThrPhe: 2.039 ± 0.022	4.273ThrGly: 4.273 ± 0.033	1.179ThrHis: 1.179 ± 0.014	2.721ThrIle: 2.721 ± 0.027	2.442ThrLys: 2.442 ± 0.024	4.903ThrLeu: 4.903 ± 0.032	1.169ThrMet: 1.169 ± 0.013	1.919ThrAsn: 1.919 ± 0.02	4.305ThrPro: 4.305 ± 0.039	1.97ThrGln: 1.97 ± 0.022	3.306ThrArg: 3.306 ± 0.027	5.014ThrSer: 5.014 ± 0.039	4.257ThrThr: 4.257 ± 0.04	3.72ThrVal: 3.72 ± 0.032	0.835ThrTrp: 0.835 ± 0.014	1.55ThrTyr: 1.55 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.694ValAla: 5.694 ± 0.039	0.769ValCys: 0.769 ± 0.014	3.886ValAsp: 3.886 ± 0.029	4.03ValGlu: 4.03 ± 0.028	2.36ValPhe: 2.36 ± 0.027	4.203ValGly: 4.203 ± 0.032	1.361ValHis: 1.361 ± 0.019	2.794ValIle: 2.794 ± 0.031	2.882ValLys: 2.882 ± 0.029	5.63ValLeu: 5.63 ± 0.041	1.29ValMet: 1.29 ± 0.016	2.202ValAsn: 2.202 ± 0.023	3.707ValPro: 3.707 ± 0.032	2.26ValGln: 2.26 ± 0.022	3.826ValArg: 3.826 ± 0.028	4.465ValSer: 4.465 ± 0.028	3.547ValThr: 3.547 ± 0.029	4.505ValVal: 4.505 ± 0.036	0.877ValTrp: 0.877 ± 0.014	1.717ValTyr: 1.717 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.214TrpAla: 1.214 ± 0.017	0.187TrpCys: 0.187 ± 0.006	0.979TrpAsp: 0.979 ± 0.016	0.872TrpGlu: 0.872 ± 0.013	0.528TrpPhe: 0.528 ± 0.01	0.96TrpGly: 0.96 ± 0.013	0.355TrpHis: 0.355 ± 0.009	0.72TrpIle: 0.72 ± 0.013	0.741TrpLys: 0.741 ± 0.011	1.341TrpLeu: 1.341 ± 0.018	0.347TrpMet: 0.347 ± 0.007	0.595TrpAsn: 0.595 ± 0.01	0.613TrpPro: 0.613 ± 0.011	0.543TrpGln: 0.543 ± 0.01	1.028TrpArg: 1.028 ± 0.014	0.983TrpSer: 0.983 ± 0.015	0.888TrpThr: 0.888 ± 0.015	0.918TrpVal: 0.918 ± 0.014	0.267TrpTrp: 0.267 ± 0.008	0.405TrpTyr: 0.405 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.235TyrAla: 2.235 ± 0.021	0.382TyrCys: 0.382 ± 0.009	1.748TyrAsp: 1.748 ± 0.021	1.609TyrGlu: 1.609 ± 0.02	1.116TyrPhe: 1.116 ± 0.014	2.191TyrGly: 2.191 ± 0.024	0.721TyrHis: 0.721 ± 0.011	1.238TyrIle: 1.238 ± 0.017	1.041TyrLys: 1.041 ± 0.015	2.532TyrLeu: 2.532 ± 0.024	0.612TyrMet: 0.612 ± 0.013	1.043TyrAsn: 1.043 ± 0.015	1.474TyrPro: 1.474 ± 0.021	1.02TyrGln: 1.02 ± 0.015	1.698TyrArg: 1.698 ± 0.019	1.909TyrSer: 1.909 ± 0.021	1.464TyrThr: 1.464 ± 0.016	1.664TyrVal: 1.664 ± 0.02	0.446TyrTrp: 0.446 ± 0.011	0.929TyrTyr: 0.929 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.007XaaXaa: 0.007 ± 0.006

Statistics based on 11059 proteins (5384106 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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