Amino acid dipepetide frequency for Hypoxylon sp. CO27-5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.487AlaAla: 8.487 ± 0.053	1.057AlaCys: 1.057 ± 0.014	4.11AlaAsp: 4.11 ± 0.03	4.945AlaGlu: 4.945 ± 0.041	3.117AlaPhe: 3.117 ± 0.026	5.53AlaGly: 5.53 ± 0.034	1.714AlaHis: 1.714 ± 0.02	4.428AlaIle: 4.428 ± 0.036	4.07AlaLys: 4.07 ± 0.035	7.547AlaLeu: 7.547 ± 0.039	1.864AlaMet: 1.864 ± 0.02	3.044AlaAsn: 3.044 ± 0.026	4.439AlaPro: 4.439 ± 0.039	3.2AlaGln: 3.2 ± 0.028	4.747AlaArg: 4.747 ± 0.034	6.862AlaSer: 6.862 ± 0.04	5.184AlaThr: 5.184 ± 0.037	5.151AlaVal: 5.151 ± 0.033	1.164AlaTrp: 1.164 ± 0.017	2.229AlaTyr: 2.229 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	0.939CysAla: 0.939 ± 0.013	0.278CysCys: 0.278 ± 0.01	0.659CysAsp: 0.659 ± 0.012	0.612CysGlu: 0.612 ± 0.012	0.539CysPhe: 0.539 ± 0.011	0.953CysGly: 0.953 ± 0.016	0.344CysHis: 0.344 ± 0.009	0.768CysIle: 0.768 ± 0.013	0.531CysLys: 0.531 ± 0.01	1.255CysLeu: 1.255 ± 0.015	0.275CysMet: 0.275 ± 0.008	0.46CysAsn: 0.46 ± 0.009	0.675CysPro: 0.675 ± 0.012	0.453CysGln: 0.453 ± 0.009	0.769CysArg: 0.769 ± 0.013	0.922CysSer: 0.922 ± 0.014	0.695CysThr: 0.695 ± 0.012	0.785CysVal: 0.785 ± 0.012	0.221CysTrp: 0.221 ± 0.006	0.376CysTyr: 0.376 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.534AspAla: 4.534 ± 0.035	0.616AspCys: 0.616 ± 0.01	4.329AspAsp: 4.329 ± 0.043	4.55AspGlu: 4.55 ± 0.039	2.271AspPhe: 2.271 ± 0.021	4.11AspGly: 4.11 ± 0.027	1.234AspHis: 1.234 ± 0.015	3.311AspIle: 3.311 ± 0.03	2.465AspLys: 2.465 ± 0.024	5.017AspLeu: 5.017 ± 0.031	1.236AspMet: 1.236 ± 0.014	2.018AspAsn: 2.018 ± 0.02	3.419AspPro: 3.419 ± 0.025	1.813AspGln: 1.813 ± 0.019	2.988AspArg: 2.988 ± 0.029	4.08AspSer: 4.08 ± 0.031	2.954AspThr: 2.954 ± 0.024	3.682AspVal: 3.682 ± 0.029	0.919AspTrp: 0.919 ± 0.016	1.694AspTyr: 1.694 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.284GluAla: 5.284 ± 0.039	0.638GluCys: 0.638 ± 0.009	4.254GluAsp: 4.254 ± 0.039	5.293GluGlu: 5.293 ± 0.051	2.043GluPhe: 2.043 ± 0.02	3.703GluGly: 3.703 ± 0.03	1.379GluHis: 1.379 ± 0.016	3.173GluIle: 3.173 ± 0.026	3.787GluLys: 3.787 ± 0.035	5.311GluLeu: 5.311 ± 0.039	1.363GluMet: 1.363 ± 0.017	2.431GluAsn: 2.431 ± 0.019	2.811GluPro: 2.811 ± 0.028	2.303GluGln: 2.303 ± 0.021	3.921GluArg: 3.921 ± 0.037	4.248GluSer: 4.248 ± 0.032	3.428GluThr: 3.428 ± 0.025	3.612GluVal: 3.612 ± 0.024	0.927GluTrp: 0.927 ± 0.012	1.737GluTyr: 