Amino acid dipepetide frequency for Sphingobacteriales bacterium UPWRP_1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.294AlaAla: 8.294 ± 0.074	1.087AlaCys: 1.087 ± 0.025	4.393AlaAsp: 4.393 ± 0.044	4.202AlaGlu: 4.202 ± 0.048	3.694AlaPhe: 3.694 ± 0.036	7.22AlaGly: 7.22 ± 0.087	1.393AlaHis: 1.393 ± 0.024	5.129AlaIle: 5.129 ± 0.051	3.677AlaLys: 3.677 ± 0.048	8.006AlaLeu: 8.006 ± 0.071	1.713AlaMet: 1.713 ± 0.025	4.799AlaAsn: 4.799 ± 0.055	3.529AlaPro: 3.529 ± 0.045	4.181AlaGln: 4.181 ± 0.043	2.757AlaArg: 2.757 ± 0.037	4.566AlaSer: 4.566 ± 0.068	6.232AlaThr: 6.232 ± 0.095	5.569AlaVal: 5.569 ± 0.058	0.866AlaTrp: 0.866 ± 0.019	3.045AlaTyr: 3.045 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.046CysAla: 1.046 ± 0.027	0.253CysCys: 0.253 ± 0.011	0.579CysAsp: 0.579 ± 0.028	0.503CysGlu: 0.503 ± 0.018	0.633CysPhe: 0.633 ± 0.015	1.036CysGly: 1.036 ± 0.029	0.281CysHis: 0.281 ± 0.013	0.775CysIle: 0.775 ± 0.015	0.489CysLys: 0.489 ± 0.014	1.231CysLeu: 1.231 ± 0.023	0.227CysMet: 0.227 ± 0.009	0.956CysAsn: 0.956 ± 0.028	0.743CysPro: 0.743 ± 0.023	0.466CysGln: 0.466 ± 0.019	0.512CysArg: 0.512 ± 0.014	1.051CysSer: 1.051 ± 0.03	1.137CysThr: 1.137 ± 0.037	0.679CysVal: 0.679 ± 0.017	0.129CysTrp: 0.129 ± 0.008	0.441CysTyr: 0.441 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.296AspAla: 4.296 ± 0.045	0.644AspCys: 0.644 ± 0.021	2.251AspAsp: 2.251 ± 0.036	2.733AspGlu: 2.733 ± 0.038	2.778AspPhe: 2.778 ± 0.033	3.454AspGly: 3.454 ± 0.047	0.636AspHis: 0.636 ± 0.016	3.238AspIle: 3.238 ± 0.035	2.469AspLys: 2.469 ± 0.04	4.172AspLeu: 4.172 ± 0.044	1.079AspMet: 1.079 ± 0.019	2.83AspAsn: 2.83 ± 0.039	1.894AspPro: 1.894 ± 0.032	1.143AspGln: 1.143 ± 0.021	1.609AspArg: 1.609 ± 0.03	2.361AspSer: 2.361 ± 0.033	3.031AspThr: 3.031 ± 0.045	3.207AspVal: 3.207 ± 0.03	0.699AspTrp: 0.699 ± 0.016	2.152AspTyr: 2.152 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	3.845GluAla: 3.845 ± 0.053	0.381GluCys: 0.381 ± 0.012	2.062GluAsp: 2.062 ± 0.032	3.194GluGlu: 3.194 ± 0.05	2.074GluPhe: 2.074 ± 0.027	2.988GluGly: 2.988 ± 0.036	0.899GluHis: 0.899 ± 0.022	3.456GluIle: 3.456 ± 0.044	3.4GluLys: 3.4 ± 0.053	4.877GluLeu: 4.877 ± 0.052	1.293GluMet: 1.293 ± 0.025	2.996GluAsn: 2.996 ± 0.037	1.898GluPro: 1.898 ± 0.032	2.822GluGln: 2.822 ± 0.041	2.059GluArg: 2.059 ± 0.035	2.003GluSer: 2.003 ± 0.026	3.518GluThr: 3.518 ± 0.042	3.457GluVal: 3.457 ± 0.038	0.696GluTrp: 0.696 ± 0.016	1.809GluTyr: 1.809 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.991PheAla: 3.991 ± 0.041	0.765PheCys: 0.765 ± 0.016	2.565PheAsp: 2.565 ± 0.033	2.614PheGlu: 2.614 ± 0.03	2.462PhePhe: 2.462 ± 0.038	3.325PheGly: 3.325 ± 0.038	0.636PheHis: 0.636 ± 0.016	2.986PheIle: 2.986 ± 0.035	2.191PheLys: 2.191 ± 0.037	4.076PheLeu: 4.076 ± 0.046	1.053PheMet: 1.053 ± 0.02	2.994PheAsn: 2.994 ± 0.035	1.646PhePro: 1.646 ± 0.025	1.147PheGln: 1.147 ± 0.02	1.52PheArg: 1.52 ± 0.025	3.444PheSer: 3.444 ± 0.038	4.396PheThr: 4.396 ± 0.048	2.883PheVal: 2.883 ± 0.037	0.613PheTrp: 0.613 ± 0.014	2.085PheTyr: 2.085 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	5.466GlyAla: 5.466 ± 0.069	1.331GlyCys: 1.331 ± 0.04	2.691GlyAsp: 2.691 ± 0.036	2.839GlyGlu: 2.839 ± 0.038	3.574GlyPhe: 3.574 ± 0.044	6.004GlyGly: 6.004 ± 0.096	1.047GlyHis: 1.047 ± 0.021	5.277GlyIle: 5.277 ± 0.046	4.225GlyLys: 4.225 ± 0.052	5.784GlyLeu: 5.784 ± 0.047	1.583GlyMet: 1.583 ± 0.026	5.297GlyAsn: 5.297 ± 0.059	1.621GlyPro: 1.621 ± 0.035	2.909GlyGln: 2.909 ± 0.034	2.164GlyArg: 2.164 ± 0.03	5.104GlySer: 5.104 ± 0.085	5.706GlyThr: 5.706 ± 0.11	4.449GlyVal: 4.449 ± 0.048	0.914GlyTrp: 0.914 ± 0.018	3.038GlyTyr: 3.038 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	1.257HisAla: 1.257 ± 0.024	0.238HisCys: 0.238 ± 0.01	0.67HisAsp: 0.67 ± 0.016	0.834HisGlu: 0.834 ± 0.017	1.117HisPhe: 1.117 ± 0.022	0.987HisGly: 0.987 ± 0.023	0.551HisHis: 0.551 ± 0.02	1.397HisIle: 1.397 ± 0.027	0.903HisLys: 0.903 ± 0.022	2.128HisLeu: 2.128 ± 0.036	0.289HisMet: 0.289 ± 0.009	1.079HisAsn: 1.079 ± 0.02	1.115HisPro: 1.115 ± 0.023	0.734HisGln: 0.734 ± 0.018	0.927HisArg: 0.927 ± 0.018	0.91HisSer: 0.91 ± 0.021	1.277HisThr: 1.277 ± 0.02	0.91HisVal: 0.91 ± 0.019	0.251HisTrp: 0.251 ± 0.008	0.891HisTyr: 0.891 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.046IleAla: 6.046 ± 0.049	0.945IleCys: 0.945 ± 0.023	3.775IleAsp: 3.775 ± 0.042	3.606IleGlu: 3.606 ± 0.048	2.511IlePhe: 2.511 ± 0.031	4.193IleGly: 4.193 ± 0.045	1.093IleHis: 1.093 ± 0.019	3.69IleIle: 3.69 ± 0.045	3.055IleLys: 3.055 ± 0.046	5.023IleLeu: 5.023 ± 0.053	1.128IleMet: 1.128 ± 0.024	3.621IleAsn: 3.621 ± 0.035	2.95IlePro: 2.95 ± 0.036	2.242IleGln: 2.242 ± 0.028	2.011IleArg: 2.011 ± 0.027	4.102IleSer: 4.102 ± 0.045	5.372IleThr: 5.372 ± 0.064	3.699IleVal: 3.699 ± 0.037	0.728IleTrp: 0.728 ± 0.016	2.405IleTyr: 2.405 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.733LysAla: 3.733 ± 0.05	0.32LysCys: 0.32 ± 0.011	2.421LysAsp: 2.421 ± 0.037	3.14LysGlu: 3.14 ± 0.046	1.755LysPhe: 1.755 ± 0.028	2.998LysGly: 2.998 ± 0.039	0.961LysHis: 0.961 ± 0.018	3.349LysIle: 3.349 ± 0.048	3.406LysLys: 3.406 ± 0.049	4.665LysLeu: 4.665 ± 0.057	1.381LysMet: 1.381 ± 0.023	3.035LysAsn: 3.035 ± 0.042	2.374LysPro: 2.374 ± 0.04	2.629LysGln: 2.629 ± 0.041	2.09LysArg: 2.09 ± 0.036	2.493LysSer: 2.493 ± 0.04	3.675LysThr: 3.675 ± 0.045	3.035LysVal: 3.035 ± 0.037	0.611LysTrp: 0.611 ± 0.017	1.962LysTyr: 1.962 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	7.218LeuAla: 7.218 ± 0.058	1.209LeuCys: 1.209 ± 0.024	3.695LeuAsp: 3.695 ± 0.039	4.289LeuGlu: 4.289 ± 0.048	4.884LeuPhe: 4.884 ± 0.049	5.465LeuGly: 5.465 ± 0.049	2.181LeuHis: 2.181 ± 0.032	5.014LeuIle: 5.014 ± 0.053	4.999LeuLys: 4.999 ± 0.058	11.579LeuLeu: 11.579 ± 0.099	1.879LeuMet: 1.879 ± 0.028	5.491LeuAsn: 5.491 ± 0.044	6.098LeuPro: 6.098 ± 0.059	5.8LeuGln: 5.8 ± 0.062	3.68LeuArg: 3.68 ± 0.039	6.108LeuSer: 6.108 ± 0.045	6.274LeuThr: 6.274 ± 0.054	5.34LeuVal: 5.34 ± 0.043	1.136LeuTrp: 1.136 ± 0.023	3.909LeuTyr: 3.909 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	1.71MetAla: 1.71 ± 0.027	0.185MetCys: 0.185 ± 0.007	0.745MetAsp: 0.745 ± 0.017	1.191MetGlu: 1.191 ± 0.024	0.809MetPhe: 0.809 ± 0.017	1.419MetGly: 1.419 ± 0.024	0.453MetHis: 0.453 ± 0.013	0.868MetIle: 0.868 ± 0.018	1.386MetLys: 1.386 ± 0.023	2.244MetLeu: 2.244 ± 0.028	0.41MetMet: 0.41 ± 0.013	1.088MetAsn: 1.088 ± 0.02	1.356MetPro: 1.356 ± 0.022	1.241MetGln: 1.241 ± 0.022	0.977MetArg: 0.977 ± 0.021	1.16MetSer: 1.16 ± 0.019	0.906MetThr: 0.906 ± 0.021	1.524MetVal: 1.524 ± 0.024	0.188MetTrp: 0.188 ± 0.008	0.749MetTyr: 0.749 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	5.063AsnAla: 5.063 ± 0.05	0.963AsnCys: 0.963 ± 0.031	2.523AsnAsp: 2.523 ± 0.037	2.575AsnGlu: 2.575 ± 0.033	2.686AsnPhe: 2.686 ± 0.037	5.149AsnGly: 5.149 ± 0.077	1.095AsnHis: 1.095 ± 0.019	3.932AsnIle: 3.932 ± 0.039	2.556AsnLys: 2.556 ± 0.039	5.846AsnLeu: 5.846 ± 0.054	1.216AsnMet: 1.216 ± 0.021	4.324AsnAsn: 4.324 ± 0.056	4.05AsnPro: 4.05 ± 0.048	2.249AsnGln: 2.249 ± 0.031	2.557AsnArg: 2.557 ± 0.035	3.604AsnSer: 3.604 ± 0.043	4.645AsnThr: 4.645 ± 0.072	3.118AsnVal: 3.118 ± 0.041	0.862AsnTrp: 0.862 ± 0.018	2.669AsnTyr: 2.669 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	5.03ProAla: 5.03 ± 0.066	0.556ProCys: 0.556 ± 0.019	3.597ProAsp: 3.597 ± 0.043	2.826ProGlu: 2.826 ± 0.036	2.231ProPhe: 2.231 ± 0.034	3.153ProGly: 3.153 ± 0.04	0.896ProHis: 0.896 ± 0.02	2.24ProIle: 2.24 ± 0.033	1.828ProLys: 1.828 ± 0.033	3.978ProLeu: 3.978 ± 0.044	0.883ProMet: 0.883 ± 0.017	3.027ProAsn: 3.027 ± 0.038	2.839ProPro: 2.839 ± 0.047	2.41ProGln: 2.41 ± 0.031	1.101ProArg: 1.101 ± 0.022	2.157ProSer: 2.157 ± 0.033	2.567ProThr: 2.567 ± 0.046	4.146ProVal: 4.146 ± 0.043	0.423ProTrp: 0.423 ± 0.013	1.881ProTyr: 1.881 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.084GlnAla: 3.084 ± 0.037	0.419GlnCys: 0.419 ± 0.012	1.447GlnAsp: 1.447 ± 0.021	2.042GlnGlu: 2.042 ± 0.028	1.903GlnPhe: 1.903 ± 0.025	2.213GlnGly: 2.213 ± 0.027	1.133GlnHis: 1.133 ± 0.023	3.059GlnIle: 3.059 ± 0.034	2.492GlnLys: 2.492 ± 0.038	5.085GlnLeu: 5.085 ± 0.055	1.082GlnMet: 1.082 ± 0.023	3.065GlnAsn: 3.065 ± 0.035	2.652GlnPro: 2.652 ± 0.034	3.306GlnGln: 3.306 ± 0.057	1.564GlnArg: 1.564 ± 0.028	2.186GlnSer: 2.186 ± 0.031	3.664GlnThr: 3.664 ± 0.045	2.553GlnVal: 2.553 ± 0.031	0.675GlnTrp: 0.675 ± 0.018	2.029GlnTyr: 2.029 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	2.267ArgAla: 2.267 ± 0.033	0.346ArgCys: 0.346 ± 0.011	1.225ArgAsp: 1.225 ± 0.021	1.748ArgGlu: 1.748 ± 0.035	2.192ArgPhe: 2.192 ± 0.031	1.838ArgGly: 1.838 ± 0.029	0.865ArgHis: 0.865 ± 0.018	2.718ArgIle: 2.718 ± 0.04	2.236ArgLys: 2.236 ± 0.034	4.021ArgLeu: 4.021 ± 0.044	0.987ArgMet: 0.987 ± 0.021	2.226ArgAsn: 2.226 ± 0.028	1.269ArgPro: 1.269 ± 0.026	2.2ArgGln: 2.2 ± 0.038	1.676ArgArg: 1.676 ± 0.031	1.768ArgSer: 1.768 ± 0.025	1.973ArgThr: 1.973 ± 0.027	2.147ArgVal: 2.147 ± 0.03	0.484ArgTrp: 0.484 ± 0.013	1.806ArgTyr: 1.806 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	5.227SerAla: 5.227 ± 0.059	0.835SerCys: 0.835 ± 0.024	2.797SerAsp: 2.797 ± 0.031	2.595SerGlu: 2.595 ± 0.038	2.886SerPhe: 2.886 ± 0.034	6.282SerGly: 6.282 ± 0.106	0.871SerHis: 0.871 ± 0.017	3.519SerIle: 3.519 ± 0.041	2.426SerLys: 2.426 ± 0.037	5.022SerLeu: 5.022 ± 0.047	1.081SerMet: 1.081 ± 0.021	3.483SerAsn: 3.483 ± 0.057	2.621SerPro: 2.621 ± 0.039	1.803SerGln: 1.803 ± 0.027	1.878SerArg: 1.878 ± 0.029	3.338SerSer: 3.338 ± 0.059	3.328SerThr: 3.328 ± 0.057	4.563SerVal: 4.563 ± 0.056	0.717SerTrp: 0.717 ± 0.017	2.361SerTyr: 2.361 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	7.211ThrAla: 7.211 ± 0.102	0.936ThrCys: 0.936 ± 0.035	4.189ThrAsp: 4.189 ± 0.054	3.333ThrGlu: 3.333 ± 0.041	3.007ThrPhe: 3.007 ± 0.04	6.534ThrGly: 6.534 ± 0.087	1.196ThrHis: 1.196 ± 0.021	4.732ThrIle: 4.732 ± 0.061	2.218ThrLys: 2.218 ± 0.032	6.819ThrLeu: 6.819 ± 0.056	0.972ThrMet: 0.972 ± 0.019	3.698ThrAsn: 3.698 ± 0.052	4.205ThrPro: 4.205 ± 0.055	2.894ThrGln: 2.894 ± 0.036	1.99ThrArg: 1.99 ± 0.031	3.365ThrSer: 3.365 ± 0.055	5.057ThrThr: 5.057 ± 0.093	5.771ThrVal: 5.771 ± 0.122	0.807ThrTrp: 0.807 ± 0.022	3.155ThrTyr: 3.155 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	5.423ValAla: 5.423 ± 0.054	1.048ValCys: 1.048 ± 0.027	2.391ValAsp: 2.391 ± 0.037	2.846ValGlu: 2.846 ± 0.033	3.423ValPhe: 3.423 ± 0.039	3.435ValGly: 3.435 ± 0.043	1.027ValHis: 1.027 ± 0.021	3.944ValIle: 3.944 ± 0.037	3.596ValLys: 3.596 ± 0.044	6.201ValLeu: 6.201 ± 0.052	1.373ValMet: 1.373 ± 0.023	4.045ValAsn: 4.045 ± 0.048	2.788ValPro: 2.788 ± 0.036	2.775ValGln: 2.775 ± 0.035	2.212ValArg: 2.212 ± 0.028	4.513ValSer: 4.513 ± 0.056	5.397ValThr: 5.397 ± 0.121	4.771ValVal: 4.771 ± 0.055	0.857ValTrp: 0.857 ± 0.018	2.882ValTyr: 2.882 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.866TrpAla: 0.866 ± 0.019	0.142TrpCys: 0.142 ± 0.007	0.552TrpAsp: 0.552 ± 0.015	0.615TrpGlu: 0.615 ± 0.015	0.6TrpPhe: 0.6 ± 0.016	0.857TrpGly: 0.857 ± 0.019	0.286TrpHis: 0.286 ± 0.011	0.61TrpIle: 0.61 ± 0.017	0.603TrpLys: 0.603 ± 0.015	1.301TrpLeu: 1.301 ± 0.025	0.275TrpMet: 0.275 ± 0.01	0.785TrpAsn: 0.785 ± 0.019	0.246TrpPro: 0.246 ± 0.008	0.888TrpGln: 0.888 ± 0.017	0.508TrpArg: 0.508 ± 0.012	0.876TrpSer: 0.876 ± 0.03	0.737TrpThr: 0.737 ± 0.02	0.858TrpVal: 0.858 ± 0.017	0.195TrpTrp: 0.195 ± 0.009	0.586TrpTyr: 0.586 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.28TyrAla: 3.28 ± 0.031	0.561TyrCys: 0.561 ± 0.013	2.108TyrAsp: 2.108 ± 0.029	2.004TyrGlu: 2.004 ± 0.028	2.173TyrPhe: 2.173 ± 0.029	2.473TyrGly: 2.473 ± 0.033	0.967TyrHis: 0.967 ± 0.018	2.261TyrIle: 2.261 ± 0.027	1.877TyrLys: 1.877 ± 0.03	4.188TyrLeu: 4.188 ± 0.042	0.703TyrMet: 0.703 ± 0.016	2.844TyrAsn: 2.844 ± 0.041	1.877TyrPro: 1.877 ± 0.027	1.815TyrGln: 1.815 ± 0.026	2.196TyrArg: 2.196 ± 0.031	2.527TyrSer: 2.527 ± 0.038	3.2TyrThr: 3.2 ± 0.05	2.266TyrVal: 2.266 ± 0.032	0.536TyrTrp: 0.536 ± 0.013	2.101TyrTyr: 2.101 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7781 proteins (2977425 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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