Amino acid dipepetide frequency for Prauserella shujinwangii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.335AlaAla: 21.335 ± 0.138	1.046AlaCys: 1.046 ± 0.022	8.691AlaAsp: 8.691 ± 0.074	10.213AlaGlu: 10.213 ± 0.103	3.606AlaPhe: 3.606 ± 0.049	14.147AlaGly: 14.147 ± 0.098	2.679AlaHis: 2.679 ± 0.043	3.816AlaIle: 3.816 ± 0.047	2.344AlaLys: 2.344 ± 0.039	14.642AlaLeu: 14.642 ± 0.112	2.368AlaMet: 2.368 ± 0.036	2.006AlaAsn: 2.006 ± 0.03	6.377AlaPro: 6.377 ± 0.067	3.197AlaGln: 3.197 ± 0.052	11.037AlaArg: 11.037 ± 0.104	5.329AlaSer: 5.329 ± 0.06	7.098AlaThr: 7.098 ± 0.068	12.486AlaVal: 12.486 ± 0.092	1.79AlaTrp: 1.79 ± 0.031	2.258AlaTyr: 2.258 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.108CysAla: 1.108 ± 0.027	0.106CysCys: 0.106 ± 0.009	0.42CysAsp: 0.42 ± 0.014	0.385CysGlu: 0.385 ± 0.015	0.198CysPhe: 0.198 ± 0.01	0.937CysGly: 0.937 ± 0.028	0.186CysHis: 0.186 ± 0.011	0.134CysIle: 0.134 ± 0.008	0.084CysLys: 0.084 ± 0.008	0.716CysLeu: 0.716 ± 0.018	0.094CysMet: 0.094 ± 0.007	0.111CysAsn: 0.111 ± 0.007	0.479CysPro: 0.479 ± 0.015	0.161CysGln: 0.161 ± 0.009	0.578CysArg: 0.578 ± 0.018	0.386CysSer: 0.386 ± 0.016	0.459CysThr: 0.459 ± 0.016	0.652CysVal: 0.652 ± 0.018	0.128CysTrp: 0.128 ± 0.007	0.187CysTyr: 0.187 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.432AspAla: 7.432 ± 0.072	0.38AspCys: 0.38 ± 0.013	3.627AspAsp: 3.627 ± 0.045	4.203AspGlu: 4.203 ± 0.05	1.554AspPhe: 1.554 ± 0.031	6.101AspGly: 6.101 ± 0.061	1.34AspHis: 1.34 ± 0.026	1.874AspIle: 1.874 ± 0.035	0.839AspLys: 0.839 ± 0.024	6.251AspLeu: 6.251 ± 0.067	0.708AspMet: 0.708 ± 0.019	0.869AspAsn: 0.869 ± 0.02	4.668AspPro: 4.668 ± 0.053	1.495AspGln: 1.495 ± 0.026	5.219AspArg: 5.219 ± 0.057	2.375AspSer: 2.375 ± 0.039	3.14AspThr: 3.14 ± 0.037	5.559AspVal: 5.559 ± 0.057	0.944AspTrp: 0.944 ± 0.022	1.181AspTyr: 1.181 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	6.86GluAla: 6.86 ± 0.067	0.353GluCys: 0.353 ± 0.012	2.621GluAsp: 2.621 ± 0.039	3.152GluGlu: 3.152 ± 0.045	1.782GluPhe: 1.782 ± 0.031	4.302GluGly: 4.302 ± 0.048	1.967GluHis: 1.967 ± 0.032	2.331GluIle: 2.331 ± 0.039	1.126GluLys: 1.126 ± 0.03	7.778GluLeu: 7.778 ± 0.072	0.863GluMet: 0.863 ± 0.02	1.063GluAsn: 1.063 ± 0.023	4.117GluPro: 4.117 ± 0.06	2.41GluGln: 2.41 ± 0.036	6.614GluArg: 6.614 ± 0.065	2.558GluSer: 2.558 ± 0.037	2.838GluThr: 2.838 ± 0.044	5.052GluVal: 5.052 ± 0.064	0.815GluTrp: 0.815 ± 0.021	1.144GluTyr: 1.144 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.161PheAla: 4.161 ± 0.051	0.282PheCys: 0.282 ± 0.012	2.042PheAsp: 2.042 ± 0.04	1.391PheGlu: 1.391 ± 0.026	0.871PhePhe: 0.871 ± 0.024	3.424PheGly: 3.424 ± 0.044	0.626PheHis: 0.626 ± 0.02	0.602PheIle: 0.602 ± 0.02	0.339PheLys: 0.339 ± 0.014	2.69PheLeu: 2.69 ± 0.036	0.312PheMet: 0.312 ± 0.014	0.498PheAsn: 0.498 ± 0.018	1.393PhePro: 1.393 ± 0.03	0.592PheGln: 0.592 ± 0.018	2.01PheArg: 2.01 ± 0.033	1.365PheSer: 1.365 ± 0.027	1.93PheThr: 1.93 ± 0.032	2.589PheVal: 2.589 ± 0.042	0.388PheTrp: 0.388 ± 0.017	0.567PheTyr: 0.567 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	11.252GlyAla: 11.252 ± 0.083	0.814GlyCys: 0.814 ± 0.029	5.374GlyAsp: 5.374 ± 0.055	5.929GlyGlu: 5.929 ± 0.062	3.041GlyPhe: 3.041 ± 0.045	9.143GlyGly: 9.143 ± 0.092	2.271GlyHis: 2.271 ± 0.035	3.521GlyIle: 3.521 ± 0.048	2.055GlyLys: 2.055 ± 0.035	9.62GlyLeu: 9.62 ± 0.08	2.011GlyMet: 2.011 ± 0.035	1.775GlyAsn: 1.775 ± 0.037	5.033GlyPro: 5.033 ± 0.055	2.655GlyGln: 2.655 ± 0.05	7.988GlyArg: 7.988 ± 0.079	5.08GlySer: 5.08 ± 0.057	6.324GlyThr: 6.324 ± 0.065	8.11GlyVal: 8.11 ± 0.065	1.781GlyTrp: 1.781 ± 0.031	2.383GlyTyr: 2.383 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	2.852HisAla: 2.852 ± 0.04	0.212HisCys: 0.212 ± 0.01	1.37HisAsp: 1.37 ± 0.033	1.261HisGlu: 1.261 ± 0.028	0.602HisPhe: 0.602 ± 0.018	2.48HisGly: 2.48 ± 0.038	0.664HisHis: 0.664 ± 0.02	0.547HisIle: 0.547 ± 0.018	0.266HisLys: 0.266 ± 0.012	2.346HisLeu: 2.346 ± 0.038	0.273HisMet: 0.273 ± 0.013	0.371HisAsn: 0.371 ± 0.014	1.68HisPro: 1.68 ± 0.034	0.592HisGln: 0.592 ± 0.017	2.179HisArg: 2.179 ± 0.035	0.93HisSer: 0.93 ± 0.023	1.16HisThr: 1.16 ± 0.025	1.957HisVal: 1.957 ± 0.034	0.345HisTrp: 0.345 ± 0.014	0.497HisTyr: 0.497 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	4.855IleAla: 4.855 ± 0.051	0.246IleCys: 0.246 ± 0.011	2.316IleAsp: 2.316 ± 0.038	2.056IleGlu: 2.056 ± 0.042	0.66IlePhe: 0.66 ± 0.023	3.556IleGly: 3.556 ± 0.049	0.545IleHis: 0.545 ± 0.017	0.824IleIle: 0.824 ± 0.022	0.553IleLys: 0.553 ± 0.022	2.225IleLeu: 2.225 ± 0.043	0.417IleMet: 0.417 ± 0.015	0.639IleAsn: 0.639 ± 0.019	1.641IlePro: 1.641 ± 0.036	0.647IleGln: 0.647 ± 0.017	2.252IleArg: 2.252 ± 0.033	1.495IleSer: 1.495 ± 0.032	2.124IleThr: 2.124 ± 0.035	2.966IleVal: 2.966 ± 0.048	0.325IleTrp: 0.325 ± 0.013	0.533IleTyr: 0.533 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.13LysAla: 2.13 ± 0.036	0.089LysCys: 0.089 ± 0.006	0.839LysAsp: 0.839 ± 0.024	0.897LysGlu: 0.897 ± 0.024	0.388LysPhe: 0.388 ± 0.014	1.262LysGly: 1.262 ± 0.028	0.378LysHis: 0.378 ± 0.015	0.701LysIle: 0.701 ± 0.022	0.466LysLys: 0.466 ± 0.022	1.728LysLeu: 1.728 ± 0.033	0.283LysMet: 0.283 ± 0.012	0.347LysAsn: 0.347 ± 0.014	1.161LysPro: 1.161 ± 0.031	0.556LysGln: 0.556 ± 0.02	1.365LysArg: 1.365 ± 0.028	0.825LysSer: 0.825 ± 0.023	0.94LysThr: 0.94 ± 0.029	1.567LysVal: 1.567 ± 0.032	0.197LysTrp: 0.197 ± 0.01	0.356LysTyr: 0.356 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	16.941LeuAla: 16.941 ± 0.126	0.803LeuCys: 0.803 ± 0.023	6.995LeuAsp: 6.995 ± 0.069	4.731LeuGlu: 4.731 ± 0.058	2.727LeuPhe: 2.727 ± 0.037	10.135LeuGly: 10.135 ± 0.088	2.229LeuHis: 2.229 ± 0.036	2.755LeuIle: 2.755 ± 0.045	1.336LeuLys: 1.336 ± 0.027	11.832LeuLeu: 11.832 ± 0.119	1.289LeuMet: 1.289 ± 0.029	1.57LeuAsn: 1.57 ± 0.029	6.639LeuPro: 6.639 ± 0.072	1.796LeuGln: 1.796 ± 0.033	10.119LeuArg: 10.119 ± 0.093	5.167LeuSer: 5.167 ± 0.055	6.357LeuThr: 6.357 ± 0.062	9.991LeuVal: 9.991 ± 0.083	1.269LeuTrp: 1.269 ± 0.026	1.688LeuTyr: 1.688 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.082MetAla: 2.082 ± 0.034	0.106MetCys: 0.106 ± 0.008	0.737MetAsp: 0.737 ± 0.023	0.598MetGlu: 0.598 ± 0.019	0.46MetPhe: 0.46 ± 0.018	1.13MetGly: 1.13 ± 0.025	0.294MetHis: 0.294 ± 0.012	0.646MetIle: 0.646 ± 0.022	0.311MetLys: 0.311 ± 0.016	1.736MetLeu: 1.736 ± 0.032	0.236MetMet: 0.236 ± 0.011	0.38MetAsn: 0.38 ± 0.014	1.065MetPro: 1.065 ± 0.02	0.331MetGln: 0.331 ± 0.012	1.44MetArg: 1.44 ± 0.029	1.221MetSer: 1.221 ± 0.025	1.493MetThr: 1.493 ± 0.026	1.224MetVal: 1.224 ± 0.025	0.182MetTrp: 0.182 ± 0.011	0.244MetTyr: 0.244 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.129AsnAla: 2.129 ± 0.039	0.141AsnCys: 0.141 ± 0.009	0.888AsnAsp: 0.888 ± 0.025	0.873AsnGlu: 0.873 ± 0.026	0.456AsnPhe: 0.456 ± 0.016	1.656AsnGly: 1.656 ± 0.033	0.386AsnHis: 0.386 ± 0.015	0.599AsnIle: 0.599 ± 0.021	0.305AsnLys: 0.305 ± 0.014	1.688AsnLeu: 1.688 ± 0.03	0.258AsnMet: 0.258 ± 0.012	0.376AsnAsn: 0.376 ± 0.016	1.329AsnPro: 1.329 ± 0.03	0.476AsnGln: 0.476 ± 0.019	1.311AsnArg: 1.311 ± 0.026	0.821AsnSer: 0.821 ± 0.023	1.025AsnThr: 1.025 ± 0.023	1.416AsnVal: 1.416 ± 0.025	0.276AsnTrp: 0.276 ± 0.012	0.417AsnTyr: 0.417 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	8.39ProAla: 8.39 ± 0.074	0.322ProCys: 0.322 ± 0.013	4.529ProAsp: 4.529 ± 0.054	4.682ProGlu: 4.682 ± 0.054	1.587ProPhe: 1.587 ± 0.033	7.125ProGly: 7.125 ± 0.073	1.298ProHis: 1.298 ± 0.031	1.444ProIle: 1.444 ± 0.031	1.006ProLys: 1.006 ± 0.028	5.199ProLeu: 5.199 ± 0.049	0.911ProMet: 0.911 ± 0.021	0.914ProAsn: 0.914 ± 0.026	3.867ProPro: 3.867 ± 0.069	1.402ProGln: 1.402 ± 0.031	4.38ProArg: 4.38 ± 0.055	2.772ProSer: 2.772 ± 0.038	2.887ProThr: 2.887 ± 0.042	5.608ProVal: 5.608 ± 0.062	0.897ProTrp: 0.897 ± 0.023	1.167ProTyr: 1.167 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.408GlnAla: 3.408 ± 0.049	0.162GlnCys: 0.162 ± 0.009	1.138GlnAsp: 1.138 ± 0.027	1.216GlnGlu: 1.216 ± 0.026	0.635GlnPhe: 0.635 ± 0.017	1.983GlnGly: 1.983 ± 0.036	0.6GlnHis: 0.6 ± 0.018	0.894GlnIle: 0.894 ± 0.022	0.38GlnLys: 0.38 ± 0.016	2.971GlnLeu: 2.971 ± 0.045	0.364GlnMet: 0.364 ± 0.013	0.429GlnAsn: 0.429 ± 0.015	1.731GlnPro: 1.731 ± 0.037	1.077GlnGln: 1.077 ± 0.035	2.714GlnArg: 2.714 ± 0.045	1.04GlnSer: 1.04 ± 0.026	1.028GlnThr: 1.028 ± 0.023	2.338GlnVal: 2.338 ± 0.034	0.396GlnTrp: 0.396 ± 0.018	0.503GlnTyr: 0.503 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	10.911ArgAla: 10.911 ± 0.104	0.655ArgCys: 0.655 ± 0.025	4.849ArgAsp: 4.849 ± 0.055	5.448ArgGlu: 5.448 ± 0.056	2.685ArgPhe: 2.685 ± 0.046	6.55ArgGly: 6.55 ± 0.071	2.264ArgHis: 2.264 ± 0.038	3.243ArgIle: 3.243 ± 0.038	1.608ArgLys: 1.608 ± 0.03	9.555ArgLeu: 9.555 ± 0.079	1.97ArgMet: 1.97 ± 0.035	1.462ArgAsn: 1.462 ± 0.029	5.146ArgPro: 5.146 ± 0.059	2.442ArgGln: 2.442 ± 0.032	8.954ArgArg: 8.954 ± 0.089	4.186ArgSer: 4.186 ± 0.049	5.165ArgThr: 5.165 ± 0.057	6.815ArgVal: 6.815 ± 0.059	1.622ArgTrp: 1.622 ± 0.032	1.99ArgTyr: 1.99 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.441SerAla: 6.441 ± 0.072	0.356SerCys: 0.356 ± 0.015	2.363SerAsp: 2.363 ± 0.038	2.311SerGlu: 2.311 ± 0.041	1.443SerPhe: 1.443 ± 0.029	5.805SerGly: 5.805 ± 0.06	0.818SerHis: 0.818 ± 0.022	1.465SerIle: 1.465 ± 0.029	0.757SerLys: 0.757 ± 0.021	4.462SerLeu: 4.462 ± 0.054	1.079SerMet: 1.079 ± 0.024	0.747SerAsn: 0.747 ± 0.021	2.845SerPro: 2.845 ± 0.044	1.025SerGln: 1.025 ± 0.025	3.659SerArg: 3.659 ± 0.047	2.357SerSer: 2.357 ± 0.033	2.858SerThr: 2.858 ± 0.043	4.26SerVal: 4.26 ± 0.054	0.861SerTrp: 0.861 ± 0.022	1.068SerTyr: 1.068 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	7.892ThrAla: 7.892 ± 0.08	0.386ThrCys: 0.386 ± 0.017	3.421ThrAsp: 3.421 ± 0.044	3.605ThrGlu: 3.605 ± 0.044	1.64ThrPhe: 1.64 ± 0.033	6.563ThrGly: 6.563 ± 0.06	1.073ThrHis: 1.073 ± 0.027	1.864ThrIle: 1.864 ± 0.035	0.971ThrLys: 0.971 ± 0.027	5.626ThrLeu: 5.626 ± 0.064	1.003ThrMet: 1.003 ± 0.021	0.877ThrAsn: 0.877 ± 0.023	3.478ThrPro: 3.478 ± 0.049	1.17ThrGln: 1.17 ± 0.027	4.097ThrArg: 4.097 ± 0.049	2.858ThrSer: 2.858 ± 0.048	3.71ThrThr: 3.71 ± 0.061	6.146ThrVal: 6.146 ± 0.06	0.877ThrTrp: 0.877 ± 0.022	1.13ThrTyr: 1.13 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	12.232ValAla: 12.232 ± 0.105	0.74ValCys: 0.74 ± 0.019	5.507ValAsp: 5.507 ± 0.062	5.03ValGlu: 5.03 ± 0.059	2.576ValPhe: 2.576 ± 0.044	6.965ValGly: 6.965 ± 0.066	2.1ValHis: 2.1 ± 0.035	2.692ValIle: 2.692 ± 0.043	1.235ValLys: 1.235 ± 0.032	11.009ValLeu: 11.009 ± 0.092	1.057ValMet: 1.057 ± 0.027	1.706ValAsn: 1.706 ± 0.036	5.739ValPro: 5.739 ± 0.064	1.843ValGln: 1.843 ± 0.032	8.131ValArg: 8.131 ± 0.074	4.429ValSer: 4.429 ± 0.05	5.823ValThr: 5.823 ± 0.053	9.015ValVal: 9.015 ± 0.087	1.11ValTrp: 1.11 ± 0.024	1.528ValTyr: 1.528 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.612TrpAla: 1.612 ± 0.029	0.141TrpCys: 0.141 ± 0.009	0.743TrpAsp: 0.743 ± 0.02	0.665TrpGlu: 0.665 ± 0.021	0.515TrpPhe: 0.515 ± 0.018	0.935TrpGly: 0.935 ± 0.026	0.386TrpHis: 0.386 ± 0.014	0.532TrpIle: 0.532 ± 0.017	0.24TrpLys: 0.24 ± 0.012	2.017TrpLeu: 2.017 ± 0.039	0.256TrpMet: 0.256 ± 0.013	0.357TrpAsn: 0.357 ± 0.014	0.873TrpPro: 0.873 ± 0.024	0.561TrpGln: 0.561 ± 0.02	1.552TrpArg: 1.552 ± 0.029	0.836TrpSer: 0.836 ± 0.025	0.933TrpThr: 0.933 ± 0.024	1.04TrpVal: 1.04 ± 0.02	0.365TrpTrp: 0.365 ± 0.015	0.316TrpTyr: 0.316 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.441TyrAla: 2.441 ± 0.033	0.168TyrCys: 0.168 ± 0.009	1.293TyrAsp: 1.293 ± 0.035	1.1TyrGlu: 1.1 ± 0.024	0.644TyrPhe: 0.644 ± 0.019	1.964TyrGly: 1.964 ± 0.036	0.477TyrHis: 0.477 ± 0.018	0.392TyrIle: 0.392 ± 0.015	0.25TyrLys: 0.25 ± 0.013	2.276TyrLeu: 2.276 ± 0.038	0.164TyrMet: 0.164 ± 0.01	0.329TyrAsn: 0.329 ± 0.014	1.125TyrPro: 1.125 ± 0.026	0.579TyrGln: 0.579 ± 0.019	1.922TyrArg: 1.922 ± 0.034	0.952TyrSer: 0.952 ± 0.023	1.095TyrThr: 1.095 ± 0.028	1.675TyrVal: 1.675 ± 0.03	0.308TyrTrp: 0.308 ± 0.014	0.456TyrTyr: 0.456 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5884 proteins (1850372 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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