Amino acid dipepetide frequency for Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.547AlaAla: 22.547 ± 0.279	1.216AlaCys: 1.216 ± 0.035	7.014AlaAsp: 7.014 ± 0.079	9.932AlaGlu: 9.932 ± 0.125	4.498AlaPhe: 4.498 ± 0.072	12.234AlaGly: 12.234 ± 0.138	2.462AlaHis: 2.462 ± 0.043	5.607AlaIle: 5.607 ± 0.063	4.087AlaLys: 4.087 ± 0.077	16.557AlaLeu: 16.557 ± 0.2	3.882AlaMet: 3.882 ± 0.056	2.41AlaAsn: 2.41 ± 0.05	7.465AlaPro: 7.465 ± 0.12	5.18AlaGln: 5.18 ± 0.097	11.043AlaArg: 11.043 ± 0.125	5.459AlaSer: 5.459 ± 0.067	6.592AlaThr: 6.592 ± 0.077	9.216AlaVal: 9.216 ± 0.103	1.505AlaTrp: 1.505 ± 0.04	2.273AlaTyr: 2.273 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.201CysAla: 1.201 ± 0.029	0.101CysCys: 0.101 ± 0.01	0.588CysAsp: 0.588 ± 0.024	0.399CysGlu: 0.399 ± 0.019	0.3CysPhe: 0.3 ± 0.016	0.973CysGly: 0.973 ± 0.033	0.253CysHis: 0.253 ± 0.014	0.364CysIle: 0.364 ± 0.02	0.196CysLys: 0.196 ± 0.013	0.936CysLeu: 0.936 ± 0.031	0.162CysMet: 0.162 ± 0.012	0.19CysAsn: 0.19 ± 0.011	0.6CysPro: 0.6 ± 0.024	0.202CysGln: 0.202 ± 0.015	0.63CysArg: 0.63 ± 0.027	0.422CysSer: 0.422 ± 0.018	0.461CysThr: 0.461 ± 0.021	0.522CysVal: 0.522 ± 0.02	0.111CysTrp: 0.111 ± 0.01	0.172CysTyr: 0.172 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.705AspAla: 6.705 ± 0.082	0.538AspCys: 0.538 ± 0.022	2.707AspAsp: 2.707 ± 0.056	2.707AspGlu: 2.707 ± 0.053	2.324AspPhe: 2.324 ± 0.045	4.727AspGly: 4.727 ± 0.076	1.261AspHis: 1.261 ± 0.038	2.474AspIle: 2.474 ± 0.043	1.414AspLys: 1.414 ± 0.038	7.156AspLeu: 7.156 ± 0.078	1.257AspMet: 1.257 ± 0.034	0.934AspAsn: 0.934 ± 0.028	3.95AspPro: 3.95 ± 0.064	1.573AspGln: 1.573 ± 0.042	4.46AspArg: 4.46 ± 0.064	1.882AspSer: 1.882 ± 0.043	2.695AspThr: 2.695 ± 0.069	3.417AspVal: 3.417 ± 0.058	1.265AspTrp: 1.265 ± 0.036	1.462AspTyr: 1.462 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	9.262GluAla: 9.262 ± 0.119	0.303GluCys: 0.303 ± 0.016	2.993GluAsp: 2.993 ± 0.061	3.219GluGlu: 3.219 ± 0.063	1.626GluPhe: 1.626 ± 0.043	5.013GluGly: 5.013 ± 0.07	0.909GluHis: 0.909 ± 0.029	3.734GluIle: 3.734 ± 0.058	2.063GluLys: 2.063 ± 0.05	4.873GluLeu: 4.873 ± 0.074	1.723GluMet: 1.723 ± 0.041	1.398GluAsn: 1.398 ± 0.035	2.637GluPro: 2.637 ± 0.081	1.603GluGln: 1.603 ± 0.039	4.361GluArg: 4.361 ± 0.067	2.039GluSer: 2.039 ± 0.048	4.068GluThr: 4.068 ± 0.062	4.21GluVal: 4.21 ± 0.074	0.546GluTrp: 0.546 ± 0.022	0.796GluTyr: 0.796 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.764PheAla: 4.764 ± 0.067	0.409PheCys: 0.409 ± 0.019	2.671PheAsp: 2.671 ± 0.045	2.158PheGlu: 2.158 ± 0.045	1.323PhePhe: 1.323 ± 0.04	3.76PheGly: 3.76 ± 0.064	0.686PheHis: 0.686 ± 0.024	1.332PheIle: 1.332 ± 0.036	0.814PheLys: 0.814 ± 0.026	3.614PheLeu: 3.614 ± 0.077	0.655PheMet: 0.655 ± 0.024	0.862PheAsn: 0.862 ± 0.027	1.511PhePro: 1.511 ± 0.038	0.922PheGln: 0.922 ± 0.03	2.277PheArg: 2.277 ± 0.048	1.935PheSer: 1.935 ± 0.045	2.025PheThr: 2.025 ± 0.04	2.568PheVal: 2.568 ± 0.047	0.554PheTrp: 0.554 ± 0.024	0.831PheTyr: 0.831 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	11.574GlyAla: 11.574 ± 0.132	0.925GlyCys: 0.925 ± 0.031	4.144GlyAsp: 4.144 ± 0.082	4.472GlyGlu: 4.472 ± 0.067	3.729GlyPhe: 3.729 ± 0.058	7.615GlyGly: 7.615 ± 0.122	1.894GlyHis: 1.894 ± 0.043	4.198GlyIle: 4.198 ± 0.073	3.241GlyLys: 3.241 ± 0.061	10.439GlyLeu: 10.439 ± 0.114	2.362GlyMet: 2.362 ± 0.043	1.957GlyAsn: 1.957 ± 0.066	4.266GlyPro: 4.266 ± 0.061	3.229GlyGln: 3.229 ± 0.061	6.456GlyArg: 6.456 ± 0.074	3.874GlySer: 3.874 ± 0.071	4.871GlyThr: 4.871 ± 0.08	6.259GlyVal: 6.259 ± 0.075	1.532GlyTrp: 1.532 ± 0.038	2.091GlyTyr: 2.091 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.342HisAla: 2.342 ± 0.045	0.214HisCys: 0.214 ± 0.014	1.256HisAsp: 1.256 ± 0.036	0.946HisGlu: 0.946 ± 0.03	0.78HisPhe: 0.78 ± 0.026	1.85HisGly: 1.85 ± 0.043	0.525HisHis: 0.525 ± 0.025	0.768HisIle: 0.768 ± 0.027	0.399HisLys: 0.399 ± 0.02	2.179HisLeu: 2.179 ± 0.045	0.456HisMet: 0.456 ± 0.02	0.355HisAsn: 0.355 ± 0.02	1.435HisPro: 1.435 ± 0.034	0.52HisGln: 0.52 ± 0.021	1.519HisArg: 1.519 ± 0.039	0.774HisSer: 0.774 ± 0.026	0.646HisThr: 0.646 ± 0.026	1.408HisVal: 1.408 ± 0.038	0.335HisTrp: 0.335 ± 0.018	0.515HisTyr: 0.515 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.161IleAla: 7.161 ± 0.082	0.577IleCys: 0.577 ± 0.022	3.365IleAsp: 3.365 ± 0.052	3.458IleGlu: 3.458 ± 0.057	1.592IlePhe: 1.592 ± 0.043	4.658IleGly: 4.658 ± 0.074	0.81IleHis: 0.81 ± 0.027	1.6IleIle: 1.6 ± 0.039	1.197IleLys: 1.197 ± 0.039	4.447IleLeu: 4.447 ± 0.075	0.836IleMet: 0.836 ± 0.028	1.042IleAsn: 1.042 ± 0.036	2.106IlePro: 2.106 ± 0.044	0.827IleGln: 0.827 ± 0.027	3.261IleArg: 3.261 ± 0.062	2.649IleSer: 2.649 ± 0.049	2.738IleThr: 2.738 ± 0.052	3.443IleVal: 3.443 ± 0.064	0.674IleTrp: 0.674 ± 0.028	0.981IleTyr: 0.981 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.197LysAla: 4.197 ± 0.076	0.173LysCys: 0.173 ± 0.013	1.532LysAsp: 1.532 ± 0.044	1.336LysGlu: 1.336 ± 0.043	0.871LysPhe: 0.871 ± 0.032	2.614LysGly: 2.614 ± 0.057	0.531LysHis: 0.531 ± 0.024	1.654LysIle: 1.654 ± 0.042	1.08LysLys: 1.08 ± 0.035	3.062LysLeu: 3.062 ± 0.056	0.854LysMet: 0.854 ± 0.032	0.657LysAsn: 0.657 ± 0.024	1.952LysPro: 1.952 ± 0.054	0.769LysGln: 0.769 ± 0.028	2.019LysArg: 2.019 ± 0.04	1.542LysSer: 1.542 ± 0.035	1.824LysThr: 1.824 ± 0.042	2.242LysVal: 2.242 ± 0.053	0.345LysTrp: 0.345 ± 0.019	0.574LysTyr: 0.574 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	16.109LeuAla: 16.109 ± 0.163	1.087LeuCys: 1.087 ± 0.03	6.065LeuAsp: 6.065 ± 0.072	5.142LeuGlu: 5.142 ± 0.079	3.464LeuPhe: 3.464 ± 0.065	9.45LeuGly: 9.45 ± 0.102	1.963LeuHis: 1.963 ± 0.044	5.271LeuIle: 5.271 ± 0.084	3.061LeuLys: 3.061 ± 0.058	9.274LeuLeu: 9.274 ± 0.109	2.689LeuMet: 2.689 ± 0.05	2.27LeuAsn: 2.27 ± 0.045	6.417LeuPro: 6.417 ± 0.079	2.83LeuGln: 2.83 ± 0.051	8.453LeuArg: 8.453 ± 0.112	6.641LeuSer: 6.641 ± 0.092	6.3LeuThr: 6.3 ± 0.095	7.191LeuVal: 7.191 ± 0.107	1.52LeuTrp: 1.52 ± 0.038	1.921LeuTyr: 1.921 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.546MetAla: 3.546 ± 0.059	0.16MetCys: 0.16 ± 0.011	1.137MetAsp: 1.137 ± 0.034	1.191MetGlu: 1.191 ± 0.034	0.726MetPhe: 0.726 ± 0.029	2.134MetGly: 2.134 ± 0.047	0.439MetHis: 0.439 ± 0.024	1.377MetIle: 1.377 ± 0.037	0.931MetLys: 0.931 ± 0.029	2.517MetLeu: 2.517 ± 0.048	0.698MetMet: 0.698 ± 0.025	0.684MetAsn: 0.684 ± 0.024	1.428MetPro: 1.428 ± 0.036	0.921MetGln: 0.921 ± 0.031	1.922MetArg: 1.922 ± 0.041	1.496MetSer: 1.496 ± 0.037	2.081MetThr: 2.081 ± 0.037	1.746MetVal: 1.746 ± 0.047	0.189MetTrp: 0.189 ± 0.011	0.253MetTyr: 0.253 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.711AsnAla: 2.711 ± 0.044	0.231AsnCys: 0.231 ± 0.017	1.329AsnAsp: 1.329 ± 0.06	0.912AsnGlu: 0.912 ± 0.029	0.825AsnPhe: 0.825 ± 0.031	1.958AsnGly: 1.958 ± 0.05	0.378AsnHis: 0.378 ± 0.02	1.056AsnIle: 1.056 ± 0.032	0.506AsnLys: 0.506 ± 0.021	2.231AsnLeu: 2.231 ± 0.049	0.531AsnMet: 0.531 ± 0.025	0.44AsnAsn: 0.44 ± 0.018	1.684AsnPro: 1.684 ± 0.035	0.549AsnGln: 0.549 ± 0.024	1.592AsnArg: 1.592 ± 0.036	0.885AsnSer: 0.885 ± 0.03	1.066AsnThr: 1.066 ± 0.034	1.434AsnVal: 1.434 ± 0.041	0.359AsnTrp: 0.359 ± 0.017	0.526AsnTyr: 0.526 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	7.605ProAla: 7.605 ± 0.117	0.427ProCys: 0.427 ± 0.019	3.569ProAsp: 3.569 ± 0.064	4.785ProGlu: 4.785 ± 0.093	2.015ProPhe: 2.015 ± 0.042	5.544ProGly: 5.544 ± 0.083	1.003ProHis: 1.003 ± 0.029	2.101ProIle: 2.101 ± 0.042	1.765ProLys: 1.765 ± 0.042	5.224ProLeu: 5.224 ± 0.069	1.397ProMet: 1.397 ± 0.03	1.059ProAsn: 1.059 ± 0.029	2.983ProPro: 2.983 ± 0.074	1.807ProGln: 1.807 ± 0.04	3.336ProArg: 3.336 ± 0.061	2.2ProSer: 2.2 ± 0.045	2.271ProThr: 2.271 ± 0.057	4.734ProVal: 4.734 ± 0.07	0.702ProTrp: 0.702 ± 0.026	1.002ProTyr: 1.002 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.528GlnAla: 4.528 ± 0.075	0.159GlnCys: 0.159 ± 0.013	1.407GlnAsp: 1.407 ± 0.035	1.326GlnGlu: 1.326 ± 0.037	0.964GlnPhe: 0.964 ± 0.031	2.714GlnGly: 2.714 ± 0.047	0.503GlnHis: 0.503 ± 0.022	2.079GlnIle: 2.079 ± 0.076	0.937GlnLys: 0.937 ± 0.031	2.913GlnLeu: 2.913 ± 0.054	1.051GlnMet: 1.051 ± 0.029	0.715GlnAsn: 0.715 ± 0.027	1.719GlnPro: 1.719 ± 0.048	0.874GlnGln: 0.874 ± 0.035	1.956GlnArg: 1.956 ± 0.047	1.542GlnSer: 1.542 ± 0.036	1.651GlnThr: 1.651 ± 0.045	2.394GlnVal: 2.394 ± 0.047	0.344GlnTrp: 0.344 ± 0.017	0.468GlnTyr: 0.468 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	10.03ArgAla: 10.03 ± 0.125	0.475ArgCys: 0.475 ± 0.021	4.16ArgAsp: 4.16 ± 0.068	3.852ArgGlu: 3.852 ± 0.067	2.858ArgPhe: 2.858 ± 0.052	5.323ArgGly: 5.323 ± 0.068	1.694ArgHis: 1.694 ± 0.045	4.05ArgIle: 4.05 ± 0.061	2.295ArgLys: 2.295 ± 0.052	8.787ArgLeu: 8.787 ± 0.105	2.078ArgMet: 2.078 ± 0.041	1.6ArgAsn: 1.6 ± 0.037	3.941ArgPro: 3.941 ± 0.065	2.286ArgGln: 2.286 ± 0.051	5.514ArgArg: 5.514 ± 0.091	3.132ArgSer: 3.132 ± 0.058	3.003ArgThr: 3.003 ± 0.056	4.951ArgVal: 4.951 ± 0.067	0.955ArgTrp: 0.955 ± 0.03	1.423ArgTyr: 1.423 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.996SerAla: 5.996 ± 0.093	0.411SerCys: 0.411 ± 0.018	2.649SerAsp: 2.649 ± 0.054	2.483SerGlu: 2.483 ± 0.048	2.083SerPhe: 2.083 ± 0.043	5.089SerGly: 5.089 ± 0.075	0.935SerHis: 0.935 ± 0.032	1.95SerIle: 1.95 ± 0.048	1.262SerLys: 1.262 ± 0.038	4.935SerLeu: 4.935 ± 0.065	1.081SerMet: 1.081 ± 0.03	1.031SerAsn: 1.031 ± 0.031	2.425SerPro: 2.425 ± 0.052	1.364SerGln: 1.364 ± 0.036	3.167SerArg: 3.167 ± 0.055	2.186SerSer: 2.186 ± 0.055	2.22SerThr: 2.22 ± 0.07	3.411SerVal: 3.411 ± 0.062	0.671SerTrp: 0.671 ± 0.025	1.135SerTyr: 1.135 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	7.177ThrAla: 7.177 ± 0.127	0.471ThrCys: 0.471 ± 0.022	2.917ThrAsp: 2.917 ± 0.052	3.206ThrGlu: 3.206 ± 0.059	1.759ThrPhe: 1.759 ± 0.043	5.568ThrGly: 5.568 ± 0.087	0.992ThrHis: 0.992 ± 0.031	2.436ThrIle: 2.436 ± 0.051	1.411ThrLys: 1.411 ± 0.04	6.211ThrLeu: 6.211 ± 0.085	1.081ThrMet: 1.081 ± 0.029	1.072ThrAsn: 1.072 ± 0.028	3.562ThrPro: 3.562 ± 0.065	1.47ThrGln: 1.47 ± 0.041	3.69ThrArg: 3.69 ± 0.055	2.281ThrSer: 2.281 ± 0.057	2.816ThrThr: 2.816 ± 0.072	4.185ThrVal: 4.185 ± 0.074	0.614ThrTrp: 0.614 ± 0.02	0.984ThrTyr: 0.984 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.786ValAla: 9.786 ± 0.108	0.577ValCys: 0.577 ± 0.023	3.355ValAsp: 3.355 ± 0.061	4.171ValGlu: 4.171 ± 0.063	2.674ValPhe: 2.674 ± 0.056	4.998ValGly: 4.998 ± 0.071	1.21ValHis: 1.21 ± 0.035	3.992ValIle: 3.992 ± 0.065	2.227ValLys: 2.227 ± 0.053	8.01ValLeu: 8.01 ± 0.102	2.001ValMet: 2.001 ± 0.045	1.722ValAsn: 1.722 ± 0.044	3.788ValPro: 3.788 ± 0.058	2.09ValGln: 2.09 ± 0.042	4.079ValArg: 4.079 ± 0.065	3.897ValSer: 3.897 ± 0.057	4.873ValThr: 4.873 ± 0.073	5.421ValVal: 5.421 ± 0.089	0.945ValTrp: 0.945 ± 0.032	1.205ValTyr: 1.205 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.551TrpAla: 1.551 ± 0.044	0.122TrpCys: 0.122 ± 0.011	0.674TrpAsp: 0.674 ± 0.025	0.594TrpGlu: 0.594 ± 0.023	0.489TrpPhe: 0.489 ± 0.019	1.061TrpGly: 1.061 ± 0.028	0.332TrpHis: 0.332 ± 0.017	0.618TrpIle: 0.618 ± 0.025	0.43TrpLys: 0.43 ± 0.019	1.712TrpLeu: 1.712 ± 0.045	0.35TrpMet: 0.35 ± 0.017	0.338TrpAsn: 0.338 ± 0.017	0.716TrpPro: 0.716 ± 0.027	0.657TrpGln: 0.657 ± 0.023	1.172TrpArg: 1.172 ± 0.036	0.75TrpSer: 0.75 ± 0.027	0.716TrpThr: 0.716 ± 0.026	0.952TrpVal: 0.952 ± 0.032	0.202TrpTrp: 0.202 ± 0.013	0.238TrpTyr: 0.238 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.39TyrAla: 2.39 ± 0.047	0.206TyrCys: 0.206 ± 0.012	1.376TyrAsp: 1.376 ± 0.033	1.086TyrGlu: 1.086 ± 0.033	0.771TyrPhe: 0.771 ± 0.026	1.845TyrGly: 1.845 ± 0.038	0.441TyrHis: 0.441 ± 0.021	0.764TyrIle: 0.764 ± 0.029	0.511TyrLys: 0.511 ± 0.023	2.041TyrLeu: 2.041 ± 0.044	0.432TyrMet: 0.432 ± 0.022	0.465TyrAsn: 0.465 ± 0.019	0.944TyrPro: 0.944 ± 0.028	0.575TyrGln: 0.575 ± 0.022	1.497TyrArg: 1.497 ± 0.037	0.896TyrSer: 0.896 ± 0.028	0.985TyrThr: 0.985 ± 0.03	1.317TyrVal: 1.317 ± 0.037	0.306TyrTrp: 0.306 ± 0.018	0.466TyrTyr: 0.466 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3632 proteins (1160234 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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