Amino acid dipepetide frequency for Peptidiphaga gingivicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.626AlaAla: 18.626 ± 0.3	1.142AlaCys: 1.142 ± 0.045	7.979AlaAsp: 7.979 ± 0.112	8.34AlaGlu: 8.34 ± 0.147	4.006AlaPhe: 4.006 ± 0.102	11.708AlaGly: 11.708 ± 0.168	2.028AlaHis: 2.028 ± 0.056	5.111AlaIle: 5.111 ± 0.092	4.711AlaLys: 4.711 ± 0.096	11.82AlaLeu: 11.82 ± 0.157	2.712AlaMet: 2.712 ± 0.069	2.831AlaAsn: 2.831 ± 0.066	5.705AlaPro: 5.705 ± 0.123	3.774AlaGln: 3.774 ± 0.1	8.896AlaArg: 8.896 ± 0.155	8.65AlaSer: 8.65 ± 0.145	5.947AlaThr: 5.947 ± 0.086	10.733AlaVal: 10.733 ± 0.146	1.68AlaTrp: 1.68 ± 0.052	2.511AlaTyr: 2.511 ± 0.069	0.0AlaXaa: 0.0 ± 0.0
Cys	1.05CysAla: 1.05 ± 0.042	0.083CysCys: 0.083 ± 0.011	0.447CysAsp: 0.447 ± 0.028	0.47CysGlu: 0.47 ± 0.021	0.261CysPhe: 0.261 ± 0.022	0.886CysGly: 0.886 ± 0.043	0.155CysHis: 0.155 ± 0.015	0.309CysIle: 0.309 ± 0.021	0.204CysLys: 0.204 ± 0.017	0.778CysLeu: 0.778 ± 0.035	0.126CysMet: 0.126 ± 0.013	0.156CysAsn: 0.156 ± 0.015	0.406CysPro: 0.406 ± 0.023	0.168CysGln: 0.168 ± 0.014	0.474CysArg: 0.474 ± 0.029	0.48CysSer: 0.48 ± 0.025	0.423CysThr: 0.423 ± 0.026	0.645CysVal: 0.645 ± 0.031	0.107CysTrp: 0.107 ± 0.015	0.165CysTyr: 0.165 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.572AspAla: 7.572 ± 0.114	0.407AspCys: 0.407 ± 0.024	3.657AspAsp: 3.657 ± 0.098	4.054AspGlu: 4.054 ± 0.083	1.931AspPhe: 1.931 ± 0.05	6.067AspGly: 6.067 ± 0.106	0.886AspHis: 0.886 ± 0.036	2.25AspIle: 2.25 ± 0.067	1.835AspLys: 1.835 ± 0.069	5.241AspLeu: 5.241 ± 0.093	1.18AspMet: 1.18 ± 0.045	1.147AspAsn: 1.147 ± 0.039	3.711AspPro: 3.711 ± 0.079	1.27AspGln: 1.27 ± 0.048	3.749AspArg: 3.749 ± 0.079	3.775AspSer: 3.775 ± 0.082	2.108AspThr: 2.108 ± 0.062	6.302AspVal: 6.302 ± 0.113	0.806AspTrp: 0.806 ± 0.036	1.349AspTyr: 1.349 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	8.617GluAla: 8.617 ± 0.143	0.457GluCys: 0.457 ± 0.025	3.444GluAsp: 3.444 ± 0.09	4.435GluGlu: 4.435 ± 0.096	1.777GluPhe: 1.777 ± 0.049	5.574GluGly: 5.574 ± 0.096	1.178GluHis: 1.178 ± 0.044	3.079GluIle: 3.079 ± 0.075	2.505GluLys: 2.505 ± 0.065	6.035GluLeu: 6.035 ± 0.105	1.231GluMet: 1.231 ± 0.047	1.698GluAsn: 1.698 ± 0.056	2.899GluPro: 2.899 ± 0.073	1.87GluGln: 1.87 ± 0.057	5.317GluArg: 5.317 ± 0.108	3.861GluSer: 3.861 ± 0.09	3.165GluThr: 3.165 ± 0.072	4.191GluVal: 4.191 ± 0.079	0.841GluTrp: 0.841 ± 0.04	1.372GluTyr: 1.372 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	4.074PheAla: 4.074 ± 0.085	0.26PheCys: 0.26 ± 0.019	2.222PheAsp: 2.222 ± 0.056	1.886PheGlu: 1.886 ± 0.058	1.181PhePhe: 1.181 ± 0.056	3.273PheGly: 3.273 ± 0.086	0.555PheHis: 0.555 ± 0.031	1.253PheIle: 1.253 ± 0.052	0.86PheLys: 0.86 ± 0.036	2.762PheLeu: 2.762 ± 0.08	0.582PheMet: 0.582 ± 0.031	0.769PheAsn: 0.769 ± 0.037	1.562PhePro: 1.562 ± 0.042	0.714PheGln: 0.714 ± 0.031	1.669PheArg: 1.669 ± 0.057	2.219PheSer: 2.219 ± 0.065	1.841PheThr: 1.841 ± 0.054	2.784PheVal: 2.784 ± 0.069	0.371PheTrp: 0.371 ± 0.022	0.733PheTyr: 0.733 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	10.622GlyAla: 10.622 ± 0.16	0.807GlyCys: 0.807 ± 0.036	4.998GlyAsp: 4.998 ± 0.098	5.737GlyGlu: 5.737 ± 0.094	3.161GlyPhe: 3.161 ± 0.074	8.544GlyGly: 8.544 ± 0.157	1.654GlyHis: 1.654 ± 0.051	4.305GlyIle: 4.305 ± 0.085	4.333GlyLys: 4.333 ± 0.085	8.213GlyLeu: 8.213 ± 0.124	2.232GlyMet: 2.232 ± 0.063	2.35GlyAsn: 2.35 ± 0.059	3.918GlyPro: 3.918 ± 0.082	2.877GlyGln: 2.877 ± 0.086	6.746GlyArg: 6.746 ± 0.113	6.417GlySer: 6.417 ± 0.11	4.683GlyThr: 4.683 ± 0.09	7.274GlyVal: 7.274 ± 0.105	1.353GlyTrp: 1.353 ± 0.048	2.267GlyTyr: 2.267 ± 0.066	0.0GlyXaa: 0.0 ± 0.0
His	2.038HisAla: 2.038 ± 0.054	0.156HisCys: 0.156 ± 0.015	0.945HisAsp: 0.945 ± 0.043	0.997HisGlu: 0.997 ± 0.038	0.547HisPhe: 0.547 ± 0.029	1.658HisGly: 1.658 ± 0.047	0.355HisHis: 0.355 ± 0.029	0.787HisIle: 0.787 ± 0.032	0.464HisLys: 0.464 ± 0.03	1.499HisLeu: 1.499 ± 0.048	0.358HisMet: 0.358 ± 0.025	0.511HisAsn: 0.511 ± 0.031	1.204HisPro: 1.204 ± 0.045	0.399HisGln: 0.399 ± 0.025	1.248HisArg: 1.248 ± 0.044	1.219HisSer: 1.219 ± 0.04	0.918HisThr: 0.918 ± 0.039	1.507HisVal: 1.507 ± 0.047	0.213HisTrp: 0.213 ± 0.018	0.436HisTyr: 0.436 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.702IleAla: 5.702 ± 0.106	0.277IleCys: 0.277 ± 0.024	3.375IleAsp: 3.375 ± 0.078	3.013IleGlu: 3.013 ± 0.07	1.289IlePhe: 1.289 ± 0.046	4.255IleGly: 4.255 ± 0.075	0.743IleHis: 0.743 ± 0.036	1.359IleIle: 1.359 ± 0.051	1.166IleLys: 1.166 ± 0.048	3.876IleLeu: 3.876 ± 0.09	0.701IleMet: 0.701 ± 0.034	0.914IleAsn: 0.914 ± 0.035	2.337IlePro: 2.337 ± 0.06	1.006IleGln: 1.006 ± 0.043	2.644IleArg: 2.644 ± 0.07	2.409IleSer: 2.409 ± 0.069	1.943IleThr: 1.943 ± 0.055	4.347IleVal: 4.347 ± 0.099	0.363IleTrp: 0.363 ± 0.026	0.707IleTyr: 0.707 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.832LysAla: 4.832 ± 0.108	0.156LysCys: 0.156 ± 0.017	2.074LysAsp: 2.074 ± 0.064	2.201LysGlu: 2.201 ± 0.067	0.869LysPhe: 0.869 ± 0.039	3.124LysGly: 3.124 ± 0.081	0.539LysHis: 0.539 ± 0.03	1.739LysIle: 1.739 ± 0.057	1.888LysLys: 1.888 ± 0.074	2.94LysLeu: 2.94 ± 0.07	0.857LysMet: 0.857 ± 0.035	1.047LysAsn: 1.047 ± 0.04	2.001LysPro: 2.001 ± 0.067	0.965LysGln: 0.965 ± 0.039	2.536LysArg: 2.536 ± 0.072	2.042LysSer: 2.042 ± 0.058	2.08LysThr: 2.08 ± 0.056	2.888LysVal: 2.888 ± 0.08	0.406LysTrp: 0.406 ± 0.025	0.745LysTyr: 0.745 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	13.026LeuAla: 13.026 ± 0.179	0.736LeuCys: 0.736 ± 0.037	5.73LeuAsp: 5.73 ± 0.096	5.169LeuGlu: 5.169 ± 0.096	2.674LeuPhe: 2.674 ± 0.078	8.318LeuGly: 8.318 ± 0.115	1.501LeuHis: 1.501 ± 0.051	3.482LeuIle: 3.482 ± 0.092	2.823LeuLys: 2.823 ± 0.07	8.038LeuLeu: 8.038 ± 0.143	1.669LeuMet: 1.669 ± 0.048	2.035LeuAsn: 2.035 ± 0.056	4.744LeuPro: 4.744 ± 0.088	1.991LeuGln: 1.991 ± 0.056	6.512LeuArg: 6.512 ± 0.118	5.924LeuSer: 5.924 ± 0.105	5.309LeuThr: 5.309 ± 0.09	7.617LeuVal: 7.617 ± 0.11	1.063LeuTrp: 1.063 ± 0.042	1.711LeuTyr: 1.711 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.599MetAla: 2.599 ± 0.065	0.18MetCys: 0.18 ± 0.018	1.096MetAsp: 1.096 ± 0.041	1.009MetGlu: 1.009 ± 0.038	0.616MetPhe: 0.616 ± 0.032	1.666MetGly: 1.666 ± 0.047	0.381MetHis: 0.381 ± 0.023	0.788MetIle: 0.788 ± 0.034	0.774MetLys: 0.774 ± 0.037	1.807MetLeu: 1.807 ± 0.053	0.327MetMet: 0.327 ± 0.023	0.606MetAsn: 0.606 ± 0.031	1.239MetPro: 1.239 ± 0.043	0.498MetGln: 0.498 ± 0.022	1.655MetArg: 1.655 ± 0.049	1.623MetSer: 1.623 ± 0.046	1.423MetThr: 1.423 ± 0.053	1.394MetVal: 1.394 ± 0.041	0.305MetTrp: 0.305 ± 0.021	0.397MetTyr: 0.397 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.07AsnAla: 3.07 ± 0.073	0.165AsnCys: 0.165 ± 0.016	1.363AsnAsp: 1.363 ± 0.05	1.413AsnGlu: 1.413 ± 0.046	0.699AsnPhe: 0.699 ± 0.032	2.486AsnGly: 2.486 ± 0.076	0.42AsnHis: 0.42 ± 0.029	0.949AsnIle: 0.949 ± 0.035	0.755AsnLys: 0.755 ± 0.039	2.28AsnLeu: 2.28 ± 0.058	0.455AsnMet: 0.455 ± 0.027	0.686AsnAsn: 0.686 ± 0.041	1.831AsnPro: 1.831 ± 0.054	0.68AsnGln: 0.68 ± 0.035	1.645AsnArg: 1.645 ± 0.051	1.469AsnSer: 1.469 ± 0.046	1.115AsnThr: 1.115 ± 0.042	2.101AsnVal: 2.101 ± 0.059	0.334AsnTrp: 0.334 ± 0.022	0.577AsnTyr: 0.577 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	6.093ProAla: 6.093 ± 0.111	0.304ProCys: 0.304 ± 0.021	3.296ProAsp: 3.296 ± 0.08	4.035ProGlu: 4.035 ± 0.091	1.588ProPhe: 1.588 ± 0.049	5.142ProGly: 5.142 ± 0.102	1.004ProHis: 1.004 ± 0.042	1.981ProIle: 1.981 ± 0.055	1.874ProLys: 1.874 ± 0.063	4.013ProLeu: 4.013 ± 0.071	0.949ProMet: 0.949 ± 0.036	1.304ProAsn: 1.304 ± 0.044	2.104ProPro: 2.104 ± 0.074	1.515ProGln: 1.515 ± 0.069	3.235ProArg: 3.235 ± 0.081	4.162ProSer: 4.162 ± 0.123	2.921ProThr: 2.921 ± 0.083	3.972ProVal: 3.972 ± 0.077	0.74ProTrp: 0.74 ± 0.031	1.086ProTyr: 1.086 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	3.867GlnAla: 3.867 ± 0.094	0.172GlnCys: 0.172 ± 0.019	1.152GlnAsp: 1.152 ± 0.041	1.552GlnGlu: 1.552 ± 0.049	0.742GlnPhe: 0.742 ± 0.034	2.168GlnGly: 2.168 ± 0.061	0.454GlnHis: 0.454 ± 0.029	1.555GlnIle: 1.555 ± 0.045	1.053GlnLys: 1.053 ± 0.041	2.488GlnLeu: 2.488 ± 0.063	0.658GlnMet: 0.658 ± 0.033	0.689GlnAsn: 0.689 ± 0.038	1.32GlnPro: 1.32 ± 0.064	0.931GlnGln: 0.931 ± 0.049	2.025GlnArg: 2.025 ± 0.058	1.734GlnSer: 1.734 ± 0.068	1.644GlnThr: 1.644 ± 0.049	1.88GlnVal: 1.88 ± 0.052	0.444GlnTrp: 0.444 ± 0.029	0.563GlnTyr: 0.563 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	8.225ArgAla: 8.225 ± 0.14	0.486ArgCys: 0.486 ± 0.031	3.69ArgAsp: 3.69 ± 0.088	5.244ArgGlu: 5.244 ± 0.1	2.163ArgPhe: 2.163 ± 0.059	5.607ArgGly: 5.607 ± 0.098	1.327ArgHis: 1.327 ± 0.042	3.598ArgIle: 3.598 ± 0.079	2.705ArgLys: 2.705 ± 0.079	6.765ArgLeu: 6.765 ± 0.121	1.704ArgMet: 1.704 ± 0.051	1.635ArgAsn: 1.635 ± 0.058	3.485ArgPro: 3.485 ± 0.079	2.216ArgGln: 2.216 ± 0.069	6.562ArgArg: 6.562 ± 0.147	4.488ArgSer: 4.488 ± 0.102	3.688ArgThr: 3.688 ± 0.081	4.876ArgVal: 4.876 ± 0.086	1.02ArgTrp: 1.02 ± 0.036	1.559ArgTyr: 1.559 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	8.283SerAla: 8.283 ± 0.151	0.476SerCys: 0.476 ± 0.024	3.671SerAsp: 3.671 ± 0.078	3.692SerGlu: 3.692 ± 0.077	2.257SerPhe: 2.257 ± 0.061	6.869SerGly: 6.869 ± 0.115	1.193SerHis: 1.193 ± 0.039	2.788SerIle: 2.788 ± 0.064	2.295SerLys: 2.295 ± 0.078	5.963SerLeu: 5.963 ± 0.115	1.4SerMet: 1.4 ± 0.047	1.677SerAsn: 1.677 ± 0.052	3.661SerPro: 3.661 ± 0.098	2.058SerGln: 2.058 ± 0.064	4.502SerArg: 4.502 ± 0.101	4.92SerSer: 4.92 ± 0.117	3.396SerThr: 3.396 ± 0.069	4.927SerVal: 4.927 ± 0.091	0.961SerTrp: 0.961 ± 0.033	1.47SerTyr: 1.47 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	6.343ThrAla: 6.343 ± 0.102	0.378ThrCys: 0.378 ± 0.025	2.87ThrAsp: 2.87 ± 0.065	2.682ThrGlu: 2.682 ± 0.058	1.763ThrPhe: 1.763 ± 0.05	4.981ThrGly: 4.981 ± 0.094	0.984ThrHis: 0.984 ± 0.036	2.473ThrIle: 2.473 ± 0.071	1.673ThrLys: 1.673 ± 0.051	4.836ThrLeu: 4.836 ± 0.086	1.058ThrMet: 1.058 ± 0.041	1.264ThrAsn: 1.264 ± 0.049	3.352ThrPro: 3.352 ± 0.082	1.276ThrGln: 1.276 ± 0.046	3.077ThrArg: 3.077 ± 0.068	3.422ThrSer: 3.422 ± 0.07	2.809ThrThr: 2.809 ± 0.074	4.877ThrVal: 4.877 ± 0.099	0.747ThrTrp: 0.747 ± 0.034	1.158ThrTyr: 1.158 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	10.508ValAla: 10.508 ± 0.147	0.854ValCys: 0.854 ± 0.035	5.184ValAsp: 5.184 ± 0.106	5.49ValGlu: 5.49 ± 0.117	2.796ValPhe: 2.796 ± 0.071	7.111ValGly: 7.111 ± 0.113	1.455ValHis: 1.455 ± 0.047	3.05ValIle: 3.05 ± 0.07	2.781ValLys: 2.781 ± 0.077	7.323ValLeu: 7.323 ± 0.106	1.463ValMet: 1.463 ± 0.054	2.061ValAsn: 2.061 ± 0.054	4.185ValPro: 4.185 ± 0.08	1.893ValGln: 1.893 ± 0.049	5.883ValArg: 5.883 ± 0.106	5.469ValSer: 5.469 ± 0.087	4.604ValThr: 4.604 ± 0.092	8.127ValVal: 8.127 ± 0.139	0.965ValTrp: 0.965 ± 0.044	1.765ValTyr: 1.765 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	1.396TrpAla: 1.396 ± 0.051	0.124TrpCys: 0.124 ± 0.013	0.784TrpAsp: 0.784 ± 0.034	0.712TrpGlu: 0.712 ± 0.032	0.498TrpPhe: 0.498 ± 0.03	0.971TrpGly: 0.971 ± 0.041	0.293TrpHis: 0.293 ± 0.021	0.68TrpIle: 0.68 ± 0.034	0.507TrpLys: 0.507 ± 0.029	1.363TrpLeu: 1.363 ± 0.04	0.302TrpMet: 0.302 ± 0.024	0.515TrpAsn: 0.515 ± 0.029	0.597TrpPro: 0.597 ± 0.032	0.444TrpGln: 0.444 ± 0.024	1.134TrpArg: 1.134 ± 0.044	0.772TrpSer: 0.772 ± 0.032	0.863TrpThr: 0.863 ± 0.035	0.826TrpVal: 0.826 ± 0.038	0.293TrpTrp: 0.293 ± 0.021	0.255TrpTyr: 0.255 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.366TyrAla: 2.366 ± 0.058	0.174TyrCys: 0.174 ± 0.017	1.318TyrAsp: 1.318 ± 0.044	1.413TyrGlu: 1.413 ± 0.046	0.75TyrPhe: 0.75 ± 0.036	2.086TyrGly: 2.086 ± 0.063	0.355TyrHis: 0.355 ± 0.022	0.892TyrIle: 0.892 ± 0.035	0.723TyrLys: 0.723 ± 0.036	2.032TyrLeu: 2.032 ± 0.062	0.419TyrMet: 0.419 ± 0.027	0.599TyrAsn: 0.599 ± 0.032	1.057TyrPro: 1.057 ± 0.042	0.545TyrGln: 0.545 ± 0.029	1.533TyrArg: 1.533 ± 0.044	1.404TyrSer: 1.404 ± 0.046	1.143TyrThr: 1.143 ± 0.044	1.699TyrVal: 1.699 ± 0.052	0.318TyrTrp: 0.318 ± 0.021	0.568TyrTyr: 0.568 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1994 proteins (685011 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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