Amino acid dipepetide frequency for Paraburkholderia humisilvae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.108AlaAla: 17.108 ± 0.134	1.351AlaCys: 1.351 ± 0.027	6.478AlaAsp: 6.478 ± 0.062	5.549AlaGlu: 5.549 ± 0.052	4.269AlaPhe: 4.269 ± 0.043	10.08AlaGly: 10.08 ± 0.08	3.103AlaHis: 3.103 ± 0.03	5.71AlaIle: 5.71 ± 0.056	3.494AlaLys: 3.494 ± 0.044	13.727AlaLeu: 13.727 ± 0.109	3.086AlaMet: 3.086 ± 0.04	3.419AlaAsn: 3.419 ± 0.046	5.884AlaPro: 5.884 ± 0.06	5.701AlaGln: 5.701 ± 0.058	9.3AlaArg: 9.3 ± 0.079	7.6AlaSer: 7.6 ± 0.062	6.552AlaThr: 6.552 ± 0.063	8.603AlaVal: 8.603 ± 0.069	1.707AlaTrp: 1.707 ± 0.027	2.636AlaTyr: 2.636 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	1.349CysAla: 1.349 ± 0.025	0.162CysCys: 0.162 ± 0.009	0.571CysAsp: 0.571 ± 0.015	0.515CysGlu: 0.515 ± 0.015	0.337CysPhe: 0.337 ± 0.011	1.026CysGly: 1.026 ± 0.023	0.266CysHis: 0.266 ± 0.009	0.443CysIle: 0.443 ± 0.013	0.242CysLys: 0.242 ± 0.009	0.826CysLeu: 0.826 ± 0.021	0.215CysMet: 0.215 ± 0.009	0.253CysAsn: 0.253 ± 0.012	0.456CysPro: 0.456 ± 0.014	0.244CysGln: 0.244 ± 0.009	0.684CysArg: 0.684 ± 0.018	0.564CysSer: 0.564 ± 0.015	0.509CysThr: 0.509 ± 0.015	0.852CysVal: 0.852 ± 0.021	0.125CysTrp: 0.125 ± 0.007	0.236CysTyr: 0.236 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.973AspAla: 7.973 ± 0.073	0.483AspCys: 0.483 ± 0.012	3.17AspAsp: 3.17 ± 0.041	3.363AspGlu: 3.363 ± 0.042	1.923AspPhe: 1.923 ± 0.028	4.687AspGly: 4.687 ± 0.047	1.19AspHis: 1.19 ± 0.023	2.595AspIle: 2.595 ± 0.03	1.487AspLys: 1.487 ± 0.028	5.177AspLeu: 5.177 ± 0.047	1.169AspMet: 1.169 ± 0.022	1.395AspAsn: 1.395 ± 0.028	3.015AspPro: 3.015 ± 0.034	1.671AspGln: 1.671 ± 0.026	3.516AspArg: 3.516 ± 0.042	2.675AspSer: 2.675 ± 0.03	3.003AspThr: 3.003 ± 0.033	4.416AspVal: 4.416 ± 0.04	0.899AspTrp: 0.899 ± 0.019	1.451AspTyr: 1.451 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	5.962GluAla: 5.962 ± 0.059	0.412GluCys: 0.412 ± 0.013	2.014GluAsp: 2.014 ± 0.034	2.173GluGlu: 2.173 ± 0.04	1.768GluPhe: 1.768 ± 0.033	3.089GluGly: 3.089 ± 0.038	1.481GluHis: 1.481 ± 0.027	2.638GluIle: 2.638 ± 0.031	1.666GluLys: 1.666 ± 0.03	5.353GluLeu: 5.353 ± 0.049	1.203GluMet: 1.203 ± 0.023	1.321GluAsn: 1.321 ± 0.022	2.487GluPro: 2.487 ± 0.035	2.48GluGln: 2.48 ± 0.032	4.915GluArg: 4.915 ± 0.058	2.625GluSer: 2.625 ± 0.038	2.735GluThr: 2.735 ± 0.04	3.326GluVal: 3.326 ± 0.037	0.737GluTrp: 0.737 ± 0.019	1.116GluTyr: 