Amino acid dipepetide frequency for Deinococcus puniceus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.099AlaAla: 18.099 ± 0.248	0.817AlaCys: 0.817 ± 0.038	6.541AlaAsp: 6.541 ± 0.091	7.357AlaGlu: 7.357 ± 0.118	4.135AlaPhe: 4.135 ± 0.078	11.989AlaGly: 11.989 ± 0.133	2.815AlaHis: 2.815 ± 0.064	3.966AlaIle: 3.966 ± 0.078	2.94AlaLys: 2.94 ± 0.075	15.956AlaLeu: 15.956 ± 0.194	2.175AlaMet: 2.175 ± 0.054	2.628AlaAsn: 2.628 ± 0.072	6.521AlaPro: 6.521 ± 0.12	5.557AlaGln: 5.557 ± 0.103	9.687AlaArg: 9.687 ± 0.142	5.855AlaSer: 5.855 ± 0.102	6.417AlaThr: 6.417 ± 0.13	9.155AlaVal: 9.155 ± 0.104	1.711AlaTrp: 1.711 ± 0.054	2.934AlaTyr: 2.934 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.669CysAla: 0.669 ± 0.032	0.055CysCys: 0.055 ± 0.009	0.301CysAsp: 0.301 ± 0.022	0.216CysGlu: 0.216 ± 0.017	0.167CysPhe: 0.167 ± 0.013	0.611CysGly: 0.611 ± 0.03	0.12CysHis: 0.12 ± 0.013	0.215CysIle: 0.215 ± 0.018	0.112CysLys: 0.112 ± 0.013	0.5CysLeu: 0.5 ± 0.028	0.09CysMet: 0.09 ± 0.012	0.147CysAsn: 0.147 ± 0.014	0.37CysPro: 0.37 ± 0.021	0.138CysGln: 0.138 ± 0.015	0.332CysArg: 0.332 ± 0.021	0.279CysSer: 0.279 ± 0.021	0.39CysThr: 0.39 ± 0.023	0.435CysVal: 0.435 ± 0.029	0.054CysTrp: 0.054 ± 0.007	0.106CysTyr: 0.106 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.133AspAla: 7.133 ± 0.097	0.216AspCys: 0.216 ± 0.016	2.39AspAsp: 2.39 ± 0.066	2.717AspGlu: 2.717 ± 0.061	1.815AspPhe: 1.815 ± 0.049	4.649AspGly: 4.649 ± 0.083	1.008AspHis: 1.008 ± 0.038	2.026AspIle: 2.026 ± 0.05	1.207AspLys: 1.207 ± 0.042	6.487AspLeu: 6.487 ± 0.104	0.935AspMet: 0.935 ± 0.036	1.049AspAsn: 1.049 ± 0.041	3.33AspPro: 3.33 ± 0.068	1.473AspGln: 1.473 ± 0.044	2.858AspArg: 2.858 ± 0.054	2.422AspSer: 2.422 ± 0.058	3.021AspThr: 3.021 ± 0.067	4.475AspVal: 4.475 ± 0.075	0.867AspTrp: 0.867 ± 0.036	1.177AspTyr: 1.177 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	7.359GluAla: 7.359 ± 0.121	0.216GluCys: 0.216 ± 0.015	2.517GluAsp: 2.517 ± 0.057	2.886GluGlu: 2.886 ± 0.077	1.718GluPhe: 1.718 ± 0.052	4.689GluGly: 4.689 ± 0.082	1.108GluHis: 1.108 ± 0.042	2.133GluIle: 2.133 ± 0.059	1.58GluLys: 1.58 ± 0.053	6.026GluLeu: 6.026 ± 0.101	1.09GluMet: 1.09 ± 0.037	1.255GluAsn: 1.255 ± 0.051	2.123GluPro: 2.123 ± 0.058	2.216GluGln: 2.216 ± 0.056	4.828GluArg: 4.828 ± 0.105	2.294GluSer: 2.294 ± 0.057	2.806GluThr: 2.806 ± 0.052	4.54GluVal: 4.54 ± 0.087	0.776GluTrp: 0.776 ± 0.032	1.35GluTyr: 1.35 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.742PheAla: 3.742 ± 0.086	0.18PheCys: 0.18 ± 0.016	1.935PheAsp: 1.935 ± 0.047	1.82PheGlu: 1.82 ± 0.055	0.994PhePhe: 0.994 ± 0.043	3.197PheGly: 3.197 ± 0.069	0.58PheHis: 0.58 ± 0.024	1.245PheIle: 1.245 ± 0.045	0.877PheLys: 0.877 ± 0.033	3.196PheLeu: 3.196 ± 0.08	0.585PheMet: 0.585 ± 0.026	0.924PheAsn: 0.924 ± 0.043	1.653PhePro: 1.653 ± 0.041	0.968PheGln: 0.968 ± 0.035	1.935PheArg: 1.935 ± 0.049	1.922PheSer: 1.922 ± 0.053	2.134PheThr: 2.134 ± 0.057	2.55PheVal: 2.55 ± 0.061	0.437PheTrp: 0.437 ± 0.026	0.815PheTyr: 0.815 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	9.92GlyAla: 9.92 ± 0.135	0.504GlyCys: 0.504 ± 0.026	3.996GlyAsp: 3.996 ± 0.073	5.03GlyGlu: 5.03 ± 0.092	3.189GlyPhe: 3.189 ± 0.067	8.849GlyGly: 8.849 ± 0.147	1.749GlyHis: 1.749 ± 0.048	3.758GlyIle: 3.758 ± 0.084	3.318GlyLys: 3.318 ± 0.075	10.156GlyLeu: 10.156 ± 0.127	2.112GlyMet: 2.112 ± 0.057	2.561GlyAsn: 2.561 ± 0.073	3.411GlyPro: 3.411 ± 0.071	4.11GlyGln: 4.11 ± 0.079	5.945GlyArg: 5.945 ± 0.094	4.769GlySer: 4.769 ± 0.097	5.929GlyThr: 5.929 ± 0.13	8.103GlyVal: 8.103 ± 0.101	1.548GlyTrp: 1.548 ± 0.049	2.3GlyTyr: 2.3 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.865HisAla: 2.865 ± 0.076	0.128HisCys: 0.128 ± 0.014	1.043HisAsp: 1.043 ± 0.038	1.056HisGlu: 1.056 ± 0.038	0.645HisPhe: 0.645 ± 0.031	1.844HisGly: 1.844 ± 0.056	0.597HisHis: 0.597 ± 0.028	0.767HisIle: 0.767 ± 0.035	0.41HisLys: 0.41 ± 0.023	2.528HisLeu: 2.528 ± 0.066	0.332HisMet: 0.332 ± 0.022	0.399HisAsn: 0.399 ± 0.024	1.545HisPro: 1.545 ± 0.052	0.529HisGln: 0.529 ± 0.027	1.227HisArg: 1.227 ± 0.04	0.982HisSer: 0.982 ± 0.036	1.431HisThr: 1.431 ± 0.043	1.367HisVal: 1.367 ± 0.043	0.322HisTrp: 0.322 ± 0.019	0.498HisTyr: 0.498 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	4.48IleAla: 4.48 ± 0.08	0.221IleCys: 0.221 ± 0.016	2.147IleAsp: 2.147 ± 0.06	2.396IleGlu: 2.396 ± 0.069	1.172IlePhe: 1.172 ± 0.038	3.742IleGly: 3.742 ± 0.079	0.844IleHis: 0.844 ± 0.033	1.558IleIle: 1.558 ± 0.051	1.094IleLys: 1.094 ± 0.047	3.853IleLeu: 3.853 ± 0.081	0.674IleMet: 0.674 ± 0.031	1.099IleAsn: 1.099 ± 0.036	2.339IlePro: 2.339 ± 0.051	1.22IleGln: 1.22 ± 0.04	2.614IleArg: 2.614 ± 0.05	2.284IleSer: 2.284 ± 0.062	2.561IleThr: 2.561 ± 0.067	3.083IleVal: 3.083 ± 0.066	0.399IleTrp: 0.399 ± 0.023	0.859IleTyr: 0.859 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.464LysAla: 3.464 ± 0.093	0.099LysCys: 0.099 ± 0.011	1.399LysAsp: 1.399 ± 0.042	1.257LysGlu: 1.257 ± 0.048	0.806LysPhe: 0.806 ± 0.03	2.178LysGly: 2.178 ± 0.054	0.508LysHis: 0.508 ± 0.026	1.143LysIle: 1.143 ± 0.038	1.098LysLys: 1.098 ± 0.051	3.083LysLeu: 3.083 ± 0.072	0.751LysMet: 0.751 ± 0.027	0.863LysAsn: 0.863 ± 0.035	1.679LysPro: 1.679 ± 0.056	0.911LysGln: 0.911 ± 0.031	1.806LysArg: 1.806 ± 0.05	1.326LysSer: 1.326 ± 0.044	1.903LysThr: 1.903 ± 0.056	2.285LysVal: 2.285 ± 0.057	0.308LysTrp: 0.308 ± 0.023	0.702LysTyr: 0.702 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	14.697LeuAla: 14.697 ± 0.206	0.609LeuCys: 0.609 ± 0.03	6.094LeuAsp: 6.094 ± 0.09	5.953LeuGlu: 5.953 ± 0.102	2.724LeuPhe: 2.724 ± 0.067	10.241LeuGly: 10.241 ± 0.13	2.533LeuHis: 2.533 ± 0.062	4.677LeuIle: 4.677 ± 0.089	3.406LeuLys: 3.406 ± 0.075	12.286LeuLeu: 12.286 ± 0.188	2.289LeuMet: 2.289 ± 0.058	3.708LeuAsn: 3.708 ± 0.066	7.602LeuPro: 7.602 ± 0.114	3.234LeuGln: 3.234 ± 0.066	7.7LeuArg: 7.7 ± 0.117	6.854LeuSer: 6.854 ± 0.108	8.423LeuThr: 8.423 ± 0.139	7.025LeuVal: 7.025 ± 0.101	1.343LeuTrp: 1.343 ± 0.045	2.259LeuTyr: 2.259 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	1.923MetAla: 1.923 ± 0.053	0.077MetCys: 0.077 ± 0.009	0.892MetAsp: 0.892 ± 0.032	0.887MetGlu: 0.887 ± 0.038	0.525MetPhe: 0.525 ± 0.027	1.68MetGly: 1.68 ± 0.048	0.392MetHis: 0.392 ± 0.024	0.808MetIle: 0.808 ± 0.031	0.76MetLys: 0.76 ± 0.034	2.258MetLeu: 2.258 ± 0.054	0.42MetMet: 0.42 ± 0.022	0.8MetAsn: 0.8 ± 0.032	1.179MetPro: 1.179 ± 0.035	0.817MetGln: 0.817 ± 0.034	1.351MetArg: 1.351 ± 0.048	1.199MetSer: 1.199 ± 0.04	1.945MetThr: 1.945 ± 0.046	1.182MetVal: 1.182 ± 0.038	0.193MetTrp: 0.193 ± 0.017	0.385MetTyr: 0.385 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.587AsnAla: 3.587 ± 0.078	0.153AsnCys: 0.153 ± 0.013	1.197AsnAsp: 1.197 ± 0.04	1.066AsnGlu: 1.066 ± 0.037	0.975AsnPhe: 0.975 ± 0.035	2.304AsnGly: 2.304 ± 0.063	0.504AsnHis: 0.504 ± 0.031	1.174AsnIle: 1.174 ± 0.039	0.677AsnLys: 0.677 ± 0.029	3.231AsnLeu: 3.231 ± 0.089	0.56AsnMet: 0.56 ± 0.025	0.742AsnAsn: 0.742 ± 0.041	2.039AsnPro: 2.039 ± 0.05	0.71AsnGln: 0.71 ± 0.035	1.59AsnArg: 1.59 ± 0.052	1.305AsnSer: 1.305 ± 0.05	1.78AsnThr: 1.78 ± 0.07	2.369AsnVal: 2.369 ± 0.073	0.359AsnTrp: 0.359 ± 0.024	0.716AsnTyr: 0.716 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	7.864ProAla: 7.864 ± 0.139	0.243ProCys: 0.243 ± 0.021	4.124ProAsp: 4.124 ± 0.077	4.039ProGlu: 4.039 ± 0.081	1.799ProPhe: 1.799 ± 0.053	4.892ProGly: 4.892 ± 0.078	1.282ProHis: 1.282 ± 0.046	1.97ProIle: 1.97 ± 0.047	1.498ProLys: 1.498 ± 0.043	5.78ProLeu: 5.78 ± 0.102	1.059ProMet: 1.059 ± 0.032	1.592ProAsn: 1.592 ± 0.05	3.09ProPro: 3.09 ± 0.081	2.139ProGln: 2.139 ± 0.055	2.979ProArg: 2.979 ± 0.081	2.806ProSer: 2.806 ± 0.07	3.696ProThr: 3.696 ± 0.075	4.57ProVal: 4.57 ± 0.074	0.616ProTrp: 0.616 ± 0.031	1.255ProTyr: 1.255 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	5.174GlnAla: 5.174 ± 0.084	0.15GlnCys: 0.15 ± 0.016	1.854GlnAsp: 1.854 ± 0.046	1.888GlnGlu: 1.888 ± 0.058	1.108GlnPhe: 1.108 ± 0.036	3.103GlnGly: 3.103 ± 0.064	0.797GlnHis: 0.797 ± 0.03	1.608GlnIle: 1.608 ± 0.049	1.083GlnLys: 1.083 ± 0.038	3.613GlnLeu: 3.613 ± 0.073	0.752GlnMet: 0.752 ± 0.039	1.175GlnAsn: 1.175 ± 0.04	2.357GlnPro: 2.357 ± 0.059	1.558GlnGln: 1.558 ± 0.055	2.279GlnArg: 2.279 ± 0.055	1.859GlnSer: 1.859 ± 0.055	2.538GlnThr: 2.538 ± 0.066	2.782GlnVal: 2.782 ± 0.063	0.434GlnTrp: 0.434 ± 0.027	0.726GlnTyr: 0.726 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	8.769ArgAla: 8.769 ± 0.136	0.284ArgCys: 0.284 ± 0.018	3.646ArgAsp: 3.646 ± 0.068	4.658ArgGlu: 4.658 ± 0.102	2.209ArgPhe: 2.209 ± 0.05	5.371ArgGly: 5.371 ± 0.097	1.372ArgHis: 1.372 ± 0.04	2.729ArgIle: 2.729 ± 0.061	1.693ArgLys: 1.693 ± 0.052	7.438ArgLeu: 7.438 ± 0.112	1.503ArgMet: 1.503 ± 0.049	1.562ArgAsn: 1.562 ± 0.042	3.595ArgPro: 3.595 ± 0.077	2.46ArgGln: 2.46 ± 0.061	4.613ArgArg: 4.613 ± 0.097	2.97ArgSer: 2.97 ± 0.065	3.99ArgThr: 3.99 ± 0.075	6.528ArgVal: 6.528 ± 0.088	0.95ArgTrp: 0.95 ± 0.039	1.699ArgTyr: 1.699 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	6.358SerAla: 6.358 ± 0.109	0.278SerCys: 0.278 ± 0.018	2.535SerAsp: 2.535 ± 0.057	2.447SerGlu: 2.447 ± 0.059	1.786SerPhe: 1.786 ± 0.052	5.877SerGly: 5.877 ± 0.123	0.913SerHis: 0.913 ± 0.031	2.004SerIle: 2.004 ± 0.057	1.378SerLys: 1.378 ± 0.045	5.391SerLeu: 5.391 ± 0.095	1.003SerMet: 1.003 ± 0.038	1.411SerAsn: 1.411 ± 0.051	2.856SerPro: 2.856 ± 0.056	1.564SerGln: 1.564 ± 0.05	3.183SerArg: 3.183 ± 0.062	2.88SerSer: 2.88 ± 0.074	3.024SerThr: 3.024 ± 0.081	4.492SerVal: 4.492 ± 0.08	0.566SerTrp: 0.566 ± 0.025	1.158SerTyr: 1.158 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	7.616ThrAla: 7.616 ± 0.126	0.354ThrCys: 0.354 ± 0.027	3.304ThrAsp: 3.304 ± 0.068	2.782ThrGlu: 2.782 ± 0.067	2.246ThrPhe: 2.246 ± 0.052	5.85ThrGly: 5.85 ± 0.124	1.311ThrHis: 1.311 ± 0.047	2.132ThrIle: 2.132 ± 0.062	1.256ThrLys: 1.256 ± 0.04	8.814ThrLeu: 8.814 ± 0.141	0.847ThrMet: 0.847 ± 0.032	1.433ThrAsn: 1.433 ± 0.058	5.27ThrPro: 5.27 ± 0.088	2.14ThrGln: 2.14 ± 0.062	4.23ThrArg: 4.23 ± 0.073	2.796ThrSer: 2.796 ± 0.066	3.516ThrThr: 3.516 ± 0.1	5.538ThrVal: 5.538 ± 0.113	0.707ThrTrp: 0.707 ± 0.032	1.549ThrTyr: 1.549 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	8.958ValAla: 8.958 ± 0.123	0.498ValCys: 0.498 ± 0.027	3.525ValAsp: 3.525 ± 0.076	3.463ValGlu: 3.463 ± 0.075	2.458ValPhe: 2.458 ± 0.052	6.707ValGly: 6.707 ± 0.092	1.25ValHis: 1.25 ± 0.041	3.561ValIle: 3.561 ± 0.073	2.294ValLys: 2.294 ± 0.057	8.993ValLeu: 8.993 ± 0.125	1.804ValMet: 1.804 ± 0.043	2.561ValAsn: 2.561 ± 0.059	4.341ValPro: 4.341 ± 0.08	3.591ValGln: 3.591 ± 0.076	5.953ValArg: 5.953 ± 0.088	4.448ValSer: 4.448 ± 0.083	5.694ValThr: 5.694 ± 0.116	5.956ValVal: 5.956 ± 0.089	1.148ValTrp: 1.148 ± 0.042	1.921ValTyr: 1.921 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	1.607TrpAla: 1.607 ± 0.049	0.077TrpCys: 0.077 ± 0.01	0.59TrpAsp: 0.59 ± 0.027	0.569TrpGlu: 0.569 ± 0.027	0.388TrpPhe: 0.388 ± 0.023	1.103TrpGly: 1.103 ± 0.038	0.304TrpHis: 0.304 ± 0.019	0.453TrpIle: 0.453 ± 0.027	0.367TrpLys: 0.367 ± 0.022	1.584TrpLeu: 1.584 ± 0.057	0.334TrpMet: 0.334 ± 0.021	0.533TrpAsn: 0.533 ± 0.027	0.686TrpPro: 0.686 ± 0.031	0.737TrpGln: 0.737 ± 0.03	1.024TrpArg: 1.024 ± 0.04	0.544TrpSer: 0.544 ± 0.027	0.883TrpThr: 0.883 ± 0.034	1.013TrpVal: 1.013 ± 0.034	0.241TrpTrp: 0.241 ± 0.019	0.261TrpTyr: 0.261 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.971TyrAla: 2.971 ± 0.068	0.148TyrCys: 0.148 ± 0.014	1.227TyrAsp: 1.227 ± 0.038	1.023TyrGlu: 1.023 ± 0.03	0.826TyrPhe: 0.826 ± 0.04	2.381TyrGly: 2.381 ± 0.053	0.529TyrHis: 0.529 ± 0.025	0.713TyrIle: 0.713 ± 0.032	0.52TyrLys: 0.52 ± 0.023	2.488TyrLeu: 2.488 ± 0.057	0.357TyrMet: 0.357 ± 0.022	0.599TyrAsn: 0.599 ± 0.026	1.305TyrPro: 1.305 ± 0.04	0.765TyrGln: 0.765 ± 0.034	1.905TyrArg: 1.905 ± 0.05	1.311TyrSer: 1.311 ± 0.05	1.61TyrThr: 1.61 ± 0.053	1.674TyrVal: 1.674 ± 0.044	0.317TyrTrp: 0.317 ± 0.019	0.582TyrTyr: 0.582 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2606 proteins (801718 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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