Amino acid dipepetide frequency for Lentilactobacillus curieae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.066AlaAla: 7.066 ± 0.641
0.319AlaCys: 0.319 ± 0.022
4.972AlaAsp: 4.972 ± 0.129
4.227AlaGlu: 4.227 ± 0.104
3.136AlaPhe: 3.136 ± 0.083
5.627AlaGly: 5.627 ± 0.104
1.15AlaHis: 1.15 ± 0.041
5.884AlaIle: 5.884 ± 0.106
5.851AlaLys: 5.851 ± 0.147
6.568AlaLeu: 6.568 ± 0.118
1.95AlaMet: 1.95 ± 0.054
4.222AlaAsn: 4.222 ± 0.125
2.207AlaPro: 2.207 ± 0.062
2.677AlaGln: 2.677 ± 0.09
2.448AlaArg: 2.448 ± 0.072
5.124AlaSer: 5.124 ± 0.364
4.487AlaThr: 4.487 ± 0.115
5.642AlaVal: 5.642 ± 0.123
0.652AlaTrp: 0.652 ± 0.033
2.297AlaTyr: 2.297 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
0.272CysAla: 0.272 ± 0.025
0.048CysCys: 0.048 ± 0.009
0.191CysAsp: 0.191 ± 0.017
0.221CysGlu: 0.221 ± 0.019
0.222CysPhe: 0.222 ± 0.019
0.438CysGly: 0.438 ± 0.027
0.128CysHis: 0.128 ± 0.016
0.27CysIle: 0.27 ± 0.023
0.141CysLys: 0.141 ± 0.015
0.408CysLeu: 0.408 ± 0.032
0.095CysMet: 0.095 ± 0.013
0.153CysAsn: 0.153 ± 0.015
0.189CysPro: 0.189 ± 0.02
0.108CysGln: 0.108 ± 0.015
0.141CysArg: 0.141 ± 0.015
0.266CysSer: 0.266 ± 0.024
0.202CysThr: 0.202 ± 0.021
0.329CysVal: 0.329 ± 0.023
0.058CysTrp: 0.058 ± 0.009
0.133CysTyr: 0.133 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
4.281AspAla: 4.281 ± 0.098
0.206AspCys: 0.206 ± 0.021
4.039AspAsp: 4.039 ± 0.127
4.315AspGlu: 4.315 ± 0.109
2.887AspPhe: 2.887 ± 0.074
4.102AspGly: 4.102 ± 0.105
1.318AspHis: 1.318 ± 0.046
3.885AspIle: 3.885 ± 0.092
4.227AspLys: 4.227 ± 0.102
5.33AspLeu: 5.33 ± 0.115
1.45AspMet: 1.45 ± 0.046
3.146AspAsn: 3.146 ± 0.076
2.24AspPro: 2.24 ± 0.068
2.692AspGln: 2.692 ± 0.074
2.258AspArg: 2.258 ± 0.063
3.996AspSer: 3.996 ± 0.115
2.952AspThr: 2.952 ± 0.07
4.336AspVal: 4.336 ± 0.092
0.659AspTrp: 0.659 ± 0.037
2.441AspTyr: 2.441 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
3.953GluAla: 3.953 ± 0.111
0.183GluCys: 0.183 ± 0.015
3.284GluAsp: 3.284 ± 0.104
3.523GluGlu: 3.523 ± 0.098
2.537GluPhe: 2.537 ± 0.082
2.816GluGly: 2.816 ± 0.094
1.095GluHis: 1.095 ± 0.048
4.341GluIle: 4.341 ± 0.087
4.162GluLys: 4.162 ± 0.11
5.785GluLeu: 5.785 ± 0.117
1.867GluMet: 1.867 ± 0.056
3.15GluAsn: 3.15 ± 0.082
1.769GluPro: 1.769 ± 0.07
2.463GluGln: 2.463 ± 0.075
2.267GluArg: 2.267 ± 0.061
3.332GluSer: 3.332 ± 0.113
3.186GluThr: 3.186 ± 0.089
3.968GluVal: 3.968 ± 0.083
0.516GluTrp: 0.516 ± 0.03
1.96GluTyr: 1.96 ± 0.071
0.0GluXaa: 0.0 ± 0.0
Phe
3.347PheAla: 3.347 ± 0.072
0.224PheCys: 0.224 ± 0.019
2.974PheAsp: 2.974 ± 0.066
2.429PheGlu: 2.429 ± 0.074
2.162PhePhe: 2.162 ± 0.068
3.598PheGly: 3.598 ± 0.092
0.758PheHis: 0.758 ± 0.033
3.176PheIle: 3.176 ± 0.09
2.959PheLys: 2.959 ± 0.079
3.793PheLeu: 3.793 ± 0.11
1.152PheMet: 1.152 ± 0.047
2.423PheAsn: 2.423 ± 0.06
1.538PhePro: 1.538 ± 0.05
1.334PheGln: 1.334 ± 0.052
1.26PheArg: 1.26 ± 0.05
3.302PheSer: 3.302 ± 0.079
2.627PheThr: 2.627 ± 0.077
3.321PheVal: 3.321 ± 0.082
0.589PheTrp: 0.589 ± 0.036
1.63PheTyr: 1.63 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
4.796GlyAla: 4.796 ± 0.111
0.342GlyCys: 0.342 ± 0.029
3.727GlyAsp: 3.727 ± 0.095
3.452GlyGlu: 3.452 ± 0.097
3.377GlyPhe: 3.377 ± 0.081
4.617GlyGly: 4.617 ± 0.116
1.489GlyHis: 1.489 ± 0.058
5.951GlyIle: 5.951 ± 0.126
5.156GlyLys: 5.156 ± 0.089
6.427GlyLeu: 6.427 ± 0.113
2.136GlyMet: 2.136 ± 0.072
3.262GlyAsn: 3.262 ± 0.099
1.61GlyPro: 1.61 ± 0.055
2.532GlyGln: 2.532 ± 0.072
2.489GlyArg: 2.489 ± 0.069
4.432GlySer: 4.432 ± 0.087
4.467GlyThr: 4.467 ± 0.093
5.157GlyVal: 5.157 ± 0.106
0.77GlyTrp: 0.77 ± 0.042
2.789GlyTyr: 2.789 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
1.168HisAla: 1.168 ± 0.05
0.1HisCys: 0.1 ± 0.013
1.145HisAsp: 1.145 ± 0.047
1.188HisGlu: 1.188 ± 0.045
0.928HisPhe: 0.928 ± 0.038
1.49HisGly: 1.49 ± 0.051
0.553HisHis: 0.553 ± 0.032
1.175HisIle: 1.175 ± 0.044
1.085HisLys: 1.085 ± 0.042
1.696HisLeu: 1.696 ± 0.053
0.498HisMet: 0.498 ± 0.029
0.914HisAsn: 0.914 ± 0.039
0.987HisPro: 0.987 ± 0.042
0.838HisGln: 0.838 ± 0.04
0.821HisArg: 0.821 ± 0.041
1.211HisSer: 1.211 ± 0.044
0.974HisThr: 0.974 ± 0.042
1.299HisVal: 1.299 ± 0.045
0.247HisTrp: 0.247 ± 0.021
0.896HisTyr: 0.896 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
5.984IleAla: 5.984 ± 0.107
0.451IleCys: 0.451 ± 0.026
4.746IleAsp: 4.746 ± 0.096
3.926IleGlu: 3.926 ± 0.096
3.072IlePhe: 3.072 ± 0.09
5.544IleGly: 5.544 ± 0.121
1.314IleHis: 1.314 ± 0.044
5.493IleIle: 5.493 ± 0.131
4.879IleLys: 4.879 ± 0.089
6.19IleLeu: 6.19 ± 0.124
1.734IleMet: 1.734 ± 0.058
4.003IleAsn: 4.003 ± 0.094
2.975IlePro: 2.975 ± 0.072
2.249IleGln: 2.249 ± 0.052
2.403IleArg: 2.403 ± 0.064
5.503IleSer: 5.503 ± 0.111
4.482IleThr: 4.482 ± 0.089
5.476IleVal: 5.476 ± 0.113
0.637IleTrp: 0.637 ± 0.035
2.121IleTyr: 2.121 ± 0.059
0.0IleXaa: 0.0 ± 0.0
Lys
4.832LysAla: 4.832 ± 0.113
0.108LysCys: 0.108 ± 0.013
3.888LysAsp: 3.888 ± 0.084
3.931LysGlu: 3.931 ± 0.09
2.672LysPhe: 2.672 ± 0.074
3.538LysGly: 3.538 ± 0.084
1.326LysHis: 1.326 ± 0.052
4.693LysIle: 4.693 ± 0.099
5.245LysLys: 5.245 ± 0.111
6.332LysLeu: 6.332 ± 0.101
2.295LysMet: 2.295 ± 0.066
3.966LysAsn: 3.966 ± 0.093
2.529LysPro: 2.529 ± 0.071
3.614LysGln: 3.614 ± 0.086
3.052LysArg: 3.052 ± 0.078
4.401LysSer: 4.401 ± 0.101
4.22LysThr: 4.22 ± 0.103
5.028LysVal: 5.028 ± 0.097
0.646LysTrp: 0.646 ± 0.033
2.723LysTyr: 2.723 ± 0.064
0.0LysXaa: 0.0 ± 0.0
Leu
7.552LeuAla: 7.552 ± 0.131
0.435LeuCys: 0.435 ± 0.025
5.265LeuAsp: 5.265 ± 0.101
4.301LeuGlu: 4.301 ± 0.102
4.097LeuPhe: 4.097 ± 0.108
6.47LeuGly: 6.47 ± 0.117
1.553LeuHis: 1.553 ± 0.056
6.92LeuIle: 6.92 ± 0.141
6.181LeuLys: 6.181 ± 0.118
7.96LeuLeu: 7.96 ± 0.154
2.444LeuMet: 2.444 ± 0.061
4.887LeuAsn: 4.887 ± 0.091
3.724LeuPro: 3.724 ± 0.074
2.921LeuGln: 2.921 ± 0.068
3.058LeuArg: 3.058 ± 0.078
6.794LeuSer: 6.794 ± 0.115
6.02LeuThr: 6.02 ± 0.103
6.737LeuVal: 6.737 ± 0.124
0.707LeuTrp: 0.707 ± 0.038
2.557LeuTyr: 2.557 ± 0.072
0.0LeuXaa: 0.0 ± 0.0
Met
2.24MetAla: 2.24 ± 0.064
0.115MetCys: 0.115 ± 0.015
1.518MetAsp: 1.518 ± 0.054
1.193MetGlu: 1.193 ± 0.039
1.133MetPhe: 1.133 ± 0.048
1.932MetGly: 1.932 ± 0.06
0.43MetHis: 0.43 ± 0.026
2.21MetIle: 2.21 ± 0.062
2.034MetLys: 2.034 ± 0.058
2.152MetLeu: 2.152 ± 0.064
0.806MetMet: 0.806 ± 0.035
1.566MetAsn: 1.566 ± 0.047
1.026MetPro: 1.026 ± 0.039
0.964MetGln: 0.964 ± 0.04
0.899MetArg: 0.899 ± 0.04
1.711MetSer: 1.711 ± 0.059
1.782MetThr: 1.782 ± 0.054
2.051MetVal: 2.051 ± 0.063
0.232MetTrp: 0.232 ± 0.021
0.782MetTyr: 0.782 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.641AsnAla: 3.641 ± 0.088
0.183AsnCys: 0.183 ± 0.017
3.181AsnAsp: 3.181 ± 0.084
3.083AsnGlu: 3.083 ± 0.079
2.237AsnPhe: 2.237 ± 0.067
3.948AsnGly: 3.948 ± 0.096
1.283AsnHis: 1.283 ± 0.047
3.229AsnIle: 3.229 ± 0.076
3.296AsnLys: 3.296 ± 0.072
4.622AsnLeu: 4.622 ± 0.091
1.296AsnMet: 1.296 ± 0.046
3.007AsnAsn: 3.007 ± 0.092
2.386AsnPro: 2.386 ± 0.069
2.833AsnGln: 2.833 ± 0.065
2.141AsnArg: 2.141 ± 0.073
3.566AsnSer: 3.566 ± 0.115
2.572AsnThr: 2.572 ± 0.064
3.659AsnVal: 3.659 ± 0.077
0.606AsnTrp: 0.606 ± 0.037
2.142AsnTyr: 2.142 ± 0.061
0.0AsnXaa: 0.0 ± 0.0
Pro
2.725ProAla: 2.725 ± 0.078
0.086ProCys: 0.086 ± 0.012
2.506ProAsp: 2.506 ± 0.063
2.856ProGlu: 2.856 ± 0.08
1.704ProPhe: 1.704 ± 0.054
2.373ProGly: 2.373 ± 0.074
0.619ProHis: 0.619 ± 0.031
2.605ProIle: 2.605 ± 0.064
2.428ProLys: 2.428 ± 0.071
3.062ProLeu: 3.062 ± 0.086
0.841ProMet: 0.841 ± 0.037
1.943ProAsn: 1.943 ± 0.059
0.511ProPro: 0.511 ± 0.03
1.356ProGln: 1.356 ± 0.051
1.012ProArg: 1.012 ± 0.045
2.162ProSer: 2.162 ± 0.067
2.293ProThr: 2.293 ± 0.062
2.936ProVal: 2.936 ± 0.075
0.305ProTrp: 0.305 ± 0.024
1.206ProTyr: 1.206 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
3.043GlnAla: 3.043 ± 0.087
0.098GlnCys: 0.098 ± 0.014
1.732GlnAsp: 1.732 ± 0.054
1.965GlnGlu: 1.965 ± 0.053
1.64GlnPhe: 1.64 ± 0.049
2.139GlnGly: 2.139 ± 0.071
0.71GlnHis: 0.71 ± 0.035
3.166GlnIle: 3.166 ± 0.084
2.712GlnLys: 2.712 ± 0.075
4.095GlnLeu: 4.095 ± 0.088
1.128GlnMet: 1.128 ± 0.045
1.998GlnAsn: 1.998 ± 0.06
1.455GlnPro: 1.455 ± 0.05
1.834GlnGln: 1.834 ± 0.077
1.651GlnArg: 1.651 ± 0.059
2.627GlnSer: 2.627 ± 0.084
2.453GlnThr: 2.453 ± 0.062
2.974GlnVal: 2.974 ± 0.082
0.365GlnTrp: 0.365 ± 0.026
1.465GlnTyr: 1.465 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
2.373ArgAla: 2.373 ± 0.072
0.153ArgCys: 0.153 ± 0.016
2.028ArgAsp: 2.028 ± 0.06
2.268ArgGlu: 2.268 ± 0.069
1.693ArgPhe: 1.693 ± 0.054
2.282ArgGly: 2.282 ± 0.066
0.793ArgHis: 0.793 ± 0.036
2.748ArgIle: 2.748 ± 0.077
2.572ArgLys: 2.572 ± 0.076
3.37ArgLeu: 3.37 ± 0.078
1.082ArgMet: 1.082 ± 0.04
1.907ArgAsn: 1.907 ± 0.055
1.268ArgPro: 1.268 ± 0.048
1.716ArgGln: 1.716 ± 0.058
1.654ArgArg: 1.654 ± 0.059
2.021ArgSer: 2.021 ± 0.058
1.913ArgThr: 1.913 ± 0.048
2.775ArgVal: 2.775 ± 0.069
0.262ArgTrp: 0.262 ± 0.022
1.425ArgTyr: 1.425 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
5.659SerAla: 5.659 ± 0.628
0.214SerCys: 0.214 ± 0.017
4.127SerAsp: 4.127 ± 0.09
4.024SerGlu: 4.024 ± 0.1
3.184SerPhe: 3.184 ± 0.077
5.217SerGly: 5.217 ± 0.096
1.261SerHis: 1.261 ± 0.047
4.487SerIle: 4.487 ± 0.086
4.673SerLys: 4.673 ± 0.112
6.216SerLeu: 6.216 ± 0.118
1.731SerMet: 1.731 ± 0.063
3.148SerAsn: 3.148 ± 0.084
2.024SerPro: 2.024 ± 0.053
2.69SerGln: 2.69 ± 0.079
2.446SerArg: 2.446 ± 0.06
4.671SerSer: 4.671 ± 0.133
3.981SerThr: 3.981 ± 0.102
4.933SerVal: 4.933 ± 0.095
0.639SerTrp: 0.639 ± 0.037
2.219SerTyr: 2.219 ± 0.068
0.0SerXaa: 0.0 ± 0.0
Thr
4.479ThrAla: 4.479 ± 0.096
0.192ThrCys: 0.192 ± 0.019
3.847ThrAsp: 3.847 ± 0.082
3.183ThrGlu: 3.183 ± 0.093
2.584ThrPhe: 2.584 ± 0.075
4.499ThrGly: 4.499 ± 0.092
1.128ThrHis: 1.128 ± 0.044
4.462ThrIle: 4.462 ± 0.1
4.061ThrLys: 4.061 ± 0.101
5.237ThrLeu: 5.237 ± 0.108
1.346ThrMet: 1.346 ± 0.051
3.191ThrAsn: 3.191 ± 0.079
2.725ThrPro: 2.725 ± 0.064
1.973ThrGln: 1.973 ± 0.058
1.91ThrArg: 1.91 ± 0.051
3.835ThrSer: 3.835 ± 0.083
3.888ThrThr: 3.888 ± 0.096
4.678ThrVal: 4.678 ± 0.088
0.556ThrTrp: 0.556 ± 0.033
1.991ThrTyr: 1.991 ± 0.064
0.0ThrXaa: 0.0 ± 0.0
Val
6.253ValAla: 6.253 ± 0.109
0.362ValCys: 0.362 ± 0.027
4.826ValAsp: 4.826 ± 0.096
3.886ValGlu: 3.886 ± 0.099
3.096ValPhe: 3.096 ± 0.081
5.264ValGly: 5.264 ± 0.114
1.263ValHis: 1.263 ± 0.046
5.63ValIle: 5.63 ± 0.092
4.948ValLys: 4.948 ± 0.083
6.565ValLeu: 6.565 ± 0.135
1.791ValMet: 1.791 ± 0.055
3.891ValAsn: 3.891 ± 0.086
2.791ValPro: 2.791 ± 0.062
2.202ValGln: 2.202 ± 0.059
2.406ValArg: 2.406 ± 0.068
5.401ValSer: 5.401 ± 0.1
4.832ValThr: 4.832 ± 0.103
5.908ValVal: 5.908 ± 0.121
0.636ValTrp: 0.636 ± 0.033
2.305ValTyr: 2.305 ± 0.071
0.0ValXaa: 0.0 ± 0.0
Trp
0.544TrpAla: 0.544 ± 0.029
0.033TrpCys: 0.033 ± 0.008
0.496TrpAsp: 0.496 ± 0.031
0.41TrpGlu: 0.41 ± 0.027
0.503TrpPhe: 0.503 ± 0.032
0.65TrpGly: 0.65 ± 0.039
0.242TrpHis: 0.242 ± 0.018
0.798TrpIle: 0.798 ± 0.047
0.453TrpLys: 0.453 ± 0.03
1.173TrpLeu: 1.173 ± 0.049
0.295TrpMet: 0.295 ± 0.021
0.519TrpAsn: 0.519 ± 0.035
0.277TrpPro: 0.277 ± 0.02
0.456TrpGln: 0.456 ± 0.032
0.407TrpArg: 0.407 ± 0.025
0.652TrpSer: 0.652 ± 0.034
0.526TrpThr: 0.526 ± 0.034
0.665TrpVal: 0.665 ± 0.032
0.128TrpTrp: 0.128 ± 0.014
0.395TrpTyr: 0.395 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.297TyrAla: 2.297 ± 0.071
0.163TyrCys: 0.163 ± 0.016
2.268TyrAsp: 2.268 ± 0.068
1.774TyrGlu: 1.774 ± 0.059
1.731TyrPhe: 1.731 ± 0.06
2.434TyrGly: 2.434 ± 0.067
0.802TyrHis: 0.802 ± 0.036
2.056TyrIle: 2.056 ± 0.064
1.976TyrLys: 1.976 ± 0.061
3.603TyrLeu: 3.603 ± 0.081
0.84TyrMet: 0.84 ± 0.036
1.613TyrAsn: 1.613 ± 0.052
1.298TyrPro: 1.298 ± 0.059
1.8TyrGln: 1.8 ± 0.062
1.58TyrArg: 1.58 ± 0.056
2.537TyrSer: 2.537 ± 0.076
1.905TyrThr: 1.905 ± 0.07
2.386TyrVal: 2.386 ± 0.059
0.415TyrTrp: 0.415 ± 0.024
1.538TyrTyr: 1.538 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1930 proteins (602619 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski