Amino acid dipepetide frequency for Persephonella marina (strain DSM 14350 / EX-H1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.28AlaAla: 3.28 ± 0.11	0.487AlaCys: 0.487 ± 0.031	2.907AlaAsp: 2.907 ± 0.078	4.176AlaGlu: 4.176 ± 0.105	2.867AlaPhe: 2.867 ± 0.069	4.353AlaGly: 4.353 ± 0.124	0.872AlaHis: 0.872 ± 0.039	4.351AlaIle: 4.351 ± 0.093	4.407AlaLys: 4.407 ± 0.091	5.626AlaLeu: 5.626 ± 0.126	1.144AlaMet: 1.144 ± 0.051	1.677AlaAsn: 1.677 ± 0.065	1.518AlaPro: 1.518 ± 0.058	1.47AlaGln: 1.47 ± 0.061	2.204AlaArg: 2.204 ± 0.057	3.028AlaSer: 3.028 ± 0.073	2.48AlaThr: 2.48 ± 0.069	5.66AlaVal: 5.66 ± 0.1	0.39AlaTrp: 0.39 ± 0.03	2.461AlaTyr: 2.461 ± 0.063	0.0AlaXaa: 0.0 ± 0.0
Cys	0.323CysAla: 0.323 ± 0.023	0.095CysCys: 0.095 ± 0.014	0.422CysAsp: 0.422 ± 0.028	0.538CysGlu: 0.538 ± 0.033	0.321CysPhe: 0.321 ± 0.023	0.659CysGly: 0.659 ± 0.037	0.331CysHis: 0.331 ± 0.047	0.524CysIle: 0.524 ± 0.032	0.556CysLys: 0.556 ± 0.034	0.456CysLeu: 0.456 ± 0.03	0.165CysMet: 0.165 ± 0.016	0.323CysAsn: 0.323 ± 0.025	0.509CysPro: 0.509 ± 0.033	0.153CysGln: 0.153 ± 0.016	0.363CysArg: 0.363 ± 0.026	0.527CysSer: 0.527 ± 0.032	0.344CysThr: 0.344 ± 0.029	0.463CysVal: 0.463 ± 0.028	0.063CysTrp: 0.063 ± 0.011	0.286CysTyr: 0.286 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	2.641AspAla: 2.641 ± 0.073	0.379AspCys: 0.379 ± 0.029	2.482AspAsp: 2.482 ± 0.061	4.239AspGlu: 4.239 ± 0.089	3.236AspPhe: 3.236 ± 0.068	3.365AspGly: 3.365 ± 0.089	0.85AspHis: 0.85 ± 0.033	7.469AspIle: 7.469 ± 0.103	4.348AspLys: 4.348 ± 0.094	6.06AspLeu: 6.06 ± 0.102	1.237AspMet: 1.237 ± 0.043	1.95AspAsn: 1.95 ± 0.063	2.567AspPro: 2.567 ± 0.066	1.566AspGln: 1.566 ± 0.05	3.232AspArg: 3.232 ± 0.082	2.306AspSer: 2.306 ± 0.078	2.502AspThr: 2.502 ± 0.066	3.447AspVal: 3.447 ± 0.061	0.483AspTrp: 0.483 ± 0.032	2.632AspTyr: 2.632 ± 0.076	0.0AspXaa: 0.0 ± 0.0
Glu	4.653GluAla: 4.653 ± 0.105	0.455GluCys: 0.455 ± 0.029	4.949GluAsp: 4.949 ± 0.104	8.373GluGlu: 8.373 ± 0.162	3.201GluPhe: 3.201 ± 0.078	5.408GluGly: 5.408 ± 0.093	1.033GluHis: 1.033 ± 0.037	8.291GluIle: 8.291 ± 0.137	10.324GluLys: 10.324 ± 0.178	6.498GluLeu: 6.498 ± 0.118	1.535GluMet: 1.535 ± 0.051	4.341GluAsn: 4.341 ± 0.105	1.797GluPro: 1.797 ± 0.054	1.474GluGln: 1.474 ± 0.056	4.581GluArg: 4.581 ± 0.096	3.313GluSer: 3.313 ± 0.07	3.434GluThr: 3.434 ± 0.073	4.666GluVal: 4.666 ± 0.095	0.54GluTrp: 0.54 ± 0.029	2.907GluTyr: 2.907 ± 0.066	0.0GluXaa: 0.0 ± 0.0
Phe	2.396PheAla: 2.396 ± 0.073	0.398PheCys: 0.398 ± 0.027	2.724PheAsp: 2.724 ± 0.066	3.389PheGlu: 3.389 ± 0.076	2.763PhePhe: 2.763 ± 0.099	3.185PheGly: 3.185 ± 0.071	0.763PheHis: 0.763 ± 0.036	4.9PheIle: 4.9 ± 0.114	3.667PheLys: 3.667 ± 0.086	5.493PheLeu: 5.493 ± 0.125	1.113PheMet: 1.113 ± 0.041	2.038PheAsn: 2.038 ± 0.057	1.857PhePro: 1.857 ± 0.059	1.073PheGln: 1.073 ± 0.041	2.136PheArg: 2.136 ± 0.061	3.709PheSer: 3.709 ± 0.089	2.432PheThr: 2.432 ± 0.067	3.13PheVal: 3.13 ± 0.075	0.418PheTrp: 0.418 ± 0.027	2.34PheTyr: 2.34 ± 0.068	0.0PheXaa: 0.0 ± 0.0
Gly	3.625GlyAla: 3.625 ± 0.099	0.597GlyCys: 0.597 ± 0.039	3.527GlyAsp: 3.527 ± 0.093	4.484GlyGlu: 4.484 ± 0.086	3.755GlyPhe: 3.755 ± 0.083	4.237GlyGly: 4.237 ± 0.153	1.031GlyHis: 1.031 ± 0.046	6.513GlyIle: 6.513 ± 0.106	6.651GlyLys: 6.651 ± 0.112	5.369GlyLeu: 5.369 ± 0.093	1.646GlyMet: 1.646 ± 0.057	2.747GlyAsn: 2.747 ± 0.101	1.028GlyPro: 1.028 ± 0.049	1.295GlyGln: 1.295 ± 0.05	3.034GlyArg: 3.034 ± 0.062	3.895GlySer: 3.895 ± 0.147	3.243GlyThr: 3.243 ± 0.095	4.391GlyVal: 4.391 ± 0.086	0.633GlyTrp: 0.633 ± 0.031	3.203GlyTyr: 3.203 ± 0.071	0.0GlyXaa: 0.0 ± 0.0
His	0.728HisAla: 0.728 ± 0.037	0.178HisCys: 0.178 ± 0.018	0.62HisAsp: 0.62 ± 0.033	0.8HisGlu: 0.8 ± 0.032	0.821HisPhe: 0.821 ± 0.04	0.986HisGly: 0.986 ± 0.044	0.36HisHis: 0.36 ± 0.027	1.624HisIle: 1.624 ± 0.055	1.041HisLys: 1.041 ± 0.042	1.577HisLeu: 1.577 ± 0.057	0.291HisMet: 0.291 ± 0.022	0.607HisAsn: 0.607 ± 0.032	0.924HisPro: 0.924 ± 0.037	0.369HisGln: 0.369 ± 0.028	0.92HisArg: 0.92 ± 0.039	0.88HisSer: 0.88 ± 0.04	0.803HisThr: 0.803 ± 0.035	0.747HisVal: 0.747 ± 0.035	0.133HisTrp: 0.133 ± 0.014	0.659HisTyr: 0.659 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	5.295IleAla: 5.295 ± 0.117	0.622IleCys: 0.622 ± 0.036	6.028IleAsp: 6.028 ± 0.118	7.057IleGlu: 7.057 ± 0.116	4.717IlePhe: 4.717 ± 0.114	5.509IleGly: 5.509 ± 0.099	1.518IleHis: 1.518 ± 0.054	7.491IleIle: 7.491 ± 0.133	9.303IleLys: 9.303 ± 0.14	8.773IleLeu: 8.773 ± 0.149	1.537IleMet: 1.537 ± 0.048	4.483IleAsn: 4.483 ± 0.105	4.285IlePro: 4.285 ± 0.085	2.282IleGln: 2.282 ± 0.068	3.855IleArg: 3.855 ± 0.086	5.988IleSer: 5.988 ± 0.117	4.749IleThr: 4.749 ± 0.087	5.723IleVal: 5.723 ± 0.107	0.561IleTrp: 0.561 ± 0.031	3.823IleTyr: 3.823 ± 0.083	0.0IleXaa: 0.0 ± 0.0
Lys	5.368LysAla: 5.368 ± 0.105	0.424LysCys: 0.424 ± 0.026	6.153LysAsp: 6.153 ± 0.113	9.931LysGlu: 9.931 ± 0.171	2.962LysPhe: 2.962 ± 0.069	6.087LysGly: 6.087 ± 0.11	1.251LysHis: 1.251 ± 0.045	8.545LysIle: 8.545 ± 0.141	9.918LysLys: 9.918 ± 0.187	7.618LysLeu: 7.618 ± 0.143	1.662LysMet: 1.662 ± 0.051	4.666LysAsn: 4.666 ± 0.105	3.18LysPro: 3.18 ± 0.083	1.984LysGln: 1.984 ± 0.065	4.337LysArg: 4.337 ± 0.103	3.908LysSer: 3.908 ± 0.089	4.113LysThr: 4.113 ± 0.091	5.885LysVal: 5.885 ± 0.091	0.636LysTrp: 0.636 ± 0.036	3.227LysTyr: 3.227 ± 0.079	0.0LysXaa: 0.0 ± 0.0
Leu	4.886LeuAla: 4.886 ± 0.104	0.512LeuCys: 0.512 ± 0.036	5.019LeuAsp: 5.019 ± 0.098	7.115LeuGlu: 7.115 ± 0.128	4.486LeuPhe: 4.486 ± 0.114	5.663LeuGly: 5.663 ± 0.129	1.303LeuHis: 1.303 ± 0.056	8.061LeuIle: 8.061 ± 0.141	10.328LeuLys: 10.328 ± 0.162	8.166LeuLeu: 8.166 ± 0.156	1.87LeuMet: 1.87 ± 0.06	4.256LeuAsn: 4.256 ± 0.099	3.609LeuPro: 3.609 ± 0.078	2.119LeuGln: 2.119 ± 0.064	4.264LeuArg: 4.264 ± 0.096	7.049LeuSer: 7.049 ± 0.131	4.656LeuThr: 4.656 ± 0.094	5.128LeuVal: 5.128 ± 0.098	0.782LeuTrp: 0.782 ± 0.044	3.558LeuTyr: 3.558 ± 0.079	0.0LeuXaa: 0.0 ± 0.0
Met	1.41MetAla: 1.41 ± 0.05	0.125MetCys: 0.125 ± 0.017	1.15MetAsp: 1.15 ± 0.046	1.845MetGlu: 1.845 ± 0.05	0.883MetPhe: 0.883 ± 0.039	1.373MetGly: 1.373 ± 0.049	0.268MetHis: 0.268 ± 0.022	1.659MetIle: 1.659 ± 0.057	1.98MetLys: 1.98 ± 0.063	1.688MetLeu: 1.688 ± 0.054	0.466MetMet: 0.466 ± 0.031	0.899MetAsn: 0.899 ± 0.041	0.779MetPro: 0.779 ± 0.037	0.392MetGln: 0.392 ± 0.028	1.148MetArg: 1.148 ± 0.041	1.018MetSer: 1.018 ± 0.039	0.811MetThr: 0.811 ± 0.036	1.256MetVal: 1.256 ± 0.045	0.149MetTrp: 0.149 ± 0.017	0.684MetTyr: 0.684 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.162AsnAla: 2.162 ± 0.079	0.429AsnCys: 0.429 ± 0.028	1.849AsnAsp: 1.849 ± 0.067	2.522AsnGlu: 2.522 ± 0.069	2.22AsnPhe: 2.22 ± 0.062	2.488AsnGly: 2.488 ± 0.078	0.561AsnHis: 0.561 ± 0.035	4.945AsnIle: 4.945 ± 0.104	2.909AsnLys: 2.909 ± 0.085	4.569AsnLeu: 4.569 ± 0.103	0.801AsnMet: 0.801 ± 0.044	1.727AsnAsn: 1.727 ± 0.143	2.398AsnPro: 2.398 ± 0.067	1.031AsnGln: 1.031 ± 0.048	2.621AsnArg: 2.621 ± 0.069	2.252AsnSer: 2.252 ± 0.093	1.992AsnThr: 1.992 ± 0.068	2.755AsnVal: 2.755 ± 0.084	0.413AsnTrp: 0.413 ± 0.025	1.767AsnTyr: 1.767 ± 0.059	0.0AsnXaa: 0.0 ± 0.0
Pro	1.889ProAla: 1.889 ± 0.061	0.239ProCys: 0.239 ± 0.02	2.886ProAsp: 2.886 ± 0.079	4.422ProGlu: 4.422 ± 0.098	2.072ProPhe: 2.072 ± 0.064	1.712ProGly: 1.712 ± 0.055	0.663ProHis: 0.663 ± 0.035	2.253ProIle: 2.253 ± 0.071	2.326ProLys: 2.326 ± 0.063	3.243ProLeu: 3.243 ± 0.079	0.583ProMet: 0.583 ± 0.03	1.172ProAsn: 1.172 ± 0.043	1.521ProPro: 1.521 ± 0.048	1.017ProGln: 1.017 ± 0.037	1.07ProArg: 1.07 ± 0.042	2.127ProSer: 2.127 ± 0.059	1.531ProThr: 1.531 ± 0.051	3.954ProVal: 3.954 ± 0.086	0.283ProTrp: 0.283 ± 0.021	1.746ProTyr: 1.746 ± 0.059	0.0ProXaa: 0.0 ± 0.0
Gln	1.365GlnAla: 1.365 ± 0.055	0.135GlnCys: 0.135 ± 0.014	1.084GlnAsp: 1.084 ± 0.047	1.931GlnGlu: 1.931 ± 0.055	1.116GlnPhe: 1.116 ± 0.041	1.147GlnGly: 1.147 ± 0.039	0.369GlnHis: 0.369 ± 0.022	2.767GlnIle: 2.767 ± 0.066	2.269GlnLys: 2.269 ± 0.058	2.319GlnLeu: 2.319 ± 0.057	0.578GlnMet: 0.578 ± 0.029	1.086GlnAsn: 1.086 ± 0.041	0.808GlnPro: 0.808 ± 0.035	0.636GlnGln: 0.636 ± 0.033	1.031GlnArg: 1.031 ± 0.049	1.092GlnSer: 1.092 ± 0.049	1.087GlnThr: 1.087 ± 0.048	1.399GlnVal: 1.399 ± 0.052	0.214GlnTrp: 0.214 ± 0.018	0.846GlnTyr: 0.846 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.265ArgAla: 2.265 ± 0.067	0.384ArgCys: 0.384 ± 0.028	2.637ArgAsp: 2.637 ± 0.07	4.313ArgGlu: 4.313 ± 0.093	2.791ArgPhe: 2.791 ± 0.069	2.408ArgGly: 2.408 ± 0.068	0.596ArgHis: 0.596 ± 0.028	4.573ArgIle: 4.573 ± 0.099	4.592ArgLys: 4.592 ± 0.094	4.154ArgLeu: 4.154 ± 0.082	1.153ArgMet: 1.153 ± 0.042	1.958ArgAsn: 1.958 ± 0.06	1.479ArgPro: 1.479 ± 0.049	0.973ArgGln: 0.973 ± 0.038	2.006ArgArg: 2.006 ± 0.064	2.565ArgSer: 2.565 ± 0.059	1.849ArgThr: 1.849 ± 0.051	2.782ArgVal: 2.782 ± 0.065	0.591ArgTrp: 0.591 ± 0.035	2.571ArgTyr: 2.571 ± 0.076	0.0ArgXaa: 0.0 ± 0.0
Ser	3.114SerAla: 3.114 ± 0.086	0.578SerCys: 0.578 ± 0.041	3.145SerAsp: 3.145 ± 0.08	4.022SerGlu: 4.022 ± 0.086	3.307SerPhe: 3.307 ± 0.092	4.174SerGly: 4.174 ± 0.148	0.871SerHis: 0.871 ± 0.037	5.164SerIle: 5.164 ± 0.084	4.406SerLys: 4.406 ± 0.095	5.636SerLeu: 5.636 ± 0.113	1.145SerMet: 1.145 ± 0.043	1.961SerAsn: 1.961 ± 0.081	2.168SerPro: 2.168 ± 0.053	1.568SerGln: 1.568 ± 0.048	2.178SerArg: 2.178 ± 0.055	3.421SerSer: 3.421 ± 0.108	2.29SerThr: 2.29 ± 0.066	4.414SerVal: 4.414 ± 0.13	0.421SerTrp: 0.421 ± 0.026	2.777SerTyr: 2.777 ± 0.069	0.0SerXaa: 0.0 ± 0.0
Thr	3.469ThrAla: 3.469 ± 0.096	0.357ThrCys: 0.357 ± 0.03	2.885ThrAsp: 2.885 ± 0.08	3.513ThrGlu: 3.513 ± 0.073	2.29ThrPhe: 2.29 ± 0.062	4.462ThrGly: 4.462 ± 0.107	0.67ThrHis: 0.67 ± 0.034	3.142ThrIle: 3.142 ± 0.071	3.066ThrLys: 3.066 ± 0.073	4.157ThrLeu: 4.157 ± 0.081	0.67ThrMet: 0.67 ± 0.04	1.444ThrAsn: 1.444 ± 0.058	2.07ThrPro: 2.07 ± 0.066	1.025ThrGln: 1.025 ± 0.049	1.397ThrArg: 1.397 ± 0.045	2.104ThrSer: 2.104 ± 0.061	2.212ThrThr: 2.212 ± 0.076	4.722ThrVal: 4.722 ± 0.102	0.307ThrTrp: 0.307 ± 0.025	1.661ThrTyr: 1.661 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	3.943ValAla: 3.943 ± 0.096	0.612ValCys: 0.612 ± 0.036	3.76ValAsp: 3.76 ± 0.084	5.53ValGlu: 5.53 ± 0.1	3.534ValPhe: 3.534 ± 0.087	4.21ValGly: 4.21 ± 0.092	0.922ValHis: 0.922 ± 0.039	6.293ValIle: 6.293 ± 0.109	6.108ValLys: 6.108 ± 0.109	6.498ValLeu: 6.498 ± 0.115	1.322ValMet: 1.322 ± 0.046	2.91ValAsn: 2.91 ± 0.088	2.303ValPro: 2.303 ± 0.062	1.5ValGln: 1.5 ± 0.06	2.918ValArg: 2.918 ± 0.077	4.56ValSer: 4.56 ± 0.112	2.713ValThr: 2.713 ± 0.08	5.098ValVal: 5.098 ± 0.113	0.556ValTrp: 0.556 ± 0.031	3.098ValTyr: 3.098 ± 0.072	0.0ValXaa: 0.0 ± 0.0
Trp	0.424TrpAla: 0.424 ± 0.028	0.071TrpCys: 0.071 ± 0.011	0.498TrpAsp: 0.498 ± 0.032	0.716TrpGlu: 0.716 ± 0.035	0.398TrpPhe: 0.398 ± 0.027	0.543TrpGly: 0.543 ± 0.031	0.154TrpHis: 0.154 ± 0.016	0.813TrpIle: 0.813 ± 0.038	0.744TrpLys: 0.744 ± 0.038	0.731TrpLeu: 0.731 ± 0.033	0.186TrpMet: 0.186 ± 0.019	0.421TrpAsn: 0.421 ± 0.028	0.164TrpPro: 0.164 ± 0.018	0.231TrpGln: 0.231 ± 0.023	0.35TrpArg: 0.35 ± 0.026	0.353TrpSer: 0.353 ± 0.027	0.368TrpThr: 0.368 ± 0.026	0.474TrpVal: 0.474 ± 0.031	0.101TrpTrp: 0.101 ± 0.013	0.297TrpTyr: 0.297 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.12TyrAla: 2.12 ± 0.054	0.342TyrCys: 0.342 ± 0.024	2.265TyrAsp: 2.265 ± 0.055	2.861TyrGlu: 2.861 ± 0.08	2.183TyrPhe: 2.183 ± 0.063	2.936TyrGly: 2.936 ± 0.076	0.683TyrHis: 0.683 ± 0.034	4.221TyrIle: 4.221 ± 0.095	2.912TyrLys: 2.912 ± 0.076	4.198TyrLeu: 4.198 ± 0.086	0.88TyrMet: 0.88 ± 0.039	1.743TyrAsn: 1.743 ± 0.051	1.744TyrPro: 1.744 ± 0.057	1.124TyrGln: 1.124 ± 0.042	2.994TyrArg: 2.994 ± 0.069	2.665TyrSer: 2.665 ± 0.084	2.013TyrThr: 2.013 ± 0.068	2.295TyrVal: 2.295 ± 0.059	0.365TyrTrp: 0.365 ± 0.028	1.91TyrTyr: 1.91 ± 0.067	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2048 proteins (622608 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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