1.116 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	4.681PheAla: 4.681 ± 0.044	0.423PheCys: 0.423 ± 0.013	2.748PheAsp: 2.748 ± 0.031	1.982PheGlu: 1.982 ± 0.029	1.387PhePhe: 1.387 ± 0.026	3.558PheGly: 3.558 ± 0.04	0.768PheHis: 0.768 ± 0.017	1.628PheIle: 1.628 ± 0.028	0.949PheLys: 0.949 ± 0.019	2.836PheLeu: 2.836 ± 0.035	0.756PheMet: 0.756 ± 0.017	1.215PheAsn: 1.215 ± 0.022	1.533PhePro: 1.533 ± 0.027	0.953PheGln: 0.953 ± 0.018	2.134PheArg: 2.134 ± 0.029	2.311PheSer: 2.311 ± 0.033	1.979PheThr: 1.979 ± 0.034	3.079PheVal: 3.079 ± 0.033	0.469PheTrp: 0.469 ± 0.013	0.932PheTyr: 0.932 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	9.244GlyAla: 9.244 ± 0.08	0.86GlyCys: 0.86 ± 0.017	4.048GlyAsp: 4.048 ± 0.041	3.961GlyGlu: 3.961 ± 0.049	3.296GlyPhe: 3.296 ± 0.034	6.444GlyGly: 6.444 ± 0.091	1.894GlyHis: 1.894 ± 0.025	4.174GlyIle: 4.174 ± 0.041	3.079GlyLys: 3.079 ± 0.041	7.549GlyLeu: 7.549 ± 0.064	2.117GlyMet: 2.117 ± 0.029	2.462GlyAsn: 2.462 ± 0.042	2.951GlyPro: 2.951 ± 0.036	2.743GlyGln: 2.743 ± 0.039	5.193GlyArg: 5.193 ± 0.051	4.763GlySer: 4.763 ± 0.058	4.751GlyThr: 4.751 ± 0.064	6.382GlyVal: 6.382 ± 0.055	1.303GlyTrp: 1.303 ± 0.025	2.308GlyTyr: 2.308 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	3.32HisAla: 3.32 ± 0.037	0.289HisCys: 0.289 ± 0.011	1.42HisAsp: 1.42 ± 0.027	1.277HisGlu: 1.277 ± 0.022	0.969HisPhe: 0.969 ± 0.022	2.245HisGly: 2.245 ± 0.03	0.699HisHis: 0.699 ± 0.018	0.994HisIle: 0.994 ± 0.019	0.558HisLys: 0.558 ± 0.018	2.23HisLeu: 2.23 ± 0.032	0.513HisMet: 0.513 ± 0.014	0.555HisAsn: 0.555 ± 0.015	1.468HisPro: 1.468 ± 0.026	0.721HisGln: 0.721 ± 0.017	1.718HisArg: 1.718 ± 0.027	1.177HisSer: 1.177 ± 0.02	1.216HisThr: 1.216 ± 0.024	1.794HisVal: 1.794 ± 0.026	0.409HisTrp: 0.409 ± 0.013	0.698HisTyr: 0.698 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	6.969IleAla: 6.969 ± 0.064	0.457IleCys: 0.457 ± 0.013	3.636IleAsp: 3.636 ± 0.039	3.291IleGlu: 3.291 ± 0.036	1.426IlePhe: 1.426 ± 0.025	4.653IleGly: 4.653 ± 0.049	0.954IleHis: 0.954 ± 0.019	1.627IleIle: 1.627 ± 0.027	1.337IleLys: 1.337 ± 0.023	3.273IleLeu: 3.273 ± 0.043	0.723IleMet: 0.723 ± 0.017	1.497IleAsn: 1.497 ± 0.028	2.085IlePro: 2.085 ± 0.029	1.244IleGln: 1.244 ± 0.024	2.992IleArg: 2.992 ± 0.036	2.598IleSer: 2.598 ± 0.029	2.417IleThr: 2.417 ± 0.032	4.353IleVal: 4.353 ± 0.042	0.543IleTrp: 0.543 ± 0.016	0.998IleTyr: 0.998 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	3.42LysAla: 3.42 ± 0.047	0.187LysCys: 0.187 ± 0.008	1.502LysAsp: 1.502 ± 0.029	1.365LysGlu: 1.365 ± 0.026	0.877LysPhe: 0.877 ± 0.019	2.061LysGly: 2.061 ± 0.03	0.692LysHis: 0.692 ± 0.017	1.504LysIle: 1.504 ± 0.027	1.167LysLys: 1.167 ± 0.027	3.209LysLeu: 3.209 ± 0.042	0.74LysMet: 0.74 ± 0.017	0.861LysAsn: 0.861 ± 0.022	1.895LysPro: 1.895 ± 0.031	1.246LysGln: 1.246 ± 0.025	2.457LysArg: 2.457 ± 0.037	1.751LysSer: 1.751 ± 0.027	1.804LysThr: 1.804 ± 0.03	2.21LysVal: 2.21 ± 0.034	0.379LysTrp: 0.379 ± 0.012	0.696LysTyr: 0.696 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	13.151LeuAla: 13.151 ± 0.1	1.086LeuCys: 1.086 ± 0.021	5.836LeuAsp: 5.836 ± 0.053	4.88LeuGlu: 4.88 ± 0.052	3.553LeuPhe: 3.553 ± 0.043	7.376LeuGly: 7.376 ± 0.06	2.381LeuHis: 2.381 ± 0.034	4.658LeuIle: 4.658 ± 0.05	3.266LeuLys: 3.266 ± 0.041	9.669LeuLeu: 9.669 ± 0.085	2.252LeuMet: 2.252 ± 0.029	2.978LeuAsn: 2.978 ± 0.038	5.76LeuPro: 5.76 ± 0.055	3.467LeuGln: 3.467 ± 0.035	7.281LeuArg: 7.281 ± 0.067	6.257LeuSer: 6.257 ± 0.049	5.724LeuThr: 5.724 ± 0.055	7.168LeuVal: 7.168 ± 0.054	1.123LeuTrp: 1.123 ± 0.024	2.195LeuTyr: 2.195 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.311MetAla: 2.311 ± 0.027	0.189MetCys: 0.189 ± 0.008	0.935MetAsp: 0.935 ± 0.02	0.88MetGlu: 0.88 ± 0.02	0.728MetPhe: 0.728 ± 0.018	1.358MetGly: 1.358 ± 0.024	0.603MetHis: 0.603 ± 0.014	1.103MetIle: 1.103 ± 0.025	1.029MetLys: 1.029 ± 0.022	2.691MetLeu: 2.691 ± 0.038	0.578MetMet: 0.578 ± 0.016	0.937MetAsn: 0.937 ± 0.021	1.483MetPro: 1.483 ± 0.026	1.001MetGln: 1.001 ± 0.021	1.925MetArg: 1.925 ± 0.032	1.774MetSer: 1.774 ± 0.025	1.633MetThr: 1.633 ± 0.028	1.457MetVal: 1.457 ± 0.026	0.216MetTrp: 0.216 ± 0.009	0.405MetTyr: 0.405 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.692AsnAla: 3.692 ± 0.05	0.276AsnCys: 0.276 ± 0.01	1.587AsnAsp: 1.587 ± 0.025	1.409AsnGlu: 1.409 ± 0.024	0.97AsnPhe: 0.97 ± 0.02	2.824AsnGly: 2.824 ± 0.051	0.574AsnHis: 0.574 ± 0.016	1.255AsnIle: 1.255 ± 0.022	0.655AsnLys: 0.655 ± 0.018	2.78AsnLeu: 2.78 ± 0.035	0.575AsnMet: 0.575 ± 0.015	0.92AsnAsn: 0.92 ± 0.025	1.887AsnPro: 1.887 ± 0.031	0.99AsnGln: 0.99 ± 0.023	2.021AsnArg: 2.021 ± 0.028	1.528AsnSer: 1.528 ± 0.036	1.628AsnThr: 1.628 ± 0.031	2.361AsnVal: 2.361 ± 0.039	0.422AsnTrp: 0.422 ± 0.013	0.736AsnTyr: 0.736 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	6.648ProAla: 6.648 ± 0.066	0.392ProCys: 0.392 ± 0.012	3.496ProAsp: 3.496 ± 0.041	2.825ProGlu: 2.825 ± 0.037	1.914ProPhe: 1.914 ± 0.025	4.199ProGly: 4.199 ± 0.044	1.336ProHis: 1.336 ± 0.025	2.079ProIle: 2.079 ± 0.032	1.341ProLys: 1.341 ± 0.025	5.11ProLeu: 5.11 ± 0.051	1.096ProMet: 1.096 ± 0.021	1.465ProAsn: 1.465 ± 0.024	2.703ProPro: 2.703 ± 0.052	1.976ProGln: 1.976 ± 0.031	3.058ProArg: 3.058 ± 0.036	3.044ProSer: 3.044 ± 0.043	2.694ProThr: 2.694 ± 0.037	4.398ProVal: 4.398 ± 0.041	0.634ProTrp: 0.634 ± 0.016	1.249ProTyr: 1.249 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	4.486GlnAla: 4.486 ± 0.049	0.322GlnCys: 0.322 ± 0.011	1.427GlnAsp: 1.427 ± 0.021	1.333GlnGlu: 1.333 ± 0.021	1.321GlnPhe: 1.321 ± 0.022	2.408GlnGly: 2.408 ± 0.03	1.022GlnHis: 1.022 ± 0.021	2.005GlnIle: 2.005 ± 0.03	1.1GlnLys: 1.1 ± 0.021	3.921GlnLeu: 3.921 ± 0.042	1.016GlnMet: 1.016 ± 0.02	1.008GlnAsn: 1.008 ± 0.024	2.208GlnPro: 2.208 ± 0.037	2.043GlnGln: 2.043 ± 0.036	3.179GlnArg: 3.179 ± 0.041	2.245GlnSer: 2.245 ± 0.029	2.198GlnThr: 2.198 ± 0.03	2.607GlnVal: 2.607 ± 0.037	0.587GlnTrp: 0.587 ± 0.017	0.962GlnTyr: 0.962 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.489ArgAla: 8.489 ± 0.061	0.703ArgCys: 0.703 ± 0.02	4.094ArgAsp: 4.094 ± 0.043	4.179ArgGlu: 4.179 ± 0.049	3.015ArgPhe: 3.015 ± 0.035	4.731ArgGly: 4.731 ± 0.043	2.061ArgHis: 2.061 ± 0.033	3.761ArgIle: 3.761 ± 0.045	2.241ArgLys: 2.241 ± 0.035	7.324ArgLeu: 7.324 ± 0.065	1.914ArgMet: 1.914 ± 0.027	2.079ArgAsn: 2.079 ± 0.029	3.23ArgPro: 3.23 ± 0.042	2.692ArgGln: 2.692 ± 0.034	5.761ArgArg: 5.761 ± 0.071	3.921ArgSer: 3.921 ± 0.041	3.735ArgThr: 3.735 ± 0.037	5.403ArgVal: 5.403 ± 0.054	1.122ArgTrp: 1.122 ± 0.022	2.1ArgTyr: 2.1 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	7.177SerAla: 7.177 ± 0.062	0.553SerCys: 0.553 ± 0.015	3.075SerAsp: 3.075 ± 0.037	2.555SerGlu: 2.555 ± 0.035	2.234SerPhe: 2.234 ± 0.03	5.645SerGly: 5.645 ± 0.067	1.297SerHis: 1.297 ± 0.022	2.906SerIle: 2.906 ± 0.034	1.613SerLys: 1.613 ± 0.029	5.802SerLeu: 5.802 ± 0.051	1.466SerMet: 1.466 ± 0.025	1.809SerAsn: 1.809 ± 0.031	2.956SerPro: 2.956 ± 0.035	1.955SerGln: 1.955 ± 0.028	3.904SerArg: 3.904 ± 0.037	3.723SerSer: 3.723 ± 0.05	3.503SerThr: 3.503 ± 0.047	4.553SerVal: 4.553 ± 0.045	0.749SerTrp: 0.749 ± 0.019	1.348SerTyr: 1.348 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	6.099ThrAla: 6.099 ± 0.056	0.493ThrCys: 0.493 ± 0.015	2.803ThrAsp: 2.803 ± 0.036	2.284ThrGlu: 2.284 ± 0.033	2.004ThrPhe: 2.004 ± 0.028	4.811ThrGly: 4.811 ± 0.049	1.359ThrHis: 1.359 ± 0.023	2.72ThrIle: 2.72 ± 0.038	1.331ThrLys: 1.331 ± 0.024	6.479ThrLeu: 6.479 ± 0.056	1.193ThrMet: 1.193 ± 0.023	1.515ThrAsn: 1.515 ± 0.033	3.621ThrPro: 3.621 ± 0.039	2.133ThrGln: 2.133 ± 0.034	3.898ThrArg: 3.898 ± 0.046	3.305ThrSer: 3.305 ± 0.045	3.107ThrThr: 3.107 ± 0.047	4.583ThrVal: 4.583 ± 0.064	0.719ThrTrp: 0.719 ± 0.021	1.325ThrTyr: 1.325 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	9.361ValAla: 9.361 ± 0.068	0.814ValCys: 0.814 ± 0.019	4.421ValAsp: 4.421 ± 0.044	3.967ValGlu: 3.967 ± 0.039	2.782ValPhe: 2.782 ± 0.034	5.41ValGly: 5.41 ± 0.053	1.652ValHis: 1.652 ± 0.026	3.705ValIle: 3.705 ± 0.043	2.434ValLys: 2.434 ± 0.033	7.769ValLeu: 7.769 ± 0.069	1.817ValMet: 1.817 ± 0.029	2.318ValAsn: 2.318 ± 0.034	4.08ValPro: 4.08 ± 0.043	2.531ValGln: 2.531 ± 0.028	5.296ValArg: 5.296 ± 0.053	4.765ValSer: 4.765 ± 0.051	4.593ValThr: 4.593 ± 0.049	6.129ValVal: 6.129 ± 0.068	0.971ValTrp: 0.971 ± 0.022	1.657ValTyr: 1.657 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.18TrpAla: 1.18 ± 0.022	0.157TrpCys: 0.157 ± 0.008	0.599TrpAsp: 0.599 ± 0.014	0.491TrpGlu: 0.491 ± 0.015	0.551TrpPhe: 0.551 ± 0.016	0.822TrpGly: 0.822 ± 0.018	0.411TrpHis: 0.411 ± 0.012	0.705TrpIle: 0.705 ± 0.018	0.428TrpLys: 0.428 ± 0.012	1.82TrpLeu: 1.82 ± 0.027	0.371TrpMet: 0.371 ± 0.012	0.458TrpAsn: 0.458 ± 0.016	0.676TrpPro: 0.676 ± 0.018	0.681TrpGln: 0.681 ± 0.013	1.275TrpArg: 1.275 ± 0.022	0.888TrpSer: 0.888 ± 0.019	0.749TrpThr: 0.749 ± 0.02	0.922TrpVal: 0.922 ± 0.019	0.212TrpTrp: 0.212 ± 0.01	0.32TrpTyr: 0.32 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.736TyrAla: 2.736 ± 0.032	0.266TyrCys: 0.266 ± 0.01	1.4TyrAsp: 1.4 ± 0.028	1.223TyrGlu: 1.223 ± 0.021	0.995TyrPhe: 0.995 ± 0.018	2.094TyrGly: 2.094 ± 0.033	0.529TyrHis: 0.529 ± 0.014	0.865TyrIle: 0.865 ± 0.022	0.608TyrLys: 0.608 ± 0.016	2.515TyrLeu: 2.515 ± 0.033	0.436TyrMet: 0.436 ± 0.014	0.624TyrAsn: 0.624 ± 0.017	1.277TyrPro: 1.277 ± 0.021	0.924TyrGln: 0.924 ± 0.02	2.05TyrArg: 2.05 ± 0.028	1.308TyrSer: 1.308 ± 0.023	1.253TyrThr: 1.253 ± 0.024	1.877TyrVal: 1.877 ± 0.03	0.39TyrTrp: 0.39 ± 0.014	0.638TyrTyr: 0.638 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8698 proteins (2609239 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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