Amino acid dipepetide frequency for Edwardsiella phage MSW-3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.19AlaAla: 13.19 ± 1.667
1.027AlaCys: 1.027 ± 0.245
6.556AlaAsp: 6.556 ± 1.191
5.45AlaGlu: 5.45 ± 0.606
3.08AlaPhe: 3.08 ± 0.511
7.898AlaGly: 7.898 ± 0.989
1.343AlaHis: 1.343 ± 0.361
4.028AlaIle: 4.028 ± 0.54
4.265AlaLys: 4.265 ± 0.715
6.871AlaLeu: 6.871 ± 0.608
2.843AlaMet: 2.843 ± 0.504
4.423AlaAsn: 4.423 ± 0.981
5.45AlaPro: 5.45 ± 1.26
4.028AlaGln: 4.028 ± 0.671
5.371AlaArg: 5.371 ± 0.696
5.608AlaSer: 5.608 ± 0.629
6.477AlaThr: 6.477 ± 1.016
6.161AlaVal: 6.161 ± 0.765
1.501AlaTrp: 1.501 ± 0.384
3.159AlaTyr: 3.159 ± 0.486
0.0AlaXaa: 0.0 ± 0.0
Cys
1.027CysAla: 1.027 ± 0.298
0.079CysCys: 0.079 ± 0.084
1.185CysAsp: 1.185 ± 0.343
0.869CysGlu: 0.869 ± 0.325
0.553CysPhe: 0.553 ± 0.189
1.501CysGly: 1.501 ± 0.43
0.553CysHis: 0.553 ± 0.174
0.395CysIle: 0.395 ± 0.162
0.79CysLys: 0.79 ± 0.242
0.316CysLeu: 0.316 ± 0.16
0.237CysMet: 0.237 ± 0.116
0.711CysAsn: 0.711 ± 0.216
0.395CysPro: 0.395 ± 0.181
0.79CysGln: 0.79 ± 0.247
1.422CysArg: 1.422 ± 0.363
0.553CysSer: 0.553 ± 0.194
0.711CysThr: 0.711 ± 0.202
1.343CysVal: 1.343 ± 0.364
0.237CysTrp: 0.237 ± 0.129
0.395CysTyr: 0.395 ± 0.19
0.0CysXaa: 0.0 ± 0.0
Asp
8.451AspAla: 8.451 ± 0.958
0.79AspCys: 0.79 ± 0.285
3.475AspAsp: 3.475 ± 0.571
4.344AspGlu: 4.344 ± 0.793
2.843AspPhe: 2.843 ± 0.437
5.687AspGly: 5.687 ± 0.644
1.422AspHis: 1.422 ± 0.263
4.344AspIle: 4.344 ± 0.56
3.159AspLys: 3.159 ± 0.505
5.45AspLeu: 5.45 ± 1.098
1.106AspMet: 1.106 ± 0.353
2.133AspAsn: 2.133 ± 0.366
3.317AspPro: 3.317 ± 0.529
1.343AspGln: 1.343 ± 0.322
3.238AspArg: 3.238 ± 0.494
2.606AspSer: 2.606 ± 0.546
2.606AspThr: 2.606 ± 0.426
5.766AspVal: 5.766 ± 0.628
1.659AspTrp: 1.659 ± 0.304
1.58AspTyr: 1.58 ± 0.303
0.0AspXaa: 0.0 ± 0.0
Glu
4.897GluAla: 4.897 ± 0.767
0.948GluCys: 0.948 ± 0.226
1.896GluAsp: 1.896 ± 0.551
3.554GluGlu: 3.554 ± 0.592
2.133GluPhe: 2.133 ± 0.397
3.001GluGly: 3.001 ± 0.374
1.422GluHis: 1.422 ± 0.283
4.107GluIle: 4.107 ± 0.539
2.448GluLys: 2.448 ± 0.512
5.45GluLeu: 5.45 ± 0.74
1.659GluMet: 1.659 ± 0.38
1.264GluAsn: 1.264 ± 0.342
1.501GluPro: 1.501 ± 0.392
3.712GluGln: 3.712 ± 0.756
3.554GluArg: 3.554 ± 0.476
3.238GluSer: 3.238 ± 0.621
2.448GluThr: 2.448 ± 0.39
3.712GluVal: 3.712 ± 0.801
1.185GluTrp: 1.185 ± 0.286
2.369GluTyr: 2.369 ± 0.431
0.0GluXaa: 0.0 ± 0.0
Phe
2.29PheAla: 2.29 ± 0.484
0.395PheCys: 0.395 ± 0.175
2.054PheAsp: 2.054 ± 0.401
2.527PheGlu: 2.527 ± 0.453
0.948PhePhe: 0.948 ± 0.302
2.606PheGly: 2.606 ± 0.45
0.395PheHis: 0.395 ± 0.186
1.896PheIle: 1.896 ± 0.354
2.448PheLys: 2.448 ± 0.388
1.501PheLeu: 1.501 ± 0.355
0.948PheMet: 0.948 ± 0.268
2.29PheAsn: 2.29 ± 0.401
1.659PhePro: 1.659 ± 0.362
0.711PheGln: 0.711 ± 0.243
2.212PheArg: 2.212 ± 0.468
2.448PheSer: 2.448 ± 0.344
2.764PheThr: 2.764 ± 0.388
2.448PheVal: 2.448 ± 0.389
0.395PheTrp: 0.395 ± 0.162
1.738PheTyr: 1.738 ± 0.33
0.0PheXaa: 0.0 ± 0.0
Gly
8.451GlyAla: 8.451 ± 1.124
1.185GlyCys: 1.185 ± 0.319
5.608GlyAsp: 5.608 ± 0.715
4.897GlyGlu: 4.897 ± 0.691
2.133GlyPhe: 2.133 ± 0.421
6.793GlyGly: 6.793 ± 1.243
1.738GlyHis: 1.738 ± 0.342
3.238GlyIle: 3.238 ± 0.46
5.134GlyLys: 5.134 ± 0.77
5.529GlyLeu: 5.529 ± 0.613
2.133GlyMet: 2.133 ± 0.473
2.843GlyAsn: 2.843 ± 0.6
1.185GlyPro: 1.185 ± 0.335
2.369GlyGln: 2.369 ± 0.456
3.001GlyArg: 3.001 ± 0.559
3.949GlySer: 3.949 ± 0.645
5.292GlyThr: 5.292 ± 0.814
6.871GlyVal: 6.871 ± 0.771
1.817GlyTrp: 1.817 ± 0.364
2.843GlyTyr: 2.843 ± 0.493
0.0GlyXaa: 0.0 ± 0.0
His
1.817HisAla: 1.817 ± 0.406
0.237HisCys: 0.237 ± 0.176
1.185HisAsp: 1.185 ± 0.222
0.711HisGlu: 0.711 ± 0.214
1.343HisPhe: 1.343 ± 0.302
1.343HisGly: 1.343 ± 0.294
0.474HisHis: 0.474 ± 0.201
1.185HisIle: 1.185 ± 0.345
0.948HisLys: 0.948 ± 0.235
1.027HisLeu: 1.027 ± 0.338
0.395HisMet: 0.395 ± 0.172
0.711HisAsn: 0.711 ± 0.222
0.711HisPro: 0.711 ± 0.209
0.395HisGln: 0.395 ± 0.17
1.422HisArg: 1.422 ± 0.38
0.869HisSer: 0.869 ± 0.189
1.106HisThr: 1.106 ± 0.271
1.975HisVal: 1.975 ± 0.399
0.474HisTrp: 0.474 ± 0.149
0.316HisTyr: 0.316 ± 0.153
0.0HisXaa: 0.0 ± 0.0
Ile
4.739IleAla: 4.739 ± 0.488
0.474IleCys: 0.474 ± 0.181
3.712IleAsp: 3.712 ± 0.544
2.764IleGlu: 2.764 ± 0.482
1.343IlePhe: 1.343 ± 0.287
4.265IleGly: 4.265 ± 0.55
1.58IleHis: 1.58 ± 0.39
2.606IleIle: 2.606 ± 0.398
2.369IleLys: 2.369 ± 0.358
2.764IleLeu: 2.764 ± 0.441
0.869IleMet: 0.869 ± 0.296
3.159IleAsn: 3.159 ± 0.481
2.764IlePro: 2.764 ± 0.479
1.817IleGln: 1.817 ± 0.54
2.843IleArg: 2.843 ± 0.513
2.448IleSer: 2.448 ± 0.298
5.134IleThr: 5.134 ± 0.597
4.028IleVal: 4.028 ± 0.556
0.474IleTrp: 0.474 ± 0.179
1.738IleTyr: 1.738 ± 0.331
0.0IleXaa: 0.0 ± 0.0
Lys
3.712LysAla: 3.712 ± 0.583
0.948LysCys: 0.948 ± 0.21
2.764LysAsp: 2.764 ± 0.444
1.501LysGlu: 1.501 ± 0.361
1.343LysPhe: 1.343 ± 0.291
3.317LysGly: 3.317 ± 0.462
0.948LysHis: 0.948 ± 0.346
2.29LysIle: 2.29 ± 0.415
2.054LysLys: 2.054 ± 0.373
4.818LysLeu: 4.818 ± 0.588
2.133LysMet: 2.133 ± 0.369
2.369LysAsn: 2.369 ± 0.408
2.29LysPro: 2.29 ± 0.403
1.264LysGln: 1.264 ± 0.331
4.186LysArg: 4.186 ± 0.764
4.028LysSer: 4.028 ± 0.51
3.159LysThr: 3.159 ± 0.532
2.606LysVal: 2.606 ± 0.493
0.79LysTrp: 0.79 ± 0.226
1.027LysTyr: 1.027 ± 0.27
0.0LysXaa: 0.0 ± 0.0
Leu
5.608LeuAla: 5.608 ± 0.61
1.264LeuCys: 1.264 ± 0.271
5.608LeuAsp: 5.608 ± 0.626
3.475LeuGlu: 3.475 ± 0.6
2.922LeuPhe: 2.922 ± 0.58
4.897LeuGly: 4.897 ± 0.566
0.237LeuHis: 0.237 ± 0.107
3.633LeuIle: 3.633 ± 0.535
3.633LeuLys: 3.633 ± 0.542
4.818LeuLeu: 4.818 ± 0.638
3.001LeuMet: 3.001 ± 0.458
3.633LeuAsn: 3.633 ± 0.61
2.685LeuPro: 2.685 ± 0.403
2.527LeuGln: 2.527 ± 0.502
5.45LeuArg: 5.45 ± 1.16
5.292LeuSer: 5.292 ± 0.615
6.003LeuThr: 6.003 ± 0.687
3.87LeuVal: 3.87 ± 0.441
1.027LeuTrp: 1.027 ± 0.301
2.369LeuTyr: 2.369 ± 0.547
0.0LeuXaa: 0.0 ± 0.0
Met
2.606MetAla: 2.606 ± 0.681
0.553MetCys: 0.553 ± 0.278
0.869MetAsp: 0.869 ± 0.309
1.106MetGlu: 1.106 ± 0.281
1.343MetPhe: 1.343 ± 0.311
1.975MetGly: 1.975 ± 0.385
0.316MetHis: 0.316 ± 0.142
1.896MetIle: 1.896 ± 0.316
2.054MetLys: 2.054 ± 0.427
2.212MetLeu: 2.212 ± 0.411
1.185MetMet: 1.185 ± 0.253
1.343MetAsn: 1.343 ± 0.33
0.948MetPro: 0.948 ± 0.274
1.422MetGln: 1.422 ± 0.311
2.685MetArg: 2.685 ± 0.364
1.659MetSer: 1.659 ± 0.382
2.29MetThr: 2.29 ± 0.485
1.817MetVal: 1.817 ± 0.379
0.237MetTrp: 0.237 ± 0.13
1.185MetTyr: 1.185 ± 0.348
0.0MetXaa: 0.0 ± 0.0
Asn
4.186AsnAla: 4.186 ± 0.568
0.711AsnCys: 0.711 ± 0.227
2.369AsnAsp: 2.369 ± 0.4
1.501AsnGlu: 1.501 ± 0.355
1.738AsnPhe: 1.738 ± 0.356
3.238AsnGly: 3.238 ± 0.696
1.027AsnHis: 1.027 ± 0.295
2.922AsnIle: 2.922 ± 0.484
2.054AsnLys: 2.054 ± 0.357
3.712AsnLeu: 3.712 ± 0.915
1.264AsnMet: 1.264 ± 0.333
2.133AsnAsn: 2.133 ± 0.461
2.764AsnPro: 2.764 ± 0.497
1.817AsnGln: 1.817 ± 0.413
1.896AsnArg: 1.896 ± 0.384
2.764AsnSer: 2.764 ± 0.472
2.527AsnThr: 2.527 ± 0.528
4.186AsnVal: 4.186 ± 0.601
0.632AsnTrp: 0.632 ± 0.193
1.106AsnTyr: 1.106 ± 0.323
0.0AsnXaa: 0.0 ± 0.0
Pro
4.976ProAla: 4.976 ± 1.08
0.474ProCys: 0.474 ± 0.297
3.159ProAsp: 3.159 ± 0.423
3.317ProGlu: 3.317 ± 0.819
1.501ProPhe: 1.501 ± 0.294
3.949ProGly: 3.949 ± 0.625
0.632ProHis: 0.632 ± 0.195
2.054ProIle: 2.054 ± 0.381
1.264ProLys: 1.264 ± 0.306
2.922ProLeu: 2.922 ± 0.477
1.106ProMet: 1.106 ± 0.298
2.212ProAsn: 2.212 ± 0.455
2.133ProPro: 2.133 ± 0.534
1.264ProGln: 1.264 ± 0.313
2.054ProArg: 2.054 ± 0.388
2.606ProSer: 2.606 ± 0.504
2.29ProThr: 2.29 ± 0.534
4.423ProVal: 4.423 ± 0.976
0.395ProTrp: 0.395 ± 0.136
1.422ProTyr: 1.422 ± 0.256
0.0ProXaa: 0.0 ± 0.0
Gln
3.712GlnAla: 3.712 ± 0.704
0.553GlnCys: 0.553 ± 0.322
1.58GlnAsp: 1.58 ± 0.299
1.738GlnGlu: 1.738 ± 0.316
1.422GlnPhe: 1.422 ± 0.316
1.738GlnGly: 1.738 ± 0.33
0.711GlnHis: 0.711 ± 0.221
2.448GlnIle: 2.448 ± 0.374
0.948GlnLys: 0.948 ± 0.35
4.107GlnLeu: 4.107 ± 0.62
1.501GlnMet: 1.501 ± 0.364
1.106GlnAsn: 1.106 ± 0.252
1.738GlnPro: 1.738 ± 0.494
2.29GlnGln: 2.29 ± 0.483
2.369GlnArg: 2.369 ± 0.42
2.133GlnSer: 2.133 ± 0.442
2.212GlnThr: 2.212 ± 0.425
1.738GlnVal: 1.738 ± 0.325
0.79GlnTrp: 0.79 ± 0.251
1.264GlnTyr: 1.264 ± 0.263
0.0GlnXaa: 0.0 ± 0.0
Arg
5.371ArgAla: 5.371 ± 0.71
0.869ArgCys: 0.869 ± 0.219
4.581ArgAsp: 4.581 ± 0.77
4.186ArgGlu: 4.186 ± 0.923
2.448ArgPhe: 2.448 ± 0.531
4.107ArgGly: 4.107 ± 0.782
1.738ArgHis: 1.738 ± 0.551
4.107ArgIle: 4.107 ± 0.554
2.922ArgLys: 2.922 ± 0.519
3.949ArgLeu: 3.949 ± 0.524
1.896ArgMet: 1.896 ± 0.393
3.159ArgAsn: 3.159 ± 0.448
2.606ArgPro: 2.606 ± 0.498
2.685ArgGln: 2.685 ± 0.507
4.186ArgArg: 4.186 ± 0.659
3.633ArgSer: 3.633 ± 0.443
2.29ArgThr: 2.29 ± 0.393
4.502ArgVal: 4.502 ± 0.713
1.343ArgTrp: 1.343 ± 0.273
1.343ArgTyr: 1.343 ± 0.294
0.0ArgXaa: 0.0 ± 0.0
Ser
6.398SerAla: 6.398 ± 0.966
0.79SerCys: 0.79 ± 0.264
5.292SerAsp: 5.292 ± 0.66
2.369SerGlu: 2.369 ± 0.367
2.133SerPhe: 2.133 ± 0.391
4.107SerGly: 4.107 ± 0.533
1.027SerHis: 1.027 ± 0.322
2.606SerIle: 2.606 ± 0.437
2.133SerLys: 2.133 ± 0.375
3.08SerLeu: 3.08 ± 0.437
1.975SerMet: 1.975 ± 0.36
3.554SerAsn: 3.554 ± 0.528
1.738SerPro: 1.738 ± 0.397
2.606SerGln: 2.606 ± 0.406
4.265SerArg: 4.265 ± 0.57
4.897SerSer: 4.897 ± 0.833
3.159SerThr: 3.159 ± 0.607
5.213SerVal: 5.213 ± 0.641
0.632SerTrp: 0.632 ± 0.246
1.975SerTyr: 1.975 ± 0.326
0.0SerXaa: 0.0 ± 0.0
Thr
6.398ThrAla: 6.398 ± 0.754
1.106ThrCys: 1.106 ± 0.286
4.897ThrAsp: 4.897 ± 0.625
3.238ThrGlu: 3.238 ± 0.499
2.133ThrPhe: 2.133 ± 0.33
7.266ThrGly: 7.266 ± 0.834
1.185ThrHis: 1.185 ± 0.26
2.922ThrIle: 2.922 ± 0.546
2.369ThrLys: 2.369 ± 0.354
5.134ThrLeu: 5.134 ± 0.674
1.343ThrMet: 1.343 ± 0.368
1.896ThrAsn: 1.896 ± 0.497
3.633ThrPro: 3.633 ± 0.493
1.422ThrGln: 1.422 ± 0.329
3.396ThrArg: 3.396 ± 0.697
3.238ThrSer: 3.238 ± 0.459
4.107ThrThr: 4.107 ± 0.614
5.766ThrVal: 5.766 ± 0.76
0.948ThrTrp: 0.948 ± 0.233
1.738ThrTyr: 1.738 ± 0.518
0.0ThrXaa: 0.0 ± 0.0
Val
7.424ValAla: 7.424 ± 0.929
0.948ValCys: 0.948 ± 0.25
5.134ValAsp: 5.134 ± 0.52
5.292ValGlu: 5.292 ± 0.523
1.501ValPhe: 1.501 ± 0.33
5.292ValGly: 5.292 ± 0.722
0.869ValHis: 0.869 ± 0.299
3.712ValIle: 3.712 ± 0.525
4.344ValLys: 4.344 ± 0.507
4.265ValLeu: 4.265 ± 0.63
2.764ValMet: 2.764 ± 0.408
3.396ValAsn: 3.396 ± 0.5
4.344ValPro: 4.344 ± 0.955
2.369ValGln: 2.369 ± 0.379
4.739ValArg: 4.739 ± 0.538
5.292ValSer: 5.292 ± 0.82
6.714ValThr: 6.714 ± 0.792
5.213ValVal: 5.213 ± 0.609
0.948ValTrp: 0.948 ± 0.279
2.369ValTyr: 2.369 ± 0.444
0.0ValXaa: 0.0 ± 0.0
Trp
1.027TrpAla: 1.027 ± 0.21
0.316TrpCys: 0.316 ± 0.146
0.79TrpAsp: 0.79 ± 0.208
0.711TrpGlu: 0.711 ± 0.229
0.869TrpPhe: 0.869 ± 0.251
0.711TrpGly: 0.711 ± 0.201
0.632TrpHis: 0.632 ± 0.181
0.474TrpIle: 0.474 ± 0.181
0.711TrpLys: 0.711 ± 0.264
1.422TrpLeu: 1.422 ± 0.265
0.474TrpMet: 0.474 ± 0.159
0.711TrpAsn: 0.711 ± 0.245
0.553TrpPro: 0.553 ± 0.268
0.158TrpGln: 0.158 ± 0.112
1.185TrpArg: 1.185 ± 0.292
1.027TrpSer: 1.027 ± 0.275
0.711TrpThr: 0.711 ± 0.26
1.975TrpVal: 1.975 ± 0.421
0.553TrpTrp: 0.553 ± 0.176
1.264TrpTyr: 1.264 ± 0.292
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.448TyrAla: 2.448 ± 0.5
0.395TyrCys: 0.395 ± 0.199
2.606TyrAsp: 2.606 ± 0.58
1.027TyrGlu: 1.027 ± 0.308
0.948TyrPhe: 0.948 ± 0.244
3.317TyrGly: 3.317 ± 0.427
0.395TyrHis: 0.395 ± 0.157
1.027TyrIle: 1.027 ± 0.275
1.501TyrLys: 1.501 ± 0.32
2.606TyrLeu: 2.606 ± 0.48
0.79TyrMet: 0.79 ± 0.219
1.501TyrAsn: 1.501 ± 0.321
1.738TyrPro: 1.738 ± 0.38
1.106TyrGln: 1.106 ± 0.313
2.448TyrArg: 2.448 ± 0.449
1.659TyrSer: 1.659 ± 0.387
2.133TyrThr: 2.133 ± 0.419
3.317TyrVal: 3.317 ± 0.507
0.237TyrTrp: 0.237 ± 0.13
0.79TyrTyr: 0.79 ± 0.269
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 66 proteins (12662 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski