Amino acid dipepetide frequency for Rhodoferax sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.339AlaAla: 15.339 ± 0.165
1.314AlaCys: 1.314 ± 0.031
5.977AlaAsp: 5.977 ± 0.066
5.687AlaGlu: 5.687 ± 0.085
3.916AlaPhe: 3.916 ± 0.051
9.02AlaGly: 9.02 ± 0.093
3.025AlaHis: 3.025 ± 0.053
5.333AlaIle: 5.333 ± 0.066
5.069AlaLys: 5.069 ± 0.078
14.909AlaLeu: 14.909 ± 0.227
3.722AlaMet: 3.722 ± 0.056
3.511AlaAsn: 3.511 ± 0.066
5.473AlaPro: 5.473 ± 0.083
7.098AlaGln: 7.098 ± 0.095
6.86AlaArg: 6.86 ± 0.077
7.426AlaSer: 7.426 ± 0.091
6.345AlaThr: 6.345 ± 0.066
8.609AlaVal: 8.609 ± 0.103
1.94AlaTrp: 1.94 ± 0.045
2.655AlaTyr: 2.655 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
1.265CysAla: 1.265 ± 0.032
0.106CysCys: 0.106 ± 0.009
0.497CysAsp: 0.497 ± 0.018
0.507CysGlu: 0.507 ± 0.02
0.335CysPhe: 0.335 ± 0.017
0.956CysGly: 0.956 ± 0.024
0.259CysHis: 0.259 ± 0.014
0.467CysIle: 0.467 ± 0.018
0.331CysLys: 0.331 ± 0.015
0.924CysLeu: 0.924 ± 0.032
0.247CysMet: 0.247 ± 0.012
0.268CysAsn: 0.268 ± 0.013
0.463CysPro: 0.463 ± 0.021
0.313CysGln: 0.313 ± 0.015
0.435CysArg: 0.435 ± 0.017
0.56CysSer: 0.56 ± 0.021
0.558CysThr: 0.558 ± 0.019
0.832CysVal: 0.832 ± 0.027
0.14CysTrp: 0.14 ± 0.01
0.205CysTyr: 0.205 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
6.82AspAla: 6.82 ± 0.083
0.479AspCys: 0.479 ± 0.019
2.426AspAsp: 2.426 ± 0.052
2.684AspGlu: 2.684 ± 0.05
2.021AspPhe: 2.021 ± 0.039
4.0AspGly: 4.0 ± 0.065
1.11AspHis: 1.11 ± 0.028
2.591AspIle: 2.591 ± 0.062
2.05AspLys: 2.05 ± 0.046
5.372AspLeu: 5.372 ± 0.064
1.289AspMet: 1.289 ± 0.03
1.325AspAsn: 1.325 ± 0.033
2.476AspPro: 2.476 ± 0.043
1.863AspGln: 1.863 ± 0.079
2.639AspArg: 2.639 ± 0.049
2.517AspSer: 2.517 ± 0.042
2.748AspThr: 2.748 ± 0.052
3.999AspVal: 3.999 ± 0.058
0.87AspTrp: 0.87 ± 0.025
1.471AspTyr: 1.471 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
5.963GluAla: 5.963 ± 0.076
0.409GluCys: 0.409 ± 0.017
2.19GluAsp: 2.19 ± 0.043
2.291GluGlu: 2.291 ± 0.055
1.911GluPhe: 1.911 ± 0.035
3.371GluGly: 3.371 ± 0.052
1.292GluHis: 1.292 ± 0.036
2.555GluIle: 2.555 ± 0.047
2.101GluLys: 2.101 ± 0.052
5.738GluLeu: 5.738 ± 0.079
1.266GluMet: 1.266 ± 0.033
1.303GluAsn: 1.303 ± 0.031
2.195GluPro: 2.195 ± 0.043
2.499GluGln: 2.499 ± 0.05
3.789GluArg: 3.789 ± 0.067
2.771GluSer: 2.771 ± 0.038
2.526GluThr: 2.526 ± 0.064
4.02GluVal: 4.02 ± 0.054
0.681GluTrp: 0.681 ± 0.023
1.092GluTyr: 1.092 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
4.322PheAla: 4.322 ± 0.059
0.419PheCys: 0.419 ± 0.018
2.507PheAsp: 2.507 ± 0.042
2.121PheGlu: 2.121 ± 0.04
1.436PhePhe: 1.436 ± 0.039
3.158PheGly: 3.158 ± 0.051
0.722PheHis: 0.722 ± 0.024
1.537PheIle: 1.537 ± 0.035
1.555PheLys: 1.555 ± 0.039
2.877PheLeu: 2.877 ± 0.049
0.822PheMet: 0.822 ± 0.027
1.247PheAsn: 1.247 ± 0.03
1.428PhePro: 1.428 ± 0.046
1.149PheGln: 1.149 ± 0.029
1.505PheArg: 1.505 ± 0.037
2.437PheSer: 2.437 ± 0.044
2.018PheThr: 2.018 ± 0.034
2.855PheVal: 2.855 ± 0.047
0.537PheTrp: 0.537 ± 0.02
0.955PheTyr: 0.955 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
8.46GlyAla: 8.46 ± 0.098
0.86GlyCys: 0.86 ± 0.028
3.669GlyAsp: 3.669 ± 0.066
3.837GlyGlu: 3.837 ± 0.056
3.235GlyPhe: 3.235 ± 0.051
6.135GlyGly: 6.135 ± 0.103
1.851GlyHis: 1.851 ± 0.041
3.756GlyIle: 3.756 ± 0.057
3.724GlyLys: 3.724 ± 0.062
8.609GlyLeu: 8.609 ± 0.096
2.275GlyMet: 2.275 ± 0.045
2.359GlyAsn: 2.359 ± 0.057
2.703GlyPro: 2.703 ± 0.049
3.414GlyGln: 3.414 ± 0.05
4.3GlyArg: 4.3 ± 0.063
4.555GlySer: 4.555 ± 0.063
4.29GlyThr: 4.29 ± 0.064
6.508GlyVal: 6.508 ± 0.085
1.259GlyTrp: 1.259 ± 0.032
2.232GlyTyr: 2.232 ± 0.039
0.0GlyXaa: 0.0 ± 0.0
His
3.052HisAla: 3.052 ± 0.053
0.312HisCys: 0.312 ± 0.016
1.099HisAsp: 1.099 ± 0.031
1.091HisGlu: 1.091 ± 0.031
0.953HisPhe: 0.953 ± 0.028
1.998HisGly: 1.998 ± 0.046
0.686HisHis: 0.686 ± 0.025
1.135HisIle: 1.135 ± 0.029
0.741HisLys: 0.741 ± 0.022
2.352HisLeu: 2.352 ± 0.047
0.64HisMet: 0.64 ± 0.021
0.595HisAsn: 0.595 ± 0.021
1.375HisPro: 1.375 ± 0.03
0.884HisGln: 0.884 ± 0.028
1.337HisArg: 1.337 ± 0.035
1.337HisSer: 1.337 ± 0.033
1.402HisThr: 1.402 ± 0.031
1.62HisVal: 1.62 ± 0.037
0.452HisTrp: 0.452 ± 0.022
0.659HisTyr: 0.659 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
6.221IleAla: 6.221 ± 0.069
0.445IleCys: 0.445 ± 0.019
2.788IleAsp: 2.788 ± 0.045
3.018IleGlu: 3.018 ± 0.055
1.285IlePhe: 1.285 ± 0.034
3.824IleGly: 3.824 ± 0.052
0.936IleHis: 0.936 ± 0.029
1.519IleIle: 1.519 ± 0.033
1.901IleLys: 1.901 ± 0.041
3.306IleLeu: 3.306 ± 0.058
0.854IleMet: 0.854 ± 0.026
1.611IleAsn: 1.611 ± 0.035
2.037IlePro: 2.037 ± 0.038
1.651IleGln: 1.651 ± 0.065
2.406IleArg: 2.406 ± 0.047
2.735IleSer: 2.735 ± 0.047
2.722IleThr: 2.722 ± 0.055
3.278IleVal: 3.278 ± 0.051
0.477IleTrp: 0.477 ± 0.017
0.996IleTyr: 0.996 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
4.875LysAla: 4.875 ± 0.083
0.204LysCys: 0.204 ± 0.012
2.03LysAsp: 2.03 ± 0.049
1.851LysGlu: 1.851 ± 0.051
1.203LysPhe: 1.203 ± 0.031
2.926LysGly: 2.926 ± 0.058
0.891LysHis: 0.891 ± 0.025
1.75LysIle: 1.75 ± 0.04
1.771LysLys: 1.771 ± 0.045
4.203LysLeu: 4.203 ± 0.057
0.975LysMet: 0.975 ± 0.026
1.221LysAsn: 1.221 ± 0.033
2.386LysPro: 2.386 ± 0.04
1.49LysGln: 1.49 ± 0.038
2.541LysArg: 2.541 ± 0.045
2.278LysSer: 2.278 ± 0.043
2.499LysThr: 2.499 ± 0.051
3.113LysVal: 3.113 ± 0.058
0.411LysTrp: 0.411 ± 0.017
0.797LysTyr: 0.797 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
13.777LeuAla: 13.777 ± 0.12
1.109LeuCys: 1.109 ± 0.032
5.75LeuAsp: 5.75 ± 0.081
5.309LeuGlu: 5.309 ± 0.071
3.324LeuPhe: 3.324 ± 0.052
8.572LeuGly: 8.572 ± 0.11
2.523LeuHis: 2.523 ± 0.049
4.254LeuIle: 4.254 ± 0.068
4.192LeuLys: 4.192 ± 0.054
10.789LeuLeu: 10.789 ± 0.127
2.732LeuMet: 2.732 ± 0.049
3.172LeuAsn: 3.172 ± 0.062
5.666LeuPro: 5.666 ± 0.081
5.033LeuGln: 5.033 ± 0.071
6.681LeuArg: 6.681 ± 0.09
6.791LeuSer: 6.791 ± 0.092
5.658LeuThr: 5.658 ± 0.15
8.168LeuVal: 8.168 ± 0.08
1.413LeuTrp: 1.413 ± 0.036
2.035LeuTyr: 2.035 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
3.317MetAla: 3.317 ± 0.052
0.204MetCys: 0.204 ± 0.013
1.345MetAsp: 1.345 ± 0.032
1.216MetGlu: 1.216 ± 0.029
0.745MetPhe: 0.745 ± 0.026
2.235MetGly: 2.235 ± 0.042
0.621MetHis: 0.621 ± 0.021
0.826MetIle: 0.826 ± 0.025
1.051MetLys: 1.051 ± 0.03
2.759MetLeu: 2.759 ± 0.047
0.593MetMet: 0.593 ± 0.022
0.858MetAsn: 0.858 ± 0.025
1.533MetPro: 1.533 ± 0.034
1.35MetGln: 1.35 ± 0.034
1.732MetArg: 1.732 ± 0.033
1.593MetSer: 1.593 ± 0.031
1.545MetThr: 1.545 ± 0.031
2.094MetVal: 2.094 ± 0.036
0.273MetTrp: 0.273 ± 0.013
0.436MetTyr: 0.436 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.884AsnAla: 3.884 ± 0.064
0.288AsnCys: 0.288 ± 0.015
1.418AsnAsp: 1.418 ± 0.044
1.297AsnGlu: 1.297 ± 0.031
1.069AsnPhe: 1.069 ± 0.032
2.291AsnGly: 2.291 ± 0.046
0.664AsnHis: 0.664 ± 0.022
1.426AsnIle: 1.426 ± 0.039
1.034AsnLys: 1.034 ± 0.026
2.929AsnLeu: 2.929 ± 0.051
0.722AsnMet: 0.722 ± 0.023
0.969AsnAsn: 0.969 ± 0.031
2.02AsnPro: 2.02 ± 0.041
1.264AsnGln: 1.264 ± 0.052
1.583AsnArg: 1.583 ± 0.037
1.648AsnSer: 1.648 ± 0.038
1.875AsnThr: 1.875 ± 0.049
2.09AsnVal: 2.09 ± 0.041
0.493AsnTrp: 0.493 ± 0.019
0.774AsnTyr: 0.774 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
5.72ProAla: 5.72 ± 0.081
0.397ProCys: 0.397 ± 0.015
2.622ProAsp: 2.622 ± 0.039
2.848ProGlu: 2.848 ± 0.051
1.694ProPhe: 1.694 ± 0.037
3.624ProGly: 3.624 ± 0.061
1.187ProHis: 1.187 ± 0.031
1.964ProIle: 1.964 ± 0.038
1.938ProLys: 1.938 ± 0.04
4.922ProLeu: 4.922 ± 0.065
1.427ProMet: 1.427 ± 0.037
1.507ProAsn: 1.507 ± 0.035
2.061ProPro: 2.061 ± 0.044
2.262ProGln: 2.262 ± 0.042
2.284ProArg: 2.284 ± 0.046
3.166ProSer: 3.166 ± 0.05
2.757ProThr: 2.757 ± 0.051
3.989ProVal: 3.989 ± 0.055
0.825ProTrp: 0.825 ± 0.024
1.168ProTyr: 1.168 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
6.75GlnAla: 6.75 ± 0.113
0.363GlnCys: 0.363 ± 0.015
1.992GlnAsp: 1.992 ± 0.042
1.987GlnGlu: 1.987 ± 0.035
1.502GlnPhe: 1.502 ± 0.032
3.547GlnGly: 3.547 ± 0.053
1.175GlnHis: 1.175 ± 0.033
1.895GlnIle: 1.895 ± 0.082
1.384GlnLys: 1.384 ± 0.03
4.72GlnLeu: 4.72 ± 0.06
1.058GlnMet: 1.058 ± 0.026
1.101GlnAsn: 1.101 ± 0.033
1.912GlnPro: 1.912 ± 0.036
2.056GlnGln: 2.056 ± 0.04
3.334GlnArg: 3.334 ± 0.057
2.579GlnSer: 2.579 ± 0.05
2.538GlnThr: 2.538 ± 0.047
3.558GlnVal: 3.558 ± 0.147
0.903GlnTrp: 0.903 ± 0.028
0.909GlnTyr: 0.909 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
6.311ArgAla: 6.311 ± 0.071
0.543ArgCys: 0.543 ± 0.02
2.942ArgAsp: 2.942 ± 0.056
3.181ArgGlu: 3.181 ± 0.054
2.368ArgPhe: 2.368 ± 0.044
3.67ArgGly: 3.67 ± 0.057
1.412ArgHis: 1.412 ± 0.031
3.064ArgIle: 3.064 ± 0.048
2.324ArgLys: 2.324 ± 0.045
6.538ArgLeu: 6.538 ± 0.073
1.813ArgMet: 1.813 ± 0.032
1.841ArgAsn: 1.841 ± 0.038
2.445ArgPro: 2.445 ± 0.041
2.615ArgGln: 2.615 ± 0.042
3.261ArgArg: 3.261 ± 0.057
3.292ArgSer: 3.292 ± 0.051
3.096ArgThr: 3.096 ± 0.049
4.473ArgVal: 4.473 ± 0.059
1.013ArgTrp: 1.013 ± 0.028
1.66ArgTyr: 1.66 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
7.329SerAla: 7.329 ± 0.078
0.479SerCys: 0.479 ± 0.02
2.911SerAsp: 2.911 ± 0.048
2.746SerGlu: 2.746 ± 0.044
2.263SerPhe: 2.263 ± 0.042
5.192SerGly: 5.192 ± 0.073
1.402SerHis: 1.402 ± 0.037
2.696SerIle: 2.696 ± 0.05
2.298SerLys: 2.298 ± 0.048
6.175SerLeu: 6.175 ± 0.072
1.544SerMet: 1.544 ± 0.03
1.852SerAsn: 1.852 ± 0.039
3.032SerPro: 3.032 ± 0.053
2.484SerGln: 2.484 ± 0.048
3.107SerArg: 3.107 ± 0.051
3.76SerSer: 3.76 ± 0.076
3.717SerThr: 3.717 ± 0.069
4.41SerVal: 4.41 ± 0.061
0.751SerTrp: 0.751 ± 0.025
1.42SerTyr: 1.42 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
6.346ThrAla: 6.346 ± 0.101
0.44ThrCys: 0.44 ± 0.017
2.693ThrAsp: 2.693 ± 0.072
2.692ThrGlu: 2.692 ± 0.046
1.836ThrPhe: 1.836 ± 0.038
4.586ThrGly: 4.586 ± 0.078
1.414ThrHis: 1.414 ± 0.032
2.278ThrIle: 2.278 ± 0.047
1.76ThrLys: 1.76 ± 0.04
6.634ThrLeu: 6.634 ± 0.07
1.335ThrMet: 1.335 ± 0.032
1.496ThrAsn: 1.496 ± 0.052
3.585ThrPro: 3.585 ± 0.053
2.638ThrGln: 2.638 ± 0.057
2.965ThrArg: 2.965 ± 0.057
3.144ThrSer: 3.144 ± 0.073
3.253ThrThr: 3.253 ± 0.133
4.635ThrVal: 4.635 ± 0.067
0.733ThrTrp: 0.733 ± 0.022
1.171ThrTyr: 1.171 ± 0.033
0.0ThrXaa: 0.0 ± 0.0
Val
9.252ValAla: 9.252 ± 0.115
0.819ValCys: 0.819 ± 0.026
4.068ValAsp: 4.068 ± 0.059
3.944ValGlu: 3.944 ± 0.058
2.953ValPhe: 2.953 ± 0.048
5.91ValGly: 5.91 ± 0.084
1.724ValHis: 1.724 ± 0.033
3.431ValIle: 3.431 ± 0.055
2.838ValLys: 2.838 ± 0.052
8.667ValLeu: 8.667 ± 0.103
2.036ValMet: 2.036 ± 0.04
2.395ValAsn: 2.395 ± 0.048
3.709ValPro: 3.709 ± 0.059
3.414ValGln: 3.414 ± 0.072
4.596ValArg: 4.596 ± 0.055
4.692ValSer: 4.692 ± 0.055
4.023ValThr: 4.023 ± 0.07
6.544ValVal: 6.544 ± 0.076
1.068ValTrp: 1.068 ± 0.028
1.7ValTyr: 1.7 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
1.507TrpAla: 1.507 ± 0.036
0.183TrpCys: 0.183 ± 0.011
0.673TrpAsp: 0.673 ± 0.021
0.558TrpGlu: 0.558 ± 0.023
0.562TrpPhe: 0.562 ± 0.021
1.028TrpGly: 1.028 ± 0.029
0.377TrpHis: 0.377 ± 0.016
0.657TrpIle: 0.657 ± 0.023
0.494TrpLys: 0.494 ± 0.021
2.024TrpLeu: 2.024 ± 0.046
0.471TrpMet: 0.471 ± 0.018
0.459TrpAsn: 0.459 ± 0.02
0.672TrpPro: 0.672 ± 0.021
0.765TrpGln: 0.765 ± 0.024
1.039TrpArg: 1.039 ± 0.033
0.903TrpSer: 0.903 ± 0.028
0.743TrpThr: 0.743 ± 0.026
1.209TrpVal: 1.209 ± 0.035
0.286TrpTrp: 0.286 ± 0.017
0.301TrpTyr: 0.301 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.718TyrAla: 2.718 ± 0.045
0.294TyrCys: 0.294 ± 0.013
1.156TyrAsp: 1.156 ± 0.031
1.1TyrGlu: 1.1 ± 0.03
0.997TyrPhe: 0.997 ± 0.03
1.987TyrGly: 1.987 ± 0.044
0.445TyrHis: 0.445 ± 0.019
0.872TyrIle: 0.872 ± 0.028
0.861TyrLys: 0.861 ± 0.026
2.501TyrLeu: 2.501 ± 0.046
0.504TyrMet: 0.504 ± 0.02
0.648TyrAsn: 0.648 ± 0.021
1.19TyrPro: 1.19 ± 0.034
1.02TyrGln: 1.02 ± 0.027
1.471TyrArg: 1.471 ± 0.036
1.384TyrSer: 1.384 ± 0.031
1.323TyrThr: 1.323 ± 0.035
1.779TyrVal: 1.779 ± 0.036
0.386TyrTrp: 0.386 ± 0.016
0.578TyrTyr: 0.578 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4235 proteins (1418997 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski