Amino acid dipepetide frequency for Codonopsis vein clearing virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.826AlaAla: 5.826 ± 2.766
0.416AlaCys: 0.416 ± 0.21
4.994AlaAsp: 4.994 ± 3.123
4.994AlaGlu: 4.994 ± 1.478
2.913AlaPhe: 2.913 ± 1.471
3.745AlaGly: 3.745 ± 1.987
2.497AlaHis: 2.497 ± 0.91
4.161AlaIle: 4.161 ± 1.175
3.745AlaLys: 3.745 ± 1.987
6.658AlaLeu: 6.658 ± 5.307
3.329AlaMet: 3.329 ± 1.01
1.665AlaAsn: 1.665 ± 0.841
2.081AlaPro: 2.081 ± 2.029
4.578AlaGln: 4.578 ± 1.713
3.329AlaArg: 3.329 ± 0.963
3.745AlaSer: 3.745 ± 1.264
3.745AlaThr: 3.745 ± 2.444
2.497AlaVal: 2.497 ± 0.91
1.248AlaTrp: 1.248 ± 0.63
3.329AlaTyr: 3.329 ± 1.681
0.0AlaXaa: 0.0 ± 0.0
Cys
1.248CysAla: 1.248 ± 0.63
0.416CysCys: 0.416 ± 0.21
0.416CysAsp: 0.416 ± 0.21
0.416CysGlu: 0.416 ± 0.21
1.248CysPhe: 1.248 ± 1.159
1.665CysGly: 1.665 ± 0.841
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
3.329CysLys: 3.329 ± 2.082
0.0CysLeu: 0.0 ± 0.0
0.832CysMet: 0.832 ± 0.42
1.248CysAsn: 1.248 ± 0.63
1.248CysPro: 1.248 ± 0.63
0.416CysGln: 0.416 ± 0.21
0.0CysArg: 0.0 ± 0.0
1.665CysSer: 1.665 ± 0.841
1.665CysThr: 1.665 ± 0.841
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.745AspAla: 3.745 ± 1.053
0.416AspCys: 0.416 ± 0.21
3.745AspAsp: 3.745 ± 1.891
3.745AspGlu: 3.745 ± 1.59
2.913AspPhe: 2.913 ± 0.913
0.832AspGly: 0.832 ± 0.42
0.832AspHis: 0.832 ± 0.42
1.665AspIle: 1.665 ± 0.841
3.329AspLys: 3.329 ± 1.567
6.242AspLeu: 6.242 ± 5.796
0.416AspMet: 0.416 ± 0.21
2.497AspAsn: 2.497 ± 1.605
2.913AspPro: 2.913 ± 2.193
2.913AspGln: 2.913 ± 3.592
2.913AspArg: 2.913 ± 2.193
3.745AspSer: 3.745 ± 1.264
3.745AspThr: 3.745 ± 1.264
0.832AspVal: 0.832 ± 1.97
1.248AspTrp: 1.248 ± 0.63
2.081AspTyr: 2.081 ± 1.051
0.0AspXaa: 0.0 ± 0.0
Glu
6.242GluAla: 6.242 ± 2.865
1.665GluCys: 1.665 ± 1.041
3.745GluAsp: 3.745 ± 1.987
10.82GluGlu: 10.82 ± 1.167
2.497GluPhe: 2.497 ± 0.91
5.41GluGly: 5.41 ± 1.923
2.913GluHis: 2.913 ± 1.471
6.242GluIle: 6.242 ± 2.865
4.161GluLys: 4.161 ± 1.175
7.907GluLeu: 7.907 ± 2.221
2.497GluMet: 2.497 ± 1.261
2.497GluAsn: 2.497 ± 1.261
3.329GluPro: 3.329 ± 1.567
2.497GluGln: 2.497 ± 2.318
4.161GluArg: 4.161 ± 1.175
3.329GluSer: 3.329 ± 0.963
3.329GluThr: 3.329 ± 1.681
6.242GluVal: 6.242 ± 3.083
1.248GluTrp: 1.248 ± 0.63
3.329GluTyr: 3.329 ± 1.567
0.0GluXaa: 0.0 ± 0.0
Phe
2.913PheAla: 2.913 ± 0.913
1.248PheCys: 1.248 ± 0.63
1.248PheAsp: 1.248 ± 1.159
2.497PheGlu: 2.497 ± 0.91
0.832PhePhe: 0.832 ± 0.42
0.416PheGly: 0.416 ± 0.21
1.248PheHis: 1.248 ± 1.159
3.745PheIle: 3.745 ± 1.891
2.497PheLys: 2.497 ± 0.91
1.248PheLeu: 1.248 ± 0.63
0.0PheMet: 0.0 ± 0.0
0.416PheAsn: 0.416 ± 0.21
1.248PhePro: 1.248 ± 0.63
0.832PheGln: 0.832 ± 1.97
2.913PheArg: 2.913 ± 3.592
3.745PheSer: 3.745 ± 1.053
1.248PheThr: 1.248 ± 1.159
2.081PheVal: 2.081 ± 2.029
0.0PheTrp: 0.0 ± 0.0
2.081PheTyr: 2.081 ± 1.051
0.0PheXaa: 0.0 ± 0.0
Gly
1.665GlyAla: 1.665 ± 1.041
1.248GlyCys: 1.248 ± 0.63
2.497GlyAsp: 2.497 ± 1.605
3.329GlyGlu: 3.329 ± 1.681
2.913GlyPhe: 2.913 ± 1.637
4.994GlyGly: 4.994 ± 2.522
0.416GlyHis: 0.416 ± 0.21
4.578GlyIle: 4.578 ± 2.312
4.994GlyLys: 4.994 ± 7.399
4.578GlyLeu: 4.578 ± 1.318
1.248GlyMet: 1.248 ± 0.63
2.913GlyAsn: 2.913 ± 1.471
2.913GlyPro: 2.913 ± 1.471
2.497GlyGln: 2.497 ± 1.831
2.081GlyArg: 2.081 ± 1.051
2.913GlySer: 2.913 ± 1.572
4.994GlyThr: 4.994 ± 2.522
4.161GlyVal: 4.161 ± 2.102
1.665GlyTrp: 1.665 ± 0.841
2.081GlyTyr: 2.081 ± 1.051
0.0GlyXaa: 0.0 ± 0.0
His
1.665HisAla: 1.665 ± 1.041
0.0HisCys: 0.0 ± 0.0
1.665HisAsp: 1.665 ± 0.841
0.416HisGlu: 0.416 ± 0.21
1.248HisPhe: 1.248 ± 1.159
0.416HisGly: 0.416 ± 0.21
0.416HisHis: 0.416 ± 0.21
2.497HisIle: 2.497 ± 1.261
0.832HisLys: 0.832 ± 0.42
2.913HisLeu: 2.913 ± 3.592
0.0HisMet: 0.0 ± 0.0
1.248HisAsn: 1.248 ± 0.63
0.832HisPro: 0.832 ± 0.42
1.248HisGln: 1.248 ± 1.159
0.832HisArg: 0.832 ± 0.42
0.416HisSer: 0.416 ± 0.21
0.416HisThr: 0.416 ± 1.459
2.081HisVal: 2.081 ± 1.664
0.832HisTrp: 0.832 ± 0.42
1.665HisTyr: 1.665 ± 0.841
0.0HisXaa: 0.0 ± 0.0
Ile
2.497IleAla: 2.497 ± 1.261
1.665IleCys: 1.665 ± 0.841
2.497IleAsp: 2.497 ± 1.261
3.745IleGlu: 3.745 ± 1.053
1.665IlePhe: 1.665 ± 0.841
2.497IleGly: 2.497 ± 1.261
2.081IleHis: 2.081 ± 3.282
4.578IleIle: 4.578 ± 1.318
5.826IleLys: 5.826 ± 1.827
2.497IleLeu: 2.497 ± 1.605
0.832IleMet: 0.832 ± 0.42
1.665IleAsn: 1.665 ± 0.841
4.994IlePro: 4.994 ± 1.821
3.745IleGln: 3.745 ± 3.494
2.913IleArg: 2.913 ± 1.471
5.41IleSer: 5.41 ± 2.732
4.994IleThr: 4.994 ± 2.522
2.913IleVal: 2.913 ± 0.913
0.0IleTrp: 0.0 ± 0.0
0.416IleTyr: 0.416 ± 0.21
0.0IleXaa: 0.0 ± 0.0
Lys
5.826LysAla: 5.826 ± 5.44
2.081LysCys: 2.081 ± 1.051
4.578LysAsp: 4.578 ± 3.86
7.491LysGlu: 7.491 ± 2.217
2.081LysPhe: 2.081 ± 1.664
6.658LysGly: 6.658 ± 4.926
0.416LysHis: 0.416 ± 0.21
3.329LysIle: 3.329 ± 1.681
4.994LysLys: 4.994 ± 2.522
4.161LysLeu: 4.161 ± 2.235
3.745LysMet: 3.745 ± 1.891
2.497LysAsn: 2.497 ± 0.91
4.578LysPro: 4.578 ± 1.318
2.913LysGln: 2.913 ± 1.471
3.329LysArg: 3.329 ± 0.963
4.161LysSer: 4.161 ± 1.91
2.913LysThr: 2.913 ± 0.913
6.242LysVal: 6.242 ± 1.865
0.832LysTrp: 0.832 ± 1.301
2.081LysTyr: 2.081 ± 1.051
0.0LysXaa: 0.0 ± 0.0
Leu
7.491LeuAla: 7.491 ± 6.373
1.248LeuCys: 1.248 ± 0.63
4.161LeuAsp: 4.161 ± 1.175
7.907LeuGlu: 7.907 ± 0.412
2.081LeuPhe: 2.081 ± 2.029
4.994LeuGly: 4.994 ± 1.809
0.832LeuHis: 0.832 ± 0.42
3.329LeuIle: 3.329 ± 3.494
8.323LeuLys: 8.323 ± 5.205
4.994LeuLeu: 4.994 ± 0.797
0.832LeuMet: 0.832 ± 0.366
3.745LeuAsn: 3.745 ± 1.59
5.826LeuPro: 5.826 ± 1.403
2.913LeuGln: 2.913 ± 0.913
7.074LeuArg: 7.074 ± 3.743
7.491LeuSer: 7.491 ± 3.845
4.578LeuThr: 4.578 ± 3.181
4.578LeuVal: 4.578 ± 1.318
0.0LeuTrp: 0.0 ± 0.0
2.081LeuTyr: 2.081 ± 1.051
0.0LeuXaa: 0.0 ± 0.0
Met
2.081MetAla: 2.081 ± 1.051
0.0MetCys: 0.0 ± 0.0
0.832MetAsp: 0.832 ± 0.42
2.497MetGlu: 2.497 ± 1.261
0.0MetPhe: 0.0 ± 0.0
0.0MetGly: 0.0 ± 0.0
0.416MetHis: 0.416 ± 0.21
1.248MetIle: 1.248 ± 0.63
2.081MetLys: 2.081 ± 1.051
2.497MetLeu: 2.497 ± 1.261
0.832MetMet: 0.832 ± 0.42
0.832MetAsn: 0.832 ± 0.42
1.248MetPro: 1.248 ± 0.63
0.0MetGln: 0.0 ± 0.0
0.416MetArg: 0.416 ± 1.459
0.832MetSer: 0.832 ± 1.97
2.081MetThr: 2.081 ± 1.051
2.497MetVal: 2.497 ± 1.261
0.832MetTrp: 0.832 ± 0.42
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.497AsnAla: 2.497 ± 1.605
0.832AsnCys: 0.832 ± 0.42
1.248AsnAsp: 1.248 ± 0.63
1.248AsnGlu: 1.248 ± 0.63
1.665AsnPhe: 1.665 ± 0.841
2.081AsnGly: 2.081 ± 1.051
0.832AsnHis: 0.832 ± 0.42
2.497AsnIle: 2.497 ± 1.605
2.497AsnLys: 2.497 ± 1.261
4.161AsnLeu: 4.161 ± 2.235
1.248AsnMet: 1.248 ± 0.63
2.081AsnAsn: 2.081 ± 1.664
1.665AsnPro: 1.665 ± 0.841
0.832AsnGln: 0.832 ± 0.42
2.081AsnArg: 2.081 ± 1.664
1.665AsnSer: 1.665 ± 0.841
4.994AsnThr: 4.994 ± 0.797
1.665AsnVal: 1.665 ± 1.041
0.416AsnTrp: 0.416 ± 0.21
1.665AsnTyr: 1.665 ± 0.841
0.0AsnXaa: 0.0 ± 0.0
Pro
4.161ProAla: 4.161 ± 2.102
0.416ProCys: 0.416 ± 1.459
4.578ProAsp: 4.578 ± 1.854
7.074ProGlu: 7.074 ± 2.399
1.665ProPhe: 1.665 ± 1.041
2.913ProGly: 2.913 ± 1.471
0.832ProHis: 0.832 ± 1.97
2.497ProIle: 2.497 ± 0.91
4.994ProLys: 4.994 ± 3.035
3.745ProLeu: 3.745 ± 1.987
0.832ProMet: 0.832 ± 0.42
2.081ProAsn: 2.081 ± 2.029
4.161ProPro: 4.161 ± 1.175
1.248ProGln: 1.248 ± 0.63
1.665ProArg: 1.665 ± 0.841
3.745ProSer: 3.745 ± 1.891
3.745ProThr: 3.745 ± 1.053
3.329ProVal: 3.329 ± 1.447
1.248ProTrp: 1.248 ± 0.63
2.081ProTyr: 2.081 ± 1.051
0.0ProXaa: 0.0 ± 0.0
Gln
4.161GlnAla: 4.161 ± 1.91
0.416GlnCys: 0.416 ± 0.21
0.0GlnAsp: 0.0 ± 0.0
2.497GlnGlu: 2.497 ± 1.261
1.665GlnPhe: 1.665 ± 1.747
2.497GlnGly: 2.497 ± 1.261
0.416GlnHis: 0.416 ± 0.21
2.497GlnIle: 2.497 ± 1.831
1.665GlnLys: 1.665 ± 0.841
6.242GlnLeu: 6.242 ± 5.263
0.416GlnMet: 0.416 ± 0.21
1.665GlnAsn: 1.665 ± 1.747
1.665GlnPro: 1.665 ± 1.747
2.497GlnGln: 2.497 ± 1.261
4.994GlnArg: 4.994 ± 1.809
1.665GlnSer: 1.665 ± 0.841
1.665GlnThr: 1.665 ± 2.229
4.161GlnVal: 4.161 ± 3.335
0.0GlnTrp: 0.0 ± 0.0
1.248GlnTyr: 1.248 ± 1.159
0.0GlnXaa: 0.0 ± 0.0
Arg
3.329ArgAla: 3.329 ± 0.963
0.0ArgCys: 0.0 ± 0.0
3.745ArgAsp: 3.745 ± 3.406
6.242ArgGlu: 6.242 ± 4.272
1.665ArgPhe: 1.665 ± 0.841
3.329ArgGly: 3.329 ± 1.567
1.665ArgHis: 1.665 ± 0.841
2.081ArgIle: 2.081 ± 1.051
5.826ArgLys: 5.826 ± 1.403
3.745ArgLeu: 3.745 ± 1.053
1.248ArgMet: 1.248 ± 0.63
2.913ArgAsn: 2.913 ± 1.471
3.745ArgPro: 3.745 ± 1.264
1.665ArgGln: 1.665 ± 1.747
2.913ArgArg: 2.913 ± 1.471
1.665ArgSer: 1.665 ± 0.841
1.248ArgThr: 1.248 ± 0.63
4.161ArgVal: 4.161 ± 1.09
1.248ArgTrp: 1.248 ± 0.63
1.665ArgTyr: 1.665 ± 1.041
0.0ArgXaa: 0.0 ± 0.0
Ser
3.329SerAla: 3.329 ± 0.963
0.416SerCys: 0.416 ± 0.21
2.913SerAsp: 2.913 ± 0.913
2.497SerGlu: 2.497 ± 1.261
1.248SerPhe: 1.248 ± 0.63
4.578SerGly: 4.578 ± 2.312
1.665SerHis: 1.665 ± 0.841
3.745SerIle: 3.745 ± 1.053
3.745SerLys: 3.745 ± 1.59
7.907SerLeu: 7.907 ± 3.326
0.416SerMet: 0.416 ± 1.326
2.081SerAsn: 2.081 ± 1.051
3.329SerPro: 3.329 ± 0.963
2.913SerGln: 2.913 ± 0.913
4.161SerArg: 4.161 ± 1.175
8.323SerSer: 8.323 ± 1.399
4.994SerThr: 4.994 ± 0.797
2.913SerVal: 2.913 ± 2.193
1.248SerTrp: 1.248 ± 1.85
3.329SerTyr: 3.329 ± 0.963
0.0SerXaa: 0.0 ± 0.0
Thr
3.745ThrAla: 3.745 ± 1.987
2.081ThrCys: 2.081 ± 0.955
2.913ThrAsp: 2.913 ± 1.637
7.491ThrGlu: 7.491 ± 2.592
1.665ThrPhe: 1.665 ± 1.041
6.658ThrGly: 6.658 ± 0.992
2.497ThrHis: 2.497 ± 1.605
3.329ThrIle: 3.329 ± 0.963
3.329ThrLys: 3.329 ± 1.447
6.242ThrLeu: 6.242 ± 3.083
0.832ThrMet: 0.832 ± 0.42
2.497ThrAsn: 2.497 ± 1.605
3.329ThrPro: 3.329 ± 1.567
1.665ThrGln: 1.665 ± 0.841
3.329ThrArg: 3.329 ± 0.963
3.745ThrSer: 3.745 ± 1.053
4.994ThrThr: 4.994 ± 3.035
2.497ThrVal: 2.497 ± 1.261
0.416ThrTrp: 0.416 ± 0.21
0.832ThrTyr: 0.832 ± 0.42
0.0ThrXaa: 0.0 ± 0.0
Val
2.913ValAla: 2.913 ± 0.913
1.248ValCys: 1.248 ± 0.63
3.745ValAsp: 3.745 ± 3.406
4.578ValGlu: 4.578 ± 2.027
2.081ValPhe: 2.081 ± 1.051
1.665ValGly: 1.665 ± 1.747
0.416ValHis: 0.416 ± 0.21
2.081ValIle: 2.081 ± 1.051
4.578ValLys: 4.578 ± 0.932
4.578ValLeu: 4.578 ± 2.312
1.248ValMet: 1.248 ± 0.63
2.497ValAsn: 2.497 ± 2.318
3.329ValPro: 3.329 ± 2.082
3.329ValGln: 3.329 ± 3.494
2.497ValArg: 2.497 ± 1.261
4.161ValSer: 4.161 ± 1.91
5.826ValThr: 5.826 ± 2.968
7.074ValVal: 7.074 ± 4.024
0.416ValTrp: 0.416 ± 2.104
2.497ValTyr: 2.497 ± 0.91
0.0ValXaa: 0.0 ± 0.0
Trp
0.416TrpAla: 0.416 ± 0.21
0.0TrpCys: 0.0 ± 0.0
0.416TrpAsp: 0.416 ± 0.21
1.665TrpGlu: 1.665 ± 1.041
0.0TrpPhe: 0.0 ± 0.0
1.248TrpGly: 1.248 ± 0.63
0.416TrpHis: 0.416 ± 0.21
0.416TrpIle: 0.416 ± 0.21
1.248TrpLys: 1.248 ± 0.63
2.081TrpLeu: 2.081 ± 1.051
0.0TrpMet: 0.0 ± 0.0
0.416TrpAsn: 0.416 ± 0.21
0.0TrpPro: 0.0 ± 0.0
0.832TrpGln: 0.832 ± 1.97
0.832TrpArg: 0.832 ± 0.42
1.248TrpSer: 1.248 ± 1.85
1.248TrpThr: 1.248 ± 0.63
0.416TrpVal: 0.416 ± 0.21
0.0TrpTrp: 0.0 ± 0.0
0.416TrpTyr: 0.416 ± 0.21
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.745TyrAla: 3.745 ± 1.891
0.0TyrCys: 0.0 ± 0.0
0.832TyrAsp: 0.832 ± 0.42
2.913TyrGlu: 2.913 ± 1.471
0.416TyrPhe: 0.416 ± 0.21
2.081TyrGly: 2.081 ± 1.051
0.832TyrHis: 0.832 ± 0.42
2.913TyrIle: 2.913 ± 0.913
2.913TyrLys: 2.913 ± 1.471
2.081TyrLeu: 2.081 ± 1.051
0.0TyrMet: 0.0 ± 0.0
0.416TyrAsn: 0.416 ± 0.21
4.578TyrPro: 4.578 ± 1.854
2.497TyrGln: 2.497 ± 0.91
1.665TyrArg: 1.665 ± 1.747
2.497TyrSer: 2.497 ± 1.261
1.665TyrThr: 1.665 ± 0.841
0.416TyrVal: 0.416 ± 0.21
0.416TyrTrp: 0.416 ± 0.21
1.248TyrTyr: 1.248 ± 0.63
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (2404 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski