Amino acid dipepetide frequency for Xenorhabdus stockiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.021AlaAla: 7.021 ± 0.106
0.955AlaCys: 0.955 ± 0.029
4.325AlaAsp: 4.325 ± 0.07
5.547AlaGlu: 5.547 ± 0.088
3.155AlaPhe: 3.155 ± 0.053
6.266AlaGly: 6.266 ± 0.094
1.658AlaHis: 1.658 ± 0.04
5.861AlaIle: 5.861 ± 0.075
4.074AlaLys: 4.074 ± 0.074
9.175AlaLeu: 9.175 ± 0.12
2.21AlaMet: 2.21 ± 0.045
3.222AlaAsn: 3.222 ± 0.057
2.84AlaPro: 2.84 ± 0.055
3.63AlaGln: 3.63 ± 0.08
4.067AlaArg: 4.067 ± 0.073
4.651AlaSer: 4.651 ± 0.061
4.032AlaThr: 4.032 ± 0.063
5.333AlaVal: 5.333 ± 0.069
0.914AlaTrp: 0.914 ± 0.027
2.427AlaTyr: 2.427 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
0.808CysAla: 0.808 ± 0.024
0.172CysCys: 0.172 ± 0.011
0.578CysAsp: 0.578 ± 0.021
0.592CysGlu: 0.592 ± 0.021
0.46CysPhe: 0.46 ± 0.019
0.923CysGly: 0.923 ± 0.031
0.386CysHis: 0.386 ± 0.017
0.678CysIle: 0.678 ± 0.023
0.352CysLys: 0.352 ± 0.016
1.041CysLeu: 1.041 ± 0.029
0.233CysMet: 0.233 ± 0.013
0.392CysAsn: 0.392 ± 0.018
0.483CysPro: 0.483 ± 0.019
0.549CysGln: 0.549 ± 0.022
0.611CysArg: 0.611 ± 0.02
0.719CysSer: 0.719 ± 0.023
0.467CysThr: 0.467 ± 0.024
0.644CysVal: 0.644 ± 0.024
0.185CysTrp: 0.185 ± 0.012
0.395CysTyr: 0.395 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.979AspAla: 3.979 ± 0.072
0.557AspCys: 0.557 ± 0.019
2.668AspAsp: 2.668 ± 0.053
3.449AspGlu: 3.449 ± 0.055
2.296AspPhe: 2.296 ± 0.046
3.633AspGly: 3.633 ± 0.066
1.021AspHis: 1.021 ± 0.03
4.401AspIle: 4.401 ± 0.06
2.984AspLys: 2.984 ± 0.054
4.698AspLeu: 4.698 ± 0.065
1.29AspMet: 1.29 ± 0.031
2.682AspAsn: 2.682 ± 0.052
2.138AspPro: 2.138 ± 0.05
1.637AspGln: 1.637 ± 0.037
2.386AspArg: 2.386 ± 0.05
3.097AspSer: 3.097 ± 0.042
2.583AspThr: 2.583 ± 0.046
3.269AspVal: 3.269 ± 0.048
0.827AspTrp: 0.827 ± 0.027
1.995AspTyr: 1.995 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
4.613GluAla: 4.613 ± 0.074
0.578GluCys: 0.578 ± 0.024
2.492GluAsp: 2.492 ± 0.045
3.565GluGlu: 3.565 ± 0.068
2.087GluPhe: 2.087 ± 0.037
3.336GluGly: 3.336 ± 0.061
1.597GluHis: 1.597 ± 0.039
4.276GluIle: 4.276 ± 0.067
4.262GluLys: 4.262 ± 0.073
6.633GluLeu: 6.633 ± 0.085
1.696GluMet: 1.696 ± 0.036
3.02GluAsn: 3.02 ± 0.053
2.027GluPro: 2.027 ± 0.044
4.013GluGln: 4.013 ± 0.067
3.689GluArg: 3.689 ± 0.072
3.424GluSer: 3.424 ± 0.053
3.069GluThr: 3.069 ± 0.046
3.421GluVal: 3.421 ± 0.058
0.852GluTrp: 0.852 ± 0.024
1.916GluTyr: 1.916 ± 0.044
0.0GluXaa: 0.0 ± 0.0
Phe
3.023PheAla: 3.023 ± 0.057
0.556PheCys: 0.556 ± 0.022
2.431PheAsp: 2.431 ± 0.05
2.079PheGlu: 2.079 ± 0.041
1.737PhePhe: 1.737 ± 0.044
3.014PheGly: 3.014 ± 0.059
0.915PheHis: 0.915 ± 0.027
3.053PheIle: 3.053 ± 0.058
1.614PheLys: 1.614 ± 0.042
3.478PheLeu: 3.478 ± 0.059
1.037PheMet: 1.037 ± 0.031
2.032PheAsn: 2.032 ± 0.047
1.564PhePro: 1.564 ± 0.035
1.253PheGln: 1.253 ± 0.034
1.836PheArg: 1.836 ± 0.04
3.609PheSer: 3.609 ± 0.065
2.322PheThr: 2.322 ± 0.048
2.342PheVal: 2.342 ± 0.048
0.595PheTrp: 0.595 ± 0.023
1.384PheTyr: 1.384 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
5.045GlyAla: 5.045 ± 0.082
0.833GlyCys: 0.833 ± 0.028
3.356GlyAsp: 3.356 ± 0.063
4.206GlyGlu: 4.206 ± 0.056
3.036GlyPhe: 3.036 ± 0.054
4.862GlyGly: 4.862 ± 0.083
1.626GlyHis: 1.626 ± 0.042
5.417GlyIle: 5.417 ± 0.081
4.187GlyLys: 4.187 ± 0.074
6.773GlyLeu: 6.773 ± 0.088
2.027GlyMet: 2.027 ± 0.045
2.981GlyAsn: 2.981 ± 0.075
1.579GlyPro: 1.579 ± 0.036
2.889GlyGln: 2.889 ± 0.051
3.534GlyArg: 3.534 ± 0.065
4.01GlySer: 4.01 ± 0.062
3.524GlyThr: 3.524 ± 0.062
4.895GlyVal: 4.895 ± 0.07
1.096GlyTrp: 1.096 ± 0.03
2.741GlyTyr: 2.741 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
1.65HisAla: 1.65 ± 0.034
0.362HisCys: 0.362 ± 0.017
1.154HisAsp: 1.154 ± 0.029
1.254HisGlu: 1.254 ± 0.034
1.107HisPhe: 1.107 ± 0.034
1.611HisGly: 1.611 ± 0.038
0.871HisHis: 0.871 ± 0.032
1.618HisIle: 1.618 ± 0.034
0.991HisLys: 0.991 ± 0.029
2.401HisLeu: 2.401 ± 0.052
0.526HisMet: 0.526 ± 0.018
1.006HisAsn: 1.006 ± 0.03
1.227HisPro: 1.227 ± 0.03
1.309HisGln: 1.309 ± 0.035
1.213HisArg: 1.213 ± 0.033
1.533HisSer: 1.533 ± 0.036
1.234HisThr: 1.234 ± 0.03
1.243HisVal: 1.243 ± 0.033
0.375HisTrp: 0.375 ± 0.015
1.023HisTyr: 1.023 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
6.336IleAla: 6.336 ± 0.076
0.818IleCys: 0.818 ± 0.025
3.976IleAsp: 3.976 ± 0.06
4.27IleGlu: 4.27 ± 0.057
2.61IlePhe: 2.61 ± 0.064
4.993IleGly: 4.993 ± 0.077
1.518IleHis: 1.518 ± 0.033
4.533IleIle: 4.533 ± 0.085
3.453IleLys: 3.453 ± 0.072
6.253IleLeu: 6.253 ± 0.092
1.412IleMet: 1.412 ± 0.033
3.521IleAsn: 3.521 ± 0.06
3.277IlePro: 3.277 ± 0.053
2.501IleGln: 2.501 ± 0.042
3.504IleArg: 3.504 ± 0.052
4.987IleSer: 4.987 ± 0.071
4.36IleThr: 4.36 ± 0.065
3.976IleVal: 3.976 ± 0.059
0.866IleTrp: 0.866 ± 0.023
2.133IleTyr: 2.133 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
4.211LysAla: 4.211 ± 0.068
0.321LysCys: 0.321 ± 0.018
2.381LysAsp: 2.381 ± 0.055
3.284LysGlu: 3.284 ± 0.064
1.488LysPhe: 1.488 ± 0.039
3.206LysGly: 3.206 ± 0.059
1.057LysHis: 1.057 ± 0.031
3.459LysIle: 3.459 ± 0.063
3.293LysLys: 3.293 ± 0.074
5.167LysLeu: 5.167 ± 0.073
1.429LysMet: 1.429 ± 0.033
2.819LysAsn: 2.819 ± 0.056
2.256LysPro: 2.256 ± 0.046
2.66LysGln: 2.66 ± 0.047
2.576LysArg: 2.576 ± 0.047
3.045LysSer: 3.045 ± 0.059
3.027LysThr: 3.027 ± 0.053
3.168LysVal: 3.168 ± 0.066
0.587LysTrp: 0.587 ± 0.024
1.504LysTyr: 1.504 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
9.667LeuAla: 9.667 ± 0.136
1.162LeuCys: 1.162 ± 0.03
5.316LeuAsp: 5.316 ± 0.08
5.722LeuGlu: 5.722 ± 0.078
4.344LeuPhe: 4.344 ± 0.072
6.664LeuGly: 6.664 ± 0.087
2.251LeuHis: 2.251 ± 0.041
6.605LeuIle: 6.605 ± 0.085
5.183LeuLys: 5.183 ± 0.083
11.226LeuLeu: 11.226 ± 0.159
2.569LeuMet: 2.569 ± 0.044
4.891LeuAsn: 4.891 ± 0.058
5.629LeuPro: 5.629 ± 0.107
4.17LeuGln: 4.17 ± 0.071
5.337LeuArg: 5.337 ± 0.067
8.283LeuSer: 8.283 ± 0.099
6.227LeuThr: 6.227 ± 0.088
6.241LeuVal: 6.241 ± 0.082
1.172LeuTrp: 1.172 ± 0.033
2.836LeuTyr: 2.836 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
2.387MetAla: 2.387 ± 0.048
0.204MetCys: 0.204 ± 0.013
1.118MetAsp: 1.118 ± 0.029
1.336MetGlu: 1.336 ± 0.029
0.893MetPhe: 0.893 ± 0.028
1.68MetGly: 1.68 ± 0.042
0.414MetHis: 0.414 ± 0.018
1.522MetIle: 1.522 ± 0.041
1.482MetLys: 1.482 ± 0.037
2.842MetLeu: 2.842 ± 0.047
0.779MetMet: 0.779 ± 0.027
1.179MetAsn: 1.179 ± 0.028
1.195MetPro: 1.195 ± 0.031
1.109MetGln: 1.109 ± 0.031
1.196MetArg: 1.196 ± 0.03
1.772MetSer: 1.772 ± 0.039
1.545MetThr: 1.545 ± 0.03
1.673MetVal: 1.673 ± 0.04
0.203MetTrp: 0.203 ± 0.013
0.577MetTyr: 0.577 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.269AsnAla: 3.269 ± 0.065
0.424AsnCys: 0.424 ± 0.017
2.304AsnAsp: 2.304 ± 0.046
2.445AsnGlu: 2.445 ± 0.045
1.628AsnPhe: 1.628 ± 0.037
3.232AsnGly: 3.232 ± 0.065
1.062AsnHis: 1.062 ± 0.03
3.563AsnIle: 3.563 ± 0.062
2.532AsnLys: 2.532 ± 0.06
4.052AsnLeu: 4.052 ± 0.065
1.077AsnMet: 1.077 ± 0.033
2.345AsnAsn: 2.345 ± 0.053
2.223AsnPro: 2.223 ± 0.049
2.158AsnGln: 2.158 ± 0.053
2.325AsnArg: 2.325 ± 0.043
2.887AsnSer: 2.887 ± 0.051
2.561AsnThr: 2.561 ± 0.046
2.501AsnVal: 2.501 ± 0.049
0.644AsnTrp: 0.644 ± 0.024
1.624AsnTyr: 1.624 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
3.613ProAla: 3.613 ± 0.063
0.363ProCys: 0.363 ± 0.017
3.099ProAsp: 3.099 ± 0.077
3.706ProGlu: 3.706 ± 0.059
1.809ProPhe: 1.809 ± 0.038
2.353ProGly: 2.353 ± 0.047
1.029ProHis: 1.029 ± 0.03
2.637ProIle: 2.637 ± 0.05
1.852ProLys: 1.852 ± 0.044
4.654ProLeu: 4.654 ± 0.096
0.96ProMet: 0.96 ± 0.028
1.693ProAsn: 1.693 ± 0.036
1.507ProPro: 1.507 ± 0.043
1.875ProGln: 1.875 ± 0.045
1.512ProArg: 1.512 ± 0.034
2.412ProSer: 2.412 ± 0.05
2.149ProThr: 2.149 ± 0.05
3.515ProVal: 3.515 ± 0.066
0.575ProTrp: 0.575 ± 0.023
1.363ProTyr: 1.363 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
4.165GlnAla: 4.165 ± 0.08
0.453GlnCys: 0.453 ± 0.02
1.93GlnAsp: 1.93 ± 0.04
2.588GlnGlu: 2.588 ± 0.048
1.692GlnPhe: 1.692 ± 0.038
3.061GlnGly: 3.061 ± 0.056
1.305GlnHis: 1.305 ± 0.031
2.827GlnIle: 2.827 ± 0.049
2.338GlnLys: 2.338 ± 0.047
5.37GlnLeu: 5.37 ± 0.094
1.044GlnMet: 1.044 ± 0.029
1.801GlnAsn: 1.801 ± 0.036
2.134GlnPro: 2.134 ± 0.061
3.433GlnGln: 3.433 ± 0.091
2.645GlnArg: 2.645 ± 0.049
2.666GlnSer: 2.666 ± 0.047
2.258GlnThr: 2.258 ± 0.057
2.948GlnVal: 2.948 ± 0.064
0.727GlnTrp: 0.727 ± 0.025
1.424GlnTyr: 1.424 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
3.415ArgAla: 3.415 ± 0.05
0.529ArgCys: 0.529 ± 0.02
2.5ArgAsp: 2.5 ± 0.05
3.347ArgGlu: 3.347 ± 0.056
2.324ArgPhe: 2.324 ± 0.046
2.898ArgGly: 2.898 ± 0.051
1.523ArgHis: 1.523 ± 0.039
3.593ArgIle: 3.593 ± 0.054
2.525ArgLys: 2.525 ± 0.047
5.821ArgLeu: 5.821 ± 0.079
1.315ArgMet: 1.315 ± 0.028
2.273ArgAsn: 2.273 ± 0.044
1.972ArgPro: 1.972 ± 0.046
2.943ArgGln: 2.943 ± 0.057
2.779ArgArg: 2.779 ± 0.052
2.73ArgSer: 2.73 ± 0.045
2.409ArgThr: 2.409 ± 0.036
3.079ArgVal: 3.079 ± 0.05
0.796ArgTrp: 0.796 ± 0.026
2.094ArgTyr: 2.094 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
5.147SerAla: 5.147 ± 0.055
0.651SerCys: 0.651 ± 0.028
3.538SerAsp: 3.538 ± 0.061
3.88SerGlu: 3.88 ± 0.051
2.568SerPhe: 2.568 ± 0.048
5.319SerGly: 5.319 ± 0.08
1.68SerHis: 1.68 ± 0.042
4.134SerIle: 4.134 ± 0.065
2.686SerLys: 2.686 ± 0.054
7.267SerLeu: 7.267 ± 0.089
1.482SerMet: 1.482 ± 0.035
2.469SerAsn: 2.469 ± 0.054
2.808SerPro: 2.808 ± 0.046
3.023SerGln: 3.023 ± 0.057
3.236SerArg: 3.236 ± 0.05
4.233SerSer: 4.233 ± 0.069
3.174SerThr: 3.174 ± 0.049
4.478SerVal: 4.478 ± 0.07
0.924SerTrp: 0.924 ± 0.029
2.043SerTyr: 2.043 ± 0.037
0.0SerXaa: 0.0 ± 0.0
Thr
4.491ThrAla: 4.491 ± 0.063
0.469ThrCys: 0.469 ± 0.02
2.867ThrAsp: 2.867 ± 0.046
3.416ThrGlu: 3.416 ± 0.051
2.02ThrPhe: 2.02 ± 0.043
4.274ThrGly: 4.274 ± 0.061
1.238ThrHis: 1.238 ± 0.03
3.477ThrIle: 3.477 ± 0.056
2.093ThrLys: 2.093 ± 0.043
6.743ThrLeu: 6.743 ± 0.087
1.024ThrMet: 1.024 ± 0.028
1.904ThrAsn: 1.904 ± 0.045
2.985ThrPro: 2.985 ± 0.056
2.39ThrGln: 2.39 ± 0.058
2.496ThrArg: 2.496 ± 0.046
3.232ThrSer: 3.232 ± 0.05
2.906ThrThr: 2.906 ± 0.057
3.7ThrVal: 3.7 ± 0.057
0.614ThrTrp: 0.614 ± 0.023
1.518ThrTyr: 1.518 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
5.384ValAla: 5.384 ± 0.064
0.697ValCys: 0.697 ± 0.022
3.288ValAsp: 3.288 ± 0.052
3.695ValGlu: 3.695 ± 0.059
2.574ValPhe: 2.574 ± 0.052
4.182ValGly: 4.182 ± 0.065
1.192ValHis: 1.192 ± 0.03
4.862ValIle: 4.862 ± 0.069
3.152ValLys: 3.152 ± 0.053
6.287ValLeu: 6.287 ± 0.086
1.916ValMet: 1.916 ± 0.043
2.834ValAsn: 2.834 ± 0.052
2.669ValPro: 2.669 ± 0.057
2.23ValGln: 2.23 ± 0.048
3.043ValArg: 3.043 ± 0.054
4.459ValSer: 4.459 ± 0.058
3.938ValThr: 3.938 ± 0.056
4.337ValVal: 4.337 ± 0.07
0.804ValTrp: 0.804 ± 0.028
1.762ValTyr: 1.762 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
0.831TrpAla: 0.831 ± 0.024
0.157TrpCys: 0.157 ± 0.01
0.618TrpAsp: 0.618 ± 0.025
0.667TrpGlu: 0.667 ± 0.026
0.612TrpPhe: 0.612 ± 0.024
0.819TrpGly: 0.819 ± 0.028
0.424TrpHis: 0.424 ± 0.02
0.736TrpIle: 0.736 ± 0.026
0.6TrpLys: 0.6 ± 0.019
1.968TrpLeu: 1.968 ± 0.045
0.357TrpMet: 0.357 ± 0.018
0.531TrpAsn: 0.531 ± 0.02
0.563TrpPro: 0.563 ± 0.022
1.078TrpGln: 1.078 ± 0.03
0.845TrpArg: 0.845 ± 0.027
0.846TrpSer: 0.846 ± 0.027
0.441TrpThr: 0.441 ± 0.019
0.818TrpVal: 0.818 ± 0.028
0.192TrpTrp: 0.192 ± 0.012
0.376TrpTyr: 0.376 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.306TyrAla: 2.306 ± 0.046
0.408TyrCys: 0.408 ± 0.019
1.653TyrAsp: 1.653 ± 0.046
1.518TyrGlu: 1.518 ± 0.035
1.434TyrPhe: 1.434 ± 0.037
2.293TyrGly: 2.293 ± 0.043
0.94TyrHis: 0.94 ± 0.025
2.046TyrIle: 2.046 ± 0.046
1.281TyrLys: 1.281 ± 0.032
3.649TyrLeu: 3.649 ± 0.071
0.724TyrMet: 0.724 ± 0.024
1.263TyrAsn: 1.263 ± 0.032
1.598TyrPro: 1.598 ± 0.041
1.96TyrGln: 1.96 ± 0.046
2.037TyrArg: 2.037 ± 0.041
2.144TyrSer: 2.144 ± 0.046
1.63TyrThr: 1.63 ± 0.037
1.719TyrVal: 1.719 ± 0.04
0.532TyrTrp: 0.532 ± 0.022
1.06TyrTyr: 1.06 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3997 proteins (1305138 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski