Amino acid dipepetide frequency for Rhizobium phage vB_RglS_P106B

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.165AlaAla: 11.165 ± 0.933
1.209AlaCys: 1.209 ± 0.226
4.835AlaAsp: 4.835 ± 0.502
4.835AlaGlu: 4.835 ± 0.56
5.007AlaPhe: 5.007 ± 0.421
7.424AlaGly: 7.424 ± 0.819
1.266AlaHis: 1.266 ± 0.238
7.309AlaIle: 7.309 ± 0.724
5.295AlaLys: 5.295 ± 0.573
7.309AlaLeu: 7.309 ± 0.643
2.417AlaMet: 2.417 ± 0.411
4.662AlaAsn: 4.662 ± 0.535
4.259AlaPro: 4.259 ± 0.7
3.741AlaGln: 3.741 ± 0.436
4.719AlaArg: 4.719 ± 0.531
5.64AlaSer: 5.64 ± 0.72
6.504AlaThr: 6.504 ± 0.536
5.583AlaVal: 5.583 ± 0.611
1.784AlaTrp: 1.784 ± 0.325
3.453AlaTyr: 3.453 ± 0.374
0.0AlaXaa: 0.0 ± 0.0
Cys
0.748CysAla: 0.748 ± 0.222
0.403CysCys: 0.403 ± 0.17
0.288CysAsp: 0.288 ± 0.116
1.036CysGlu: 1.036 ± 0.32
0.345CysPhe: 0.345 ± 0.131
1.094CysGly: 1.094 ± 0.227
0.115CysHis: 0.115 ± 0.126
0.576CysIle: 0.576 ± 0.16
0.633CysLys: 0.633 ± 0.164
0.403CysLeu: 0.403 ± 0.155
0.058CysMet: 0.058 ± 0.057
0.46CysAsn: 0.46 ± 0.245
0.23CysPro: 0.23 ± 0.123
0.518CysGln: 0.518 ± 0.169
0.576CysArg: 0.576 ± 0.192
0.46CysSer: 0.46 ± 0.157
0.748CysThr: 0.748 ± 0.223
0.863CysVal: 0.863 ± 0.266
0.115CysTrp: 0.115 ± 0.073
0.403CysTyr: 0.403 ± 0.144
0.0CysXaa: 0.0 ± 0.0
Asp
6.101AspAla: 6.101 ± 0.556
0.518AspCys: 0.518 ± 0.18
3.626AspAsp: 3.626 ± 0.446
4.086AspGlu: 4.086 ± 0.511
1.727AspPhe: 1.727 ± 0.339
5.698AspGly: 5.698 ± 0.646
0.921AspHis: 0.921 ± 0.212
3.338AspIle: 3.338 ± 0.377
2.475AspLys: 2.475 ± 0.361
4.201AspLeu: 4.201 ± 0.509
1.957AspMet: 1.957 ± 0.321
2.763AspAsn: 2.763 ± 0.381
3.05AspPro: 3.05 ± 0.407
2.187AspGln: 2.187 ± 0.317
3.165AspArg: 3.165 ± 0.463
1.842AspSer: 1.842 ± 0.348
2.763AspThr: 2.763 ± 0.363
3.971AspVal: 3.971 ± 0.52
1.324AspTrp: 1.324 ± 0.268
2.245AspTyr: 2.245 ± 0.402
0.0AspXaa: 0.0 ± 0.0
Glu
6.676GluAla: 6.676 ± 0.795
0.748GluCys: 0.748 ± 0.203
2.36GluAsp: 2.36 ± 0.391
3.223GluGlu: 3.223 ± 0.469
2.59GluPhe: 2.59 ± 0.484
2.36GluGly: 2.36 ± 0.355
1.151GluHis: 1.151 ± 0.285
4.432GluIle: 4.432 ± 0.536
3.626GluLys: 3.626 ± 0.529
5.583GluLeu: 5.583 ± 0.637
2.532GluMet: 2.532 ± 0.446
2.36GluAsn: 2.36 ± 0.348
2.532GluPro: 2.532 ± 0.43
2.417GluGln: 2.417 ± 0.389
4.892GluArg: 4.892 ± 0.577
2.245GluSer: 2.245 ± 0.305
3.683GluThr: 3.683 ± 0.537
2.245GluVal: 2.245 ± 0.425
1.612GluTrp: 1.612 ± 0.32
2.014GluTyr: 2.014 ± 0.352
0.0GluXaa: 0.0 ± 0.0
Phe
3.799PheAla: 3.799 ± 0.445
0.518PheCys: 0.518 ± 0.198
3.108PheAsp: 3.108 ± 0.458
2.072PheGlu: 2.072 ± 0.345
1.266PhePhe: 1.266 ± 0.245
3.223PheGly: 3.223 ± 0.403
0.46PheHis: 0.46 ± 0.12
2.532PheIle: 2.532 ± 0.378
2.59PheLys: 2.59 ± 0.357
2.072PheLeu: 2.072 ± 0.341
0.863PheMet: 0.863 ± 0.205
2.014PheAsn: 2.014 ± 0.301
1.842PhePro: 1.842 ± 0.408
1.381PheGln: 1.381 ± 0.281
2.245PheArg: 2.245 ± 0.365
1.899PheSer: 1.899 ± 0.335
2.36PheThr: 2.36 ± 0.344
2.705PheVal: 2.705 ± 0.407
0.403PheTrp: 0.403 ± 0.164
1.209PheTyr: 1.209 ± 0.244
0.0PheXaa: 0.0 ± 0.0
Gly
8.173GlyAla: 8.173 ± 0.739
0.518GlyCys: 0.518 ± 0.136
4.432GlyAsp: 4.432 ± 0.581
4.086GlyGlu: 4.086 ± 0.469
3.165GlyPhe: 3.165 ± 0.481
6.561GlyGly: 6.561 ± 1.253
0.806GlyHis: 0.806 ± 0.182
3.396GlyIle: 3.396 ± 0.439
4.489GlyLys: 4.489 ± 0.596
5.122GlyLeu: 5.122 ± 0.52
2.014GlyMet: 2.014 ± 0.301
3.914GlyAsn: 3.914 ± 0.505
2.36GlyPro: 2.36 ± 0.374
2.36GlyGln: 2.36 ± 0.418
4.201GlyArg: 4.201 ± 0.431
4.604GlySer: 4.604 ± 0.546
5.928GlyThr: 5.928 ± 0.949
5.871GlyVal: 5.871 ± 0.449
1.381GlyTrp: 1.381 ± 0.284
3.683GlyTyr: 3.683 ± 0.478
0.0GlyXaa: 0.0 ± 0.0
His
1.266HisAla: 1.266 ± 0.235
0.403HisCys: 0.403 ± 0.144
0.863HisAsp: 0.863 ± 0.189
0.691HisGlu: 0.691 ± 0.216
0.806HisPhe: 0.806 ± 0.226
1.266HisGly: 1.266 ± 0.251
0.288HisHis: 0.288 ± 0.137
0.748HisIle: 0.748 ± 0.18
0.691HisLys: 0.691 ± 0.175
1.381HisLeu: 1.381 ± 0.301
0.633HisMet: 0.633 ± 0.186
1.209HisAsn: 1.209 ± 0.299
0.748HisPro: 0.748 ± 0.21
0.633HisGln: 0.633 ± 0.187
1.151HisArg: 1.151 ± 0.299
0.806HisSer: 0.806 ± 0.276
0.806HisThr: 0.806 ± 0.24
1.957HisVal: 1.957 ± 0.391
0.46HisTrp: 0.46 ± 0.154
0.518HisTyr: 0.518 ± 0.181
0.0HisXaa: 0.0 ± 0.0
Ile
4.95IleAla: 4.95 ± 0.55
0.691IleCys: 0.691 ± 0.2
5.122IleAsp: 5.122 ± 0.486
4.95IleGlu: 4.95 ± 0.52
1.727IlePhe: 1.727 ± 0.31
4.547IleGly: 4.547 ± 0.506
0.978IleHis: 0.978 ± 0.294
3.914IleIle: 3.914 ± 0.472
3.511IleLys: 3.511 ± 0.388
4.259IleLeu: 4.259 ± 0.51
1.496IleMet: 1.496 ± 0.271
3.396IleAsn: 3.396 ± 0.381
3.05IlePro: 3.05 ± 0.427
2.187IleGln: 2.187 ± 0.446
3.396IleArg: 3.396 ± 0.386
3.626IleSer: 3.626 ± 0.453
4.201IleThr: 4.201 ± 0.668
5.007IleVal: 5.007 ± 0.62
1.151IleTrp: 1.151 ± 0.268
1.554IleTyr: 1.554 ± 0.234
0.0IleXaa: 0.0 ± 0.0
Lys
5.18LysAla: 5.18 ± 0.523
0.403LysCys: 0.403 ± 0.174
2.647LysAsp: 2.647 ± 0.559
1.554LysGlu: 1.554 ± 0.298
2.072LysPhe: 2.072 ± 0.487
4.317LysGly: 4.317 ± 0.559
1.324LysHis: 1.324 ± 0.269
3.338LysIle: 3.338 ± 0.379
2.36LysLys: 2.36 ± 0.519
4.547LysLeu: 4.547 ± 0.511
1.439LysMet: 1.439 ± 0.275
2.302LysAsn: 2.302 ± 0.31
2.705LysPro: 2.705 ± 0.428
2.302LysGln: 2.302 ± 0.423
3.914LysArg: 3.914 ± 0.474
2.878LysSer: 2.878 ± 0.427
3.568LysThr: 3.568 ± 0.589
2.993LysVal: 2.993 ± 0.488
0.863LysTrp: 0.863 ± 0.237
1.727LysTyr: 1.727 ± 0.32
0.0LysXaa: 0.0 ± 0.0
Leu
6.734LeuAla: 6.734 ± 0.562
0.576LeuCys: 0.576 ± 0.164
4.317LeuAsp: 4.317 ± 0.544
5.122LeuGlu: 5.122 ± 0.704
2.532LeuPhe: 2.532 ± 0.38
4.201LeuGly: 4.201 ± 0.475
1.324LeuHis: 1.324 ± 0.229
4.892LeuIle: 4.892 ± 0.44
4.259LeuLys: 4.259 ± 0.36
5.007LeuLeu: 5.007 ± 0.471
1.554LeuMet: 1.554 ± 0.322
4.662LeuAsn: 4.662 ± 0.476
3.453LeuPro: 3.453 ± 0.444
2.302LeuGln: 2.302 ± 0.421
4.144LeuArg: 4.144 ± 0.547
4.604LeuSer: 4.604 ± 0.583
6.043LeuThr: 6.043 ± 0.525
3.568LeuVal: 3.568 ± 0.388
1.094LeuTrp: 1.094 ± 0.283
1.957LeuTyr: 1.957 ± 0.348
0.0LeuXaa: 0.0 ± 0.0
Met
2.129MetAla: 2.129 ± 0.304
0.115MetCys: 0.115 ± 0.081
1.094MetAsp: 1.094 ± 0.252
1.036MetGlu: 1.036 ± 0.214
1.094MetPhe: 1.094 ± 0.223
1.151MetGly: 1.151 ± 0.271
0.403MetHis: 0.403 ± 0.144
1.612MetIle: 1.612 ± 0.303
2.417MetLys: 2.417 ± 0.354
2.36MetLeu: 2.36 ± 0.358
0.576MetMet: 0.576 ± 0.169
1.554MetAsn: 1.554 ± 0.339
1.266MetPro: 1.266 ± 0.281
1.899MetGln: 1.899 ± 0.364
2.59MetArg: 2.59 ± 0.398
0.921MetSer: 0.921 ± 0.212
2.072MetThr: 2.072 ± 0.33
1.266MetVal: 1.266 ± 0.229
0.115MetTrp: 0.115 ± 0.075
0.576MetTyr: 0.576 ± 0.166
0.0MetXaa: 0.0 ± 0.0
Asn
4.892AsnAla: 4.892 ± 0.537
0.576AsnCys: 0.576 ± 0.175
2.532AsnAsp: 2.532 ± 0.391
2.82AsnGlu: 2.82 ± 0.445
1.266AsnPhe: 1.266 ± 0.264
6.446AsnGly: 6.446 ± 0.671
1.036AsnHis: 1.036 ± 0.264
2.705AsnIle: 2.705 ± 0.371
2.302AsnLys: 2.302 ± 0.344
3.511AsnLeu: 3.511 ± 0.414
0.921AsnMet: 0.921 ± 0.224
2.993AsnAsn: 2.993 ± 0.461
2.705AsnPro: 2.705 ± 0.39
1.324AsnGln: 1.324 ± 0.249
2.302AsnArg: 2.302 ± 0.468
3.05AsnSer: 3.05 ± 0.374
2.878AsnThr: 2.878 ± 0.415
2.993AsnVal: 2.993 ± 0.503
0.921AsnTrp: 0.921 ± 0.238
1.842AsnTyr: 1.842 ± 0.337
0.0AsnXaa: 0.0 ± 0.0
Pro
4.777ProAla: 4.777 ± 0.555
0.115ProCys: 0.115 ± 0.083
3.05ProAsp: 3.05 ± 0.467
3.396ProGlu: 3.396 ± 0.422
1.727ProPhe: 1.727 ± 0.335
4.259ProGly: 4.259 ± 0.49
0.921ProHis: 0.921 ± 0.249
1.899ProIle: 1.899 ± 0.345
1.669ProLys: 1.669 ± 0.374
2.705ProLeu: 2.705 ± 0.32
1.094ProMet: 1.094 ± 0.247
2.302ProAsn: 2.302 ± 0.344
1.727ProPro: 1.727 ± 0.356
2.014ProGln: 2.014 ± 0.494
2.417ProArg: 2.417 ± 0.347
2.705ProSer: 2.705 ± 0.33
3.165ProThr: 3.165 ± 0.357
4.259ProVal: 4.259 ± 0.63
0.863ProTrp: 0.863 ± 0.203
1.324ProTyr: 1.324 ± 0.37
0.0ProXaa: 0.0 ± 0.0
Gln
3.396GlnAla: 3.396 ± 0.471
0.46GlnCys: 0.46 ± 0.207
1.957GlnAsp: 1.957 ± 0.304
2.302GlnGlu: 2.302 ± 0.398
1.727GlnPhe: 1.727 ± 0.299
2.129GlnGly: 2.129 ± 0.332
0.518GlnHis: 0.518 ± 0.146
3.05GlnIle: 3.05 ± 0.423
1.784GlnLys: 1.784 ± 0.306
3.108GlnLeu: 3.108 ± 0.379
1.094GlnMet: 1.094 ± 0.273
1.381GlnAsn: 1.381 ± 0.285
2.647GlnPro: 2.647 ± 0.822
3.741GlnGln: 3.741 ± 0.977
2.072GlnArg: 2.072 ± 0.373
2.878GlnSer: 2.878 ± 0.531
2.129GlnThr: 2.129 ± 0.364
2.245GlnVal: 2.245 ± 0.325
0.691GlnTrp: 0.691 ± 0.195
0.921GlnTyr: 0.921 ± 0.239
0.0GlnXaa: 0.0 ± 0.0
Arg
5.007ArgAla: 5.007 ± 0.495
0.806ArgCys: 0.806 ± 0.179
4.144ArgAsp: 4.144 ± 0.455
3.568ArgGlu: 3.568 ± 0.502
1.957ArgPhe: 1.957 ± 0.351
3.799ArgGly: 3.799 ± 0.398
1.496ArgHis: 1.496 ± 0.294
4.604ArgIle: 4.604 ± 0.453
3.338ArgLys: 3.338 ± 0.47
4.201ArgLeu: 4.201 ± 0.468
1.899ArgMet: 1.899 ± 0.383
2.82ArgAsn: 2.82 ± 0.374
1.612ArgPro: 1.612 ± 0.341
2.647ArgGln: 2.647 ± 0.387
2.935ArgArg: 2.935 ± 0.426
2.014ArgSer: 2.014 ± 0.369
3.05ArgThr: 3.05 ± 0.42
3.799ArgVal: 3.799 ± 0.503
0.806ArgTrp: 0.806 ± 0.222
1.899ArgTyr: 1.899 ± 0.325
0.0ArgXaa: 0.0 ± 0.0
Ser
6.158SerAla: 6.158 ± 0.755
0.403SerCys: 0.403 ± 0.158
3.338SerAsp: 3.338 ± 0.452
3.396SerGlu: 3.396 ± 0.425
2.302SerPhe: 2.302 ± 0.413
4.432SerGly: 4.432 ± 0.527
0.978SerHis: 0.978 ± 0.297
3.453SerIle: 3.453 ± 0.465
2.302SerLys: 2.302 ± 0.367
3.856SerLeu: 3.856 ± 0.445
1.209SerMet: 1.209 ± 0.259
3.223SerAsn: 3.223 ± 0.405
2.302SerPro: 2.302 ± 0.379
1.899SerGln: 1.899 ± 0.262
2.82SerArg: 2.82 ± 0.328
3.568SerSer: 3.568 ± 0.492
3.281SerThr: 3.281 ± 0.366
3.856SerVal: 3.856 ± 0.552
0.691SerTrp: 0.691 ± 0.228
1.324SerTyr: 1.324 ± 0.236
0.0SerXaa: 0.0 ± 0.0
Thr
7.079ThrAla: 7.079 ± 0.678
0.46ThrCys: 0.46 ± 0.186
4.086ThrAsp: 4.086 ± 0.445
3.683ThrGlu: 3.683 ± 0.359
2.36ThrPhe: 2.36 ± 0.414
5.468ThrGly: 5.468 ± 0.549
1.151ThrHis: 1.151 ± 0.235
4.547ThrIle: 4.547 ± 0.457
2.82ThrLys: 2.82 ± 0.458
5.237ThrLeu: 5.237 ± 0.629
1.784ThrMet: 1.784 ± 0.343
2.878ThrAsn: 2.878 ± 0.424
3.741ThrPro: 3.741 ± 0.369
1.842ThrGln: 1.842 ± 0.35
2.705ThrArg: 2.705 ± 0.393
2.705ThrSer: 2.705 ± 0.532
3.799ThrThr: 3.799 ± 0.503
4.892ThrVal: 4.892 ± 0.528
1.439ThrTrp: 1.439 ± 0.349
2.072ThrTyr: 2.072 ± 0.354
0.0ThrXaa: 0.0 ± 0.0
Val
6.216ValAla: 6.216 ± 0.528
0.691ValCys: 0.691 ± 0.187
3.683ValAsp: 3.683 ± 0.373
4.604ValGlu: 4.604 ± 0.606
2.245ValPhe: 2.245 ± 0.363
4.662ValGly: 4.662 ± 0.474
1.036ValHis: 1.036 ± 0.191
4.029ValIle: 4.029 ± 0.44
3.453ValLys: 3.453 ± 0.444
3.396ValLeu: 3.396 ± 0.422
1.612ValMet: 1.612 ± 0.257
2.647ValAsn: 2.647 ± 0.379
3.165ValPro: 3.165 ± 0.416
2.993ValGln: 2.993 ± 0.373
3.741ValArg: 3.741 ± 0.429
4.95ValSer: 4.95 ± 0.609
4.374ValThr: 4.374 ± 0.577
3.165ValVal: 3.165 ± 0.399
1.036ValTrp: 1.036 ± 0.225
2.302ValTyr: 2.302 ± 0.348
0.0ValXaa: 0.0 ± 0.0
Trp
1.266TrpAla: 1.266 ± 0.278
0.115TrpCys: 0.115 ± 0.083
0.748TrpAsp: 0.748 ± 0.178
1.036TrpGlu: 1.036 ± 0.255
0.978TrpPhe: 0.978 ± 0.243
1.554TrpGly: 1.554 ± 0.268
0.518TrpHis: 0.518 ± 0.15
1.381TrpIle: 1.381 ± 0.295
1.324TrpLys: 1.324 ± 0.212
1.496TrpLeu: 1.496 ± 0.313
0.518TrpMet: 0.518 ± 0.18
0.748TrpAsn: 0.748 ± 0.162
0.576TrpPro: 0.576 ± 0.182
0.691TrpGln: 0.691 ± 0.184
0.633TrpArg: 0.633 ± 0.254
1.094TrpSer: 1.094 ± 0.252
1.554TrpThr: 1.554 ± 0.296
0.806TrpVal: 0.806 ± 0.195
0.403TrpTrp: 0.403 ± 0.148
0.403TrpTyr: 0.403 ± 0.138
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.705TyrAla: 2.705 ± 0.392
0.345TyrCys: 0.345 ± 0.123
1.727TyrAsp: 1.727 ± 0.333
1.784TyrGlu: 1.784 ± 0.299
1.669TyrPhe: 1.669 ± 0.332
2.532TyrGly: 2.532 ± 0.461
0.633TyrHis: 0.633 ± 0.186
1.957TyrIle: 1.957 ± 0.318
1.094TyrLys: 1.094 ± 0.252
2.59TyrLeu: 2.59 ± 0.37
0.518TyrMet: 0.518 ± 0.137
1.727TyrAsn: 1.727 ± 0.321
2.417TyrPro: 2.417 ± 0.411
1.151TyrGln: 1.151 ± 0.307
1.784TyrArg: 1.784 ± 0.275
2.302TyrSer: 2.302 ± 0.396
1.842TyrThr: 1.842 ± 0.3
1.957TyrVal: 1.957 ± 0.363
0.691TyrTrp: 0.691 ± 0.196
0.748TyrTyr: 0.748 ± 0.211
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 95 proteins (17376 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski