Amino acid dipepetide frequency for Reptilian orthoreovirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.574AlaAla: 8.574 ± 1.318
1.169AlaCys: 1.169 ± 0.318
4.417AlaAsp: 4.417 ± 0.476
3.118AlaGlu: 3.118 ± 0.617
2.598AlaPhe: 2.598 ± 0.491
3.118AlaGly: 3.118 ± 0.651
1.169AlaHis: 1.169 ± 0.235
4.157AlaIle: 4.157 ± 0.747
3.378AlaLys: 3.378 ± 0.6
8.314AlaLeu: 8.314 ± 1.083
3.248AlaMet: 3.248 ± 1.041
4.417AlaAsn: 4.417 ± 0.648
4.027AlaPro: 4.027 ± 0.558
3.507AlaGln: 3.507 ± 0.433
4.417AlaArg: 4.417 ± 0.529
6.625AlaSer: 6.625 ± 1.133
6.495AlaThr: 6.495 ± 0.967
4.677AlaVal: 4.677 ± 0.63
0.65AlaTrp: 0.65 ± 0.294
3.248AlaTyr: 3.248 ± 0.526
0.0AlaXaa: 0.0 ± 0.0
Cys
0.909CysAla: 0.909 ± 0.246
0.26CysCys: 0.26 ± 0.289
1.169CysAsp: 1.169 ± 0.261
0.909CysGlu: 0.909 ± 0.425
0.52CysPhe: 0.52 ± 0.288
0.52CysGly: 0.52 ± 0.302
0.39CysHis: 0.39 ± 0.331
0.779CysIle: 0.779 ± 0.331
0.26CysLys: 0.26 ± 0.228
1.559CysLeu: 1.559 ± 0.397
0.779CysMet: 0.779 ± 0.188
0.26CysAsn: 0.26 ± 0.146
0.52CysPro: 0.52 ± 0.22
0.39CysGln: 0.39 ± 0.209
0.39CysArg: 0.39 ± 0.201
0.909CysSer: 0.909 ± 0.335
0.39CysThr: 0.39 ± 0.161
0.52CysVal: 0.52 ± 0.213
0.26CysTrp: 0.26 ± 0.145
0.52CysTyr: 0.52 ± 0.224
0.0CysXaa: 0.0 ± 0.0
Asp
5.196AspAla: 5.196 ± 0.552
0.13AspCys: 0.13 ± 0.133
4.936AspAsp: 4.936 ± 0.982
2.598AspGlu: 2.598 ± 0.585
2.208AspPhe: 2.208 ± 0.489
3.767AspGly: 3.767 ± 0.746
1.689AspHis: 1.689 ± 0.506
3.897AspIle: 3.897 ± 0.748
2.598AspLys: 2.598 ± 0.61
4.547AspLeu: 4.547 ± 1.206
1.299AspMet: 1.299 ± 0.389
1.299AspAsn: 1.299 ± 0.272
3.248AspPro: 3.248 ± 0.731
3.118AspGln: 3.118 ± 0.665
2.858AspArg: 2.858 ± 0.487
4.936AspSer: 4.936 ± 0.772
3.507AspThr: 3.507 ± 0.685
5.716AspVal: 5.716 ± 0.775
1.039AspTrp: 1.039 ± 0.381
2.338AspTyr: 2.338 ± 0.694
0.0AspXaa: 0.0 ± 0.0
Glu
2.988GluAla: 2.988 ± 0.544
0.65GluCys: 0.65 ± 0.242
2.598GluAsp: 2.598 ± 1.107
1.689GluGlu: 1.689 ± 0.504
1.689GluPhe: 1.689 ± 0.334
2.208GluGly: 2.208 ± 0.845
0.909GluHis: 0.909 ± 0.567
2.728GluIle: 2.728 ± 0.6
2.338GluLys: 2.338 ± 0.393
4.417GluLeu: 4.417 ± 0.837
1.949GluMet: 1.949 ± 0.455
1.559GluAsn: 1.559 ± 0.36
1.559GluPro: 1.559 ± 0.279
1.819GluGln: 1.819 ± 0.627
3.378GluArg: 3.378 ± 0.651
3.248GluSer: 3.248 ± 0.567
2.598GluThr: 2.598 ± 0.521
3.767GluVal: 3.767 ± 0.746
0.779GluTrp: 0.779 ± 0.275