1.737 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.004PheAla: 3.004 ± 0.026	0.569PheCys: 0.569 ± 0.012	2.317PheAsp: 2.317 ± 0.019	2.259PheGlu: 2.259 ± 0.022	1.67PhePhe: 1.67 ± 0.02	2.885PheGly: 2.885 ± 0.03	0.895PheHis: 0.895 ± 0.013	1.968PheIle: 1.968 ± 0.02	1.612PheLys: 1.612 ± 0.018	3.574PheLeu: 3.574 ± 0.031	0.79PheMet: 0.79 ± 0.012	1.502PheAsn: 1.502 ± 0.017	1.982PhePro: 1.982 ± 0.019	1.388PheGln: 1.388 ± 0.016	2.059PheArg: 2.059 ± 0.019	2.963PheSer: 2.963 ± 0.024	2.186PheThr: 2.186 ± 0.021	2.445PheVal: 2.445 ± 0.027	0.691PheTrp: 0.691 ± 0.013	1.179PheTyr: 1.179 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.178GlyAla: 5.178 ± 0.038	0.902GlyCys: 0.902 ± 0.014	3.656GlyAsp: 3.656 ± 0.024	3.605GlyGlu: 3.605 ± 0.028	2.848GlyPhe: 2.848 ± 0.025	5.687GlyGly: 5.687 ± 0.05	1.679GlyHis: 1.679 ± 0.019	3.779GlyIle: 3.779 ± 0.029	3.465GlyLys: 3.465 ± 0.026	6.004GlyLeu: 6.004 ± 0.035	1.511GlyMet: 1.511 ± 0.018	2.719GlyAsn: 2.719 ± 0.025	3.374GlyPro: 3.374 ± 0.029	2.483GlyGln: 2.483 ± 0.024	4.065GlyArg: 4.065 ± 0.031	5.693GlySer: 5.693 ± 0.046	4.066GlyThr: 4.066 ± 0.031	4.404GlyVal: 4.404 ± 0.031	1.209GlyTrp: 1.209 ± 0.016	2.183GlyTyr: 2.183 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	1.661HisAla: 1.661 ± 0.017	0.341HisCys: 0.341 ± 0.01	1.286HisAsp: 1.286 ± 0.015	1.316HisGlu: 1.316 ± 0.016	0.906HisPhe: 0.906 ± 0.011	1.684HisGly: 1.684 ± 0.02	0.823HisHis: 0.823 ± 0.015	1.305HisIle: 1.305 ± 0.016	0.919HisLys: 0.919 ± 0.015	2.16HisLeu: 2.16 ± 0.022	0.486HisMet: 0.486 ± 0.009	0.888HisAsn: 0.888 ± 0.012	1.647HisPro: 1.647 ± 0.02	0.952HisGln: 0.952 ± 0.015	1.52HisArg: 1.52 ± 0.018	1.761HisSer: 1.761 ± 0.023	1.235HisThr: 1.235 ± 0.015	1.408HisVal: 1.408 ± 0.016	0.341HisTrp: 0.341 ± 0.008	0.727HisTyr: 0.727 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.329IleAla: 4.329 ± 0.03	0.809IleCys: 0.809 ± 0.011	3.075IleAsp: 3.075 ± 0.024	3.066IleGlu: 3.066 ± 0.025	2.15IlePhe: 2.15 ± 0.02	3.425IleGly: 3.425 ± 0.027	1.24IleHis: 1.24 ± 0.013	2.86IleIle: 2.86 ± 0.027	2.369IleLys: 2.369 ± 0.023	4.803IleLeu: 4.803 ± 0.033	1.097IleMet: 1.097 ± 0.015	1.991IleAsn: 1.991 ± 0.017	3.296IlePro: 3.296 ± 0.027	2.027IleGln: 2.027 ± 0.019	3.044IleArg: 3.044 ± 0.026	4.086IleSer: 4.086 ± 0.03	3.075IleThr: 3.075 ± 0.025	3.335IleVal: 3.335 ± 0.027	0.819IleTrp: 0.819 ± 0.013	1.532IleTyr: 1.532 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.311LysAla: 4.311 ± 0.033	0.509LysCys: 0.509 ± 0.011	2.835LysAsp: 2.835 ± 0.025	3.467LysGlu: 3.467 ± 0.036	1.545LysPhe: 1.545 ± 0.017	3.059LysGly: 3.059 ± 0.024	1.126LysHis: 1.126 ± 0.014	2.459LysIle: 2.459 ± 0.021	3.399LysLys: 3.399 ± 0.039	4.245LysLeu: 4.245 ± 0.033	0.973LysMet: 0.973 ± 0.015	1.819LysAsn: 1.819 ± 0.021	2.837LysPro: 2.837 ± 0.028	1.847LysGln: 1.847 ± 0.022	3.369LysArg: 3.369 ± 0.031	3.576LysSer: 3.576 ± 0.031	2.855LysThr: 2.855 ± 0.025	2.856LysVal: 2.856 ± 0.023	0.724LysTrp: 0.724 ± 0.013	1.475LysTyr: 1.475 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	7.683LeuAla: 7.683 ± 0.05	1.202LeuCys: 1.202 ± 0.016	5.14LeuAsp: 5.14 ± 0.034	5.519LeuGlu: 5.519 ± 0.038	3.375LeuPhe: 3.375 ± 0.03	6.065LeuGly: 6.065 ± 0.033	2.14LeuHis: 2.14 ± 0.021	4.222LeuIle: 4.222 ± 0.03	4.363LeuLys: 4.363 ± 0.035	8.282LeuLeu: 8.282 ± 0.054	1.726LeuMet: 1.726 ± 0.019	3.253LeuAsn: 3.253 ± 0.026	5.39LeuPro: 5.39 ± 0.033	3.609LeuGln: 3.609 ± 0.026	5.754LeuArg: 5.754 ± 0.037	7.152LeuSer: 7.152 ± 0.037	4.814LeuThr: 4.814 ± 0.036	5.483LeuVal: 5.483 ± 0.038	1.285LeuTrp: 1.285 ± 0.016	2.426LeuTyr: 2.426 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	2.144MetAla: 2.144 ± 0.019	0.242MetCys: 0.242 ± 0.006	1.215MetAsp: 1.215 ± 0.015	1.215MetGlu: 1.215 ± 0.018	0.741MetPhe: 0.741 ± 0.012	1.404MetGly: 1.404 ± 0.017	0.45MetHis: 0.45 ± 0.01	1.044MetIle: 1.044 ± 0.014	1.038MetLys: 1.038 ± 0.014	1.78MetLeu: 1.78 ± 0.019	0.563MetMet: 0.563 ± 0.011	0.808MetAsn: 0.808 ± 0.013	1.219MetPro: 1.219 ± 0.013	0.78MetGln: 0.78 ± 0.012	1.243MetArg: 1.243 ± 0.017	1.817MetSer: 1.817 ± 0.018	1.269MetThr: 1.269 ± 0.014	1.287MetVal: 1.287 ± 0.014	0.276MetTrp: 0.276 ± 0.007	0.549MetTyr: 0.549 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.148AsnAla: 3.148 ± 0.026	0.49AsnCys: 0.49 ± 0.011	2.108AsnAsp: 2.108 ± 0.021	2.15AsnGlu: 2.15 ± 0.023	1.45AsnPhe: 1.45 ± 0.016	3.149AsnGly: 3.149 ± 0.029	0.853AsnHis: 0.853 ± 0.012	2.202AsnIle: 2.202 ± 0.017	1.604AsnLys: 1.604 ± 0.017	3.43AsnLeu: 3.43 ± 0.03	0.849AsnMet: 0.849 ± 0.012	1.634AsnAsn: 1.634 ± 0.02	2.561AsnPro: 2.561 ± 0.021	1.419AsnGln: 1.419 ± 0.018	2.072AsnArg: 2.072 ± 0.017	2.99AsnSer: 2.99 ± 0.025	2.296AsnThr: 2.296 ± 0.022	2.396AsnVal: 2.396 ± 0.02	0.623AsnTrp: 0.623 ± 0.011	1.179AsnTyr: 1.179 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	4.677ProAla: 4.677 ± 0.038	0.523ProCys: 0.523 ± 0.012	3.261ProAsp: 3.261 ± 0.027	3.875ProGlu: 3.875 ± 0.028	2.084ProPhe: 2.084 ± 0.023	3.975ProGly: 3.975 ± 0.038	1.304ProHis: 1.304 ± 0.018	2.823ProIle: 2.823 ± 0.025	2.809ProLys: 2.809 ± 0.029	4.718ProLeu: 4.718 ± 0.029	1.088ProMet: 1.088 ± 0.015	2.42ProAsn: 2.42 ± 0.025	5.093ProPro: 5.093 ± 0.07	2.445ProGln: 2.445 ± 0.028	3.446ProArg: 3.446 ± 0.035	5.756ProSer: 5.756 ± 0.049	4.044ProThr: 4.044 ± 0.035	3.419ProVal: 3.419 ± 0.028	0.787ProTrp: 0.787 ± 0.013	1.617ProTyr: 1.617 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.233GlnAla: 3.233 ± 0.027	0.462GlnCys: 0.462 ± 0.01	2.029GlnAsp: 2.029 ± 0.018	2.332GlnGlu: 2.332 ± 0.022	1.316GlnPhe: 1.316 ± 0.017	2.32GlnGly: 2.32 ± 0.022	1.01GlnHis: 1.01 ± 0.015	1.954GlnIle: 1.954 ± 0.021	1.933GlnLys: 1.933 ± 0.022	3.384GlnLeu: 3.384 ± 0.029	0.808GlnMet: 0.808 ± 0.013	1.557GlnAsn: 1.557 ± 0.018	2.496GlnPro: 2.496 ± 0.029	2.108GlnGln: 2.108 ± 0.033	2.505GlnArg: 2.505 ± 0.023	2.958GlnSer: 2.958 ± 0.027	2.22GlnThr: 2.22 ± 0.021	2.172GlnVal: 2.172 ± 0.021	0.593GlnTrp: 0.593 ± 0.01	1.171GlnTyr: 1.171 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.551ArgAla: 4.551 ± 0.033	0.723ArgCys: 0.723 ± 0.012	3.513ArgAsp: 3.513 ± 0.032	3.853ArgGlu: 3.853 ± 0.039	2.175ArgPhe: 2.175 ± 0.018	3.776ArgGly: 3.776 ± 0.031	1.567ArgHis: 1.567 ± 0.016	3.086ArgIle: 3.086 ± 0.022	3.465ArgLys: 3.465 ± 0.03	5.433ArgLeu: 5.433 ± 0.038	1.281ArgMet: 1.281 ± 0.016	2.403ArgAsn: 2.403 ± 0.024	3.512ArgPro: 3.512 ± 0.034	2.536ArgGln: 2.536 ± 0.023	5.092ArgArg: 5.092 ± 0.044	4.605ArgSer: 4.605 ± 0.041	3.228ArgThr: 3.228 ± 0.025	3.338ArgVal: 3.338 ± 0.023	0.972ArgTrp: 0.972 ± 0.014	1.765ArgTyr: 1.765 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.245SerAla: 6.245 ± 0.036	0.901SerCys: 0.901 ± 0.013	4.176SerAsp: 4.176 ± 0.031	4.078SerGlu: 4.078 ± 0.029	3.031SerPhe: 3.031 ± 0.025	5.484SerGly: 5.484 ± 0.035	1.899SerHis: 1.899 ± 0.022	4.244SerIle: 4.244 ± 0.03	3.777SerLys: 3.777 ± 0.03	7.016SerLeu: 7.016 ± 0.041	1.681SerMet: 1.681 ± 0.017	3.168SerAsn: 3.168 ± 0.028	5.332SerPro: 5.332 ± 0.059	3.217SerGln: 3.217 ± 0.029	4.991SerArg: 4.991 ± 0.041	8.651SerSer: 8.651 ± 0.069	5.494SerThr: 5.494 ± 0.043	4.436SerVal: 4.436 ± 0.031	1.18SerTrp: 1.18 ± 0.013	2.228SerTyr: 2.228 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	4.993ThrAla: 4.993 ± 0.032	0.781ThrCys: 0.781 ± 0.014	2.814ThrAsp: 2.814 ± 0.025	3.097ThrGlu: 3.097 ± 0.024	2.305ThrPhe: 2.305 ± 0.023	4.129ThrGly: 4.129 ± 0.032	1.235ThrHis: 1.235 ± 0.015	3.29ThrIle: 3.29 ± 0.028	2.693ThrLys: 2.693 ± 0.026	5.158ThrLeu: 5.158 ± 0.031	1.21ThrMet: 1.21 ± 0.015	2.291ThrAsn: 2.291 ± 0.018	4.252ThrPro: 4.252 ± 0.038	2.096ThrGln: 2.096 ± 0.019	3.193ThrArg: 3.193 ± 0.025	5.389ThrSer: 5.389 ± 0.035	4.337ThrThr: 4.337 ± 0.041	3.651ThrVal: 3.651 ± 0.031	0.919ThrTrp: 0.919 ± 0.015	1.737ThrTyr: 1.737 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	5.163ValAla: 5.163 ± 0.035	0.807ValCys: 0.807 ± 0.013	3.747ValAsp: 3.747 ± 0.025	3.832ValGlu: 3.832 ± 0.029	2.482ValPhe: 2.482 ± 0.023	4.033ValGly: 4.033 ± 0.028	1.329ValHis: 1.329 ± 0.016	3.11ValIle: 3.11 ± 0.024	2.95ValLys: 2.95 ± 0.028	5.562ValLeu: 5.562 ± 0.04	1.271ValMet: 1.271 ± 0.019	2.334ValAsn: 2.334 ± 0.022	3.586ValPro: 3.586 ± 0.03	2.219ValGln: 2.219 ± 0.021	3.416ValArg: 3.416 ± 0.023	4.529ValSer: 4.529 ± 0.029	3.551ValThr: 3.551 ± 0.027	4.255ValVal: 4.255 ± 0.033	0.866ValTrp: 0.866 ± 0.014	1.78ValTyr: 1.78 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.154TrpAla: 1.154 ± 0.014	0.203TrpCys: 0.203 ± 0.006	0.958TrpAsp: 0.958 ± 0.015	0.892TrpGlu: 0.892 ± 0.013	0.598TrpPhe: 0.598 ± 0.01	0.994TrpGly: 0.994 ± 0.016	0.373TrpHis: 0.373 ± 0.008	0.871TrpIle: 0.871 ± 0.013	0.84TrpLys: 0.84 ± 0.012	1.427TrpLeu: 1.427 ± 0.018	0.361TrpMet: 0.361 ± 0.008	0.67TrpAsn: 0.67 ± 0.012	0.65TrpPro: 0.65 ± 0.012	0.572TrpGln: 0.572 ± 0.01	0.997TrpArg: 0.997 ± 0.015	1.049TrpSer: 1.049 ± 0.013	0.953TrpThr: 0.953 ± 0.014	0.946TrpVal: 0.946 ± 0.014	0.294TrpTrp: 0.294 ± 0.007	0.479TrpTyr: 0.479 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.173TyrAla: 2.173 ± 0.021	0.459TyrCys: 0.459 ± 0.008	1.758TyrAsp: 1.758 ± 0.019	1.692TyrGlu: 1.692 ± 0.02	1.292TyrPhe: 1.292 ± 0.016	2.146TyrGly: 2.146 ± 0.024	0.772TyrHis: 0.772 ± 0.013	1.534TyrIle: 1.534 ± 0.015	1.197TyrLys: 1.197 ± 0.017	2.776TyrLeu: 2.776 ± 0.027	0.65TyrMet: 0.65 ± 0.009	1.194TyrAsn: 1.194 ± 0.014	1.591TyrPro: 1.591 ± 0.023	1.093TyrGln: 1.093 ± 0.015	1.683TyrArg: 1.683 ± 0.017	2.142TyrSer: 2.142 ± 0.019	1.683TyrThr: 1.683 ± 0.02	1.759TyrVal: 1.759 ± 0.02	0.469TyrTrp: 0.469 ± 0.01	1.054TyrTyr: 1.054 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12244 proteins (5616406 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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