Amino acid dipepetide frequency for Tenacibaculum sp. MAR_2009_124

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.118AlaAla: 3.118 ± 0.07	0.503AlaCys: 0.503 ± 0.019	2.917AlaAsp: 2.917 ± 0.094	3.101AlaGlu: 3.101 ± 0.055	2.766AlaPhe: 2.766 ± 0.054	3.548AlaGly: 3.548 ± 0.084	0.912AlaHis: 0.912 ± 0.028	4.807AlaIle: 4.807 ± 0.068	4.143AlaLys: 4.143 ± 0.078	5.049AlaLeu: 5.049 ± 0.087	1.124AlaMet: 1.124 ± 0.032	3.36AlaAsn: 3.36 ± 0.072	1.782AlaPro: 1.782 ± 0.058	1.902AlaGln: 1.902 ± 0.039	1.644AlaArg: 1.644 ± 0.042	4.084AlaSer: 4.084 ± 0.096	3.426AlaThr: 3.426 ± 0.11	3.346AlaVal: 3.346 ± 0.063	0.501AlaTrp: 0.501 ± 0.021	2.207AlaTyr: 2.207 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.398CysAla: 0.398 ± 0.026	0.124CysCys: 0.124 ± 0.01	0.606CysAsp: 0.606 ± 0.063	0.421CysGlu: 0.421 ± 0.019	0.459CysPhe: 0.459 ± 0.019	0.572CysGly: 0.572 ± 0.025	0.17CysHis: 0.17 ± 0.013	0.63CysIle: 0.63 ± 0.027	0.515CysLys: 0.515 ± 0.02	0.661CysLeu: 0.661 ± 0.029	0.151CysMet: 0.151 ± 0.011	0.508CysAsn: 0.508 ± 0.032	0.304CysPro: 0.304 ± 0.018	0.203CysGln: 0.203 ± 0.013	0.2CysArg: 0.2 ± 0.012	0.767CysSer: 0.767 ± 0.054	0.436CysThr: 0.436 ± 0.031	0.475CysVal: 0.475 ± 0.03	0.079CysTrp: 0.079 ± 0.008	0.323CysTyr: 0.323 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.195AspAla: 3.195 ± 0.089	0.438AspCys: 0.438 ± 0.021	2.9AspAsp: 2.9 ± 0.074	3.409AspGlu: 3.409 ± 0.055	3.498AspPhe: 3.498 ± 0.056	4.403AspGly: 4.403 ± 0.357	0.884AspHis: 0.884 ± 0.029	4.635AspIle: 4.635 ± 0.073	4.09AspLys: 4.09 ± 0.064	5.35AspLeu: 5.35 ± 0.085	0.888AspMet: 0.888 ± 0.023	3.632AspAsn: 3.632 ± 0.1	1.812AspPro: 1.812 ± 0.144	1.483AspGln: 1.483 ± 0.042	1.799AspArg: 1.799 ± 0.046	3.68AspSer: 3.68 ± 0.118	3.2AspThr: 3.2 ± 0.141	3.693AspVal: 3.693 ± 0.076	0.655AspTrp: 0.655 ± 0.022	2.732AspTyr: 2.732 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	3.726GluAla: 3.726 ± 0.071	0.353GluCys: 0.353 ± 0.017	3.391GluAsp: 3.391 ± 0.054	5.27GluGlu: 5.27 ± 0.111	3.049GluPhe: 3.049 ± 0.053	3.83GluGly: 3.83 ± 0.062	1.155GluHis: 1.155 ± 0.033	5.619GluIle: 5.619 ± 0.076	6.241GluLys: 6.241 ± 0.105	6.749GluLeu: 6.749 ± 0.152	1.401GluMet: 1.401 ± 0.033	5.03GluAsn: 5.03 ± 0.076	1.472GluPro: 1.472 ± 0.039	2.163GluGln: 2.163 ± 0.048	2.43GluArg: 2.43 ± 0.049	3.703GluSer: 3.703 ± 0.058	3.657GluThr: 3.657 ± 0.076	4.489GluVal: 4.489 ± 0.062	0.566GluTrp: 0.566 ± 0.02	2.675GluTyr: 2.675 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	2.478PheAla: 2.478 ± 0.053	0.404PheCys: 0.404 ± 0.018	3.144PheAsp: 3.144 ± 0.053	3.362PheGlu: 3.362 ± 0.044	2.746PhePhe: 2.746 ± 0.057	3.355PheGly: 3.355 ± 0.05	0.88PheHis: 0.88 ± 0.028	4.094PheIle: 4.094 ± 0.067	3.941PheLys: 3.941 ± 0.064	4.549PheLeu: 4.549 ± 0.089	1.015PheMet: 1.015 ± 0.028	3.648PheAsn: 3.648 ± 0.057	1.5PhePro: 1.5 ± 0.034	1.492PheGln: 1.492 ± 0.037	1.595PheArg: 1.595 ± 0.039	4.318PheSer: 4.318 ± 0.058	3.164PheThr: 3.164 ± 0.061	2.988PheVal: 2.988 ± 0.048	0.561PheTrp: 0.561 ± 0.022	2.236PheTyr: 2.236 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	3.834GlyAla: 3.834 ± 0.077	0.664GlyCys: 0.664 ± 0.054	3.7GlyAsp: 3.7 ± 0.18	3.621GlyGlu: 3.621 ± 0.064	3.397GlyPhe: 3.397 ± 0.057	4.531GlyGly: 4.531 ± 0.095	1.058GlyHis: 1.058 ± 0.034	5.325GlyIle: 5.325 ± 0.093	4.846GlyLys: 4.846 ± 0.076	5.203GlyLeu: 5.203 ± 0.071	1.367GlyMet: 1.367 ± 0.033	4.114GlyAsn: 4.114 ± 0.072	1.142GlyPro: 1.142 ± 0.033	1.707GlyGln: 1.707 ± 0.043	2.008GlyArg: 2.008 ± 0.048	4.21GlySer: 4.21 ± 0.112	4.134GlyThr: 4.134 ± 0.128	4.804GlyVal: 4.804 ± 0.108	0.697GlyTrp: 0.697 ± 0.022	2.833GlyTyr: 2.833 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	0.823HisAla: 0.823 ± 0.025	0.168HisCys: 0.168 ± 0.012	0.886HisAsp: 0.886 ± 0.039	0.992HisGlu: 0.992 ± 0.031	1.029HisPhe: 1.029 ± 0.028	0.979HisGly: 0.979 ± 0.023	0.474HisHis: 0.474 ± 0.023	1.381HisIle: 1.381 ± 0.035	1.332HisLys: 1.332 ± 0.036	1.783HisLeu: 1.783 ± 0.035	0.298HisMet: 0.298 ± 0.015	1.04HisAsn: 1.04 ± 0.031	0.755HisPro: 0.755 ± 0.025	0.694HisGln: 0.694 ± 0.022	0.604HisArg: 0.604 ± 0.022	1.155HisSer: 1.155 ± 0.034	0.901HisThr: 0.901 ± 0.026	0.914HisVal: 0.914 ± 0.027	0.189HisTrp: 0.189 ± 0.012	0.849HisTyr: 0.849 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	4.88IleAla: 4.88 ± 0.065	0.73IleCys: 0.73 ± 0.032	5.337IleAsp: 5.337 ± 0.091	6.05IleGlu: 6.05 ± 0.104	3.457IlePhe: 3.457 ± 0.062	5.016IleGly: 5.016 ± 0.069	1.438IleHis: 1.438 ± 0.036	6.031IleIle: 6.031 ± 0.105	6.261IleLys: 6.261 ± 0.104	6.762IleLeu: 6.762 ± 0.084	1.257IleMet: 1.257 ± 0.032	5.376IleAsn: 5.376 ± 0.077	3.261IlePro: 3.261 ± 0.061	2.615IleGln: 2.615 ± 0.046	2.48IleArg: 2.48 ± 0.046	6.137IleSer: 6.137 ± 0.073	5.127IleThr: 5.127 ± 0.122	4.716IleVal: 4.716 ± 0.064	0.736IleTrp: 0.736 ± 0.024	2.884IleTyr: 2.884 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	4.39LysAla: 4.39 ± 0.078	0.379LysCys: 0.379 ± 0.016	4.325LysAsp: 4.325 ± 0.073	7.458LysGlu: 7.458 ± 0.131	3.026LysPhe: 3.026 ± 0.059	4.676LysGly: 4.676 ± 0.078	1.467LysHis: 1.467 ± 0.046	6.38LysIle: 6.38 ± 0.109	8.028LysLys: 8.028 ± 0.154	6.95LysLeu: 6.95 ± 0.102	1.797LysMet: 1.797 ± 0.042	5.89LysAsn: 5.89 ± 0.104	2.231LysPro: 2.231 ± 0.04	2.781LysGln: 2.781 ± 0.056	3.013LysArg: 3.013 ± 0.058	5.025LysSer: 5.025 ± 0.075	4.818LysThr: 4.818 ± 0.081	4.831LysVal: 4.831 ± 0.069	0.806LysTrp: 0.806 ± 0.024	3.178LysTyr: 3.178 ± 0.065	0.0LysXaa: 0.0 ± 0.0
Leu	4.928LeuAla: 4.928 ± 0.069	0.645LeuCys: 0.645 ± 0.023	5.021LeuAsp: 5.021 ± 0.107	5.984LeuGlu: 5.984 ± 0.093	4.859LeuPhe: 4.859 ± 0.093	5.641LeuGly: 5.641 ± 0.104	1.546LeuHis: 1.546 ± 0.037	6.862LeuIle: 6.862 ± 0.104	8.082LeuLys: 8.082 ± 0.126	8.549LeuLeu: 8.549 ± 0.138	1.746LeuMet: 1.746 ± 0.045	6.201LeuAsn: 6.201 ± 0.071	3.452LeuPro: 3.452 ± 0.076	3.004LeuGln: 3.004 ± 0.069	2.944LeuArg: 2.944 ± 0.054	7.175LeuSer: 7.175 ± 0.107	5.326LeuThr: 5.326 ± 0.087	5.211LeuVal: 5.211 ± 0.083	0.777LeuTrp: 0.777 ± 0.028	3.115LeuTyr: 3.115 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.154MetAla: 1.154 ± 0.035	0.134MetCys: 0.134 ± 0.009	0.905MetAsp: 0.905 ± 0.023	1.148MetGlu: 1.148 ± 0.031	0.84MetPhe: 0.84 ± 0.029	1.063MetGly: 1.063 ± 0.033	0.334MetHis: 0.334 ± 0.016	1.489MetIle: 1.489 ± 0.038	1.986MetLys: 1.986 ± 0.044	1.722MetLeu: 1.722 ± 0.042	0.44MetMet: 0.44 ± 0.019	1.357MetAsn: 1.357 ± 0.034	0.661MetPro: 0.661 ± 0.022	0.598MetGln: 0.598 ± 0.021	0.738MetArg: 0.738 ± 0.025	1.349MetSer: 1.349 ± 0.032	1.017MetThr: 1.017 ± 0.028	1.165MetVal: 1.165 ± 0.031	0.127MetTrp: 0.127 ± 0.01	0.66MetTyr: 0.66 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.54AsnAla: 3.54 ± 0.066	0.502AsnCys: 0.502 ± 0.023	3.937AsnAsp: 3.937 ± 0.102	4.351AsnGlu: 4.351 ± 0.057	3.415AsnPhe: 3.415 ± 0.056	4.544AsnGly: 4.544 ± 0.088	1.252AsnHis: 1.252 ± 0.046	5.396AsnIle: 5.396 ± 0.069	5.166AsnLys: 5.166 ± 0.084	5.879AsnLeu: 5.879 ± 0.077	1.152AsnMet: 1.152 ± 0.034	4.94AsnAsn: 4.94 ± 0.084	2.745AsnPro: 2.745 ± 0.068	2.381AsnGln: 2.381 ± 0.048	2.372AsnArg: 2.372 ± 0.042	4.684AsnSer: 4.684 ± 0.074	4.361AsnThr: 4.361 ± 0.098	3.872AsnVal: 3.872 ± 0.066	0.822AsnTrp: 0.822 ± 0.024	3.159AsnTyr: 3.159 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	1.531ProAla: 1.531 ± 0.041	0.327ProCys: 0.327 ± 0.052	2.075ProAsp: 2.075 ± 0.105	2.539ProGlu: 2.539 ± 0.053	1.857ProPhe: 1.857 ± 0.043	1.594ProGly: 1.594 ± 0.042	0.563ProHis: 0.563 ± 0.023	2.626ProIle: 2.626 ± 0.043	2.477ProLys: 2.477 ± 0.051	2.691ProLeu: 2.691 ± 0.078	0.612ProMet: 0.612 ± 0.022	2.458ProAsn: 2.458 ± 0.067	0.738ProPro: 0.738 ± 0.025	0.947ProGln: 0.947 ± 0.027	0.854ProArg: 0.854 ± 0.029	2.304ProSer: 2.304 ± 0.049	2.276ProThr: 2.276 ± 0.118	2.034ProVal: 2.034 ± 0.05	0.325ProTrp: 0.325 ± 0.017	1.303ProTyr: 1.303 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	1.639GlnAla: 1.639 ± 0.051	0.183GlnCys: 0.183 ± 0.011	1.443GlnAsp: 1.443 ± 0.043	2.447GlnGlu: 2.447 ± 0.061	1.608GlnPhe: 1.608 ± 0.036	1.785GlnGly: 1.785 ± 0.04	0.572GlnHis: 0.572 ± 0.022	2.481GlnIle: 2.481 ± 0.044	2.803GlnLys: 2.803 ± 0.056	3.26GlnLeu: 3.26 ± 0.056	0.655GlnMet: 0.655 ± 0.021	2.224GlnAsn: 2.224 ± 0.055	0.961GlnPro: 0.961 ± 0.041	1.337GlnGln: 1.337 ± 0.034	1.125GlnArg: 1.125 ± 0.031	1.913GlnSer: 1.913 ± 0.045	1.855GlnThr: 1.855 ± 0.054	1.947GlnVal: 1.947 ± 0.048	0.382GlnTrp: 0.382 ± 0.016	1.37GlnTyr: 1.37 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	1.677ArgAla: 1.677 ± 0.039	0.193ArgCys: 0.193 ± 0.011	1.664ArgAsp: 1.664 ± 0.038	2.073ArgGlu: 2.073 ± 0.049	1.754ArgPhe: 1.754 ± 0.038	1.887ArgGly: 1.887 ± 0.037	0.583ArgHis: 0.583 ± 0.027	2.882ArgIle: 2.882 ± 0.05	3.055ArgLys: 3.055 ± 0.058	3.043ArgLeu: 3.043 ± 0.054	0.756ArgMet: 0.756 ± 0.026	2.284ArgAsn: 2.284 ± 0.046	0.879ArgPro: 0.879 ± 0.025	0.905ArgGln: 0.905 ± 0.029	1.235ArgArg: 1.235 ± 0.039	2.032ArgSer: 2.032 ± 0.053	1.787ArgThr: 1.787 ± 0.043	2.067ArgVal: 2.067 ± 0.046	0.352ArgTrp: 0.352 ± 0.019	1.49ArgTyr: 1.49 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	3.433SerAla: 3.433 ± 0.078	0.718SerCys: 0.718 ± 0.027	4.066SerAsp: 4.066 ± 0.132	4.518SerGlu: 4.518 ± 0.081	4.273SerPhe: 4.273 ± 0.06	4.833SerGly: 4.833 ± 0.1	1.002SerHis: 1.002 ± 0.028	6.092SerIle: 6.092 ± 0.091	5.597SerLys: 5.597 ± 0.077	6.724SerLeu: 6.724 ± 0.094	1.224SerMet: 1.224 ± 0.031	4.95SerAsn: 4.95 ± 0.072	2.113SerPro: 2.113 ± 0.045	2.126SerGln: 2.126 ± 0.058	1.988SerArg: 1.988 ± 0.046	5.316SerSer: 5.316 ± 0.085	3.967SerThr: 3.967 ± 0.111	4.067SerVal: 4.067 ± 0.071	0.767SerTrp: 0.767 ± 0.033	3.24SerTyr: 3.24 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	3.303ThrAla: 3.303 ± 0.12	0.445ThrCys: 0.445 ± 0.046	3.694ThrAsp: 3.694 ± 0.199	3.353ThrGlu: 3.353 ± 0.049	3.024ThrPhe: 3.024 ± 0.059	4.065ThrGly: 4.065 ± 0.136	1.009ThrHis: 1.009 ± 0.031	5.582ThrIle: 5.582 ± 0.155	4.068ThrLys: 4.068 ± 0.065	5.432ThrLeu: 5.432 ± 0.067	0.904ThrMet: 0.904 ± 0.031	3.889ThrAsn: 3.889 ± 0.087	2.59ThrPro: 2.59 ± 0.05	1.815ThrGln: 1.815 ± 0.047	1.646ThrArg: 1.646 ± 0.042	4.572ThrSer: 4.572 ± 0.147	3.924ThrThr: 3.924 ± 0.133	4.07ThrVal: 4.07 ± 0.166	0.604ThrTrp: 0.604 ± 0.032	2.619ThrTyr: 2.619 ± 0.077	0.0ThrXaa: 0.0 ± 0.0
Val	3.656ValAla: 3.656 ± 0.09	0.638ValCys: 0.638 ± 0.047	3.542ValAsp: 3.542 ± 0.086	3.797ValGlu: 3.797 ± 0.066	3.409ValPhe: 3.409 ± 0.059	3.676ValGly: 3.676 ± 0.066	0.957ValHis: 0.957 ± 0.027	4.644ValIle: 4.644 ± 0.074	4.567ValLys: 4.567 ± 0.079	5.903ValLeu: 5.903 ± 0.097	1.133ValMet: 1.133 ± 0.03	4.082ValAsn: 4.082 ± 0.087	2.071ValPro: 2.071 ± 0.086	1.836ValGln: 1.836 ± 0.052	1.874ValArg: 1.874 ± 0.042	4.865ValSer: 4.865 ± 0.063	3.992ValThr: 3.992 ± 0.143	4.193ValVal: 4.193 ± 0.087	0.577ValTrp: 0.577 ± 0.02	2.468ValTyr: 2.468 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.501TrpAla: 0.501 ± 0.019	0.1TrpCys: 0.1 ± 0.008	0.541TrpAsp: 0.541 ± 0.022	0.638TrpGlu: 0.638 ± 0.025	0.578TrpPhe: 0.578 ± 0.021	0.641TrpGly: 0.641 ± 0.019	0.2TrpHis: 0.2 ± 0.012	0.731TrpIle: 0.731 ± 0.023	0.881TrpLys: 0.881 ± 0.025	0.959TrpLeu: 0.959 ± 0.03	0.266TrpMet: 0.266 ± 0.015	0.709TrpAsn: 0.709 ± 0.023	0.175TrpPro: 0.175 ± 0.012	0.407TrpGln: 0.407 ± 0.019	0.377TrpArg: 0.377 ± 0.018	0.744TrpSer: 0.744 ± 0.036	0.519TrpThr: 0.519 ± 0.02	0.609TrpVal: 0.609 ± 0.021	0.14TrpTrp: 0.14 ± 0.01	0.434TrpTyr: 0.434 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.037TyrAla: 2.037 ± 0.038	0.357TyrCys: 0.357 ± 0.017	2.281TyrAsp: 2.281 ± 0.048	2.435TyrGlu: 2.435 ± 0.044	2.428TyrPhe: 2.428 ± 0.053	2.552TyrGly: 2.552 ± 0.043	0.794TyrHis: 0.794 ± 0.025	2.864TyrIle: 2.864 ± 0.051	3.371TyrLys: 3.371 ± 0.059	3.847TyrLeu: 3.847 ± 0.068	0.704TyrMet: 0.704 ± 0.027	2.779TyrAsn: 2.779 ± 0.048	1.485TyrPro: 1.485 ± 0.051	1.594TyrGln: 1.594 ± 0.039	1.674TyrArg: 1.674 ± 0.036	2.979TyrSer: 2.979 ± 0.057	2.719TyrThr: 2.719 ± 0.114	2.389TyrVal: 2.389 ± 0.056	0.486TyrTrp: 0.486 ± 0.019	1.93TyrTyr: 1.93 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4480 proteins (1587372 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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