Amino acid dipepetide frequency for Ktedonosporobacter rubrisoli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.987AlaAla: 9.987 ± 0.077	1.19AlaCys: 1.19 ± 0.019	4.25AlaAsp: 4.25 ± 0.042	6.08AlaGlu: 6.08 ± 0.051	3.756AlaPhe: 3.756 ± 0.039	7.148AlaGly: 7.148 ± 0.059	2.562AlaHis: 2.562 ± 0.028	5.945AlaIle: 5.945 ± 0.045	2.651AlaLys: 2.651 ± 0.033	13.128AlaLeu: 13.128 ± 0.086	2.325AlaMet: 2.325 ± 0.03	2.835AlaAsn: 2.835 ± 0.041	4.133AlaPro: 4.133 ± 0.043	5.301AlaGln: 5.301 ± 0.052	6.866AlaArg: 6.866 ± 0.055	6.516AlaSer: 6.516 ± 0.055	5.266AlaThr: 5.266 ± 0.043	5.976AlaVal: 5.976 ± 0.044	1.521AlaTrp: 1.521 ± 0.023	2.994AlaTyr: 2.994 ± 0.03	0.0AlaXaa: 0.0 ± 0.0
Cys	0.968CysAla: 0.968 ± 0.021	0.161CysCys: 0.161 ± 0.008	0.427CysAsp: 0.427 ± 0.012	0.532CysGlu: 0.532 ± 0.014	0.413CysPhe: 0.413 ± 0.014	0.944CysGly: 0.944 ± 0.018	0.27CysHis: 0.27 ± 0.008	0.598CysIle: 0.598 ± 0.014	0.279CysLys: 0.279 ± 0.011	1.188CysLeu: 1.188 ± 0.021	0.238CysMet: 0.238 ± 0.008	0.314CysAsn: 0.314 ± 0.01	0.518CysPro: 0.518 ± 0.014	0.507CysGln: 0.507 ± 0.013	0.544CysArg: 0.544 ± 0.014	0.72CysSer: 0.72 ± 0.016	0.544CysThr: 0.544 ± 0.013	0.605CysVal: 0.605 ± 0.016	0.197CysTrp: 0.197 ± 0.007	0.402CysTyr: 0.402 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.103AspAla: 4.103 ± 0.031	0.408AspCys: 0.408 ± 0.011	1.93AspAsp: 1.93 ± 0.027	3.196AspGlu: 3.196 ± 0.036	1.737AspPhe: 1.737 ± 0.024	3.189AspGly: 3.189 ± 0.043	1.022AspHis: 1.022 ± 0.021	2.874AspIle: 2.874 ± 0.029	1.513AspLys: 1.513 ± 0.023	5.17AspLeu: 5.17 ± 0.046	1.035AspMet: 1.035 ± 0.017	1.258AspAsn: 1.258 ± 0.021	2.695AspPro: 2.695 ± 0.029	1.885AspGln: 1.885 ± 0.027	2.373AspArg: 2.373 ± 0.031	2.059AspSer: 2.059 ± 0.027	2.285AspThr: 2.285 ± 0.028	3.022AspVal: 3.022 ± 0.034	0.785AspTrp: 0.785 ± 0.015	1.466AspTyr: 1.466 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	6.739GluAla: 6.739 ± 0.06	0.467GluCys: 0.467 ± 0.013	2.566GluAsp: 2.566 ± 0.032	4.749GluGlu: 4.749 ± 0.052	1.502GluPhe: 1.502 ± 0.023	3.609GluGly: 3.609 ± 0.037	1.941GluHis: 1.941 ± 0.027	3.446GluIle: 3.446 ± 0.042	2.506GluLys: 2.506 ± 0.035	6.672GluLeu: 6.672 ± 0.058	1.53GluMet: 1.53 ± 0.025	1.674GluAsn: 1.674 ± 0.028	2.612GluPro: 2.612 ± 0.032	4.724GluGln: 4.724 ± 0.052	5.081GluArg: 5.081 ± 0.052	2.55GluSer: 2.55 ± 0.033	2.972GluThr: 2.972 ± 0.032	3.91GluVal: 3.91 ± 0.039	0.701GluTrp: 0.701 ± 0.018	1.547GluTyr: 1.547 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.795PheAla: 3.795 ± 0.038	0.5PheCys: 0.5 ± 0.013	1.797PheAsp: 1.797 ± 0.023	1.94PheGlu: 1.94 ± 0.025	1.669PhePhe: 1.669 ± 0.027	2.739PheGly: 2.739 ± 0.031	0.879PheHis: 0.879 ± 0.018	2.035PheIle: 2.035 ± 0.031	1.009PheLys: 1.009 ± 0.017	4.304PheLeu: 4.304 ± 0.042	0.801PheMet: 0.801 ± 0.017	1.047PheAsn: 1.047 ± 0.019	1.851PhePro: 1.851 ± 0.026	1.448PheGln: 1.448 ± 0.023	1.826PheArg: 1.826 ± 0.023	2.635PheSer: 2.635 ± 0.03	2.152PheThr: 2.152 ± 0.027	2.557PheVal: 2.557 ± 0.037	0.653PheTrp: 0.653 ± 0.016	1.169PheTyr: 1.169 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	5.958GlyAla: 5.958 ± 0.061	0.807GlyCys: 0.807 ± 0.017	2.811GlyAsp: 2.811 ± 0.031	3.892GlyGlu: 3.892 ± 0.039	2.7GlyPhe: 2.7 ± 0.032	4.887GlyGly: 4.887 ± 0.047	1.742GlyHis: 1.742 ± 0.028	4.692GlyIle: 4.692 ± 0.045	3.379GlyLys: 3.379 ± 0.03	7.884GlyLeu: 7.884 ± 0.063	1.822GlyMet: 1.822 ± 0.026	2.286GlyAsn: 2.286 ± 0.031	2.833GlyPro: 2.833 ± 0.032	3.343GlyGln: 3.343 ± 0.041	4.029GlyArg: 4.029 ± 0.039	4.491GlySer: 4.491 ± 0.043	3.959GlyThr: 3.959 ± 0.036	4.536GlyVal: 4.536 ± 0.042	1.315GlyTrp: 1.315 ± 0.023	2.557GlyTyr: 2.557 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	2.176HisAla: 2.176 ± 0.027	0.297HisCys: 0.297 ± 0.009	1.101HisAsp: 1.101 ± 0.022	1.453HisGlu: 1.453 ± 0.021	1.081HisPhe: 1.081 ± 0.019	1.745HisGly: 1.745 ± 0.025	0.679HisHis: 0.679 ± 0.017	1.728HisIle: 1.728 ± 0.026	0.846HisLys: 0.846 ± 0.018	3.184HisLeu: 3.184 ± 0.035	0.604HisMet: 0.604 ± 0.014	0.803HisAsn: 0.803 ± 0.018	1.637HisPro: 1.637 ± 0.023	1.011HisGln: 1.011 ± 0.019	1.32HisArg: 1.32 ± 0.019	1.412HisSer: 1.412 ± 0.022	1.454HisThr: 1.454 ± 0.023	1.571HisVal: 1.571 ± 0.022	0.436HisTrp: 0.436 ± 0.012	0.925HisTyr: 0.925 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.476IleAla: 6.476 ± 0.05	0.742IleCys: 0.742 ± 0.016	2.815IleAsp: 2.815 ± 0.034	3.763IleGlu: 3.763 ± 0.039	2.312IlePhe: 2.312 ± 0.034	4.354IleGly: 4.354 ± 0.049	1.306IleHis: 1.306 ± 0.021	3.391IleIle: 3.391 ± 0.038	1.841IleLys: 1.841 ± 0.025	6.011IleLeu: 6.011 ± 0.051	1.103IleMet: 1.103 ± 0.019	1.728IleAsn: 1.728 ± 0.026	2.959IlePro: 2.959 ± 0.033	2.224IleGln: 2.224 ± 0.022	3.061IleArg: 3.061 ± 0.034	3.869IleSer: 3.869 ± 0.036	3.284IleThr: 3.284 ± 0.035	4.284IleVal: 4.284 ± 0.044	0.853IleTrp: 0.853 ± 0.018	1.757IleTyr: 1.757 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.332LysAla: 3.332 ± 0.035	0.204LysCys: 0.204 ± 0.009	1.647LysAsp: 1.647 ± 0.026	2.283LysGlu: 2.283 ± 0.031	0.829LysPhe: 0.829 ± 0.019	2.262LysGly: 2.262 ± 0.029	0.895LysHis: 0.895 ± 0.016	1.778LysIle: 1.778 ± 0.028	1.398LysLys: 1.398 ± 0.026	3.621LysLeu: 3.621 ± 0.039	0.818LysMet: 0.818 ± 0.018	1.005LysAsn: 1.005 ± 0.018	1.76LysPro: 1.76 ± 0.025	2.092LysGln: 2.092 ± 0.029	2.538LysArg: 2.538 ± 0.033	1.657LysSer: 1.657 ± 0.025	1.77LysThr: 1.77 ± 0.025	2.18LysVal: 2.18 ± 0.031	0.393LysTrp: 0.393 ± 0.012	0.93LysTyr: 0.93 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	13.243LeuAla: 13.243 ± 0.083	1.343LeuCys: 1.343 ± 0.023	5.378LeuAsp: 5.378 ± 0.05	6.545LeuGlu: 6.545 ± 0.061	4.332LeuPhe: 4.332 ± 0.047	7.942LeuGly: 7.942 ± 0.065	3.047LeuHis: 3.047 ± 0.033	6.453LeuIle: 6.453 ± 0.051	3.763LeuLys: 3.763 ± 0.041	15.038LeuLeu: 15.038 ± 0.115	2.209LeuMet: 2.209 ± 0.027	3.233LeuAsn: 3.233 ± 0.033	6.572LeuPro: 6.572 ± 0.051	5.772LeuGln: 5.772 ± 0.054	7.271LeuArg: 7.271 ± 0.06	7.938LeuSer: 7.938 ± 0.061	6.265LeuThr: 6.265 ± 0.052	7.42LeuVal: 7.42 ± 0.056	1.55LeuTrp: 1.55 ± 0.025	3.183LeuTyr: 3.183 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	2.254MetAla: 2.254 ± 0.025	0.176MetCys: 0.176 ± 0.008	0.899MetAsp: 0.899 ± 0.019	1.164MetGlu: 1.164 ± 0.02	0.645MetPhe: 0.645 ± 0.016	1.413MetGly: 1.413 ± 0.021	0.596MetHis: 0.596 ± 0.014	1.147MetIle: 1.147 ± 0.018	0.85MetLys: 0.85 ± 0.017	2.881MetLeu: 2.881 ± 0.027	0.484MetMet: 0.484 ± 0.012	0.74MetAsn: 0.74 ± 0.016	1.301MetPro: 1.301 ± 0.022	1.354MetGln: 1.354 ± 0.023	1.598MetArg: 1.598 ± 0.023	1.488MetSer: 1.488 ± 0.022	1.208MetThr: 1.208 ± 0.022	1.372MetVal: 1.372 ± 0.022	0.226MetTrp: 0.226 ± 0.009	0.521MetTyr: 0.521 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.777AsnAla: 2.777 ± 0.032	0.302AsnCys: 0.302 ± 0.01	1.345AsnAsp: 1.345 ± 0.021	1.614AsnGlu: 1.614 ± 0.024	1.135AsnPhe: 1.135 ± 0.019	2.228AsnGly: 2.228 ± 0.034	0.604AsnHis: 0.604 ± 0.013	1.898AsnIle: 1.898 ± 0.027	1.035AsnLys: 1.035 ± 0.021	3.138AsnLeu: 3.138 ± 0.036	0.681AsnMet: 0.681 ± 0.015	1.082AsnAsn: 1.082 ± 0.026	1.814AsnPro: 1.814 ± 0.029	1.294AsnGln: 1.294 ± 0.024	1.583AsnArg: 1.583 ± 0.025	1.662AsnSer: 1.662 ± 0.024	1.737AsnThr: 1.737 ± 0.027	1.924AsnVal: 1.924 ± 0.027	0.509AsnTrp: 0.509 ± 0.016	0.986AsnTyr: 0.986 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	5.368ProAla: 5.368 ± 0.054	0.394ProCys: 0.394 ± 0.011	2.815ProAsp: 2.815 ± 0.035	3.779ProGlu: 3.779 ± 0.037	2.053ProPhe: 2.053 ± 0.027	3.92ProGly: 3.92 ± 0.04	1.298ProHis: 1.298 ± 0.018	2.49ProIle: 2.49 ± 0.028	1.236ProLys: 1.236 ± 0.022	5.821ProLeu: 5.821 ± 0.051	0.952ProMet: 0.952 ± 0.018	1.38ProAsn: 1.38 ± 0.024	2.443ProPro: 2.443 ± 0.04	2.578ProGln: 2.578 ± 0.034	2.613ProArg: 2.613 ± 0.028	3.05ProSer: 3.05 ± 0.034	2.895ProThr: 2.895 ± 0.034	3.238ProVal: 3.238 ± 0.033	0.741ProTrp: 0.741 ± 0.016	1.488ProTyr: 1.488 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	6.316GlnAla: 6.316 ± 0.05	0.345GlnCys: 0.345 ± 0.01	2.08GlnAsp: 2.08 ± 0.03	3.724GlnGlu: 3.724 ± 0.048	1.42GlnPhe: 1.42 ± 0.024	3.533GlnGly: 3.533 ± 0.032	1.468GlnHis: 1.468 ± 0.021	2.713GlnIle: 2.713 ± 0.026	1.817GlnLys: 1.817 ± 0.027	5.44GlnLeu: 5.44 ± 0.047	1.178GlnMet: 1.178 ± 0.016	1.351GlnAsn: 1.351 ± 0.021	2.579GlnPro: 2.579 ± 0.038	3.668GlnGln: 3.668 ± 0.044	3.802GlnArg: 3.802 ± 0.04	2.568GlnSer: 2.568 ± 0.035	2.489GlnThr: 2.489 ± 0.027	3.222GlnVal: 3.222 ± 0.03	0.673GlnTrp: 0.673 ± 0.015	1.173GlnTyr: 1.173 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	5.793ArgAla: 5.793 ± 0.052	0.635ArgCys: 0.635 ± 0.015	2.601ArgAsp: 2.601 ± 0.032	4.34ArgGlu: 4.34 ± 0.042	2.41ArgPhe: 2.41 ± 0.03	3.68ArgGly: 3.68 ± 0.035	1.576ArgHis: 1.576 ± 0.024	3.558ArgIle: 3.558 ± 0.037	2.43ArgLys: 2.43 ± 0.032	7.529ArgLeu: 7.529 ± 0.054	1.499ArgMet: 1.499 ± 0.023	1.734ArgAsn: 1.734 ± 0.027	2.779ArgPro: 2.779 ± 0.032	3.532ArgGln: 3.532 ± 0.035	4.569ArgArg: 4.569 ± 0.047	3.631ArgSer: 3.631 ± 0.035	3.141ArgThr: 3.141 ± 0.035	3.847ArgVal: 3.847 ± 0.041	1.137ArgTrp: 1.137 ± 0.022	2.267ArgTyr: 2.267 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	5.684SerAla: 5.684 ± 0.045	0.623SerCys: 0.623 ± 0.016	2.508SerAsp: 2.508 ± 0.03	3.243SerGlu: 3.243 ± 0.037	2.552SerPhe: 2.552 ± 0.032	4.668SerGly: 4.668 ± 0.042	1.427SerHis: 1.427 ± 0.023	3.612SerIle: 3.612 ± 0.032	1.857SerLys: 1.857 ± 0.021	7.314SerLeu: 7.314 ± 0.056	1.532SerMet: 1.532 ± 0.022	1.792SerAsn: 1.792 ± 0.032	3.276SerPro: 3.276 ± 0.041	2.923SerGln: 2.923 ± 0.035	3.4SerArg: 3.4 ± 0.037	4.529SerSer: 4.529 ± 0.047	3.505SerThr: 3.505 ± 0.04	3.654SerVal: 3.654 ± 0.032	1.119SerTrp: 1.119 ± 0.02	1.943SerTyr: 1.943 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	4.946ThrAla: 4.946 ± 0.042	0.547ThrCys: 0.547 ± 0.015	2.221ThrAsp: 2.221 ± 0.029	2.643ThrGlu: 2.643 ± 0.031	2.28ThrPhe: 2.28 ± 0.026	3.953ThrGly: 3.953 ± 0.043	1.383ThrHis: 1.383 ± 0.023	3.501ThrIle: 3.501 ± 0.039	1.374ThrLys: 1.374 ± 0.019	6.853ThrLeu: 6.853 ± 0.053	1.105ThrMet: 1.105 ± 0.017	1.665ThrAsn: 1.665 ± 0.027	3.294ThrPro: 3.294 ± 0.039	2.391ThrGln: 2.391 ± 0.028	3.156ThrArg: 3.156 ± 0.033	3.526ThrSer: 3.526 ± 0.041	3.313ThrThr: 3.313 ± 0.037	3.537ThrVal: 3.537 ± 0.034	0.804ThrTrp: 0.804 ± 0.02	1.718ThrTyr: 1.718 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	6.537ValAla: 6.537 ± 0.051	0.691ValCys: 0.691 ± 0.017	2.79ValAsp: 2.79 ± 0.035	3.952ValGlu: 3.952 ± 0.033	2.264ValPhe: 2.264 ± 0.031	4.571ValGly: 4.571 ± 0.042	1.45ValHis: 1.45 ± 0.024	3.843ValIle: 3.843 ± 0.039	2.163ValLys: 2.163 ± 0.033	7.616ValLeu: 7.616 ± 0.062	1.438ValMet: 1.438 ± 0.024	1.903ValAsn: 1.903 ± 0.029	3.312ValPro: 3.312 ± 0.036	2.88ValGln: 2.88 ± 0.031	3.805ValArg: 3.805 ± 0.036	4.138ValSer: 4.138 ± 0.042	3.542ValThr: 3.542 ± 0.043	4.598ValVal: 4.598 ± 0.045	0.83ValTrp: 0.83 ± 0.018	1.768ValTyr: 1.768 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.066TrpAla: 1.066 ± 0.02	0.153TrpCys: 0.153 ± 0.007	0.62TrpAsp: 0.62 ± 0.016	0.81TrpGlu: 0.81 ± 0.015	0.562TrpPhe: 0.562 ± 0.015	0.924TrpGly: 0.924 ± 0.023	0.452TrpHis: 0.452 ± 0.013	0.797TrpIle: 0.797 ± 0.018	0.57TrpLys: 0.57 ± 0.012	2.219TrpLeu: 2.219 ± 0.036	0.338TrpMet: 0.338 ± 0.011	0.55TrpAsn: 0.55 ± 0.013	0.695TrpPro: 0.695 ± 0.017	1.05TrpGln: 1.05 ± 0.022	1.075TrpArg: 1.075 ± 0.022	1.057TrpSer: 1.057 ± 0.022	0.689TrpThr: 0.689 ± 0.015	0.807TrpVal: 0.807 ± 0.015	0.27TrpTrp: 0.27 ± 0.011	0.512TrpTyr: 0.512 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.913TyrAla: 2.913 ± 0.028	0.383TyrCys: 0.383 ± 0.012	1.401TyrAsp: 1.401 ± 0.021	1.796TyrGlu: 1.796 ± 0.031	1.152TyrPhe: 1.152 ± 0.02	2.214TyrGly: 2.214 ± 0.03	0.864TyrHis: 0.864 ± 0.017	1.636TyrIle: 1.636 ± 0.024	0.873TyrLys: 0.873 ± 0.015	3.488TyrLeu: 3.488 ± 0.032	0.626TyrMet: 0.626 ± 0.016	0.966TyrAsn: 0.966 ± 0.021	1.489TyrPro: 1.489 ± 0.023	1.583TyrGln: 1.583 ± 0.024	2.18TyrArg: 2.18 ± 0.03	1.664TyrSer: 1.664 ± 0.027	1.74TyrThr: 1.74 ± 0.023	1.833TyrVal: 1.833 ± 0.026	0.506TyrTrp: 0.506 ± 0.015	1.035TyrTyr: 1.035 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9315 proteins (3002708 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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