Amino acid dipepetide frequency for Piscine orthoreovirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.054AlaAla: 6.054 ± 0.959
1.185AlaCys: 1.185 ± 0.251
2.632AlaAsp: 2.632 ± 0.746
3.159AlaGlu: 3.159 ± 0.848
2.501AlaPhe: 2.501 ± 0.474
4.738AlaGly: 4.738 ± 0.823
0.79AlaHis: 0.79 ± 0.332
4.606AlaIle: 4.606 ± 1.096
3.027AlaLys: 3.027 ± 0.778
8.555AlaLeu: 8.555 ± 1.521
3.027AlaMet: 3.027 ± 0.694
5.265AlaAsn: 5.265 ± 1.058
3.422AlaPro: 3.422 ± 0.752
1.843AlaGln: 1.843 ± 0.596
4.212AlaArg: 4.212 ± 0.583
6.449AlaSer: 6.449 ± 0.756
4.606AlaThr: 4.606 ± 0.711
4.475AlaVal: 4.475 ± 0.724
0.921AlaTrp: 0.921 ± 0.407
1.711AlaTyr: 1.711 ± 0.537
0.0AlaXaa: 0.0 ± 0.0
Cys
1.185CysAla: 1.185 ± 0.308
0.132CysCys: 0.132 ± 0.134
1.579CysAsp: 1.579 ± 0.359
0.395CysGlu: 0.395 ± 0.23
0.526CysPhe: 0.526 ± 0.229
1.448CysGly: 1.448 ± 0.508
0.132CysHis: 0.132 ± 0.109
0.526CysIle: 0.526 ± 0.295
0.395CysLys: 0.395 ± 0.194
0.79CysLeu: 0.79 ± 0.384
0.395CysMet: 0.395 ± 0.345
0.263CysAsn: 0.263 ± 0.138
0.921CysPro: 0.921 ± 0.258
0.79CysGln: 0.79 ± 0.354
0.79CysArg: 0.79 ± 0.382
1.053CysSer: 1.053 ± 0.367
0.263CysThr: 0.263 ± 0.219
0.79CysVal: 0.79 ± 0.351
0.263CysTrp: 0.263 ± 0.193
0.79CysTyr: 0.79 ± 0.406
0.0CysXaa: 0.0 ± 0.0
Asp
3.817AspAla: 3.817 ± 0.455
0.658AspCys: 0.658 ± 0.317
4.606AspAsp: 4.606 ± 0.824
3.29AspGlu: 3.29 ± 0.63
2.895AspPhe: 2.895 ± 0.845
3.159AspGly: 3.159 ± 0.724
1.316AspHis: 1.316 ± 0.459
2.764AspIle: 2.764 ± 0.523
2.501AspLys: 2.501 ± 0.578
5.528AspLeu: 5.528 ± 0.759
1.843AspMet: 1.843 ± 0.408
2.764AspAsn: 2.764 ± 0.619
3.29AspPro: 3.29 ± 0.612
2.369AspGln: 2.369 ± 0.358
2.764AspArg: 2.764 ± 0.374
5.001AspSer: 5.001 ± 0.776
4.08AspThr: 4.08 ± 0.488
5.659AspVal: 5.659 ± 1.465
1.448AspTrp: 1.448 ± 0.271
2.632AspTyr: 2.632 ± 0.547
0.0AspXaa: 0.0 ± 0.0
Glu
3.422GluAla: 3.422 ± 0.529
0.921GluCys: 0.921 ± 0.284
2.369GluAsp: 2.369 ± 0.781
2.237GluGlu: 2.237 ± 0.402
1.974GluPhe: 1.974 ± 0.531
1.974GluGly: 1.974 ± 0.337
1.316GluHis: 1.316 ± 0.441
3.159GluIle: 3.159 ± 0.865
2.237GluLys: 2.237 ± 0.445
4.475GluLeu: 4.475 ± 0.717
0.921GluMet: 0.921 ± 0.462
0.921GluAsn: 0.921 ± 0.37
2.106GluPro: 2.106 ± 0.496
1.185GluGln: 1.185 ± 0.292
2.501GluArg: 2.501 ± 0.751
3.422GluSer: 3.422 ± 0.835
2.632GluThr: 2.632 ± 0.337
3.027GluVal: 3.027 ± 0.559
0.79GluTrp: 0.79 ± 0.452
1.974GluTyr: 1.974 ± 0.615
0.0GluXaa: 0.0 ± 0.0
Phe
1.711PheAla: 1.711 ± 0.439
0.263PheCys: 0.263 ± 0.183
3.817PheAsp: 3.817 ± 0.799
1.974PheGlu: 1.974 ± 0.426
1.579PhePhe: 1.579 ± 0.324
2.764PheGly: 2.764 ± 0.448
0.658PheHis: 0.658 ± 0.337
2.369PheIle: 2.369 ± 0.39
1.316PheLys: 1.316 ± 0.578
4.08PheLeu: 4.08 ± 1.239
1.579PheMet: 1.579 ± 0.467
2.369PheAsn: 2.369 ± 0.61
1.974PhePro: 1.974 ± 0.361
1.579PheGln: 1.579 ± 0.598
2.106PheArg: 2.106 ± 0.446
4.343PheSer: 4.343 ± 0.62
1.579PheThr: 1.579 ± 0.413
2.369PheVal: 2.369 ± 0.524
0.395PheTrp: 0.395 ± 0.179
0.79PheTyr: 0.79 ± 0.336
0.0PheXaa: 0.0 ± 0.0
Gly
3.29GlyAla: 3.29 ± 0.76
1.053GlyCys: 1.053 ± 0.326
4.212GlyAsp: 4.212 ± 1.157
1.711GlyGlu: 1.711 ± 0.271
2.237GlyPhe: 2.237 ± 0.597
3.948GlyGly: 3.948 ± 1.023
1.316GlyHis: 1.316 ± 0.794
3.554GlyIle: 3.554 ± 0.559
3.685GlyLys: 3.685 ± 0.699
4.738GlyLeu: 4.738 ± 0.466
2.895GlyMet: 2.895 ± 0.782
2.369GlyAsn: 2.369 ± 0.847
1.843GlyPro: 1.843 ± 0.447
1.711GlyGln: 1.711 ± 0.384
2.895GlyArg: 2.895 ± 0.254
5.133GlySer: 5.133 ± 0.471
5.001GlyThr: 5.001 ± 0.347
6.581GlyVal: 6.581 ± 0.775
0.79GlyTrp: 0.79 ± 0.333
2.632GlyTyr: 2.632 ± 0.577
0.0GlyXaa: 0.0 ± 0.0
His
1.185HisAla: 1.185 ± 0.311
0.132HisCys: 0.132 ± 0.134
0.395HisAsp: 0.395 ± 0.195
0.79HisGlu: 0.79 ± 0.353
0.921HisPhe: 0.921 ± 0.31
1.053HisGly: 1.053 ± 0.375
0.658HisHis: 0.658 ± 0.245
0.921HisIle: 0.921 ± 0.34
0.658HisLys: 0.658 ± 0.312
2.106HisLeu: 2.106 ± 0.525
0.526HisMet: 0.526 ± 0.414
1.448HisAsn: 1.448 ± 0.57
0.921HisPro: 0.921 ± 0.263
0.526HisGln: 0.526 ± 0.18
1.053HisArg: 1.053 ± 0.493
1.448HisSer: 1.448 ± 0.494
1.053HisThr: 1.053 ± 0.643
1.053HisVal: 1.053 ± 0.222
0.395HisTrp: 0.395 ± 0.239
1.316HisTyr: 1.316 ± 0.403
0.0HisXaa: 0.0 ± 0.0
Ile
3.027IleAla: 3.027 ± 0.766
1.053IleCys: 1.053 ± 0.312
4.343IleAsp: 4.343 ± 0.777
3.554IleGlu: 3.554 ± 0.574
2.764IlePhe: 2.764 ± 0.443
3.817IleGly: 3.817 ± 0.574
1.579IleHis: 1.579 ± 0.5
3.554IleIle: 3.554 ± 0.794
2.237IleLys: 2.237 ± 0.418
4.08IleLeu: 4.08 ± 0.667
1.579IleMet: 1.579 ± 0.576
3.817IleAsn: 3.817 ± 0.737
3.685IlePro: 3.685 ± 0.529
2.501IleGln: 2.501 ± 0.408
2.632IleArg: 2.632 ± 0.381
4.343IleSer: 4.343 ± 0.832
4.87IleThr: 4.87 ± 0.852
4.08IleVal: 4.08 ± 0.888
0.79IleTrp: 0.79 ± 0.34
1.053IleTyr: 1.053 ± 0.355
0.0IleXaa: 0.0 ± 0.0
Lys
3.554LysAla: 3.554 ± 0.709
0.658LysCys: 0.658 ± 0.211
2.632LysAsp: 2.632 ± 0.64
1.579LysGlu: 1.579 ± 0.34
1.579LysPhe: 1.579 ± 0.48
1.711LysGly: 1.711 ± 0.5
0.263LysHis: 0.263 ± 0.234
3.159LysIle: 3.159 ± 0.642
1.974LysLys: 1.974 ± 0.621
4.87LysLeu: 4.87 ± 0.587
1.843LysMet: 1.843 ± 0.605
1.579LysAsn: 1.579 ± 0.422
2.369LysPro: 2.369 ± 0.674
0.79LysGln: 0.79 ± 0.473
2.237LysArg: 2.237 ± 0.527
3.027LysSer: 3.027 ± 0.883
3.685LysThr: 3.685 ± 1.036
2.369LysVal: 2.369 ± 0.396
0.79LysTrp: 0.79 ± 0.395
1.711LysTyr: 1.711 ± 0.335
0.0LysXaa: 0.0 ± 0.0
Leu
4.738LeuAla: 4.738 ± 0.822
1.185LeuCys: 1.185 ± 0.279
5.001LeuAsp: 5.001 ± 0.705
4.08LeuGlu: 4.08 ± 0.851
4.212LeuPhe: 4.212 ± 1.148
5.133LeuGly: 5.133 ± 0.678
1.843LeuHis: 1.843 ± 0.566
5.133LeuIle: 5.133 ± 0.521
5.923LeuLys: 5.923 ± 1.309
8.686LeuLeu: 8.686 ± 1.252
2.106LeuMet: 2.106 ± 0.309
4.475LeuAsn: 4.475 ± 0.643
6.581LeuPro: 6.581 ± 1.139
2.632LeuGln: 2.632 ± 0.777
5.528LeuArg: 5.528 ± 0.785
9.739LeuSer: 9.739 ± 0.944
7.634LeuThr: 7.634 ± 0.931
6.449LeuVal: 6.449 ± 1.136
0.921LeuTrp: 0.921 ± 0.374
1.974LeuTyr: 1.974 ± 0.361
0.0LeuXaa: 0.0 ± 0.0
Met
2.895MetAla: 2.895 ± 0.567
0.526MetCys: 0.526 ± 0.251
1.448MetAsp: 1.448 ± 0.417
1.316MetGlu: 1.316 ± 0.347
0.79MetPhe: 0.79 ± 0.309
0.921MetGly: 0.921 ± 0.236
0.921MetHis: 0.921 ± 0.283
2.369MetIle: 2.369 ± 0.423
1.053MetLys: 1.053 ± 0.453
1.711MetLeu: 1.711 ± 0.494
0.79MetMet: 0.79 ± 0.476
0.921MetAsn: 0.921 ± 0.359
1.711MetPro: 1.711 ± 0.679
0.921MetGln: 0.921 ± 0.348
1.711MetArg: 1.711 ± 0.668
2.369MetSer: 2.369 ± 0.536
2.764MetThr: 2.764 ± 0.453
2.369MetVal: 2.369 ± 0.612
0.395MetTrp: 0.395 ± 0.228
1.316MetTyr: 1.316 ± 0.443
0.0MetXaa: 0.0 ± 0.0
Asn
3.948AsnAla: 3.948 ± 0.947
0.395AsnCys: 0.395 ± 0.205
3.027AsnAsp: 3.027 ± 0.621
1.316AsnGlu: 1.316 ± 0.429
1.711AsnPhe: 1.711 ± 0.491
4.08AsnGly: 4.08 ± 0.725
0.658AsnHis: 0.658 ± 0.282
2.237AsnIle: 2.237 ± 0.505
1.316AsnLys: 1.316 ± 0.295
3.422AsnLeu: 3.422 ± 0.53
0.921AsnMet: 0.921 ± 0.29
2.106AsnAsn: 2.106 ± 0.4
2.501AsnPro: 2.501 ± 0.631
1.711AsnGln: 1.711 ± 0.402
2.501AsnArg: 2.501 ± 0.649
2.501AsnSer: 2.501 ± 0.62
3.027AsnThr: 3.027 ± 0.62
4.475AsnVal: 4.475 ± 0.878
0.658AsnTrp: 0.658 ± 0.245
1.974AsnTyr: 1.974 ± 0.518
0.0AsnXaa: 0.0 ± 0.0
Pro
4.343ProAla: 4.343 ± 0.715
0.132ProCys: 0.132 ± 0.107
1.843ProAsp: 1.843 ± 0.649
1.974ProGlu: 1.974 ± 0.47
2.501ProPhe: 2.501 ± 0.59
3.159ProGly: 3.159 ± 0.483
1.316ProHis: 1.316 ± 0.326
3.159ProIle: 3.159 ± 0.517
1.579ProLys: 1.579 ± 0.585
6.186ProLeu: 6.186 ± 0.921
1.185ProMet: 1.185 ± 0.329
2.369ProAsn: 2.369 ± 0.741
3.159ProPro: 3.159 ± 0.685
1.974ProGln: 1.974 ± 0.408
3.29ProArg: 3.29 ± 1.006
3.685ProSer: 3.685 ± 0.61
5.001ProThr: 5.001 ± 0.373
4.212ProVal: 4.212 ± 0.77
1.053ProTrp: 1.053 ± 0.359
1.053ProTyr: 1.053 ± 0.298
0.0ProXaa: 0.0 ± 0.0
Gln
3.817GlnAla: 3.817 ± 0.615
0.79GlnCys: 0.79 ± 0.378
1.448GlnAsp: 1.448 ± 0.415
1.316GlnGlu: 1.316 ± 0.321
1.579GlnPhe: 1.579 ± 0.452
1.579GlnGly: 1.579 ± 0.374
0.526GlnHis: 0.526 ± 0.245
2.237GlnIle: 2.237 ± 0.64
1.843GlnLys: 1.843 ± 0.451
3.685GlnLeu: 3.685 ± 0.608
1.053GlnMet: 1.053 ± 0.494
1.316GlnAsn: 1.316 ± 0.255
1.711GlnPro: 1.711 ± 0.381
1.316GlnGln: 1.316 ± 0.4
2.106GlnArg: 2.106 ± 0.456
2.632GlnSer: 2.632 ± 0.498
2.369GlnThr: 2.369 ± 0.715
2.632GlnVal: 2.632 ± 0.43
0.132GlnTrp: 0.132 ± 0.107
0.921GlnTyr: 0.921 ± 0.432
0.0GlnXaa: 0.0 ± 0.0
Arg
4.212ArgAla: 4.212 ± 1.043
0.921ArgCys: 0.921 ± 0.38
3.685ArgAsp: 3.685 ± 0.46
1.843ArgGlu: 1.843 ± 0.485
2.369ArgPhe: 2.369 ± 0.458
4.343ArgGly: 4.343 ± 0.672
1.053ArgHis: 1.053 ± 0.253
3.554ArgIle: 3.554 ± 0.701
1.843ArgLys: 1.843 ± 0.282
5.001ArgLeu: 5.001 ± 0.774
1.579ArgMet: 1.579 ± 0.402
1.579ArgAsn: 1.579 ± 0.387
2.501ArgPro: 2.501 ± 0.487
1.843ArgGln: 1.843 ± 0.343
3.422ArgArg: 3.422 ± 0.765
3.685ArgSer: 3.685 ± 0.41
2.501ArgThr: 2.501 ± 0.626
3.817ArgVal: 3.817 ± 0.85
0.79ArgTrp: 0.79 ± 0.279
2.501ArgTyr: 2.501 ± 0.736
0.0ArgXaa: 0.0 ± 0.0
Ser
6.844SerAla: 6.844 ± 1.469
0.658SerCys: 0.658 ± 0.215
5.133SerAsp: 5.133 ± 0.774
3.29SerGlu: 3.29 ± 0.905
2.632SerPhe: 2.632 ± 0.626
5.923SerGly: 5.923 ± 0.87
1.316SerHis: 1.316 ± 0.54
3.422SerIle: 3.422 ± 0.682
3.948SerLys: 3.948 ± 0.538
8.95SerLeu: 8.95 ± 2.039
1.843SerMet: 1.843 ± 0.568
2.369SerAsn: 2.369 ± 0.569
3.948SerPro: 3.948 ± 0.799
2.764SerGln: 2.764 ± 0.531
3.948SerArg: 3.948 ± 0.686
7.239SerSer: 7.239 ± 1.336
6.844SerThr: 6.844 ± 0.699
6.581SerVal: 6.581 ± 0.904
1.448SerTrp: 1.448 ± 0.332
1.843SerTyr: 1.843 ± 0.559
0.0SerXaa: 0.0 ± 0.0
Thr
6.712ThrAla: 6.712 ± 0.731
1.185ThrCys: 1.185 ± 0.417
5.528ThrAsp: 5.528 ± 0.486
2.895ThrGlu: 2.895 ± 0.452
3.29ThrPhe: 3.29 ± 0.65
4.212ThrGly: 4.212 ± 1.096
1.053ThrHis: 1.053 ± 0.315
5.001ThrIle: 5.001 ± 0.909
1.843ThrLys: 1.843 ± 0.456
6.317ThrLeu: 6.317 ± 1.385
1.974ThrMet: 1.974 ± 0.604
3.027ThrAsn: 3.027 ± 0.679
3.685ThrPro: 3.685 ± 0.73
3.422ThrGln: 3.422 ± 0.965
2.501ThrArg: 2.501 ± 0.495
5.923ThrSer: 5.923 ± 1.109
6.054ThrThr: 6.054 ± 0.905
5.791ThrVal: 5.791 ± 0.895
1.579ThrTrp: 1.579 ± 0.453
1.711ThrTyr: 1.711 ± 0.476
0.0ThrXaa: 0.0 ± 0.0
Val
5.265ValAla: 5.265 ± 0.615
1.185ValCys: 1.185 ± 0.326
5.791ValAsp: 5.791 ± 1.178
4.212ValGlu: 4.212 ± 0.577
2.106ValPhe: 2.106 ± 0.554
4.738ValGly: 4.738 ± 0.874
1.448ValHis: 1.448 ± 0.325
5.923ValIle: 5.923 ± 0.751
3.29ValLys: 3.29 ± 0.465
5.659ValLeu: 5.659 ± 0.824
1.974ValMet: 1.974 ± 0.373
3.422ValAsn: 3.422 ± 0.61
4.212ValPro: 4.212 ± 1.101
3.027ValGln: 3.027 ± 0.651
4.738ValArg: 4.738 ± 0.913
5.396ValSer: 5.396 ± 1.333
5.659ValThr: 5.659 ± 0.818
5.528ValVal: 5.528 ± 1.083
0.526ValTrp: 0.526 ± 0.178
1.843ValTyr: 1.843 ± 0.502
0.0ValXaa: 0.0 ± 0.0
Trp
1.185TrpAla: 1.185 ± 0.635
0.132TrpCys: 0.132 ± 0.109
1.185TrpAsp: 1.185 ± 0.221
0.658TrpGlu: 0.658 ± 0.309
0.395TrpPhe: 0.395 ± 0.228
0.526TrpGly: 0.526 ± 0.294
0.0TrpHis: 0.0 ± 0.0
0.658TrpIle: 0.658 ± 0.23
0.79TrpLys: 0.79 ± 0.318
1.316TrpLeu: 1.316 ± 0.405
0.658TrpMet: 0.658 ± 0.293
0.526TrpAsn: 0.526 ± 0.34
1.053TrpPro: 1.053 ± 0.385
0.132TrpGln: 0.132 ± 0.146
0.921TrpArg: 0.921 ± 0.381
1.711TrpSer: 1.711 ± 0.489
1.579TrpThr: 1.579 ± 0.303
0.79TrpVal: 0.79 ± 0.279
0.263TrpTrp: 0.263 ± 0.267
0.526TrpTyr: 0.526 ± 0.198
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.974TyrAla: 1.974 ± 0.45
0.263TyrCys: 0.263 ± 0.146
1.711TyrAsp: 1.711 ± 0.368
1.974TyrGlu: 1.974 ± 0.366
1.053TyrPhe: 1.053 ± 0.378
2.369TyrGly: 2.369 ± 0.412
0.395TyrHis: 0.395 ± 0.187
1.185TyrIle: 1.185 ± 0.408
0.921TyrLys: 0.921 ± 0.351
3.817TyrLeu: 3.817 ± 0.603
0.395TyrMet: 0.395 ± 0.218
1.579TyrAsn: 1.579 ± 0.347
1.579TyrPro: 1.579 ± 0.17
1.974TyrGln: 1.974 ± 0.365
1.185TyrArg: 1.185 ± 0.398
1.843TyrSer: 1.843 ± 0.466
2.501TyrThr: 2.501 ± 0.564
2.895TyrVal: 2.895 ± 0.813
0.658TyrTrp: 0.658 ± 0.232
1.185TyrTyr: 1.185 ± 0.3
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (7599 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski