Amino acid dipepetide frequency for Hydrogenimonas sp.

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.933AlaAla: 7.933 ± 0.145	0.697AlaCys: 0.697 ± 0.043	4.151AlaAsp: 4.151 ± 0.083	5.643AlaGlu: 5.643 ± 0.101	3.248AlaPhe: 3.248 ± 0.074	5.706AlaGly: 5.706 ± 0.107	1.395AlaHis: 1.395 ± 0.052	5.241AlaIle: 5.241 ± 0.099	5.882AlaLys: 5.882 ± 0.101	9.081AlaLeu: 9.081 ± 0.121	2.417AlaMet: 2.417 ± 0.058	2.299AlaAsn: 2.299 ± 0.062	2.405AlaPro: 2.405 ± 0.067	2.12AlaGln: 2.12 ± 0.056	3.46AlaArg: 3.46 ± 0.069	4.335AlaSer: 4.335 ± 0.092	3.271AlaThr: 3.271 ± 0.07	6.268AlaVal: 6.268 ± 0.104	0.63AlaTrp: 0.63 ± 0.034	2.695AlaTyr: 2.695 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	0.674CysAla: 0.674 ± 0.033	0.084CysCys: 0.084 ± 0.013	0.708CysAsp: 0.708 ± 0.033	0.762CysGlu: 0.762 ± 0.037	0.333CysPhe: 0.333 ± 0.024	0.946CysGly: 0.946 ± 0.04	0.399CysHis: 0.399 ± 0.045	0.546CysIle: 0.546 ± 0.029	0.469CysLys: 0.469 ± 0.027	0.518CysLeu: 0.518 ± 0.033	0.187CysMet: 0.187 ± 0.017	0.337CysAsn: 0.337 ± 0.024	0.441CysPro: 0.441 ± 0.034	0.155CysGln: 0.155 ± 0.016	0.661CysArg: 0.661 ± 0.029	0.652CysSer: 0.652 ± 0.034	0.438CysThr: 0.438 ± 0.031	0.461CysVal: 0.461 ± 0.027	0.066CysTrp: 0.066 ± 0.011	0.356CysTyr: 0.356 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	4.361AspAla: 4.361 ± 0.08	0.435AspCys: 0.435 ± 0.026	2.752AspAsp: 2.752 ± 0.068	5.089AspGlu: 5.089 ± 0.098	2.887AspPhe: 2.887 ± 0.067	3.733AspGly: 3.733 ± 0.084	0.849AspHis: 0.849 ± 0.037	4.904AspIle: 4.904 ± 0.085	2.753AspLys: 2.753 ± 0.074	5.488AspLeu: 5.488 ± 0.098	1.476AspMet: 1.476 ± 0.045	1.703AspAsn: 1.703 ± 0.058	2.569AspPro: 2.569 ± 0.063	0.871AspGln: 0.871 ± 0.04	3.349AspArg: 3.349 ± 0.069	2.992AspSer: 2.992 ± 0.082	2.839AspThr: 2.839 ± 0.068	3.184AspVal: 3.184 ± 0.077	0.446AspTrp: 0.446 ± 0.03	2.117AspTyr: 2.117 ± 0.072	0.0AspXaa: 0.0 ± 0.0
Glu	6.674GluAla: 6.674 ± 0.109	0.739GluCys: 0.739 ± 0.037	3.61GluAsp: 3.61 ± 0.084	7.378GluGlu: 7.378 ± 0.154	2.759GluPhe: 2.759 ± 0.068	5.056GluGly: 5.056 ± 0.094	1.548GluHis: 1.548 ± 0.05	6.066GluIle: 6.066 ± 0.109	6.878GluLys: 6.878 ± 0.118	7.442GluLeu: 7.442 ± 0.117	2.023GluMet: 2.023 ± 0.056	3.334GluAsn: 3.334 ± 0.066	2.575GluPro: 2.575 ± 0.068	1.997GluGln: 1.997 ± 0.057	5.719GluArg: 5.719 ± 0.097	5.359GluSer: 5.359 ± 0.098	3.497GluThr: 3.497 ± 0.077	4.749GluVal: 4.749 ± 0.098	0.868GluTrp: 0.868 ± 0.037	2.615GluTyr: 2.615 ± 0.062	0.0GluXaa: 0.0 ± 0.0
Phe	3.642PheAla: 3.642 ± 0.078	0.46PheCys: 0.46 ± 0.027	3.282PheAsp: 3.282 ± 0.071	3.678PheGlu: 3.678 ± 0.075	2.474PhePhe: 2.474 ± 0.073	3.739PheGly: 3.739 ± 0.084	0.803PheHis: 0.803 ± 0.038	3.17PheIle: 3.17 ± 0.072	2.779PheLys: 2.779 ± 0.065	4.255PheLeu: 4.255 ± 0.11	1.274PheMet: 1.274 ± 0.045	1.708PheAsn: 1.708 ± 0.056	1.366PhePro: 1.366 ± 0.041	0.829PheGln: 0.829 ± 0.033	2.275PheArg: 2.275 ± 0.065	3.166PheSer: 3.166 ± 0.073	2.378PheThr: 2.378 ± 0.064	2.933PheVal: 2.933 ± 0.076	0.478PheTrp: 0.478 ± 0.029	1.737PheTyr: 1.737 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	5.241GlyAla: 5.241 ± 0.091	0.955GlyCys: 0.955 ± 0.043	3.69GlyAsp: 3.69 ± 0.079	5.111GlyGlu: 5.111 ± 0.096	3.537GlyPhe: 3.537 ± 0.072	5.183GlyGly: 5.183 ± 0.103	1.361GlyHis: 1.361 ± 0.053	5.054GlyIle: 5.054 ± 0.097	4.84GlyLys: 4.84 ± 0.094	5.883GlyLeu: 5.883 ± 0.099	2.114GlyMet: 2.114 ± 0.063	2.232GlyAsn: 2.232 ± 0.056	1.538GlyPro: 1.538 ± 0.051	1.321GlyGln: 1.321 ± 0.051	4.243GlyArg: 4.243 ± 0.094	4.464GlySer: 4.464 ± 0.084	3.261GlyThr: 3.261 ± 0.075	5.396GlyVal: 5.396 ± 0.104	0.835GlyTrp: 0.835 ± 0.036	3.083GlyTyr: 3.083 ± 0.077	0.0GlyXaa: 0.0 ± 0.0
His	1.266HisAla: 1.266 ± 0.049	0.215HisCys: 0.215 ± 0.018	0.969HisAsp: 0.969 ± 0.044	1.312HisGlu: 1.312 ± 0.043	0.992HisPhe: 0.992 ± 0.037	1.328HisGly: 1.328 ± 0.052	0.474HisHis: 0.474 ± 0.031	1.551HisIle: 1.551 ± 0.051	1.125HisLys: 1.125 ± 0.043	1.912HisLeu: 1.912 ± 0.06	0.537HisMet: 0.537 ± 0.03	0.747HisAsn: 0.747 ± 0.037	1.128HisPro: 1.128 ± 0.049	0.463HisGln: 0.463 ± 0.026	1.118HisArg: 1.118 ± 0.044	1.067HisSer: 1.067 ± 0.039	1.052HisThr: 1.052 ± 0.042	0.877HisVal: 0.877 ± 0.038	0.185HisTrp: 0.185 ± 0.017	0.839HisTyr: 0.839 ± 0.038	0.0HisXaa: 0.0 ± 0.0
Ile	6.143IleAla: 6.143 ± 0.113	0.661IleCys: 0.661 ± 0.033	5.054IleAsp: 5.054 ± 0.087	6.86IleGlu: 6.86 ± 0.114	3.624IlePhe: 3.624 ± 0.086	5.266IleGly: 5.266 ± 0.096	1.231IleHis: 1.231 ± 0.041	4.209IleIle: 4.209 ± 0.09	4.568IleLys: 4.568 ± 0.097	6.394IleLeu: 6.394 ± 0.11	1.401IleMet: 1.401 ± 0.044	2.422IleAsn: 2.422 ± 0.064	2.787IlePro: 2.787 ± 0.067	1.338IleGln: 1.338 ± 0.047	3.454IleArg: 3.454 ± 0.07	4.496IleSer: 4.496 ± 0.094	3.281IleThr: 3.281 ± 0.07	5.396IleVal: 5.396 ± 0.095	0.507IleTrp: 0.507 ± 0.027	2.634IleTyr: 2.634 ± 0.06	0.0IleXaa: 0.0 ± 0.0
Lys	4.942LysAla: 4.942 ± 0.082	0.478LysCys: 0.478 ± 0.029	3.123LysAsp: 3.123 ± 0.078	7.303LysGlu: 7.303 ± 0.12	1.964LysPhe: 1.964 ± 0.062	3.966LysGly: 3.966 ± 0.09	1.11LysHis: 1.11 ± 0.042	5.629LysIle: 5.629 ± 0.102	5.692LysLys: 5.692 ± 0.117	5.781LysLeu: 5.781 ± 0.097	2.083LysMet: 2.083 ± 0.052	2.868LysAsn: 2.868 ± 0.069	2.733LysPro: 2.733 ± 0.081	1.651LysGln: 1.651 ± 0.053	5.342LysArg: 5.342 ± 0.106	4.766LysSer: 4.766 ± 0.092	3.106LysThr: 3.106 ± 0.084	3.92LysVal: 3.92 ± 0.074	0.553LysTrp: 0.553 ± 0.03	1.997LysTyr: 1.997 ± 0.065	0.0LysXaa: 0.0 ± 0.0
Leu	7.435LeuAla: 7.435 ± 0.117	0.874LeuCys: 0.874 ± 0.039	5.445LeuAsp: 5.445 ± 0.092	7.446LeuGlu: 7.446 ± 0.127	5.71LeuPhe: 5.71 ± 0.122	6.231LeuGly: 6.231 ± 0.106	2.112LeuHis: 2.112 ± 0.059	6.097LeuIle: 6.097 ± 0.126	7.979LeuLys: 7.979 ± 0.136	10.603LeuLeu: 10.603 ± 0.192	2.465LeuMet: 2.465 ± 0.058	3.365LeuAsn: 3.365 ± 0.07	4.159LeuPro: 4.159 ± 0.094	2.954LeuGln: 2.954 ± 0.074	4.642LeuArg: 4.642 ± 0.092	6.44LeuSer: 6.44 ± 0.104	4.323LeuThr: 4.323 ± 0.079	5.664LeuVal: 5.664 ± 0.111	0.88LeuTrp: 0.88 ± 0.042	3.927LeuTyr: 3.927 ± 0.089	0.0LeuXaa: 0.0 ± 0.0
Met	2.31MetAla: 2.31 ± 0.063	0.17MetCys: 0.17 ± 0.017	1.34MetAsp: 1.34 ± 0.043	2.069MetGlu: 2.069 ± 0.062	0.911MetPhe: 0.911 ± 0.042	1.932MetGly: 1.932 ± 0.052	0.537MetHis: 0.537 ± 0.031	1.971MetIle: 1.971 ± 0.061	2.306MetLys: 2.306 ± 0.059	2.637MetLeu: 2.637 ± 0.056	0.851MetMet: 0.851 ± 0.04	0.943MetAsn: 0.943 ± 0.041	1.213MetPro: 1.213 ± 0.046	0.972MetGln: 0.972 ± 0.039	1.738MetArg: 1.738 ± 0.053	1.481MetSer: 1.481 ± 0.052	1.16MetThr: 1.16 ± 0.038	1.945MetVal: 1.945 ± 0.046	0.193MetTrp: 0.193 ± 0.017	0.587MetTyr: 0.587 ± 0.035	0.0MetXaa: 0.0 ± 0.0
Asn	2.578AsnAla: 2.578 ± 0.064	0.317AsnCys: 0.317 ± 0.023	1.844AsnAsp: 1.844 ± 0.056	2.473AsnGlu: 2.473 ± 0.072	1.59AsnPhe: 1.59 ± 0.048	2.753AsnGly: 2.753 ± 0.085	0.624AsnHis: 0.624 ± 0.031	3.084AsnIle: 3.084 ± 0.074	1.426AsnLys: 1.426 ± 0.056	3.452AsnLeu: 3.452 ± 0.07	0.806AsnMet: 0.806 ± 0.039	0.998AsnAsn: 0.998 ± 0.046	2.01AsnPro: 2.01 ± 0.049	0.702AsnGln: 0.702 ± 0.035	2.92AsnArg: 2.92 ± 0.066	2.074AsnSer: 2.074 ± 0.056	1.476AsnThr: 1.476 ± 0.05	2.091AsnVal: 2.091 ± 0.061	0.254AsnTrp: 0.254 ± 0.022	1.321AsnTyr: 1.321 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	2.678ProAla: 2.678 ± 0.069	0.294ProCys: 0.294 ± 0.022	2.394ProAsp: 2.394 ± 0.062	3.379ProGlu: 3.379 ± 0.077	2.037ProPhe: 2.037 ± 0.059	2.416ProGly: 2.416 ± 0.062	0.866ProHis: 0.866 ± 0.037	2.41ProIle: 2.41 ± 0.06	2.687ProLys: 2.687 ± 0.062	3.958ProLeu: 3.958 ± 0.077	1.045ProMet: 1.045 ± 0.042	1.288ProAsn: 1.288 ± 0.044	1.347ProPro: 1.347 ± 0.049	1.091ProGln: 1.091 ± 0.039	1.444ProArg: 1.444 ± 0.052	2.097ProSer: 2.097 ± 0.057	1.637ProThr: 1.637 ± 0.053	3.124ProVal: 3.124 ± 0.056	0.385ProTrp: 0.385 ± 0.023	1.57ProTyr: 1.57 ± 0.052	0.0ProXaa: 0.0 ± 0.0
Gln	1.686GlnAla: 1.686 ± 0.054	0.215GlnCys: 0.215 ± 0.019	0.852GlnAsp: 0.852 ± 0.038	1.603GlnGlu: 1.603 ± 0.054	0.888GlnPhe: 0.888 ± 0.039	1.234GlnGly: 1.234 ± 0.048	0.414GlnHis: 0.414 ± 0.027	2.2GlnIle: 2.2 ± 0.057	2.433GlnLys: 2.433 ± 0.06	2.14GlnLeu: 2.14 ± 0.061	0.883GlnMet: 0.883 ± 0.04	1.295GlnAsn: 1.295 ± 0.044	0.9GlnPro: 0.9 ± 0.034	0.73GlnGln: 0.73 ± 0.037	1.41GlnArg: 1.41 ± 0.044	1.55GlnSer: 1.55 ± 0.046	1.18GlnThr: 1.18 ± 0.044	1.246GlnVal: 1.246 ± 0.044	0.244GlnTrp: 0.244 ± 0.017	0.717GlnTyr: 0.717 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	3.923ArgAla: 3.923 ± 0.087	0.561ArgCys: 0.561 ± 0.031	2.672ArgAsp: 2.672 ± 0.062	4.751ArgGlu: 4.751 ± 0.095	3.282ArgPhe: 3.282 ± 0.08	3.34ArgGly: 3.34 ± 0.076	1.289ArgHis: 1.289 ± 0.046	4.047ArgIle: 4.047 ± 0.078	3.697ArgLys: 3.697 ± 0.081	6.046ArgLeu: 6.046 ± 0.09	1.654ArgMet: 1.654 ± 0.052	2.022ArgAsn: 2.022 ± 0.06	1.918ArgPro: 1.918 ± 0.053	1.334ArgGln: 1.334 ± 0.05	3.587ArgArg: 3.587 ± 0.082	3.497ArgSer: 3.497 ± 0.064	2.091ArgThr: 2.091 ± 0.061	4.041ArgVal: 4.041 ± 0.091	0.602ArgTrp: 0.602 ± 0.032	3.026ArgTyr: 3.026 ± 0.076	0.0ArgXaa: 0.0 ± 0.0
Ser	4.84SerAla: 4.84 ± 0.098	0.593SerCys: 0.593 ± 0.033	3.529SerAsp: 3.529 ± 0.079	4.239SerGlu: 4.239 ± 0.092	3.369SerPhe: 3.369 ± 0.079	5.212SerGly: 5.212 ± 0.089	1.119SerHis: 1.119 ± 0.041	4.22SerIle: 4.22 ± 0.085	3.684SerLys: 3.684 ± 0.076	6.362SerLeu: 6.362 ± 0.11	1.709SerMet: 1.709 ± 0.053	1.824SerAsn: 1.824 ± 0.056	2.172SerPro: 2.172 ± 0.057	1.397SerGln: 1.397 ± 0.041	3.599SerArg: 3.599 ± 0.086	3.78SerSer: 3.78 ± 0.088	2.733SerThr: 2.733 ± 0.062	4.317SerVal: 4.317 ± 0.084	0.575SerTrp: 0.575 ± 0.034	2.321SerTyr: 2.321 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	3.716ThrAla: 3.716 ± 0.079	0.316ThrCys: 0.316 ± 0.023	2.548ThrAsp: 2.548 ± 0.069	2.805ThrGlu: 2.805 ± 0.069	2.068ThrPhe: 2.068 ± 0.052	3.598ThrGly: 3.598 ± 0.074	0.869ThrHis: 0.869 ± 0.035	3.432ThrIle: 3.432 ± 0.077	2.601ThrLys: 2.601 ± 0.069	5.571ThrLeu: 5.571 ± 0.082	1.154ThrMet: 1.154 ± 0.039	1.335ThrAsn: 1.335 ± 0.045	2.477ThrPro: 2.477 ± 0.062	1.193ThrGln: 1.193 ± 0.041	1.875ThrArg: 1.875 ± 0.054	2.31ThrSer: 2.31 ± 0.066	2.177ThrThr: 2.177 ± 0.064	3.762ThrVal: 3.762 ± 0.083	0.323ThrTrp: 0.323 ± 0.019	1.502ThrTyr: 1.502 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	5.531ValAla: 5.531 ± 0.098	0.704ValCys: 0.704 ± 0.036	4.052ValAsp: 4.052 ± 0.083	5.673ValGlu: 5.673 ± 0.087	2.401ValPhe: 2.401 ± 0.057	4.326ValGly: 4.326 ± 0.097	1.205ValHis: 1.205 ± 0.043	4.565ValIle: 4.565 ± 0.096	4.709ValLys: 4.709 ± 0.091	6.208ValLeu: 6.208 ± 0.117	1.951ValMet: 1.951 ± 0.054	2.318ValAsn: 2.318 ± 0.061	2.623ValPro: 2.623 ± 0.068	1.528ValGln: 1.528 ± 0.043	3.17ValArg: 3.17 ± 0.068	4.314ValSer: 4.314 ± 0.078	3.707ValThr: 3.707 ± 0.087	5.174ValVal: 5.174 ± 0.102	0.652ValTrp: 0.652 ± 0.036	2.135ValTyr: 2.135 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	0.555TrpAla: 0.555 ± 0.033	0.101TrpCys: 0.101 ± 0.012	0.428TrpAsp: 0.428 ± 0.028	0.569TrpGlu: 0.569 ± 0.032	0.52TrpPhe: 0.52 ± 0.031	0.592TrpGly: 0.592 ± 0.03	0.222TrpHis: 0.222 ± 0.018	0.717TrpIle: 0.717 ± 0.038	0.491TrpLys: 0.491 ± 0.032	1.174TrpLeu: 1.174 ± 0.046	0.35TrpMet: 0.35 ± 0.025	0.33TrpAsn: 0.33 ± 0.023	0.276TrpPro: 0.276 ± 0.02	0.348TrpGln: 0.348 ± 0.021	0.572TrpArg: 0.572 ± 0.03	0.529TrpSer: 0.529 ± 0.031	0.293TrpThr: 0.293 ± 0.021	0.604TrpVal: 0.604 ± 0.035	0.139TrpTrp: 0.139 ± 0.016	0.402TrpTyr: 0.402 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.75TyrAla: 2.75 ± 0.061	0.323TyrCys: 0.323 ± 0.025	2.356TyrAsp: 2.356 ± 0.064	2.747TyrGlu: 2.747 ± 0.072	1.833TyrPhe: 1.833 ± 0.057	2.787TyrGly: 2.787 ± 0.068	0.727TyrHis: 0.727 ± 0.032	2.611TyrIle: 2.611 ± 0.059	2.01TyrLys: 2.01 ± 0.065	3.845TyrLeu: 3.845 ± 0.1	0.881TyrMet: 0.881 ± 0.034	1.427TyrAsn: 1.427 ± 0.054	1.511TyrPro: 1.511 ± 0.052	0.826TyrGln: 0.826 ± 0.04	2.801TyrArg: 2.801 ± 0.071	2.226TyrSer: 2.226 ± 0.062	1.734TyrThr: 1.734 ± 0.056	1.794TyrVal: 1.794 ± 0.059	0.392TyrTrp: 0.392 ± 0.025	1.464TyrTyr: 1.464 ± 0.058	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2173 proteins (652339 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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