Amino acid dipepetide frequency for Xanthomonas citri phage CP2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.209AlaAla: 21.209 ± 2.727
1.735AlaCys: 1.735 ± 0.516
9.304AlaAsp: 9.304 ± 1.112
8.673AlaGlu: 8.673 ± 1.578
2.838AlaPhe: 2.838 ± 0.563
11.669AlaGly: 11.669 ± 0.918
1.813AlaHis: 1.813 ± 0.361
6.15AlaIle: 6.15 ± 0.808
5.677AlaLys: 5.677 ± 0.878
10.013AlaLeu: 10.013 ± 1.05
4.021AlaMet: 4.021 ± 0.58
3.942AlaAsn: 3.942 ± 0.686
6.781AlaPro: 6.781 ± 1.284
6.465AlaGln: 6.465 ± 1.205
8.988AlaArg: 8.988 ± 1.268
6.781AlaSer: 6.781 ± 0.647
8.042AlaThr: 8.042 ± 0.719
8.436AlaVal: 8.436 ± 0.755
1.577AlaTrp: 1.577 ± 0.318
2.681AlaTyr: 2.681 ± 0.341
0.0AlaXaa: 0.0 ± 0.0
Cys
1.025CysAla: 1.025 ± 0.412
0.394CysCys: 0.394 ± 0.318
0.71CysAsp: 0.71 ± 0.272
0.71CysGlu: 0.71 ± 0.303
0.079CysPhe: 0.079 ± 0.085
1.34CysGly: 1.34 ± 1.018
0.237CysHis: 0.237 ± 0.146
0.315CysIle: 0.315 ± 0.201
0.315CysLys: 0.315 ± 0.196
0.473CysLeu: 0.473 ± 0.2
0.237CysMet: 0.237 ± 0.164
0.394CysAsn: 0.394 ± 0.221
0.394CysPro: 0.394 ± 0.203
0.237CysGln: 0.237 ± 0.16
0.473CysArg: 0.473 ± 0.228
0.315CysSer: 0.315 ± 0.196
0.315CysThr: 0.315 ± 0.168
0.631CysVal: 0.631 ± 0.223
0.158CysTrp: 0.158 ± 0.105
0.473CysTyr: 0.473 ± 0.221
0.0CysXaa: 0.0 ± 0.0
Asp
11.275AspAla: 11.275 ± 1.605
0.473AspCys: 0.473 ± 0.226
4.573AspAsp: 4.573 ± 0.63
3.469AspGlu: 3.469 ± 0.572
1.735AspPhe: 1.735 ± 0.327
5.992AspGly: 5.992 ± 0.605
0.71AspHis: 0.71 ± 0.232
1.971AspIle: 1.971 ± 0.324
1.971AspLys: 1.971 ± 0.482
4.731AspLeu: 4.731 ± 0.854
1.025AspMet: 1.025 ± 0.276
1.656AspAsn: 1.656 ± 0.332
3.627AspPro: 3.627 ± 0.541
3.785AspGln: 3.785 ± 0.486
4.258AspArg: 4.258 ± 0.914
2.996AspSer: 2.996 ± 0.49
3.075AspThr: 3.075 ± 0.403
4.494AspVal: 4.494 ± 0.626
1.34AspTrp: 1.34 ± 0.295
1.419AspTyr: 1.419 ± 0.398
0.0AspXaa: 0.0 ± 0.0
Glu
7.49GluAla: 7.49 ± 1.233
0.394GluCys: 0.394 ± 0.191
2.996GluAsp: 2.996 ± 0.454
2.681GluGlu: 2.681 ± 0.459
1.498GluPhe: 1.498 ± 0.35
5.283GluGly: 5.283 ± 0.685
0.788GluHis: 0.788 ± 0.309
2.523GluIle: 2.523 ± 0.464
2.602GluLys: 2.602 ± 0.465
4.81GluLeu: 4.81 ± 0.674
0.867GluMet: 0.867 ± 0.223
1.104GluAsn: 1.104 ± 0.271
2.129GluPro: 2.129 ± 0.45
4.1GluGln: 4.1 ± 0.849
5.046GluArg: 5.046 ± 0.79
3.233GluSer: 3.233 ± 0.335
2.602GluThr: 2.602 ± 0.399
3.942GluVal: 3.942 ± 0.6
0.631GluTrp: 0.631 ± 0.245
1.656GluTyr: 1.656 ± 0.345
0.0GluXaa: 0.0 ± 0.0
Phe
3.154PheAla: 3.154 ± 0.491
0.079PheCys: 0.079 ± 0.081
2.287PheAsp: 2.287 ± 0.4
1.892PheGlu: 1.892 ± 0.365
0.552PhePhe: 0.552 ± 0.16
2.05PheGly: 2.05 ± 0.318
0.473PheHis: 0.473 ± 0.204
1.262PheIle: 1.262 ± 0.292
1.34PheLys: 1.34 ± 0.319
2.76PheLeu: 2.76 ± 0.582
0.631PheMet: 0.631 ± 0.199
1.813PheAsn: 1.813 ± 0.397
0.946PhePro: 0.946 ± 0.356
1.419PheGln: 1.419 ± 0.285
2.365PheArg: 2.365 ± 0.405
1.656PheSer: 1.656 ± 0.459
2.129PheThr: 2.129 ± 0.447
1.892PheVal: 1.892 ± 0.479
0.237PheTrp: 0.237 ± 0.154
1.025PheTyr: 1.025 ± 0.346
0.0PheXaa: 0.0 ± 0.0
Gly
8.673GlyAla: 8.673 ± 1.09
0.946GlyCys: 0.946 ± 0.334
5.677GlyAsp: 5.677 ± 0.704
5.125GlyGlu: 5.125 ± 0.707
3.154GlyPhe: 3.154 ± 0.391
7.096GlyGly: 7.096 ± 1.082
1.813GlyHis: 1.813 ± 0.356
2.917GlyIle: 2.917 ± 0.512
4.652GlyLys: 4.652 ± 0.661
5.362GlyLeu: 5.362 ± 0.646
2.917GlyMet: 2.917 ± 0.403
3.154GlyAsn: 3.154 ± 0.544
4.967GlyPro: 4.967 ± 2.281
3.469GlyGln: 3.469 ± 0.534
5.283GlyArg: 5.283 ± 0.702
5.44GlySer: 5.44 ± 0.98
4.415GlyThr: 4.415 ± 0.818
6.781GlyVal: 6.781 ± 0.73
1.577GlyTrp: 1.577 ± 0.444
1.971GlyTyr: 1.971 ± 0.368
0.0GlyXaa: 0.0 ± 0.0
His
2.208HisAla: 2.208 ± 0.432
0.315HisCys: 0.315 ± 0.175
0.867HisAsp: 0.867 ± 0.244
0.631HisGlu: 0.631 ± 0.248
0.394HisPhe: 0.394 ± 0.169
1.498HisGly: 1.498 ± 0.495
0.552HisHis: 0.552 ± 0.334
0.315HisIle: 0.315 ± 0.131
0.315HisLys: 0.315 ± 0.171
1.498HisLeu: 1.498 ± 0.41
0.158HisMet: 0.158 ± 0.113
0.394HisAsn: 0.394 ± 0.17
0.71HisPro: 0.71 ± 0.253
0.473HisGln: 0.473 ± 0.167
0.788HisArg: 0.788 ± 0.299
0.473HisSer: 0.473 ± 0.226
1.262HisThr: 1.262 ± 0.269
1.183HisVal: 1.183 ± 0.28
0.079HisTrp: 0.079 ± 0.073
0.394HisTyr: 0.394 ± 0.144
0.0HisXaa: 0.0 ± 0.0
Ile
4.888IleAla: 4.888 ± 0.814
0.079IleCys: 0.079 ± 0.081
3.154IleAsp: 3.154 ± 0.451
3.706IleGlu: 3.706 ± 0.44
0.394IlePhe: 0.394 ± 0.188
4.021IleGly: 4.021 ± 0.776
0.631IleHis: 0.631 ± 0.205
1.498IleIle: 1.498 ± 0.468
1.656IleLys: 1.656 ± 0.29
2.444IleLeu: 2.444 ± 0.484
0.71IleMet: 0.71 ± 0.289
1.183IleAsn: 1.183 ± 0.263
2.444IlePro: 2.444 ± 0.313
2.287IleGln: 2.287 ± 0.355
3.233IleArg: 3.233 ± 0.446
2.444IleSer: 2.444 ± 0.515
2.523IleThr: 2.523 ± 0.376
2.287IleVal: 2.287 ± 0.496
0.237IleTrp: 0.237 ± 0.141
0.788IleTyr: 0.788 ± 0.239
0.0IleXaa: 0.0 ± 0.0
Lys
5.756LysAla: 5.756 ± 0.957
0.237LysCys: 0.237 ± 0.138
2.996LysAsp: 2.996 ± 0.485
1.735LysGlu: 1.735 ± 0.35
1.262LysPhe: 1.262 ± 0.284
2.917LysGly: 2.917 ± 0.414
0.867LysHis: 0.867 ± 0.278
1.656LysIle: 1.656 ± 0.31
1.577LysLys: 1.577 ± 0.411
3.863LysLeu: 3.863 ± 0.541
0.867LysMet: 0.867 ± 0.231
0.552LysAsn: 0.552 ± 0.237
1.577LysPro: 1.577 ± 0.331
1.577LysGln: 1.577 ± 0.493
2.129LysArg: 2.129 ± 0.456
1.025LysSer: 1.025 ± 0.27
2.838LysThr: 2.838 ± 0.524
2.523LysVal: 2.523 ± 0.463
0.473LysTrp: 0.473 ± 0.177
1.419LysTyr: 1.419 ± 0.25
0.0LysXaa: 0.0 ± 0.0
Leu
11.511LeuAla: 11.511 ± 1.129
0.552LeuCys: 0.552 ± 0.309
5.046LeuAsp: 5.046 ± 0.628
3.706LeuGlu: 3.706 ± 0.512
1.971LeuPhe: 1.971 ± 0.382
6.544LeuGly: 6.544 ± 0.717
0.867LeuHis: 0.867 ± 0.289
2.287LeuIle: 2.287 ± 0.347
1.34LeuLys: 1.34 ± 0.296
6.15LeuLeu: 6.15 ± 0.883
0.71LeuMet: 0.71 ± 0.243
2.129LeuAsn: 2.129 ± 0.452
4.731LeuPro: 4.731 ± 0.596
4.021LeuGln: 4.021 ± 0.501
6.544LeuArg: 6.544 ± 0.761
4.021LeuSer: 4.021 ± 0.405
3.942LeuThr: 3.942 ± 0.533
4.967LeuVal: 4.967 ± 0.832
1.419LeuTrp: 1.419 ± 0.416
1.656LeuTyr: 1.656 ± 0.368
0.0LeuXaa: 0.0 ± 0.0
Met
3.785MetAla: 3.785 ± 0.471
0.158MetCys: 0.158 ± 0.116
1.498MetAsp: 1.498 ± 0.327
0.946MetGlu: 0.946 ± 0.289
0.473MetPhe: 0.473 ± 0.229
1.971MetGly: 1.971 ± 0.384
0.237MetHis: 0.237 ± 0.143
1.104MetIle: 1.104 ± 0.268
1.025MetLys: 1.025 ± 0.31
1.419MetLeu: 1.419 ± 0.267
0.473MetMet: 0.473 ± 0.154
1.419MetAsn: 1.419 ± 0.365
1.498MetPro: 1.498 ± 0.295
1.025MetGln: 1.025 ± 0.279
1.577MetArg: 1.577 ± 0.34
1.183MetSer: 1.183 ± 0.252
1.656MetThr: 1.656 ± 0.41
0.867MetVal: 0.867 ± 0.235
0.158MetTrp: 0.158 ± 0.106
0.473MetTyr: 0.473 ± 0.167
0.0MetXaa: 0.0 ± 0.0
Asn
4.021AsnAla: 4.021 ± 0.621
0.0AsnCys: 0.0 ± 0.0
1.104AsnAsp: 1.104 ± 0.266
1.34AsnGlu: 1.34 ± 0.273
1.183AsnPhe: 1.183 ± 0.237
3.548AsnGly: 3.548 ± 0.463
0.394AsnHis: 0.394 ± 0.149
1.419AsnIle: 1.419 ± 0.297
1.262AsnLys: 1.262 ± 0.318
3.075AsnLeu: 3.075 ± 0.433
0.71AsnMet: 0.71 ± 0.237
1.104AsnAsn: 1.104 ± 0.328
3.548AsnPro: 3.548 ± 0.574
1.419AsnGln: 1.419 ± 0.283
1.419AsnArg: 1.419 ± 0.349
2.05AsnSer: 2.05 ± 0.395
2.287AsnThr: 2.287 ± 0.425
2.602AsnVal: 2.602 ± 0.494
0.394AsnTrp: 0.394 ± 0.133
0.315AsnTyr: 0.315 ± 0.133
0.0AsnXaa: 0.0 ± 0.0
Pro
6.86ProAla: 6.86 ± 1.028
1.813ProCys: 1.813 ± 1.53
3.785ProAsp: 3.785 ± 0.557
2.838ProGlu: 2.838 ± 0.458
1.735ProPhe: 1.735 ± 0.571
4.731ProGly: 4.731 ± 0.602
0.867ProHis: 0.867 ± 0.343
1.892ProIle: 1.892 ± 0.44
1.656ProLys: 1.656 ± 0.344
2.996ProLeu: 2.996 ± 0.562
1.577ProMet: 1.577 ± 0.272
2.208ProAsn: 2.208 ± 0.457
2.523ProPro: 2.523 ± 0.676
2.365ProGln: 2.365 ± 0.388
3.627ProArg: 3.627 ± 0.657
3.154ProSer: 3.154 ± 0.641
3.233ProThr: 3.233 ± 0.411
4.021ProVal: 4.021 ± 1.307
1.577ProTrp: 1.577 ± 0.574
1.577ProTyr: 1.577 ± 0.411
0.0ProXaa: 0.0 ± 0.0
Gln
9.067GlnAla: 9.067 ± 1.7
0.158GlnCys: 0.158 ± 0.111
2.76GlnAsp: 2.76 ± 0.405
3.233GlnGlu: 3.233 ± 0.599
1.971GlnPhe: 1.971 ± 0.332
3.39GlnGly: 3.39 ± 0.634
0.867GlnHis: 0.867 ± 0.293
1.813GlnIle: 1.813 ± 0.415
1.577GlnLys: 1.577 ± 0.312
3.233GlnLeu: 3.233 ± 0.434
0.631GlnMet: 0.631 ± 0.158
0.946GlnAsn: 0.946 ± 0.281
1.656GlnPro: 1.656 ± 0.389
4.1GlnGln: 4.1 ± 0.704
3.942GlnArg: 3.942 ± 0.634
2.208GlnSer: 2.208 ± 0.52
1.735GlnThr: 1.735 ± 0.329
3.942GlnVal: 3.942 ± 0.461
0.788GlnTrp: 0.788 ± 0.209
0.552GlnTyr: 0.552 ± 0.147
0.0GlnXaa: 0.0 ± 0.0
Arg
9.935ArgAla: 9.935 ± 1.652
0.552ArgCys: 0.552 ± 0.219
3.942ArgAsp: 3.942 ± 0.673
4.81ArgGlu: 4.81 ± 1.141
2.287ArgPhe: 2.287 ± 0.367
4.494ArgGly: 4.494 ± 0.73
0.788ArgHis: 0.788 ± 0.237
3.627ArgIle: 3.627 ± 0.584
2.681ArgLys: 2.681 ± 0.634
4.021ArgLeu: 4.021 ± 0.576
1.577ArgMet: 1.577 ± 0.356
2.76ArgAsn: 2.76 ± 0.42
2.838ArgPro: 2.838 ± 0.576
3.548ArgGln: 3.548 ± 0.89
5.598ArgArg: 5.598 ± 0.801
3.469ArgSer: 3.469 ± 0.468
4.021ArgThr: 4.021 ± 0.626
5.046ArgVal: 5.046 ± 0.613
1.34ArgTrp: 1.34 ± 0.396
1.419ArgTyr: 1.419 ± 0.33
0.0ArgXaa: 0.0 ± 0.0
Ser
5.677SerAla: 5.677 ± 0.693
0.473SerCys: 0.473 ± 0.338
4.021SerAsp: 4.021 ± 0.59
2.681SerGlu: 2.681 ± 0.597
1.735SerPhe: 1.735 ± 0.418
5.283SerGly: 5.283 ± 0.769
0.552SerHis: 0.552 ± 0.196
3.075SerIle: 3.075 ± 0.528
2.681SerLys: 2.681 ± 0.474
3.469SerLeu: 3.469 ± 0.531
1.104SerMet: 1.104 ± 0.437
2.129SerAsn: 2.129 ± 0.402
3.785SerPro: 3.785 ± 1.067
1.813SerGln: 1.813 ± 0.381
2.523SerArg: 2.523 ± 0.452
3.233SerSer: 3.233 ± 0.591
3.706SerThr: 3.706 ± 0.766
3.312SerVal: 3.312 ± 0.462
0.946SerTrp: 0.946 ± 0.313
1.419SerTyr: 1.419 ± 0.39
0.0SerXaa: 0.0 ± 0.0
Thr
7.806ThrAla: 7.806 ± 0.783
0.079ThrCys: 0.079 ± 0.091
3.627ThrAsp: 3.627 ± 0.596
2.05ThrGlu: 2.05 ± 0.441
2.602ThrPhe: 2.602 ± 0.543
5.44ThrGly: 5.44 ± 0.696
0.788ThrHis: 0.788 ± 0.229
3.312ThrIle: 3.312 ± 0.484
1.892ThrLys: 1.892 ± 0.415
4.967ThrLeu: 4.967 ± 0.619
1.183ThrMet: 1.183 ± 0.363
1.735ThrAsn: 1.735 ± 0.415
4.415ThrPro: 4.415 ± 0.898
1.971ThrGln: 1.971 ± 0.365
3.312ThrArg: 3.312 ± 0.515
3.39ThrSer: 3.39 ± 0.439
3.627ThrThr: 3.627 ± 0.609
4.179ThrVal: 4.179 ± 0.456
1.025ThrTrp: 1.025 ± 0.244
1.656ThrTyr: 1.656 ± 0.391
0.0ThrXaa: 0.0 ± 0.0
Val
8.279ValAla: 8.279 ± 0.962
0.552ValCys: 0.552 ± 0.241
4.021ValAsp: 4.021 ± 0.533
4.021ValGlu: 4.021 ± 0.491
2.287ValPhe: 2.287 ± 0.509
4.967ValGly: 4.967 ± 0.618
0.631ValHis: 0.631 ± 0.191
2.129ValIle: 2.129 ± 0.425
2.287ValLys: 2.287 ± 0.544
4.652ValLeu: 4.652 ± 0.545
2.444ValMet: 2.444 ± 0.39
3.312ValAsn: 3.312 ± 0.595
4.258ValPro: 4.258 ± 0.577
2.917ValGln: 2.917 ± 0.451
4.652ValArg: 4.652 ± 0.544
4.888ValSer: 4.888 ± 0.978
5.204ValThr: 5.204 ± 0.697
5.598ValVal: 5.598 ± 0.722
1.577ValTrp: 1.577 ± 0.377
1.419ValTyr: 1.419 ± 0.477
0.0ValXaa: 0.0 ± 0.0
Trp
1.813TrpAla: 1.813 ± 0.311
0.158TrpCys: 0.158 ± 0.123
0.71TrpAsp: 0.71 ± 0.215
0.552TrpGlu: 0.552 ± 0.166
1.025TrpPhe: 1.025 ± 0.285
1.34TrpGly: 1.34 ± 0.353
0.631TrpHis: 0.631 ± 0.265
0.788TrpIle: 0.788 ± 0.212
0.473TrpLys: 0.473 ± 0.198
1.892TrpLeu: 1.892 ± 0.444
0.394TrpMet: 0.394 ± 0.17
0.473TrpAsn: 0.473 ± 0.198
0.71TrpPro: 0.71 ± 0.241
0.552TrpGln: 0.552 ± 0.219
1.419TrpArg: 1.419 ± 0.292
0.946TrpSer: 0.946 ± 0.254
0.71TrpThr: 0.71 ± 0.252
1.183TrpVal: 1.183 ± 0.469
0.237TrpTrp: 0.237 ± 0.146
0.315TrpTyr: 0.315 ± 0.148
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.365TyrAla: 2.365 ± 0.497
0.079TyrCys: 0.079 ± 0.079
1.498TyrAsp: 1.498 ± 0.365
1.577TyrGlu: 1.577 ± 0.276
0.788TyrPhe: 0.788 ± 0.274
1.813TyrGly: 1.813 ± 0.338
0.0TyrHis: 0.0 ± 0.0
0.552TyrIle: 0.552 ± 0.22
0.867TyrLys: 0.867 ± 0.289
2.287TyrLeu: 2.287 ± 0.289
0.631TyrMet: 0.631 ± 0.183
0.788TyrAsn: 0.788 ± 0.312
1.498TyrPro: 1.498 ± 0.397
1.025TyrGln: 1.025 ± 0.336
1.577TyrArg: 1.577 ± 0.472
0.71TyrSer: 0.71 ± 0.21
1.735TyrThr: 1.735 ± 0.539
2.287TyrVal: 2.287 ± 0.415
0.552TyrTrp: 0.552 ± 0.174
0.394TyrTyr: 0.394 ± 0.132
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 40 proteins (12684 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski