Amino acid dipepetide frequency for Tomato mottle mosaic virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.333AlaAla: 6.333 ± 1.18
0.95AlaCys: 0.95 ± 0.309
2.533AlaAsp: 2.533 ± 0.665
3.167AlaGlu: 3.167 ± 0.393
2.85AlaPhe: 2.85 ± 0.819
4.433AlaGly: 4.433 ± 2.192
1.267AlaHis: 1.267 ± 0.381
2.533AlaIle: 2.533 ± 1.181
5.383AlaLys: 5.383 ± 0.533
8.55AlaLeu: 8.55 ± 1.384
1.583AlaMet: 1.583 ± 0.463
2.217AlaAsn: 2.217 ± 0.637
1.267AlaPro: 1.267 ± 0.657
0.633AlaGln: 0.633 ± 0.443
4.117AlaArg: 4.117 ± 0.964
4.75AlaSer: 4.75 ± 1.007
4.117AlaThr: 4.117 ± 1.004
5.066AlaVal: 5.066 ± 1.06
1.9AlaTrp: 1.9 ± 1.006
2.85AlaTyr: 2.85 ± 0.819
0.0AlaXaa: 0.0 ± 0.0
Cys
0.633CysAla: 0.633 ± 0.443
0.633CysCys: 0.633 ± 0.191
1.583CysAsp: 1.583 ± 0.463
0.317CysGlu: 0.317 ± 0.221
0.633CysPhe: 0.633 ± 0.191
1.267CysGly: 1.267 ± 0.502
0.633CysHis: 0.633 ± 0.191
0.95CysIle: 0.95 ± 0.678
1.267CysLys: 1.267 ± 0.381
2.217CysLeu: 2.217 ± 1.171
0.95CysMet: 0.95 ± 0.286
0.633CysAsn: 0.633 ± 0.191
0.95CysPro: 0.95 ± 0.601
1.267CysGln: 1.267 ± 0.381
0.95CysArg: 0.95 ± 0.601
0.633CysSer: 0.633 ± 0.191
0.95CysThr: 0.95 ± 0.503
0.633CysVal: 0.633 ± 0.191
0.0CysTrp: 0.0 ± 0.0
0.633CysTyr: 0.633 ± 0.191
0.0CysXaa: 0.0 ± 0.0
Asp
2.533AspAla: 2.533 ± 1.823
0.317AspCys: 0.317 ± 0.221
2.85AspAsp: 2.85 ± 1.245
6.016AspGlu: 6.016 ± 0.657
1.9AspPhe: 1.9 ± 0.927
2.217AspGly: 2.217 ± 0.388
0.317AspHis: 0.317 ± 0.221
6.016AspIle: 6.016 ± 1.831
3.8AspLys: 3.8 ± 0.882
4.117AspLeu: 4.117 ± 0.461
2.533AspMet: 2.533 ± 0.763
1.583AspAsn: 1.583 ± 1.637
2.217AspPro: 2.217 ± 0.922
0.633AspGln: 0.633 ± 0.684
2.85AspArg: 2.85 ± 0.819
7.916AspSer: 7.916 ± 0.957
4.75AspThr: 4.75 ± 0.388
6.65AspVal: 6.65 ± 1.911
0.95AspTrp: 0.95 ± 0.309
0.317AspTyr: 0.317 ± 0.221
0.0AspXaa: 0.0 ± 0.0
Glu
3.167GluAla: 3.167 ± 0.294
0.0GluCys: 0.0 ± 0.0
3.8GluAsp: 3.8 ± 0.727
4.117GluGlu: 4.117 ± 0.699
5.066GluPhe: 5.066 ± 1.229
2.533GluGly: 2.533 ± 0.762
0.0GluHis: 0.0 ± 0.0
3.483GluIle: 3.483 ± 1.004
2.533GluLys: 2.533 ± 0.501
5.066GluLeu: 5.066 ± 0.663
2.85GluMet: 2.85 ± 0.819
2.217GluAsn: 2.217 ± 0.498
1.267GluPro: 1.267 ± 0.381
3.483GluGln: 3.483 ± 1.004
2.85GluArg: 2.85 ± 1.803
5.066GluSer: 5.066 ± 0.728
5.066GluThr: 5.066 ± 0.645
6.966GluVal: 6.966 ± 0.758
0.95GluTrp: 0.95 ± 0.601
2.533GluTyr: 2.533 ± 0.763
0.0GluXaa: 0.0 ± 0.0
Phe
1.267PheAla: 1.267 ± 0.381
1.583PheCys: 1.583 ± 0.514
3.8PheAsp: 3.8 ± 0.81
1.267PheGlu: 1.267 ± 0.444
1.583PhePhe: 1.583 ± 0.712
3.167PheGly: 3.167 ± 0.926
2.217PheHis: 2.217 ± 0.637
2.85PheIle: 2.85 ± 0.306
2.85PheLys: 2.85 ± 0.499
4.117PheLeu: 4.117 ± 0.845
0.317PheMet: 0.317 ± 0.759
0.95PheAsn: 0.95 ± 0.309
4.433PhePro: 4.433 ± 0.946
3.167PheGln: 3.167 ± 0.571
1.267PheArg: 1.267 ± 1.369
5.7PheSer: 5.7 ± 1.26
1.9PheThr: 1.9 ± 0.363
4.117PheVal: 4.117 ± 0.27
0.0PheTrp: 0.0 ± 0.0
1.9PheTyr: 1.9 ± 0.443
0.0PheXaa: 0.0 ± 0.0
Gly
2.85GlyAla: 2.85 ± 0.306
1.9GlyCys: 1.9 ± 0.617
3.167GlyAsp: 3.167 ± 1.109
2.533GlyGlu: 2.533 ± 0.27
1.267GlyPhe: 1.267 ± 0.944
2.85GlyGly: 2.85 ± 1.803
0.317GlyHis: 0.317 ± 0.221
0.317GlyIle: 0.317 ± 0.221
2.217GlyLys: 2.217 ± 0.388
4.117GlyLeu: 4.117 ± 0.885
0.0GlyMet: 0.0 ± 0.0
3.483GlyAsn: 3.483 ± 0.697
1.583GlyPro: 1.583 ± 1.258
0.95GlyGln: 0.95 ± 0.309
3.167GlyArg: 3.167 ± 0.294
3.167GlySer: 3.167 ± 1.029
1.9GlyThr: 1.9 ± 1.006
6.333GlyVal: 6.333 ± 1.071
0.0GlyTrp: 0.0 ± 0.0
1.9GlyTyr: 1.9 ± 0.363
0.0GlyXaa: 0.0 ± 0.0
His
1.267HisAla: 1.267 ± 0.381
0.95HisCys: 0.95 ± 0.309
1.583HisAsp: 1.583 ± 0.463
1.267HisGlu: 1.267 ± 0.381
1.9HisPhe: 1.9 ± 0.572
0.0HisGly: 0.0 ± 0.0
0.317HisHis: 0.317 ± 0.221
0.95HisIle: 0.95 ± 0.309
0.95HisLys: 0.95 ± 0.309
0.95HisLeu: 0.95 ± 0.309
0.95HisMet: 0.95 ± 0.309
0.317HisAsn: 0.317 ± 0.759
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
0.317HisArg: 0.317 ± 0.221
2.85HisSer: 2.85 ± 0.819
2.533HisThr: 2.533 ± 0.762
3.167HisVal: 3.167 ± 0.294
0.0HisTrp: 0.0 ± 0.0
0.633HisTyr: 0.633 ± 0.191
0.0HisXaa: 0.0 ± 0.0
Ile
3.483IleAla: 3.483 ± 1.004
1.267IleCys: 1.267 ± 0.944
3.483IleAsp: 3.483 ± 1.167
2.217IleGlu: 2.217 ± 1.429
0.317IlePhe: 0.317 ± 0.221
1.267IleGly: 1.267 ± 0.502
0.317IleHis: 0.317 ± 0.221
2.533IleIle: 2.533 ± 0.519
3.8IleLys: 3.8 ± 0.862
3.483IleLeu: 3.483 ± 1.004
1.267IleMet: 1.267 ± 0.381
4.117IleAsn: 4.117 ± 0.845
2.85IlePro: 2.85 ± 0.819
1.9IleGln: 1.9 ± 0.617
4.433IleArg: 4.433 ± 0.56
2.85IleSer: 2.85 ± 0.677
3.167IleThr: 3.167 ± 1.733
3.8IleVal: 3.8 ± 0.727
0.633IleTrp: 0.633 ± 0.684
0.633IleTyr: 0.633 ± 0.191
0.0IleXaa: 0.0 ± 0.0
Lys
2.217LysAla: 2.217 ± 0.637
0.317LysCys: 0.317 ± 0.221
4.75LysAsp: 4.75 ± 0.767
4.117LysGlu: 4.117 ± 1.19
3.8LysPhe: 3.8 ± 0.415
4.75LysGly: 4.75 ± 0.596
0.633LysHis: 0.633 ± 0.684
1.583LysIle: 1.583 ± 1.258
4.117LysLys: 4.117 ± 0.707
6.333LysLeu: 6.333 ± 0.921
1.583LysMet: 1.583 ± 0.468
3.167LysAsn: 3.167 ± 0.294
2.533LysPro: 2.533 ± 0.519
1.9LysGln: 1.9 ± 0.603
3.483LysArg: 3.483 ± 1.603
4.117LysSer: 4.117 ± 1.51
4.117LysThr: 4.117 ± 1.416
6.966LysVal: 6.966 ± 0.998
0.633LysTrp: 0.633 ± 0.191
2.85LysTyr: 2.85 ± 0.926
0.0LysXaa: 0.0 ± 0.0
Leu
6.966LeuAla: 6.966 ± 0.146
0.95LeuCys: 0.95 ± 0.309
6.966LeuAsp: 6.966 ± 0.985
9.816LeuGlu: 9.816 ± 2.033
3.8LeuPhe: 3.8 ± 1.507
2.533LeuGly: 2.533 ± 1.823
1.9LeuHis: 1.9 ± 0.572
6.65LeuIle: 6.65 ± 0.722
4.433LeuLys: 4.433 ± 0.593
10.45LeuLeu: 10.45 ± 0.963
1.583LeuMet: 1.583 ± 0.463
3.167LeuAsn: 3.167 ± 1.109
1.583LeuPro: 1.583 ± 1.344
2.533LeuGln: 2.533 ± 0.763
2.85LeuArg: 2.85 ± 0.392
9.183LeuSer: 9.183 ± 0.533
5.7LeuThr: 5.7 ± 0.531
10.766LeuVal: 10.766 ± 0.63
0.317LeuTrp: 0.317 ± 0.221
3.167LeuTyr: 3.167 ± 0.926
0.0LeuXaa: 0.0 ± 0.0
Met
3.167MetAla: 3.167 ± 0.937
2.533MetCys: 2.533 ± 0.762
0.95MetAsp: 0.95 ± 0.309
1.9MetGlu: 1.9 ± 0.363
0.317MetPhe: 0.317 ± 0.759
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
1.267MetIle: 1.267 ± 0.502
2.217MetLys: 2.217 ± 0.637
1.267MetLeu: 1.267 ± 0.502
0.633MetMet: 0.633 ± 0.191
0.633MetAsn: 0.633 ± 0.191
1.583MetPro: 1.583 ± 0.463
1.583MetGln: 1.583 ± 0.514
1.267MetArg: 1.267 ± 0.381
2.533MetSer: 2.533 ± 1.181
1.267MetThr: 1.267 ± 0.381
1.9MetVal: 1.9 ± 0.363
0.317MetTrp: 0.317 ± 0.221
1.9MetTyr: 1.9 ± 0.572
0.0MetXaa: 0.0 ± 0.0
Asn
4.433AsnAla: 4.433 ± 0.961
0.95AsnCys: 0.95 ± 0.678
0.633AsnAsp: 0.633 ± 0.191
1.9AsnGlu: 1.9 ± 1.52
5.383AsnPhe: 5.383 ± 0.881
0.95AsnGly: 0.95 ± 0.309
1.267AsnHis: 1.267 ± 0.381
2.533AsnIle: 2.533 ± 2.204
0.95AsnLys: 0.95 ± 0.309
4.75AsnLeu: 4.75 ± 1.536
0.0AsnMet: 0.0 ± 0.0
2.217AsnAsn: 2.217 ± 1.429
0.633AsnPro: 0.633 ± 0.191
1.583AsnGln: 1.583 ± 1.643
2.533AsnArg: 2.533 ± 0.519
3.167AsnSer: 3.167 ± 0.393
2.85AsnThr: 2.85 ± 0.306
2.85AsnVal: 2.85 ± 0.499
0.0AsnTrp: 0.0 ± 0.0
2.217AsnTyr: 2.217 ± 0.388
0.0AsnXaa: 0.0 ± 0.0
Pro
4.433ProAla: 4.433 ± 0.945
0.0ProCys: 0.0 ± 0.0
2.217ProAsp: 2.217 ± 0.654
1.583ProGlu: 1.583 ± 0.463
0.317ProPhe: 0.317 ± 0.579
1.9ProGly: 1.9 ± 0.617
0.633ProHis: 0.633 ± 0.191
0.317ProIle: 0.317 ± 0.759
3.483ProLys: 3.483 ± 0.655
3.167ProLeu: 3.167 ± 0.393
1.9ProMet: 1.9 ± 0.603
2.533ProAsn: 2.533 ± 0.27
0.95ProPro: 0.95 ± 0.309
0.317ProGln: 0.317 ± 0.579
0.317ProArg: 0.317 ± 0.221
1.9ProSer: 1.9 ± 0.794
2.217ProThr: 2.217 ± 0.553
2.85ProVal: 2.85 ± 0.664
0.0ProTrp: 0.0 ± 0.0
1.9ProTyr: 1.9 ± 0.572
0.0ProXaa: 0.0 ± 0.0
Gln
1.9GlnAla: 1.9 ± 0.443
0.0GlnCys: 0.0 ± 0.0
0.95GlnAsp: 0.95 ± 0.601
1.9GlnGlu: 1.9 ± 0.363
4.117GlnPhe: 4.117 ± 1.507
0.95GlnGly: 0.95 ± 0.309
0.0GlnHis: 0.0 ± 0.0
2.85GlnIle: 2.85 ± 0.819
2.85GlnLys: 2.85 ± 0.819
1.9GlnLeu: 1.9 ± 0.927
2.217GlnMet: 2.217 ± 0.73
0.95GlnAsn: 0.95 ± 0.309
0.95GlnPro: 0.95 ± 0.309
2.85GlnGln: 2.85 ± 2.042
1.9GlnArg: 1.9 ± 0.363
2.85GlnSer: 2.85 ± 1.508
3.167GlnThr: 3.167 ± 0.701
1.583GlnVal: 1.583 ± 0.514
0.0GlnTrp: 0.0 ± 0.0
0.317GlnTyr: 0.317 ± 0.221
0.317GlnXaa: 0.317 ± 0.221
Arg
2.217ArgAla: 2.217 ± 0.388
1.267ArgCys: 1.267 ± 0.381
3.8ArgAsp: 3.8 ± 1.144
1.9ArgGlu: 1.9 ± 0.363
0.95ArgPhe: 0.95 ± 1.001
3.8ArgGly: 3.8 ± 1.012
2.217ArgHis: 2.217 ± 0.637
1.9ArgIle: 1.9 ± 0.794
5.7ArgLys: 5.7 ± 0.611
5.383ArgLeu: 5.383 ± 0.615
0.317ArgMet: 0.317 ± 0.759
1.267ArgAsn: 1.267 ± 1.699
0.633ArgPro: 0.633 ± 0.191
1.9ArgGln: 1.9 ± 0.617
4.75ArgArg: 4.75 ± 1.007
4.433ArgSer: 4.433 ± 0.19
2.85ArgThr: 2.85 ± 0.499
4.433ArgVal: 4.433 ± 0.56
0.317ArgTrp: 0.317 ± 0.221
1.9ArgTyr: 1.9 ± 0.443
0.0ArgXaa: 0.0 ± 0.0
Ser
4.117SerAla: 4.117 ± 1.464
0.0SerCys: 0.0 ± 0.0
4.117SerAsp: 4.117 ± 0.707
9.183SerGlu: 9.183 ± 0.903
4.117SerPhe: 4.117 ± 1.19
4.117SerGly: 4.117 ± 0.885
1.583SerHis: 1.583 ± 0.463
3.8SerIle: 3.8 ± 0.415
7.283SerLys: 7.283 ± 0.845
12.983SerLeu: 12.983 ± 1.16
2.85SerMet: 2.85 ± 0.946
3.167SerAsn: 3.167 ± 0.869
1.583SerPro: 1.583 ± 0.985
3.167SerGln: 3.167 ± 0.644
4.433SerArg: 4.433 ± 1.274
6.65SerSer: 6.65 ± 0.84
1.583SerThr: 1.583 ± 0.985
7.283SerVal: 7.283 ± 3.132
0.0SerTrp: 0.0 ± 0.0
2.217SerTyr: 2.217 ± 2.257
0.0SerXaa: 0.0 ± 0.0
Thr
5.7ThrAla: 5.7 ± 1.151
1.583ThrCys: 1.583 ± 0.463
0.317ThrAsp: 0.317 ± 0.221
2.85ThrGlu: 2.85 ± 0.944
6.016ThrPhe: 6.016 ± 1.289
3.8ThrGly: 3.8 ± 0.243
2.217ThrHis: 2.217 ± 0.388
2.533ThrIle: 2.533 ± 0.763
3.167ThrLys: 3.167 ± 0.937
5.7ThrLeu: 5.7 ± 0.456
1.267ThrMet: 1.267 ± 0.502
0.633ThrAsn: 0.633 ± 1.106
2.217ThrPro: 2.217 ± 0.637
3.483ThrGln: 3.483 ± 0.805
4.75ThrArg: 4.75 ± 0.728
4.433ThrSer: 4.433 ± 0.849
2.217ThrThr: 2.217 ± 1.239
4.75ThrVal: 4.75 ± 1.414
0.633ThrTrp: 0.633 ± 0.191
3.167ThrTyr: 3.167 ± 0.953
0.0ThrXaa: 0.0 ± 0.0
Val
5.7ValAla: 5.7 ± 0.501
2.533ValCys: 2.533 ± 1.06
8.55ValAsp: 8.55 ± 1.395
5.383ValGlu: 5.383 ± 1.16
1.583ValPhe: 1.583 ± 0.985
0.317ValGly: 0.317 ± 0.221
3.483ValHis: 3.483 ± 1.004
4.117ValIle: 4.117 ± 0.845
2.217ValLys: 2.217 ± 1.935
7.283ValLeu: 7.283 ± 1.335
2.85ValMet: 2.85 ± 0.392
6.016ValAsn: 6.016 ± 1.802
4.117ValPro: 4.117 ± 0.699
1.583ValGln: 1.583 ± 0.493
4.117ValArg: 4.117 ± 1.437
11.083ValSer: 11.083 ± 3.278
6.333ValThr: 6.333 ± 1.851
6.333ValVal: 6.333 ± 0.588
1.267ValTrp: 1.267 ± 0.444
5.383ValTyr: 5.383 ± 0.345
0.0ValXaa: 0.0 ± 0.0
Trp
0.317TrpAla: 0.317 ± 0.579
0.0TrpCys: 0.0 ± 0.0
0.95TrpAsp: 0.95 ± 0.309
0.633TrpGlu: 0.633 ± 0.191
1.267TrpPhe: 1.267 ± 0.381
0.633TrpGly: 0.633 ± 0.191
0.633TrpHis: 0.633 ± 0.191
0.0TrpIle: 0.0 ± 0.0
0.633TrpLys: 0.633 ± 0.519
0.95TrpLeu: 0.95 ± 0.309
0.0TrpMet: 0.0 ± 0.0
0.633TrpAsn: 0.633 ± 0.684
0.0TrpPro: 0.0 ± 0.0
0.317TrpGln: 0.317 ± 0.759
0.95TrpArg: 0.95 ± 0.309
0.0TrpSer: 0.0 ± 0.0
0.317TrpThr: 0.317 ± 0.579
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.317TrpTyr: 0.317 ± 0.221
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.8TyrAla: 3.8 ± 0.532
0.0TyrCys: 0.0 ± 0.0
3.483TyrAsp: 3.483 ± 1.068
0.95TyrGlu: 0.95 ± 0.309
1.267TyrPhe: 1.267 ± 0.502
2.533TyrGly: 2.533 ± 0.27
0.95TyrHis: 0.95 ± 0.309
0.633TyrIle: 0.633 ± 0.191
4.117TyrLys: 4.117 ± 0.461
2.533TyrLeu: 2.533 ± 0.763
1.267TyrMet: 1.267 ± 0.37
1.9TyrAsn: 1.9 ± 1.006
1.583TyrPro: 1.583 ± 0.463
0.95TyrGln: 0.95 ± 0.309
0.633TyrArg: 0.633 ± 0.519
1.267TyrSer: 1.267 ± 0.381
4.433TyrThr: 4.433 ± 0.576
3.8TyrVal: 3.8 ± 0.415
0.633TyrTrp: 0.633 ± 0.191
1.9TyrTyr: 1.9 ± 0.603
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.317XaaGln: 0.317 ± 0.221
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (3159 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski