Amino acid dipepetide frequency for Geodermatophilus sp. LHW52908

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	26.815AlaAla: 26.815 ± 0.244	1.023AlaCys: 1.023 ± 0.029	9.428AlaAsp: 9.428 ± 0.101	9.363AlaGlu: 9.363 ± 0.092	3.46AlaPhe: 3.46 ± 0.052	16.769AlaGly: 16.769 ± 0.135	2.66AlaHis: 2.66 ± 0.048	3.107AlaIle: 3.107 ± 0.057	1.451AlaLys: 1.451 ± 0.038	16.043AlaLeu: 16.043 ± 0.126	2.376AlaMet: 2.376 ± 0.038	1.499AlaAsn: 1.499 ± 0.029	8.231AlaPro: 8.231 ± 0.115	3.403AlaGln: 3.403 ± 0.054	12.466AlaArg: 12.466 ± 0.13	5.091AlaSer: 5.091 ± 0.065	7.489AlaThr: 7.489 ± 0.072	15.242AlaVal: 15.242 ± 0.116	2.057AlaTrp: 2.057 ± 0.041	2.131AlaTyr: 2.131 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.946CysAla: 0.946 ± 0.027	0.082CysCys: 0.082 ± 0.008	0.452CysAsp: 0.452 ± 0.02	0.322CysGlu: 0.322 ± 0.016	0.185CysPhe: 0.185 ± 0.01	0.879CysGly: 0.879 ± 0.028	0.155CysHis: 0.155 ± 0.011	0.161CysIle: 0.161 ± 0.011	0.059CysLys: 0.059 ± 0.006	0.64CysLeu: 0.64 ± 0.02	0.09CysMet: 0.09 ± 0.007	0.091CysAsn: 0.091 ± 0.009	0.478CysPro: 0.478 ± 0.017	0.14CysGln: 0.14 ± 0.01	0.659CysArg: 0.659 ± 0.022	0.36CysSer: 0.36 ± 0.015	0.467CysThr: 0.467 ± 0.018	0.565CysVal: 0.565 ± 0.019	0.113CysTrp: 0.113 ± 0.008	0.134CysTyr: 0.134 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.278AspAla: 8.278 ± 0.092	0.35AspCys: 0.35 ± 0.016	4.019AspAsp: 4.019 ± 0.058	3.897AspGlu: 3.897 ± 0.06	1.291AspPhe: 1.291 ± 0.032	6.464AspGly: 6.464 ± 0.067	1.181AspHis: 1.181 ± 0.027	1.227AspIle: 1.227 ± 0.028	0.581AspLys: 0.581 ± 0.022	7.177AspLeu: 7.177 ± 0.083	0.64AspMet: 0.64 ± 0.02	0.643AspAsn: 0.643 ± 0.023	5.263AspPro: 5.263 ± 0.07	1.34AspGln: 1.34 ± 0.033	5.958AspArg: 5.958 ± 0.071	1.839AspSer: 1.839 ± 0.033	2.581AspThr: 2.581 ± 0.048	6.307AspVal: 6.307 ± 0.071	0.915AspTrp: 0.915 ± 0.026	0.873AspTyr: 0.873 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	7.431GluAla: 7.431 ± 0.08	0.28GluCys: 0.28 ± 0.013	3.035GluAsp: 3.035 ± 0.05	3.518GluGlu: 3.518 ± 0.061	1.31GluPhe: 1.31 ± 0.031	4.419GluGly: 4.419 ± 0.055	1.632GluHis: 1.632 ± 0.032	1.654GluIle: 1.654 ± 0.038	0.773GluLys: 0.773 ± 0.025	6.799GluLeu: 6.799 ± 0.075	0.735GluMet: 0.735 ± 0.024	0.689GluAsn: 0.689 ± 0.02	3.394GluPro: 3.394 ± 0.055	2.266GluGln: 2.266 ± 0.042	5.585GluArg: 5.585 ± 0.067	1.882GluSer: 1.882 ± 0.035	2.5GluThr: 2.5 ± 0.045	5.868GluVal: 5.868 ± 0.072	0.713GluTrp: 0.713 ± 0.027	0.866GluTyr: 0.866 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.486PheAla: 3.486 ± 0.053	0.241PheCys: 0.241 ± 0.013	1.822PheAsp: 1.822 ± 0.033	1.249PheGlu: 1.249 ± 0.03	0.774PhePhe: 0.774 ± 0.028	2.802PheGly: 2.802 ± 0.047	0.487PheHis: 0.487 ± 0.017	0.53PheIle: 0.53 ± 0.02	0.261PheLys: 0.261 ± 0.013	2.529PheLeu: 2.529 ± 0.043	0.303PheMet: 0.303 ± 0.014	0.385PheAsn: 0.385 ± 0.019	1.346PhePro: 1.346 ± 0.031	0.523PheGln: 0.523 ± 0.018	1.708PheArg: 1.708 ± 0.032	1.303PheSer: 1.303 ± 0.031	1.677PheThr: 1.677 ± 0.036	2.407PheVal: 2.407 ± 0.045	0.408PheTrp: 0.408 ± 0.019	0.499PheTyr: 0.499 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	12.853GlyAla: 12.853 ± 0.103	0.861GlyCys: 0.861 ± 0.026	5.652GlyAsp: 5.652 ± 0.062	5.376GlyGlu: 5.376 ± 0.059	2.729GlyPhe: 2.729 ± 0.048	9.795GlyGly: 9.795 ± 0.113	2.062GlyHis: 2.062 ± 0.041	2.99GlyIle: 2.99 ± 0.051	1.384GlyLys: 1.384 ± 0.036	10.458GlyLeu: 10.458 ± 0.094	2.007GlyMet: 2.007 ± 0.042	1.386GlyAsn: 1.386 ± 0.036	6.098GlyPro: 6.098 ± 0.08	2.53GlyGln: 2.53 ± 0.046	9.5GlyArg: 9.5 ± 0.102	5.21GlySer: 5.21 ± 0.064	6.422GlyThr: 6.422 ± 0.073	8.836GlyVal: 8.836 ± 0.076	1.944GlyTrp: 1.944 ± 0.036	2.168GlyTyr: 2.168 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.593HisAla: 2.593 ± 0.048	0.183HisCys: 0.183 ± 0.011	1.211HisAsp: 1.211 ± 0.028	1.073HisGlu: 1.073 ± 0.026	0.482HisPhe: 0.482 ± 0.017	2.28HisGly: 2.28 ± 0.042	0.59HisHis: 0.59 ± 0.021	0.348HisIle: 0.348 ± 0.014	0.182HisLys: 0.182 ± 0.012	2.413HisLeu: 2.413 ± 0.037	0.256HisMet: 0.256 ± 0.012	0.274HisAsn: 0.274 ± 0.012	1.784HisPro: 1.784 ± 0.038	0.49HisGln: 0.49 ± 0.018	2.13HisArg: 2.13 ± 0.038	0.754HisSer: 0.754 ± 0.023	0.954HisThr: 0.954 ± 0.026	1.943HisVal: 1.943 ± 0.04	0.324HisTrp: 0.324 ± 0.016	0.366HisTyr: 0.366 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	3.912IleAla: 3.912 ± 0.067	0.212IleCys: 0.212 ± 0.011	1.727IleAsp: 1.727 ± 0.035	1.472IleGlu: 1.472 ± 0.031	0.419IlePhe: 0.419 ± 0.018	3.053IleGly: 3.053 ± 0.061	0.368IleHis: 0.368 ± 0.015	0.567IleIle: 0.567 ± 0.023	0.324IleLys: 0.324 ± 0.017	1.508IleLeu: 1.508 ± 0.04	0.299IleMet: 0.299 ± 0.017	0.435IleAsn: 0.435 ± 0.018	1.334IlePro: 1.334 ± 0.034	0.449IleGln: 0.449 ± 0.018	1.815IleArg: 1.815 ± 0.039	1.23IleSer: 1.23 ± 0.029	1.63IleThr: 1.63 ± 0.038	2.082IleVal: 2.082 ± 0.042	0.264IleTrp: 0.264 ± 0.014	0.356IleTyr: 0.356 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	1.547LysAla: 1.547 ± 0.039	0.056LysCys: 0.056 ± 0.006	0.648LysAsp: 0.648 ± 0.022	0.596LysGlu: 0.596 ± 0.021	0.227LysPhe: 0.227 ± 0.014	0.957LysGly: 0.957 ± 0.029	0.243LysHis: 0.243 ± 0.013	0.364LysIle: 0.364 ± 0.018	0.304LysLys: 0.304 ± 0.017	1.086LysLeu: 1.086 ± 0.028	0.208LysMet: 0.208 ± 0.011	0.233LysAsn: 0.233 ± 0.013	0.685LysPro: 0.685 ± 0.023	0.375LysGln: 0.375 ± 0.018	0.92LysArg: 0.92 ± 0.029	0.527LysSer: 0.527 ± 0.02	0.715LysThr: 0.715 ± 0.025	1.105LysVal: 1.105 ± 0.03	0.123LysTrp: 0.123 ± 0.009	0.217LysTyr: 0.217 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	18.076LeuAla: 18.076 ± 0.135	0.693LeuCys: 0.693 ± 0.022	7.036LeuAsp: 7.036 ± 0.069	4.946LeuGlu: 4.946 ± 0.055	2.458LeuPhe: 2.458 ± 0.043	10.326LeuGly: 10.326 ± 0.092	2.195LeuHis: 2.195 ± 0.037	2.003LeuIle: 2.003 ± 0.052	1.005LeuLys: 1.005 ± 0.031	12.383LeuLeu: 12.383 ± 0.141	1.248LeuMet: 1.248 ± 0.029	1.172LeuAsn: 1.172 ± 0.031	7.08LeuPro: 7.08 ± 0.07	2.451LeuGln: 2.451 ± 0.041	9.061LeuArg: 9.061 ± 0.1	4.719LeuSer: 4.719 ± 0.066	6.62LeuThr: 6.62 ± 0.073	11.516LeuVal: 11.516 ± 0.111	1.22LeuTrp: 1.22 ± 0.03	1.404LeuTyr: 1.404 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.143MetAla: 2.143 ± 0.035	0.109MetCys: 0.109 ± 0.009	0.737MetAsp: 0.737 ± 0.024	0.552MetGlu: 0.552 ± 0.02	0.32MetPhe: 0.32 ± 0.013	1.226MetGly: 1.226 ± 0.029	0.301MetHis: 0.301 ± 0.015	0.425MetIle: 0.425 ± 0.017	0.231MetLys: 0.231 ± 0.011	1.297MetLeu: 1.297 ± 0.027	0.212MetMet: 0.212 ± 0.012	0.267MetAsn: 0.267 ± 0.012	1.025MetPro: 1.025 ± 0.024	0.4MetGln: 0.4 ± 0.016	1.277MetArg: 1.277 ± 0.029	1.103MetSer: 1.103 ± 0.028	1.542MetThr: 1.542 ± 0.033	1.295MetVal: 1.295 ± 0.032	0.168MetTrp: 0.168 ± 0.01	0.225MetTyr: 0.225 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	1.691AsnAla: 1.691 ± 0.04	0.11AsnCys: 0.11 ± 0.009	0.629AsnAsp: 0.629 ± 0.021	0.565AsnGlu: 0.565 ± 0.023	0.349AsnPhe: 0.349 ± 0.015	1.243AsnGly: 1.243 ± 0.033	0.261AsnHis: 0.261 ± 0.013	0.39AsnIle: 0.39 ± 0.017	0.18AsnLys: 0.18 ± 0.01	1.333AsnLeu: 1.333 ± 0.033	0.195AsnMet: 0.195 ± 0.012	0.258AsnAsn: 0.258 ± 0.015	1.08AsnPro: 1.08 ± 0.03	0.319AsnGln: 0.319 ± 0.014	1.028AsnArg: 1.028 ± 0.031	0.563AsnSer: 0.563 ± 0.02	0.744AsnThr: 0.744 ± 0.024	1.185AsnVal: 1.185 ± 0.028	0.203AsnTrp: 0.203 ± 0.012	0.28AsnTyr: 0.28 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	10.912ProAla: 10.912 ± 0.13	0.317ProCys: 0.317 ± 0.017	4.693ProAsp: 4.693 ± 0.058	4.332ProGlu: 4.332 ± 0.053	1.5ProPhe: 1.5 ± 0.032	8.034ProGly: 8.034 ± 0.091	1.271ProHis: 1.271 ± 0.03	1.127ProIle: 1.127 ± 0.031	0.584ProLys: 0.584 ± 0.02	5.596ProLeu: 5.596 ± 0.061	0.924ProMet: 0.924 ± 0.029	0.629ProAsn: 0.629 ± 0.019	4.634ProPro: 4.634 ± 0.092	1.447ProGln: 1.447 ± 0.033	4.76ProArg: 4.76 ± 0.062	2.825ProSer: 2.825 ± 0.045	3.383ProThr: 3.383 ± 0.05	6.693ProVal: 6.693 ± 0.074	0.957ProTrp: 0.957 ± 0.025	1.001ProTyr: 1.001 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.543GlnAla: 3.543 ± 0.055	0.126GlnCys: 0.126 ± 0.01	1.105GlnAsp: 1.105 ± 0.028	1.338GlnGlu: 1.338 ± 0.037	0.608GlnPhe: 0.608 ± 0.017	1.907GlnGly: 1.907 ± 0.038	0.584GlnHis: 0.584 ± 0.02	0.724GlnIle: 0.724 ± 0.024	0.319GlnLys: 0.319 ± 0.015	3.026GlnLeu: 3.026 ± 0.044	0.382GlnMet: 0.382 ± 0.018	0.319GlnAsn: 0.319 ± 0.014	1.576GlnPro: 1.576 ± 0.039	1.002GlnGln: 1.002 ± 0.028	2.487GlnArg: 2.487 ± 0.049	0.838GlnSer: 0.838 ± 0.023	1.156GlnThr: 1.156 ± 0.029	2.741GlnVal: 2.741 ± 0.048	0.368GlnTrp: 0.368 ± 0.015	0.476GlnTyr: 0.476 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	12.198ArgAla: 12.198 ± 0.121	0.628ArgCys: 0.628 ± 0.024	4.601ArgAsp: 4.601 ± 0.06	4.748ArgGlu: 4.748 ± 0.057	2.337ArgPhe: 2.337 ± 0.036	6.949ArgGly: 6.949 ± 0.087	1.943ArgHis: 1.943 ± 0.036	2.428ArgIle: 2.428 ± 0.041	0.909ArgLys: 0.909 ± 0.029	9.721ArgLeu: 9.721 ± 0.097	1.751ArgMet: 1.751 ± 0.035	1.043ArgAsn: 1.043 ± 0.03	6.264ArgPro: 6.264 ± 0.071	2.25ArgGln: 2.25 ± 0.045	9.785ArgArg: 9.785 ± 0.13	4.235ArgSer: 4.235 ± 0.06	5.178ArgThr: 5.178 ± 0.064	7.616ArgVal: 7.616 ± 0.086	1.748ArgTrp: 1.748 ± 0.041	1.837ArgTyr: 1.837 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.056SerAla: 6.056 ± 0.065	0.332SerCys: 0.332 ± 0.018	2.188SerAsp: 2.188 ± 0.036	1.82SerGlu: 1.82 ± 0.033	1.303SerPhe: 1.303 ± 0.031	5.132SerGly: 5.132 ± 0.063	0.757SerHis: 0.757 ± 0.023	1.174SerIle: 1.174 ± 0.035	0.504SerLys: 0.504 ± 0.017	4.278SerLeu: 4.278 ± 0.06	0.882SerMet: 0.882 ± 0.023	0.598SerAsn: 0.598 ± 0.021	3.037SerPro: 3.037 ± 0.043	0.898SerGln: 0.898 ± 0.025	3.6SerArg: 3.6 ± 0.05	2.365SerSer: 2.365 ± 0.045	2.724SerThr: 2.724 ± 0.043	3.912SerVal: 3.912 ± 0.053	0.811SerTrp: 0.811 ± 0.023	0.965SerTyr: 0.965 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	8.996ThrAla: 8.996 ± 0.097	0.404ThrCys: 0.404 ± 0.015	3.323ThrAsp: 3.323 ± 0.046	2.851ThrGlu: 2.851 ± 0.046	1.454ThrPhe: 1.454 ± 0.031	6.927ThrGly: 6.927 ± 0.075	1.02ThrHis: 1.02 ± 0.027	1.383ThrIle: 1.383 ± 0.036	0.643ThrLys: 0.643 ± 0.022	5.309ThrLeu: 5.309 ± 0.066	0.792ThrMet: 0.792 ± 0.023	0.772ThrAsn: 0.772 ± 0.026	3.943ThrPro: 3.943 ± 0.052	1.104ThrGln: 1.104 ± 0.029	4.2ThrArg: 4.2 ± 0.051	2.725ThrSer: 2.725 ± 0.044	3.765ThrThr: 3.765 ± 0.076	6.088ThrVal: 6.088 ± 0.065	0.942ThrTrp: 0.942 ± 0.023	1.017ThrTyr: 1.017 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	14.397ValAla: 14.397 ± 0.119	0.695ValCys: 0.695 ± 0.025	6.491ValAsp: 6.491 ± 0.063	5.704ValGlu: 5.704 ± 0.066	2.546ValPhe: 2.546 ± 0.045	8.146ValGly: 8.146 ± 0.081	2.249ValHis: 2.249 ± 0.048	2.187ValIle: 2.187 ± 0.046	1.04ValLys: 1.04 ± 0.028	12.232ValLeu: 12.232 ± 0.115	1.179ValMet: 1.179 ± 0.03	1.421ValAsn: 1.421 ± 0.032	6.599ValPro: 6.599 ± 0.065	2.309ValGln: 2.309 ± 0.039	8.113ValArg: 8.113 ± 0.075	4.08ValSer: 4.08 ± 0.055	6.201ValThr: 6.201 ± 0.067	11.75ValVal: 11.75 ± 0.108	1.191ValTrp: 1.191 ± 0.03	1.47ValTyr: 1.47 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.906TrpAla: 1.906 ± 0.035	0.14TrpCys: 0.14 ± 0.01	0.82TrpAsp: 0.82 ± 0.027	0.668TrpGlu: 0.668 ± 0.019	0.512TrpPhe: 0.512 ± 0.017	1.107TrpGly: 1.107 ± 0.032	0.351TrpHis: 0.351 ± 0.016	0.35TrpIle: 0.35 ± 0.017	0.188TrpLys: 0.188 ± 0.013	1.925TrpLeu: 1.925 ± 0.039	0.231TrpMet: 0.231 ± 0.012	0.256TrpAsn: 0.256 ± 0.014	0.861TrpPro: 0.861 ± 0.024	0.497TrpGln: 0.497 ± 0.021	1.453TrpArg: 1.453 ± 0.03	0.929TrpSer: 0.929 ± 0.029	0.988TrpThr: 0.988 ± 0.025	1.282TrpVal: 1.282 ± 0.03	0.377TrpTrp: 0.377 ± 0.017	0.283TrpTyr: 0.283 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.325TyrAla: 2.325 ± 0.041	0.136TyrCys: 0.136 ± 0.009	1.206TyrAsp: 1.206 ± 0.03	0.961TyrGlu: 0.961 ± 0.026	0.472TyrPhe: 0.472 ± 0.019	1.848TyrGly: 1.848 ± 0.039	0.32TyrHis: 0.32 ± 0.016	0.318TyrIle: 0.318 ± 0.013	0.214TyrLys: 0.214 ± 0.013	1.86TyrLeu: 1.86 ± 0.04	0.144TyrMet: 0.144 ± 0.011	0.236TyrAsn: 0.236 ± 0.014	0.908TyrPro: 0.908 ± 0.028	0.433TyrGln: 0.433 ± 0.018	1.668TyrArg: 1.668 ± 0.035	0.755TyrSer: 0.755 ± 0.025	0.921TyrThr: 0.921 ± 0.026	1.567TyrVal: 1.567 ± 0.031	0.279TyrTrp: 0.279 ± 0.016	0.342TyrTyr: 0.342 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4784 proteins (1526184 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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