1.429GluTyr: 1.429 ± 0.306
0.0GluXaa: 0.0 ± 0.0
Phe
1.559PheAla: 1.559 ± 0.418
0.65PheCys: 0.65 ± 0.192
2.468PheAsp: 2.468 ± 0.476
1.429PheGlu: 1.429 ± 0.405
0.65PhePhe: 0.65 ± 0.171
2.208PheGly: 2.208 ± 0.363
0.39PheHis: 0.39 ± 0.282
2.208PheIle: 2.208 ± 0.615
1.949PheLys: 1.949 ± 0.457
2.858PheLeu: 2.858 ± 0.689
1.299PheMet: 1.299 ± 0.313
1.299PheAsn: 1.299 ± 0.522
1.949PhePro: 1.949 ± 0.451
1.819PheGln: 1.819 ± 0.316
1.429PheArg: 1.429 ± 0.511
2.858PheSer: 2.858 ± 0.904
2.208PheThr: 2.208 ± 0.46
1.949PheVal: 1.949 ± 0.63
0.779PheTrp: 0.779 ± 0.338
0.909PheTyr: 0.909 ± 0.189
0.0PheXaa: 0.0 ± 0.0
Gly
5.586GlyAla: 5.586 ± 1.085
0.65GlyCys: 0.65 ± 0.308
2.728GlyAsp: 2.728 ± 0.626
1.429GlyGlu: 1.429 ± 0.498
1.299GlyPhe: 1.299 ± 0.257
2.208GlyGly: 2.208 ± 0.557
0.779GlyHis: 0.779 ± 0.28
3.248GlyIle: 3.248 ± 0.653
1.949GlyLys: 1.949 ± 0.729
5.326GlyLeu: 5.326 ± 0.84
1.819GlyMet: 1.819 ± 0.309
2.728GlyAsn: 2.728 ± 0.612
2.208GlyPro: 2.208 ± 0.572
2.338GlyGln: 2.338 ± 0.836
2.468GlyArg: 2.468 ± 0.721
3.248GlySer: 3.248 ± 0.663
3.507GlyThr: 3.507 ± 0.826
5.846GlyVal: 5.846 ± 0.36
0.909GlyTrp: 0.909 ± 0.34
1.949GlyTyr: 1.949 ± 0.567
0.0GlyXaa: 0.0 ± 0.0
His
1.819HisAla: 1.819 ± 0.373
0.39HisCys: 0.39 ± 0.291
0.909HisAsp: 0.909 ± 0.253
0.779HisGlu: 0.779 ± 0.356
0.65HisPhe: 0.65 ± 0.249
1.039HisGly: 1.039 ± 0.358
0.779HisHis: 0.779 ± 0.575
1.039HisIle: 1.039 ± 0.388
0.52HisLys: 0.52 ± 0.246
0.909HisLeu: 0.909 ± 0.266
0.52HisMet: 0.52 ± 0.262
0.52HisAsn: 0.52 ± 0.238
0.65HisPro: 0.65 ± 0.255
0.52HisGln: 0.52 ± 0.158
1.559HisArg: 1.559 ± 0.237
1.429HisSer: 1.429 ± 0.53
1.039HisThr: 1.039 ± 0.273
1.039HisVal: 1.039 ± 0.257
0.52HisTrp: 0.52 ± 0.169
1.039HisTyr: 1.039 ± 0.395
0.0HisXaa: 0.0 ± 0.0
Ile
3.507IleAla: 3.507 ± 0.655
0.52IleCys: 0.52 ± 0.22
3.378IleAsp: 3.378 ± 0.942
1.299IleGlu: 1.299 ± 0.418
2.468IlePhe: 2.468 ± 0.381
2.468IleGly: 2.468 ± 0.398
0.909IleHis: 0.909 ± 0.255
2.988IleIle: 2.988 ± 0.708
2.338IleLys: 2.338 ± 0.646
4.677IleLeu: 4.677 ± 0.63
2.208IleMet: 2.208 ± 0.571
3.637IleAsn: 3.637 ± 0.859
4.547IlePro: 4.547 ± 0.635
2.338IleGln: 2.338 ± 0.599
4.157IleArg: 4.157 ± 0.33
4.677IleSer: 4.677 ± 0.737
5.066IleThr: 5.066 ± 1.012
3.897IleVal: 3.897 ± 0.808
0.52IleTrp: 0.52 ± 0.272
1.039IleTyr: 1.039 ± 0.322
0.0IleXaa: 0.0 ± 0.0
Lys
3.378LysAla: 3.378 ± 0.441
0.779LysCys: 0.779 ± 0.407
2.988LysAsp: 2.988 ± 0.577
1.949LysGlu: 1.949 ± 0.561
0.779LysPhe: 0.779 ± 0.285
2.208LysGly: 2.208 ± 0.606
0.779LysHis: 0.779 ± 0.16
2.208LysIle: 2.208 ± 0.489
1.169LysLys: 1.169 ± 0.393
5.326LysLeu: 5.326 ± 1.3
0.52LysMet: 0.52 ± 0.208
1.299LysAsn: 1.299 ± 0.567
1.819LysPro: 1.819 ± 0.485
2.338LysGln: 2.338 ± 0.564
1.949LysArg: 1.949 ± 0.632
3.248LysSer: 3.248 ± 0.9
2.468LysThr: 2.468 ± 0.561
2.598LysVal: 2.598 ± 0.562
1.429LysTrp: 1.429 ± 0.337
1.299LysTyr: 1.299 ± 0.598
0.0LysXaa: 0.0 ± 0.0
Leu
8.184LeuAla: 8.184 ± 1.182
1.559LeuCys: 1.559 ± 0.541
7.145LeuAsp: 7.145 ± 0.812
6.365LeuGlu: 6.365 ± 1.435
3.248LeuPhe: 3.248 ± 0.502
3.897LeuGly: 3.897 ± 0.582
1.819LeuHis: 1.819 ± 0.504
3.767LeuIle: 3.767 ± 0.677
4.936LeuLys: 4.936 ± 1.61
7.145LeuLeu: 7.145 ± 1.225
2.988LeuMet: 2.988 ± 0.647
5.066LeuAsn: 5.066 ± 0.69
5.326LeuPro: 5.326 ± 0.359
3.248LeuGln: 3.248 ± 0.456
5.326LeuArg: 5.326 ± 0.687
9.353LeuSer: 9.353 ± 1.093
7.924LeuThr: 7.924 ± 0.92
4.157LeuVal: 4.157 ± 0.671
1.169LeuTrp: 1.169 ± 0.357
2.078LeuTyr: 2.078 ± 0.499
0.0LeuXaa: 0.0 ± 0.0
Met
2.598MetAla: 2.598 ± 0.831
0.39MetCys: 0.39 ± 0.165
1.559MetAsp: 1.559 ± 0.425
0.909MetGlu: 0.909 ± 0.32
0.909MetPhe: 0.909 ± 0.331
1.429MetGly: 1.429 ± 0.573
0.39MetHis: 0.39 ± 0.145
1.949MetIle: 1.949 ± 0.43
1.559MetLys: 1.559 ± 0.473
2.468MetLeu: 2.468 ± 0.496
0.909MetMet: 0.909 ± 0.364
1.559MetAsn: 1.559 ± 0.55
2.728MetPro: 2.728 ± 0.394
1.169MetGln: 1.169 ± 0.318
2.208MetArg: 2.208 ± 0.447
2.988MetSer: 2.988 ± 0.513
3.507MetThr: 3.507 ± 0.803
1.819MetVal: 1.819 ± 0.589
0.52MetTrp: 0.52 ± 0.228
1.559MetTyr: 1.559 ± 0.409
0.0MetXaa: 0.0 ± 0.0
Asn
4.027AsnAla: 4.027 ± 0.921
0.909AsnCys: 0.909 ± 0.252
2.988AsnAsp: 2.988 ± 0.457
2.078AsnGlu: 2.078 ± 0.673
1.689AsnPhe: 1.689 ± 0.532
3.118AsnGly: 3.118 ± 0.759
0.26AsnHis: 0.26 ± 0.186
3.118AsnIle: 3.118 ± 0.962
1.559AsnLys: 1.559 ± 0.458
4.547AsnLeu: 4.547 ± 0.766
0.909AsnMet: 0.909 ± 0.434
1.559AsnAsn: 1.559 ± 0.395
3.118AsnPro: 3.118 ± 0.712
1.949AsnGln: 1.949 ± 0.591
1.819AsnArg: 1.819 ± 0.517
2.468AsnSer: 2.468 ± 0.425
3.507AsnThr: 3.507 ± 0.437
3.248AsnVal: 3.248 ± 0.685
0.779AsnTrp: 0.779 ± 0.34
1.819AsnTyr: 1.819 ± 0.578
0.0AsnXaa: 0.0 ± 0.0
Pro
4.806ProAla: 4.806 ± 0.985
0.779ProCys: 0.779 ± 0.278
1.819ProAsp: 1.819 ± 0.372
2.078ProGlu: 2.078 ± 0.724
2.208ProPhe: 2.208 ± 0.618
2.988ProGly: 2.988 ± 0.687
0.65ProHis: 0.65 ± 0.302
3.248ProIle: 3.248 ± 0.526
1.819ProLys: 1.819 ± 0.458
6.755ProLeu: 6.755 ± 0.641
1.819ProMet: 1.819 ± 0.387
2.208ProAsn: 2.208 ± 0.575
3.378ProPro: 3.378 ± 0.805
2.338ProGln: 2.338 ± 0.562
2.858ProArg: 2.858 ± 0.789
5.066ProSer: 5.066 ± 0.685
4.677ProThr: 4.677 ± 1.347
3.118ProVal: 3.118 ± 0.468
1.169ProTrp: 1.169 ± 0.277
2.468ProTyr: 2.468 ± 0.585
0.0ProXaa: 0.0 ± 0.0
Gln
3.118GlnAla: 3.118 ± 0.652
0.65GlnCys: 0.65 ± 0.377
2.208GlnAsp: 2.208 ± 0.524
1.559GlnGlu: 1.559 ± 0.526
1.039GlnPhe: 1.039 ± 0.347
1.949GlnGly: 1.949 ± 0.47
0.52GlnHis: 0.52 ± 0.186
2.078GlnIle: 2.078 ± 0.628
1.559GlnLys: 1.559 ± 0.349
5.196GlnLeu: 5.196 ± 0.868
2.078GlnMet: 2.078 ± 0.681
1.689GlnAsn: 1.689 ± 0.568
1.949GlnPro: 1.949 ± 0.492
1.689GlnGln: 1.689 ± 0.398
2.728GlnArg: 2.728 ± 0.852
2.598GlnSer: 2.598 ± 0.576
4.417GlnThr: 4.417 ± 0.619
2.988GlnVal: 2.988 ± 0.398
1.039GlnTrp: 1.039 ± 0.337
1.299GlnTyr: 1.299 ± 0.523
0.0GlnXaa: 0.0 ± 0.0
Arg
5.586ArgAla: 5.586 ± 0.833
0.39ArgCys: 0.39 ± 0.341
3.118ArgAsp: 3.118 ± 0.644
2.598ArgGlu: 2.598 ± 0.491
2.078ArgPhe: 2.078 ± 0.559
2.468ArgGly: 2.468 ± 0.661
1.169ArgHis: 1.169 ± 0.578
3.507ArgIle: 3.507 ± 0.539
1.299ArgLys: 1.299 ± 0.539
5.326ArgLeu: 5.326 ± 1.028
1.689ArgMet: 1.689 ± 0.255
2.598ArgAsn: 2.598 ± 0.275
2.338ArgPro: 2.338 ± 0.417
2.208ArgGln: 2.208 ± 0.608
3.248ArgArg: 3.248 ± 0.773
3.637ArgSer: 3.637 ± 0.576
2.858ArgThr: 2.858 ± 0.747
5.716ArgVal: 5.716 ± 0.755
1.559ArgTrp: 1.559 ± 0.292
2.728ArgTyr: 2.728 ± 0.557
0.0ArgXaa: 0.0 ± 0.0
Ser
4.806SerAla: 4.806 ± 0.644
0.779SerCys: 0.779 ± 0.238
3.248SerAsp: 3.248 ± 0.471
3.767SerGlu: 3.767 ± 0.695
1.949SerPhe: 1.949 ± 0.525
4.547SerGly: 4.547 ± 0.907
1.429SerHis: 1.429 ± 0.401
4.287SerIle: 4.287 ± 0.743
3.897SerLys: 3.897 ± 0.806
7.534SerLeu: 7.534 ± 0.938
2.598SerMet: 2.598 ± 0.54
3.897SerAsn: 3.897 ± 0.331
4.547SerPro: 4.547 ± 0.836
3.118SerGln: 3.118 ± 0.638
4.936SerArg: 4.936 ± 0.841
6.365SerSer: 6.365 ± 0.734
6.235SerThr: 6.235 ± 0.875
5.976SerVal: 5.976 ± 0.668
0.909SerTrp: 0.909 ± 0.241
2.338SerTyr: 2.338 ± 0.715
0.0SerXaa: 0.0 ± 0.0
Thr
5.456ThrAla: 5.456 ± 0.819
0.52ThrCys: 0.52 ± 0.238
4.027ThrAsp: 4.027 ± 0.803
4.287ThrGlu: 4.287 ± 0.865
2.208ThrPhe: 2.208 ± 0.496
4.677ThrGly: 4.677 ± 0.914
1.299ThrHis: 1.299 ± 0.488
3.378ThrIle: 3.378 ± 0.771
2.858ThrLys: 2.858 ± 0.418
5.586ThrLeu: 5.586 ± 0.872
2.598ThrMet: 2.598 ± 0.87
3.118ThrAsn: 3.118 ± 0.899
4.027ThrPro: 4.027 ± 0.934
3.118ThrGln: 3.118 ± 0.485
2.598ThrArg: 2.598 ± 0.638
6.365ThrSer: 6.365 ± 1.068
5.586ThrThr: 5.586 ± 1.343
6.365ThrVal: 6.365 ± 1.02
1.299ThrTrp: 1.299 ± 0.461
3.248ThrTyr: 3.248 ± 0.617
0.0ThrXaa: 0.0 ± 0.0
Val
5.976ValAla: 5.976 ± 0.926
0.65ValCys: 0.65 ± 0.211
5.326ValAsp: 5.326 ± 0.773
3.507ValGlu: 3.507 ± 0.822
2.208ValPhe: 2.208 ± 0.475
4.547ValGly: 4.547 ± 0.684
1.169ValHis: 1.169 ± 0.316
3.897ValIle: 3.897 ± 0.963
2.468ValLys: 2.468 ± 0.28
6.495ValLeu: 6.495 ± 0.758
2.078ValMet: 2.078 ± 0.404
4.287ValAsn: 4.287 ± 0.988
5.586ValPro: 5.586 ± 0.695
3.118ValGln: 3.118 ± 0.501
4.157ValArg: 4.157 ± 0.701
5.196ValSer: 5.196 ± 0.59
3.507ValThr: 3.507 ± 0.492
4.936ValVal: 4.936 ± 0.865
0.65ValTrp: 0.65 ± 0.46
1.949ValTyr: 1.949 ± 0.534
0.0ValXaa: 0.0 ± 0.0
Trp
1.039TrpAla: 1.039 ± 0.303
0.13TrpCys: 0.13 ± 0.133
0.909TrpAsp: 0.909 ± 0.259
0.909TrpGlu: 0.909 ± 0.328
0.52TrpPhe: 0.52 ± 0.297
0.13TrpGly: 0.13 ± 0.14
0.26TrpHis: 0.26 ± 0.203
1.169TrpIle: 1.169 ± 0.54
0.909TrpLys: 0.909 ± 0.482
1.429TrpLeu: 1.429 ± 0.438
1.169TrpMet: 1.169 ± 0.439
1.169TrpAsn: 1.169 ± 0.336
0.779TrpPro: 0.779 ± 0.275
1.039TrpGln: 1.039 ± 0.44
1.559TrpArg: 1.559 ± 0.304
0.52TrpSer: 0.52 ± 0.209
0.779TrpThr: 0.779 ± 0.346
0.65TrpVal: 0.65 ± 0.226
0.0TrpTrp: 0.0 ± 0.0
1.039TrpTyr: 1.039 ± 0.206
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.208TyrAla: 2.208 ± 0.568
0.26TyrCys: 0.26 ± 0.209
2.988TyrAsp: 2.988 ± 0.597
1.039TyrGlu: 1.039 ± 0.365
1.949TyrPhe: 1.949 ± 0.8
2.728TyrGly: 2.728 ± 0.776
0.909TyrHis: 0.909 ± 0.431
2.988TyrIle: 2.988 ± 0.535
1.169TyrLys: 1.169 ± 0.346
4.287TyrLeu: 4.287 ± 0.79
0.52TyrMet: 0.52 ± 0.237
1.299TyrAsn: 1.299 ± 0.333
1.949TyrPro: 1.949 ± 0.498
1.169TyrGln: 1.169 ± 0.439
2.078TyrArg: 2.078 ± 0.603
1.429TyrSer: 1.429 ± 0.36
2.468TyrThr: 2.468 ± 0.464
2.728TyrVal: 2.728 ± 0.921
0.13TyrTrp: 0.13 ± 0.097
1.429TyrTyr: 1.429 ± 0.398
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (7699 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski