Amino acid dipepetide frequency for Methylocella tundrae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.363AlaAla: 19.363 ± 0.188	1.208AlaCys: 1.208 ± 0.031	6.778AlaAsp: 6.778 ± 0.085	7.548AlaGlu: 7.548 ± 0.098	4.931AlaPhe: 4.931 ± 0.062	10.714AlaGly: 10.714 ± 0.107	2.573AlaHis: 2.573 ± 0.045	6.945AlaIle: 6.945 ± 0.072	4.746AlaLys: 4.746 ± 0.079	14.382AlaLeu: 14.382 ± 0.145	3.073AlaMet: 3.073 ± 0.053	3.096AlaAsn: 3.096 ± 0.052	7.184AlaPro: 7.184 ± 0.095	4.274AlaGln: 4.274 ± 0.07	9.79AlaArg: 9.79 ± 0.107	7.553AlaSer: 7.553 ± 0.085	5.793AlaThr: 5.793 ± 0.072	7.926AlaVal: 7.926 ± 0.092	1.467AlaTrp: 1.467 ± 0.037	2.55AlaTyr: 2.55 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.226CysAla: 1.226 ± 0.033	0.151CysCys: 0.151 ± 0.012	0.589CysAsp: 0.589 ± 0.021	0.483CysGlu: 0.483 ± 0.018	0.386CysPhe: 0.386 ± 0.018	1.008CysGly: 1.008 ± 0.034	0.221CysHis: 0.221 ± 0.013	0.363CysIle: 0.363 ± 0.016	0.221CysLys: 0.221 ± 0.013	0.923CysLeu: 0.923 ± 0.026	0.175CysMet: 0.175 ± 0.012	0.221CysAsn: 0.221 ± 0.014	0.498CysPro: 0.498 ± 0.024	0.258CysGln: 0.258 ± 0.015	0.781CysArg: 0.781 ± 0.023	0.536CysSer: 0.536 ± 0.022	0.335CysThr: 0.335 ± 0.016	0.726CysVal: 0.726 ± 0.024	0.127CysTrp: 0.127 ± 0.011	0.199CysTyr: 0.199 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.283AspAla: 7.283 ± 0.073	0.534AspCys: 0.534 ± 0.018	2.916AspAsp: 2.916 ± 0.056	3.393AspGlu: 3.393 ± 0.06	2.258AspPhe: 2.258 ± 0.04	4.724AspGly: 4.724 ± 0.065	1.291AspHis: 1.291 ± 0.033	2.831AspIle: 2.831 ± 0.05	1.718AspLys: 1.718 ± 0.04	6.051AspLeu: 6.051 ± 0.088	1.116AspMet: 1.116 ± 0.029	1.179AspAsn: 1.179 ± 0.035	3.526AspPro: 3.526 ± 0.051	1.717AspGln: 1.717 ± 0.036	4.253AspArg: 4.253 ± 0.066	2.241AspSer: 2.241 ± 0.041	1.807AspThr: 1.807 ± 0.038	3.904AspVal: 3.904 ± 0.062	0.874AspTrp: 0.874 ± 0.03	1.376AspTyr: 1.376 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	8.211GluAla: 8.211 ± 0.11	0.375GluCys: 0.375 ± 0.02	2.721GluAsp: 2.721 ± 0.048	2.938GluGlu: 2.938 ± 0.053	1.734GluPhe: 1.734 ± 0.039	4.046GluGly: 4.046 ± 0.065	1.16GluHis: 1.16 ± 0.029	3.596GluIle: 3.596 ± 0.059	2.409GluLys: 2.409 ± 0.047	5.098GluLeu: 5.098 ± 0.069	1.281GluMet: 1.281 ± 0.032	1.445GluAsn: 1.445 ± 0.034	2.86GluPro: 2.86 ± 0.056	1.863GluGln: 1.863 ± 0.044	4.928GluArg: 4.928 ± 0.072	2.625GluSer: 2.625 ± 0.044	3.439GluThr: 3.439 ± 0.049	3.324GluVal: 3.324 ± 0.061	0.669GluTrp: 0.669 ± 0.023	0.829GluTyr: 0.829 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.984PheAla: 4.984 ± 0.069	0.495PheCys: 0.495 ± 0.022	2.659PheAsp: 2.659 ± 0.049	2.357PheGlu: 2.357 ± 0.044	1.572PhePhe: 1.572 ± 0.035	3.887PheGly: 3.887 ± 0.057	0.784PheHis: 0.784 ± 0.024	1.808PheIle: 1.808 ± 0.039	1.133PheLys: 1.133 ± 0.029	3.599PheLeu: 3.599 ± 0.057	0.775PheMet: 0.775 ± 0.027	1.147PheAsn: 1.147 ± 0.026	1.714PhePro: 1.714 ± 0.037	1.05PheGln: 1.05 ± 0.03	2.425PheArg: 2.425 ± 0.04	2.533PheSer: 2.533 ± 0.047	1.837PheThr: 1.837 ± 0.037	2.897PheVal: 2.897 ± 0.051	0.577PheTrp: 0.577 ± 0.021	0.902PheTyr: 0.902 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	11.079GlyAla: 11.079 ± 0.113	0.861GlyCys: 0.861 ± 0.028	4.31GlyAsp: 4.31 ± 0.064	4.693GlyGlu: 4.693 ± 0.068	3.692GlyPhe: 3.692 ± 0.054	7.266GlyGly: 7.266 ± 0.097	1.717GlyHis: 1.717 ± 0.033	3.483GlyIle: 3.483 ± 0.059	3.19GlyLys: 3.19 ± 0.051	8.681GlyLeu: 8.681 ± 0.1	1.872GlyMet: 1.872 ± 0.034	1.817GlyAsn: 1.817 ± 0.045	3.648GlyPro: 3.648 ± 0.056	2.606GlyGln: 2.606 ± 0.046	6.38GlyArg: 6.38 ± 0.073	4.718GlySer: 4.718 ± 0.074	3.107GlyThr: 3.107 ± 0.053	6.695GlyVal: 6.695 ± 0.081	1.199GlyTrp: 1.199 ± 0.036	1.967GlyTyr: 1.967 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.345HisAla: 2.345 ± 0.038	0.253HisCys: 0.253 ± 0.015	1.15HisAsp: 1.15 ± 0.029	1.076HisGlu: 1.076 ± 0.028	0.972HisPhe: 0.972 ± 0.026	1.968HisGly: 1.968 ± 0.044	0.609HisHis: 0.609 ± 0.031	0.996HisIle: 0.996 ± 0.028	0.562HisLys: 0.562 ± 0.021	2.021HisLeu: 2.021 ± 0.039	0.465HisMet: 0.465 ± 0.018	0.469HisAsn: 0.469 ± 0.021	1.334HisPro: 1.334 ± 0.034	0.587HisGln: 0.587 ± 0.02	1.573HisArg: 1.573 ± 0.038	1.065HisSer: 1.065 ± 0.03	0.721HisThr: 0.721 ± 0.027	1.501HisVal: 1.501 ± 0.036	0.332HisTrp: 0.332 ± 0.019	0.55HisTyr: 0.55 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.677IleAla: 7.677 ± 0.07	0.541IleCys: 0.541 ± 0.02	3.706IleAsp: 3.706 ± 0.061	3.984IleGlu: 3.984 ± 0.053	1.987IlePhe: 1.987 ± 0.042	4.959IleGly: 4.959 ± 0.074	0.942IleHis: 0.942 ± 0.027	2.557IleIle: 2.557 ± 0.049	1.673IleLys: 1.673 ± 0.041	4.784IleLeu: 4.784 ± 0.069	0.934IleMet: 0.934 ± 0.03	1.386IleAsn: 1.386 ± 0.038	2.266IlePro: 2.266 ± 0.043	1.135IleGln: 1.135 ± 0.03	3.036IleArg: 3.036 ± 0.045	2.996IleSer: 2.996 ± 0.051	2.262IleThr: 2.262 ± 0.047	4.248IleVal: 4.248 ± 0.065	0.617IleTrp: 0.617 ± 0.023	1.154IleTyr: 1.154 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.7LysAla: 4.7 ± 0.07	0.232LysCys: 0.232 ± 0.012	1.778LysAsp: 1.778 ± 0.042	1.643LysGlu: 1.643 ± 0.039	1.02LysPhe: 1.02 ± 0.026	2.81LysGly: 2.81 ± 0.054	0.617LysHis: 0.617 ± 0.022	2.235LysIle: 2.235 ± 0.046	1.357LysLys: 1.357 ± 0.044	3.477LysLeu: 3.477 ± 0.057	0.814LysMet: 0.814 ± 0.022	0.978LysAsn: 0.978 ± 0.029	2.173LysPro: 2.173 ± 0.05	1.103LysGln: 1.103 ± 0.036	2.574LysArg: 2.574 ± 0.049	2.193LysSer: 2.193 ± 0.042	2.132LysThr: 2.132 ± 0.045	2.237LysVal: 2.237 ± 0.041	0.384LysTrp: 0.384 ± 0.019	0.684LysTyr: 0.684 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.891LeuAla: 13.891 ± 0.119	1.011LeuCys: 1.011 ± 0.026	5.973LeuAsp: 5.973 ± 0.073	5.217LeuGlu: 5.217 ± 0.074	3.901LeuPhe: 3.901 ± 0.055	7.87LeuGly: 7.87 ± 0.093	1.95LeuHis: 1.95 ± 0.043	5.478LeuIle: 5.478 ± 0.071	3.777LeuLys: 3.777 ± 0.057	9.099LeuLeu: 9.099 ± 0.116	2.159LeuMet: 2.159 ± 0.04	2.62LeuAsn: 2.62 ± 0.038	5.474LeuPro: 5.474 ± 0.062	2.777LeuGln: 2.777 ± 0.048	7.731LeuArg: 7.731 ± 0.096	6.706LeuSer: 6.706 ± 0.084	5.509LeuThr: 5.509 ± 0.07	6.688LeuVal: 6.688 ± 0.074	1.137LeuTrp: 1.137 ± 0.036	1.972LeuTyr: 1.972 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.755MetAla: 2.755 ± 0.051	0.153MetCys: 0.153 ± 0.01	0.963MetAsp: 0.963 ± 0.026	0.923MetGlu: 0.923 ± 0.027	0.679MetPhe: 0.679 ± 0.022	1.514MetGly: 1.514 ± 0.039	0.373MetHis: 0.373 ± 0.018	1.305MetIle: 1.305 ± 0.034	0.909MetLys: 0.909 ± 0.025	2.191MetLeu: 2.191 ± 0.039	0.518MetMet: 0.518 ± 0.022	0.71MetAsn: 0.71 ± 0.022	1.255MetPro: 1.255 ± 0.034	0.761MetGln: 0.761 ± 0.024	1.926MetArg: 1.926 ± 0.039	1.618MetSer: 1.618 ± 0.034	1.623MetThr: 1.623 ± 0.036	1.225MetVal: 1.225 ± 0.03	0.182MetTrp: 0.182 ± 0.011	0.257MetTyr: 0.257 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.258AsnAla: 3.258 ± 0.051	0.278AsnCys: 0.278 ± 0.017	1.417AsnAsp: 1.417 ± 0.039	1.316AsnGlu: 1.316 ± 0.036	1.025AsnPhe: 1.025 ± 0.031	2.296AsnGly: 2.296 ± 0.053	0.582AsnHis: 0.582 ± 0.02	1.329AsnIle: 1.329 ± 0.035	0.758AsnLys: 0.758 ± 0.03	2.583AsnLeu: 2.583 ± 0.041	0.519AsnMet: 0.519 ± 0.018	0.654AsnAsn: 0.654 ± 0.03	1.801AsnPro: 1.801 ± 0.041	0.795AsnGln: 0.795 ± 0.026	1.726AsnArg: 1.726 ± 0.036	1.37AsnSer: 1.37 ± 0.038	1.087AsnThr: 1.087 ± 0.038	1.945AsnVal: 1.945 ± 0.043	0.436AsnTrp: 0.436 ± 0.02	0.688AsnTyr: 0.688 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	7.047ProAla: 7.047 ± 0.084	0.452ProCys: 0.452 ± 0.018	3.515ProAsp: 3.515 ± 0.052	3.289ProGlu: 3.289 ± 0.049	2.136ProPhe: 2.136 ± 0.044	4.646ProGly: 4.646 ± 0.07	1.171ProHis: 1.171 ± 0.027	2.535ProIle: 2.535 ± 0.05	1.963ProLys: 1.963 ± 0.039	4.945ProLeu: 4.945 ± 0.067	1.155ProMet: 1.155 ± 0.027	1.472ProAsn: 1.472 ± 0.033	3.33ProPro: 3.33 ± 0.059	1.803ProGln: 1.803 ± 0.041	3.632ProArg: 3.632 ± 0.053	3.195ProSer: 3.195 ± 0.049	2.399ProThr: 2.399 ± 0.051	3.761ProVal: 3.761 ± 0.066	0.67ProTrp: 0.67 ± 0.021	1.166ProTyr: 1.166 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.785GlnAla: 3.785 ± 0.055	0.232GlnCys: 0.232 ± 0.014	1.377GlnAsp: 1.377 ± 0.035	1.349GlnGlu: 1.349 ± 0.033	1.118GlnPhe: 1.118 ± 0.029	2.347GlnGly: 2.347 ± 0.039	0.62GlnHis: 0.62 ± 0.023	1.947GlnIle: 1.947 ± 0.041	1.271GlnLys: 1.271 ± 0.039	2.776GlnLeu: 2.776 ± 0.052	0.79GlnMet: 0.79 ± 0.026	0.99GlnAsn: 0.99 ± 0.027	1.731GlnPro: 1.731 ± 0.04	1.14GlnGln: 1.14 ± 0.038	2.54GlnArg: 2.54 ± 0.045	2.11GlnSer: 2.11 ± 0.043	1.836GlnThr: 1.836 ± 0.043	1.68GlnVal: 1.68 ± 0.044	0.409GlnTrp: 0.409 ± 0.019	0.637GlnTyr: 0.637 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	9.03ArgAla: 9.03 ± 0.102	0.659ArgCys: 0.659 ± 0.023	3.967ArgAsp: 3.967 ± 0.056	4.198ArgGlu: 4.198 ± 0.061	3.166ArgPhe: 3.166 ± 0.052	5.261ArgGly: 5.261 ± 0.067	1.809ArgHis: 1.809 ± 0.042	3.963ArgIle: 3.963 ± 0.059	2.521ArgLys: 2.521 ± 0.048	8.692ArgLeu: 8.692 ± 0.108	1.736ArgMet: 1.736 ± 0.032	1.909ArgAsn: 1.909 ± 0.041	4.233ArgPro: 4.233 ± 0.061	2.738ArgGln: 2.738 ± 0.049	7.672ArgArg: 7.672 ± 0.126	4.428ArgSer: 4.428 ± 0.056	3.132ArgThr: 3.132 ± 0.053	4.559ArgVal: 4.559 ± 0.057	1.018ArgTrp: 1.018 ± 0.031	1.624ArgTyr: 1.624 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	7.197SerAla: 7.197 ± 0.09	0.56SerCys: 0.56 ± 0.022	3.022SerAsp: 3.022 ± 0.05	2.917SerGlu: 2.917 ± 0.043	2.595SerPhe: 2.595 ± 0.047	5.518SerGly: 5.518 ± 0.066	1.215SerHis: 1.215 ± 0.028	3.183SerIle: 3.183 ± 0.053	1.859SerLys: 1.859 ± 0.044	5.909SerLeu: 5.909 ± 0.063	1.373SerMet: 1.373 ± 0.032	1.593SerAsn: 1.593 ± 0.041	3.334SerPro: 3.334 ± 0.051	1.706SerGln: 1.706 ± 0.032	4.301SerArg: 4.301 ± 0.068	3.617SerSer: 3.617 ± 0.062	2.648SerThr: 2.648 ± 0.051	3.909SerVal: 3.909 ± 0.049	0.751SerTrp: 0.751 ± 0.022	1.274SerTyr: 1.274 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	5.539ThrAla: 5.539 ± 0.064	0.412ThrCys: 0.412 ± 0.018	2.377ThrAsp: 2.377 ± 0.044	2.193ThrGlu: 2.193 ± 0.052	1.873ThrPhe: 1.873 ± 0.036	4.323ThrGly: 4.323 ± 0.065	0.939ThrHis: 0.939 ± 0.028	2.899ThrIle: 2.899 ± 0.049	1.547ThrLys: 1.547 ± 0.038	5.377ThrLeu: 5.377 ± 0.073	0.954ThrMet: 0.954 ± 0.029	1.254ThrAsn: 1.254 ± 0.039	3.303ThrPro: 3.303 ± 0.053	1.452ThrGln: 1.452 ± 0.034	3.108ThrArg: 3.108 ± 0.051	2.703ThrSer: 2.703 ± 0.05	2.444ThrThr: 2.444 ± 0.051	3.3ThrVal: 3.3 ± 0.058	0.514ThrTrp: 0.514 ± 0.023	1.022ThrTyr: 1.022 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	8.857ValAla: 8.857 ± 0.095	0.661ValCys: 0.661 ± 0.021	3.921ValAsp: 3.921 ± 0.062	4.452ValGlu: 4.452 ± 0.071	2.668ValPhe: 2.668 ± 0.053	5.114ValGly: 5.114 ± 0.068	1.262ValHis: 1.262 ± 0.029	3.821ValIle: 3.821 ± 0.063	2.44ValLys: 2.44 ± 0.049	6.642ValLeu: 6.642 ± 0.081	1.457ValMet: 1.457 ± 0.035	1.929ValAsn: 1.929 ± 0.038	2.865ValPro: 2.865 ± 0.052	1.787ValGln: 1.787 ± 0.035	4.675ValArg: 4.675 ± 0.065	4.264ValSer: 4.264 ± 0.064	3.718ValThr: 3.718 ± 0.049	5.002ValVal: 5.002 ± 0.072	0.838ValTrp: 0.838 ± 0.027	1.4ValTyr: 1.4 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.114TrpAla: 1.114 ± 0.031	0.123TrpCys: 0.123 ± 0.01	0.531TrpAsp: 0.531 ± 0.021	0.463TrpGlu: 0.463 ± 0.018	0.487TrpPhe: 0.487 ± 0.021	0.796TrpGly: 0.796 ± 0.023	0.271TrpHis: 0.271 ± 0.014	0.719TrpIle: 0.719 ± 0.028	0.454TrpLys: 0.454 ± 0.019	1.62TrpLeu: 1.62 ± 0.04	0.297TrpMet: 0.297 ± 0.016	0.419TrpAsn: 0.419 ± 0.018	0.715TrpPro: 0.715 ± 0.028	0.419TrpGln: 0.419 ± 0.015	1.556TrpArg: 1.556 ± 0.039	0.855TrpSer: 0.855 ± 0.028	0.812TrpThr: 0.812 ± 0.026	0.617TrpVal: 0.617 ± 0.022	0.189TrpTrp: 0.189 ± 0.013	0.239TrpTyr: 0.239 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.551TyrAla: 2.551 ± 0.048	0.232TyrCys: 0.232 ± 0.014	1.323TyrAsp: 1.323 ± 0.033	1.12TyrGlu: 1.12 ± 0.03	0.937TyrPhe: 0.937 ± 0.027	1.913TyrGly: 1.913 ± 0.044	0.442TyrHis: 0.442 ± 0.018	0.847TyrIle: 0.847 ± 0.028	0.633TyrLys: 0.633 ± 0.024	2.09TyrLeu: 2.09 ± 0.04	0.377TyrMet: 0.377 ± 0.018	0.577TyrAsn: 0.577 ± 0.024	1.041TyrPro: 1.041 ± 0.031	0.715TyrGln: 0.715 ± 0.022	1.709TyrArg: 1.709 ± 0.04	1.153TyrSer: 1.153 ± 0.033	0.89TyrThr: 0.89 ± 0.03	1.63TyrVal: 1.63 ± 0.033	0.31TyrTrp: 0.31 ± 0.014	0.583TyrTyr: 0.583 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4853 proteins (1304048 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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