Amino acid dipepetide frequency for Planctomyces sp. SH-PL62

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.748AlaAla: 16.748 ± 0.139
1.162AlaCys: 1.162 ± 0.027
7.315AlaAsp: 7.315 ± 0.064
7.872AlaGlu: 7.872 ± 0.084
4.145AlaPhe: 4.145 ± 0.053
10.435AlaGly: 10.435 ± 0.089
1.862AlaHis: 1.862 ± 0.034
4.985AlaIle: 4.985 ± 0.051
3.423AlaLys: 3.423 ± 0.063
11.686AlaLeu: 11.686 ± 0.107
2.647AlaMet: 2.647 ± 0.039
2.312AlaAsn: 2.312 ± 0.04
7.028AlaPro: 7.028 ± 0.099
2.921AlaGln: 2.921 ± 0.045
9.81AlaArg: 9.81 ± 0.095
7.081AlaSer: 7.081 ± 0.071
6.339AlaThr: 6.339 ± 0.071
9.405AlaVal: 9.405 ± 0.071
2.027AlaTrp: 2.027 ± 0.038
2.521AlaTyr: 2.521 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
0.71CysAla: 0.71 ± 0.02
0.151CysCys: 0.151 ± 0.011
0.535CysAsp: 0.535 ± 0.018
0.476CysGlu: 0.476 ± 0.016
0.297CysPhe: 0.297 ± 0.013
0.908CysGly: 0.908 ± 0.025
0.319CysHis: 0.319 ± 0.013
0.305CysIle: 0.305 ± 0.012
0.197CysLys: 0.197 ± 0.011
0.925CysLeu: 0.925 ± 0.023
0.138CysMet: 0.138 ± 0.009
0.211CysAsn: 0.211 ± 0.011
0.542CysPro: 0.542 ± 0.018
0.256CysGln: 0.256 ± 0.013
0.792CysArg: 0.792 ± 0.023
0.427CysSer: 0.427 ± 0.015
0.42CysThr: 0.42 ± 0.016
0.596CysVal: 0.596 ± 0.019
0.159CysTrp: 0.159 ± 0.008
0.216CysTyr: 0.216 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.851AspAla: 7.851 ± 0.076
0.42AspCys: 0.42 ± 0.015
4.17AspAsp: 4.17 ± 0.063
4.175AspGlu: 4.175 ± 0.056
2.203AspPhe: 2.203 ± 0.035
6.126AspGly: 6.126 ± 0.089
1.359AspHis: 1.359 ± 0.025
1.271AspIle: 1.271 ± 0.026
1.309AspLys: 1.309 ± 0.029
6.66AspLeu: 6.66 ± 0.067
0.822AspMet: 0.822 ± 0.021
0.867AspAsn: 0.867 ± 0.021
4.964AspPro: 4.964 ± 0.048
1.826AspGln: 1.826 ± 0.039
5.773AspArg: 5.773 ± 0.063
2.648AspSer: 2.648 ± 0.043
1.507AspThr: 1.507 ± 0.032
5.166AspVal: 5.166 ± 0.054
1.057AspTrp: 1.057 ± 0.024
1.432AspTyr: 1.432 ± 0.03
0.0AspXaa: 0.0 ± 0.0
Glu
8.407GluAla: 8.407 ± 0.085
0.378GluCys: 0.378 ± 0.015
2.905GluAsp: 2.905 ± 0.045
3.408GluGlu: 3.408 ± 0.056
1.946GluPhe: 1.946 ± 0.033
4.847GluGly: 4.847 ± 0.059
1.199GluHis: 1.199 ± 0.025
2.856GluIle: 2.856 ± 0.038
2.003GluLys: 2.003 ± 0.036
5.554GluLeu: 5.554 ± 0.064
1.197GluMet: 1.197 ± 0.025
1.245GluAsn: 1.245 ± 0.029
4.041GluPro: 4.041 ± 0.056
1.835GluGln: 1.835 ± 0.032
5.085GluArg: 5.085 ± 0.06
3.464GluSer: 3.464 ± 0.05
3.318GluThr: 3.318 ± 0.044
4.41GluVal: 4.41 ± 0.057
0.786GluTrp: 0.786 ± 0.02
1.173GluTyr: 1.173 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
3.896PheAla: 3.896 ± 0.044
0.328PheCys: 0.328 ± 0.014
2.626PheAsp: 2.626 ± 0.036
2.148PheGlu: 2.148 ± 0.036
1.218PhePhe: 1.218 ± 0.027
3.4PheGly: 3.4 ± 0.047
0.839PheHis: 0.839 ± 0.022
1.092PheIle: 1.092 ± 0.025
0.812PheLys: 0.812 ± 0.021
3.811PheLeu: 3.811 ± 0.053
0.493PheMet: 0.493 ± 0.019
0.956PheAsn: 0.956 ± 0.025
1.858PhePro: 1.858 ± 0.033
1.163PheGln: 1.163 ± 0.025
2.723PheArg: 2.723 ± 0.04
1.804PheSer: 1.804 ± 0.034
1.698PheThr: 1.698 ± 0.033
2.584PheVal: 2.584 ± 0.038
0.574PheTrp: 0.574 ± 0.019
0.827PheTyr: 0.827 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
8.821GlyAla: 8.821 ± 0.095
0.937GlyCys: 0.937 ± 0.023
5.196GlyAsp: 5.196 ± 0.077
5.067GlyGlu: 5.067 ± 0.056
3.421GlyPhe: 3.421 ± 0.047
8.798GlyGly: 8.798 ± 0.201
1.575GlyHis: 1.575 ± 0.031
2.859GlyIle: 2.859 ± 0.038
2.948GlyLys: 2.948 ± 0.042
9.464GlyLeu: 9.464 ± 0.094
1.969GlyMet: 1.969 ± 0.038
1.799GlyAsn: 1.799 ± 0.05
5.241GlyPro: 5.241 ± 0.064
2.261GlyGln: 2.261 ± 0.037
8.379GlyArg: 8.379 ± 0.077
5.224GlySer: 5.224 ± 0.063
4.126GlyThr: 4.126 ± 0.056
7.122GlyVal: 7.122 ± 0.064
1.705GlyTrp: 1.705 ± 0.035
2.172GlyTyr: 2.172 ± 0.036
0.0GlyXaa: 0.0 ± 0.0
His
2.147HisAla: 2.147 ± 0.032
0.202HisCys: 0.202 ± 0.01
1.328HisAsp: 1.328 ± 0.025
1.141HisGlu: 1.141 ± 0.027
0.686HisPhe: 0.686 ± 0.019
1.854HisGly: 1.854 ± 0.036
0.596HisHis: 0.596 ± 0.018
0.611HisIle: 0.611 ± 0.019
0.467HisLys: 0.467 ± 0.015
1.981HisLeu: 1.981 ± 0.035
0.306HisMet: 0.306 ± 0.013
0.439HisAsn: 0.439 ± 0.018
1.559HisPro: 1.559 ± 0.031
0.584HisGln: 0.584 ± 0.018
1.592HisArg: 1.592 ± 0.025
0.857HisSer: 0.857 ± 0.019
0.712HisThr: 0.712 ± 0.022
1.497HisVal: 1.497 ± 0.032
0.335HisTrp: 0.335 ± 0.013
0.513HisTyr: 0.513 ± 0.015
0.0HisXaa: 0.0 ± 0.0
Ile
5.143IleAla: 5.143 ± 0.053
0.347IleCys: 0.347 ± 0.016
3.047IleAsp: 3.047 ± 0.039
2.893IleGlu: 2.893 ± 0.042
1.116IlePhe: 1.116 ± 0.025
3.613IleGly: 3.613 ± 0.049
0.917IleHis: 0.917 ± 0.02
1.229IleIle: 1.229 ± 0.031
1.143IleLys: 1.143 ± 0.03
4.182IleLeu: 4.182 ± 0.058
0.5IleMet: 0.5 ± 0.017
0.993IleAsn: 0.993 ± 0.024
2.516IlePro: 2.516 ± 0.037
1.258IleGln: 1.258 ± 0.026
3.272IleArg: 3.272 ± 0.043
1.839IleSer: 1.839 ± 0.034
1.772IleThr: 1.772 ± 0.032
3.325IleVal: 3.325 ± 0.044
0.501IleTrp: 0.501 ± 0.019
0.919IleTyr: 0.919 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
3.814LysAla: 3.814 ± 0.072
0.17LysCys: 0.17 ± 0.011
1.632LysAsp: 1.632 ± 0.029
1.47LysGlu: 1.47 ± 0.032
0.871LysPhe: 0.871 ± 0.025
2.339LysGly: 2.339 ± 0.043
0.537LysHis: 0.537 ± 0.017
1.335LysIle: 1.335 ± 0.028
1.174LysLys: 1.174 ± 0.034
3.119LysLeu: 3.119 ± 0.044
0.547LysMet: 0.547 ± 0.016
0.698LysAsn: 0.698 ± 0.021
2.273LysPro: 2.273 ± 0.035
0.882LysGln: 0.882 ± 0.025
1.979LysArg: 1.979 ± 0.04
1.67LysSer: 1.67 ± 0.035
1.702LysThr: 1.702 ± 0.029
2.24LysVal: 2.24 ± 0.039
0.331LysTrp: 0.331 ± 0.013
0.629LysTyr: 0.629 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
14.476LeuAla: 14.476 ± 0.118
0.855LeuCys: 0.855 ± 0.017
6.923LeuAsp: 6.923 ± 0.071
5.779LeuGlu: 5.779 ± 0.064
3.273LeuPhe: 3.273 ± 0.048
9.148LeuGly: 9.148 ± 0.087
1.858LeuHis: 1.858 ± 0.03
4.527LeuIle: 4.527 ± 0.055
3.381LeuLys: 3.381 ± 0.05
9.56LeuLeu: 9.56 ± 0.114
1.794LeuMet: 1.794 ± 0.033
2.173LeuAsn: 2.173 ± 0.035
5.534LeuPro: 5.534 ± 0.065
2.508LeuGln: 2.508 ± 0.035
7.608LeuArg: 7.608 ± 0.082
5.195LeuSer: 5.195 ± 0.058
5.288LeuThr: 5.288 ± 0.056
7.401LeuVal: 7.401 ± 0.079
1.253LeuTrp: 1.253 ± 0.029
2.048LeuTyr: 2.048 ± 0.034
0.0LeuXaa: 0.0 ± 0.0
Met
2.222MetAla: 2.222 ± 0.036
0.115MetCys: 0.115 ± 0.008
0.906MetAsp: 0.906 ± 0.02
0.908MetGlu: 0.908 ± 0.02
0.566MetPhe: 0.566 ± 0.017
1.655MetGly: 1.655 ± 0.036
0.316MetHis: 0.316 ± 0.015
1.066MetIle: 1.066 ± 0.024
0.748MetLys: 0.748 ± 0.02
1.901MetLeu: 1.901 ± 0.039
0.444MetMet: 0.444 ± 0.019
0.649MetAsn: 0.649 ± 0.018
1.134MetPro: 1.134 ± 0.029
0.477MetGln: 0.477 ± 0.017
1.359MetArg: 1.359 ± 0.025
1.271MetSer: 1.271 ± 0.028
1.326MetThr: 1.326 ± 0.029
1.227MetVal: 1.227 ± 0.027
0.166MetTrp: 0.166 ± 0.009
0.311MetTyr: 0.311 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
2.325AsnAla: 2.325 ± 0.037
0.214AsnCys: 0.214 ± 0.01
1.25AsnAsp: 1.25 ± 0.035
1.049AsnGlu: 1.049 ± 0.022
0.864AsnPhe: 0.864 ± 0.024
1.958AsnGly: 1.958 ± 0.051
0.51AsnHis: 0.51 ± 0.017
0.879AsnIle: 0.879 ± 0.022
0.491AsnLys: 0.491 ± 0.018
2.544AsnLeu: 2.544 ± 0.041
0.368AsnMet: 0.368 ± 0.013
0.629AsnAsn: 0.629 ± 0.024
1.841AsnPro: 1.841 ± 0.033
0.735AsnGln: 0.735 ± 0.02
1.815AsnArg: 1.815 ± 0.033
1.114AsnSer: 1.114 ± 0.029
1.038AsnThr: 1.038 ± 0.03
1.707AsnVal: 1.707 ± 0.033
0.376AsnTrp: 0.376 ± 0.015
0.672AsnTyr: 0.672 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
8.131ProAla: 8.131 ± 0.094
0.428ProCys: 0.428 ± 0.014
4.604ProAsp: 4.604 ± 0.062
4.872ProGlu: 4.872 ± 0.06
2.02ProPhe: 2.02 ± 0.037
6.033ProGly: 6.033 ± 0.073
1.11ProHis: 1.11 ± 0.024
2.838ProIle: 2.838 ± 0.037
1.879ProLys: 1.879 ± 0.038
5.075ProLeu: 5.075 ± 0.053
1.209ProMet: 1.209 ± 0.023
1.55ProAsn: 1.55 ± 0.035
4.544ProPro: 4.544 ± 0.075
1.409ProGln: 1.409 ± 0.028
4.659ProArg: 4.659 ± 0.054
4.1ProSer: 4.1 ± 0.051
3.705ProThr: 3.705 ± 0.053
4.141ProVal: 4.141 ± 0.053
0.921ProTrp: 0.921 ± 0.023
1.233ProTyr: 1.233 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
3.915GlnAla: 3.915 ± 0.048
0.228GlnCys: 0.228 ± 0.012
1.34GlnAsp: 1.34 ± 0.024
1.409GlnGlu: 1.409 ± 0.031
0.97GlnPhe: 0.97 ± 0.023
2.532GlnGly: 2.532 ± 0.037
0.461GlnHis: 0.461 ± 0.016
1.377GlnIle: 1.377 ± 0.026
0.798GlnLys: 0.798 ± 0.022
2.354GlnLeu: 2.354 ± 0.04
0.498GlnMet: 0.498 ± 0.019
0.644GlnAsn: 0.644 ± 0.018
1.651GlnPro: 1.651 ± 0.034
0.806GlnGln: 0.806 ± 0.024
1.802GlnArg: 1.802 ± 0.035
1.383GlnSer: 1.383 ± 0.027
1.419GlnThr: 1.419 ± 0.03
2.325GlnVal: 2.325 ± 0.035
0.363GlnTrp: 0.363 ± 0.014
0.587GlnTyr: 0.587 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
8.268ArgAla: 8.268 ± 0.074
0.654ArgCys: 0.654 ± 0.019
4.845ArgAsp: 4.845 ± 0.055
5.225ArgGlu: 5.225 ± 0.07
3.198ArgPhe: 3.198 ± 0.041
6.028ArgGly: 6.028 ± 0.071
1.566ArgHis: 1.566 ± 0.034
4.025ArgIle: 4.025 ± 0.047
2.572ArgLys: 2.572 ± 0.039
9.169ArgLeu: 9.169 ± 0.084
1.732ArgMet: 1.732 ± 0.033
1.81ArgAsn: 1.81 ± 0.031
5.637ArgPro: 5.637 ± 0.069
2.026ArgGln: 2.026 ± 0.03
8.522ArgArg: 8.522 ± 0.095
4.692ArgSer: 4.692 ± 0.051
3.919ArgThr: 3.919 ± 0.043
5.445ArgVal: 5.445 ± 0.06
1.469ArgTrp: 1.469 ± 0.033
1.935ArgTyr: 1.935 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
5.908SerAla: 5.908 ± 0.064
0.482SerCys: 0.482 ± 0.017
2.8SerAsp: 2.8 ± 0.047
2.655SerGlu: 2.655 ± 0.037
1.976SerPhe: 1.976 ± 0.038
5.357SerGly: 5.357 ± 0.079
1.078SerHis: 1.078 ± 0.026
2.412SerIle: 2.412 ± 0.04
1.444SerLys: 1.444 ± 0.03
5.671SerLeu: 5.671 ± 0.053
1.147SerMet: 1.147 ± 0.024
1.344SerAsn: 1.344 ± 0.03
4.182SerPro: 4.182 ± 0.049
1.516SerGln: 1.516 ± 0.028
4.788SerArg: 4.788 ± 0.051
3.407SerSer: 3.407 ± 0.053
3.084SerThr: 3.084 ± 0.049
3.605SerVal: 3.605 ± 0.046
1.012SerTrp: 1.012 ± 0.024
1.309SerTyr: 1.309 ± 0.027
0.0SerXaa: 0.0 ± 0.0
Thr
5.833ThrAla: 5.833 ± 0.071
0.408ThrCys: 0.408 ± 0.017
2.591ThrAsp: 2.591 ± 0.039
2.12ThrGlu: 2.12 ± 0.037
2.068ThrPhe: 2.068 ± 0.033
4.395ThrGly: 4.395 ± 0.062
0.963ThrHis: 0.963 ± 0.023
2.665ThrIle: 2.665 ± 0.04
1.211ThrLys: 1.211 ± 0.028
5.346ThrLeu: 5.346 ± 0.067
0.89ThrMet: 0.89 ± 0.022
1.184ThrAsn: 1.184 ± 0.03
4.038ThrPro: 4.038 ± 0.056
1.084ThrGln: 1.084 ± 0.026
3.322ThrArg: 3.322 ± 0.046
2.92ThrSer: 2.92 ± 0.046
3.028ThrThr: 3.028 ± 0.052
3.731ThrVal: 3.731 ± 0.054
0.812ThrTrp: 0.812 ± 0.025
1.24ThrTyr: 1.24 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
9.371ValAla: 9.371 ± 0.077
0.699ValCys: 0.699 ± 0.023
5.131ValAsp: 5.131 ± 0.054
5.347ValGlu: 5.347 ± 0.068
2.568ValPhe: 2.568 ± 0.034
6.47ValGly: 6.47 ± 0.065
1.466ValHis: 1.466 ± 0.028
2.696ValIle: 2.696 ± 0.041
2.197ValLys: 2.197 ± 0.04
7.5ValLeu: 7.5 ± 0.069
1.344ValMet: 1.344 ± 0.027
1.708ValAsn: 1.708 ± 0.035
3.972ValPro: 3.972 ± 0.054
2.071ValGln: 2.071 ± 0.036
6.053ValArg: 6.053 ± 0.065
3.845ValSer: 3.845 ± 0.055
3.335ValThr: 3.335 ± 0.059
7.426ValVal: 7.426 ± 0.079
1.065ValTrp: 1.065 ± 0.025
1.642ValTyr: 1.642 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
1.463TrpAla: 1.463 ± 0.034
0.168TrpCys: 0.168 ± 0.009
0.909TrpAsp: 0.909 ± 0.026
0.722TrpGlu: 0.722 ± 0.019
0.57TrpPhe: 0.57 ± 0.016
1.19TrpGly: 1.19 ± 0.027
0.293TrpHis: 0.293 ± 0.013
0.794TrpIle: 0.794 ± 0.019
0.595TrpLys: 0.595 ± 0.019
1.771TrpLeu: 1.771 ± 0.033
0.352TrpMet: 0.352 ± 0.014
0.511TrpAsn: 0.511 ± 0.019
0.778TrpPro: 0.778 ± 0.021
0.393TrpGln: 0.393 ± 0.014
1.331TrpArg: 1.331 ± 0.028
1.058TrpSer: 1.058 ± 0.019
1.034TrpThr: 1.034 ± 0.026
0.997TrpVal: 0.997 ± 0.024
0.309TrpTrp: 0.309 ± 0.013
0.363TrpTyr: 0.363 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.282TyrAla: 2.282 ± 0.038
0.231TyrCys: 0.231 ± 0.013
1.553TyrAsp: 1.553 ± 0.031
1.32TyrGlu: 1.32 ± 0.028
0.872TyrPhe: 0.872 ± 0.024
1.999TyrGly: 1.999 ± 0.038
0.584TyrHis: 0.584 ± 0.019
0.702TyrIle: 0.702 ± 0.017
0.622TyrLys: 0.622 ± 0.017
2.309TyrLeu: 2.309 ± 0.038
0.371TyrMet: 0.371 ± 0.013
0.656TyrAsn: 0.656 ± 0.022
1.131TyrPro: 1.131 ± 0.027
0.848TyrGln: 0.848 ± 0.024
2.074TyrArg: 2.074 ± 0.034
1.174TyrSer: 1.174 ± 0.03
1.074TyrThr: 1.074 ± 0.029
1.559TyrVal: 1.559 ± 0.03
0.38TyrTrp: 0.38 ± 0.015
0.692TyrTyr: 0.692 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5245 proteins (1933445 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski