Amino acid dipepetide frequency for Corynebacterium sp. 13CS0277

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.438AlaAla: 22.438 ± 0.381
1.26AlaCys: 1.26 ± 0.044
8.143AlaAsp: 8.143 ± 0.109
8.398AlaGlu: 8.398 ± 0.153
3.387AlaPhe: 3.387 ± 0.066
11.79AlaGly: 11.79 ± 0.151
3.41AlaHis: 3.41 ± 0.085
5.023AlaIle: 5.023 ± 0.091
3.398AlaLys: 3.398 ± 0.09
12.825AlaLeu: 12.825 ± 0.162
2.727AlaMet: 2.727 ± 0.06
2.464AlaAsn: 2.464 ± 0.067
7.163AlaPro: 7.163 ± 0.151
4.919AlaGln: 4.919 ± 0.107
9.1AlaArg: 9.1 ± 0.153
5.822AlaSer: 5.822 ± 0.092
8.839AlaThr: 8.839 ± 0.123
10.766AlaVal: 10.766 ± 0.157
1.807AlaTrp: 1.807 ± 0.05
2.383AlaTyr: 2.383 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
1.243CysAla: 1.243 ± 0.051
0.103CysCys: 0.103 ± 0.013
0.504CysAsp: 0.504 ± 0.026
0.492CysGlu: 0.492 ± 0.029
0.268CysPhe: 0.268 ± 0.018
1.029CysGly: 1.029 ± 0.041
0.193CysHis: 0.193 ± 0.017
0.301CysIle: 0.301 ± 0.02
0.13CysLys: 0.13 ± 0.011
0.667CysLeu: 0.667 ± 0.027
0.164CysMet: 0.164 ± 0.015
0.193CysAsn: 0.193 ± 0.016
0.504CysPro: 0.504 ± 0.029
0.239CysGln: 0.239 ± 0.017
0.494CysArg: 0.494 ± 0.026
0.415CysSer: 0.415 ± 0.025
0.559CysThr: 0.559 ± 0.031
0.782CysVal: 0.782 ± 0.033
0.108CysTrp: 0.108 ± 0.013
0.164CysTyr: 0.164 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
8.463AspAla: 8.463 ± 0.121
0.524AspCys: 0.524 ± 0.025
3.605AspAsp: 3.605 ± 0.078
3.907AspGlu: 3.907 ± 0.084
1.951AspPhe: 1.951 ± 0.054
5.106AspGly: 5.106 ± 0.091
1.251AspHis: 1.251 ± 0.043
2.959AspIle: 2.959 ± 0.063
1.508AspLys: 1.508 ± 0.054
5.092AspLeu: 5.092 ± 0.092
1.273AspMet: 1.273 ± 0.042
1.536AspAsn: 1.536 ± 0.049
3.874AspPro: 3.874 ± 0.071
1.417AspGln: 1.417 ± 0.042
3.16AspArg: 3.16 ± 0.067
2.99AspSer: 2.99 ± 0.065
4.006AspThr: 4.006 ± 0.076
5.144AspVal: 5.144 ± 0.09
0.74AspTrp: 0.74 ± 0.032
1.604AspTyr: 1.604 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
6.956GluAla: 6.956 ± 0.131
0.439GluCys: 0.439 ± 0.029
3.842GluAsp: 3.842 ± 0.091
4.239GluGlu: 4.239 ± 0.087
1.949GluPhe: 1.949 ± 0.056
3.999GluGly: 3.999 ± 0.087
1.605GluHis: 1.605 ± 0.048
2.705GluIle: 2.705 ± 0.067
1.962GluLys: 1.962 ± 0.069
6.081GluLeu: 6.081 ± 0.098
1.21GluMet: 1.21 ± 0.037
1.317GluAsn: 1.317 ± 0.046
2.538GluPro: 2.538 ± 0.079
2.437GluGln: 2.437 ± 0.062
3.801GluArg: 3.801 ± 0.086
2.395GluSer: 2.395 ± 0.062
2.647GluThr: 2.647 ± 0.07
4.557GluVal: 4.557 ± 0.086
0.725GluTrp: 0.725 ± 0.034
1.37GluTyr: 1.37 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
3.966PheAla: 3.966 ± 0.077
0.258PheCys: 0.258 ± 0.02
2.317PheAsp: 2.317 ± 0.059
1.458PheGlu: 1.458 ± 0.043
1.196PhePhe: 1.196 ± 0.036
3.111PheGly: 3.111 ± 0.069
0.727PheHis: 0.727 ± 0.031
1.297PheIle: 1.297 ± 0.049
0.563PheLys: 0.563 ± 0.029
2.91PheLeu: 2.91 ± 0.069
0.521PheMet: 0.521 ± 0.03
0.769PheAsn: 0.769 ± 0.034
1.403PhePro: 1.403 ± 0.041
0.791PheGln: 0.791 ± 0.028
1.582PheArg: 1.582 ± 0.041
1.774PheSer: 1.774 ± 0.049
2.199PheThr: 2.199 ± 0.068
2.541PheVal: 2.541 ± 0.061
0.357PheTrp: 0.357 ± 0.022
0.739PheTyr: 0.739 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
10.114GlyAla: 10.114 ± 0.146
0.866GlyCys: 0.866 ± 0.036
4.762GlyAsp: 4.762 ± 0.081
4.929GlyGlu: 4.929 ± 0.093
2.968GlyPhe: 2.968 ± 0.071
7.455GlyGly: 7.455 ± 0.134
2.076GlyHis: 2.076 ± 0.059
4.016GlyIle: 4.016 ± 0.084
2.409GlyLys: 2.409 ± 0.081
7.913GlyLeu: 7.913 ± 0.102
2.217GlyMet: 2.217 ± 0.055
1.807GlyAsn: 1.807 ± 0.055
3.589GlyPro: 3.589 ± 0.076
2.828GlyGln: 2.828 ± 0.056
5.566GlyArg: 5.566 ± 0.092
4.669GlySer: 4.669 ± 0.087
5.729GlyThr: 5.729 ± 0.088
7.943GlyVal: 7.943 ± 0.127
1.487GlyTrp: 1.487 ± 0.046
2.166GlyTyr: 2.166 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
2.913HisAla: 2.913 ± 0.08
0.201HisCys: 0.201 ± 0.016
1.392HisAsp: 1.392 ± 0.042
1.143HisGlu: 1.143 ± 0.035
0.643HisPhe: 0.643 ± 0.025
1.967HisGly: 1.967 ± 0.05
0.761HisHis: 0.761 ± 0.035
0.982HisIle: 0.982 ± 0.038
0.427HisLys: 0.427 ± 0.026
2.169HisLeu: 2.169 ± 0.062
0.515HisMet: 0.515 ± 0.026
0.55HisAsn: 0.55 ± 0.029
1.977HisPro: 1.977 ± 0.058
0.692HisGln: 0.692 ± 0.029
1.599HisArg: 1.599 ± 0.048
1.211HisSer: 1.211 ± 0.039
1.731HisThr: 1.731 ± 0.054
1.698HisVal: 1.698 ± 0.046
0.283HisTrp: 0.283 ± 0.018
0.527HisTyr: 0.527 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.258IleAla: 6.258 ± 0.097
0.323IleCys: 0.323 ± 0.019
3.309IleAsp: 3.309 ± 0.069
2.274IleGlu: 2.274 ± 0.061
1.216IlePhe: 1.216 ± 0.046
3.808IleGly: 3.808 ± 0.087
0.906IleHis: 0.906 ± 0.037
2.207IleIle: 2.207 ± 0.061
1.008IleLys: 1.008 ± 0.042
3.584IleLeu: 3.584 ± 0.072
0.842IleMet: 0.842 ± 0.029
1.251IleAsn: 1.251 ± 0.034
2.438IlePro: 2.438 ± 0.054
0.965IleGln: 0.965 ± 0.036
2.284IleArg: 2.284 ± 0.056
2.209IleSer: 2.209 ± 0.05
3.096IleThr: 3.096 ± 0.066
4.137IleVal: 4.137 ± 0.078
0.354IleTrp: 0.354 ± 0.025
0.861IleTyr: 0.861 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
3.189LysAla: 3.189 ± 0.102
0.124LysCys: 0.124 ± 0.013
1.782LysAsp: 1.782 ± 0.061
1.623LysGlu: 1.623 ± 0.059
0.714LysPhe: 0.714 ± 0.035
1.906LysGly: 1.906 ± 0.062
0.538LysHis: 0.538 ± 0.024
1.171LysIle: 1.171 ± 0.041
1.45LysLys: 1.45 ± 0.067
2.407LysLeu: 2.407 ± 0.074
0.641LysMet: 0.641 ± 0.034
0.881LysAsn: 0.881 ± 0.037
1.469LysPro: 1.469 ± 0.066
0.957LysGln: 0.957 ± 0.045
1.503LysArg: 1.503 ± 0.054
1.184LysSer: 1.184 ± 0.041
1.533LysThr: 1.533 ± 0.059
2.124LysVal: 2.124 ± 0.074
0.265LysTrp: 0.265 ± 0.016
0.536LysTyr: 0.536 ± 0.032
0.0LysXaa: 0.0 ± 0.0
Leu
13.571LeuAla: 13.571 ± 0.16
0.813LeuCys: 0.813 ± 0.041
5.627LeuAsp: 5.627 ± 0.098
4.575LeuGlu: 4.575 ± 0.081
2.629LeuPhe: 2.629 ± 0.061
8.634LeuGly: 8.634 ± 0.139
2.095LeuHis: 2.095 ± 0.054
3.939LeuIle: 3.939 ± 0.09
2.394LeuLys: 2.394 ± 0.069
9.378LeuLeu: 9.378 ± 0.175
1.874LeuMet: 1.874 ± 0.054
2.036LeuAsn: 2.036 ± 0.055
5.732LeuPro: 5.732 ± 0.087
2.803LeuGln: 2.803 ± 0.068
6.475LeuArg: 6.475 ± 0.105
5.275LeuSer: 5.275 ± 0.094
5.686LeuThr: 5.686 ± 0.093
8.321LeuVal: 8.321 ± 0.118
1.28LeuTrp: 1.28 ± 0.043
1.678LeuTyr: 1.678 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
2.579MetAla: 2.579 ± 0.061
0.18MetCys: 0.18 ± 0.018
1.134MetAsp: 1.134 ± 0.043
0.985MetGlu: 0.985 ± 0.039
0.734MetPhe: 0.734 ± 0.027
1.704MetGly: 1.704 ± 0.049
0.46MetHis: 0.46 ± 0.022
1.018MetIle: 1.018 ± 0.035
0.652MetLys: 0.652 ± 0.032
2.177MetLeu: 2.177 ± 0.055
0.513MetMet: 0.513 ± 0.024
0.566MetAsn: 0.566 ± 0.025
1.213MetPro: 1.213 ± 0.04
0.608MetGln: 0.608 ± 0.025
1.353MetArg: 1.353 ± 0.042
1.525MetSer: 1.525 ± 0.04
1.68MetThr: 1.68 ± 0.042
1.676MetVal: 1.676 ± 0.051
0.261MetTrp: 0.261 ± 0.018
0.399MetTyr: 0.399 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
2.491AsnAla: 2.491 ± 0.063
0.208AsnCys: 0.208 ± 0.017
1.243AsnAsp: 1.243 ± 0.043
1.132AsnGlu: 1.132 ± 0.04
0.749AsnPhe: 0.749 ± 0.029
1.733AsnGly: 1.733 ± 0.058
0.533AsnHis: 0.533 ± 0.027
1.141AsnIle: 1.141 ± 0.039
0.735AsnLys: 0.735 ± 0.038
2.279AsnLeu: 2.279 ± 0.055
0.497AsnMet: 0.497 ± 0.025
0.741AsnAsn: 0.741 ± 0.033
1.889AsnPro: 1.889 ± 0.056
0.722AsnGln: 0.722 ± 0.03
1.333AsnArg: 1.333 ± 0.04
1.264AsnSer: 1.264 ± 0.051
1.474AsnThr: 1.474 ± 0.071
1.694AsnVal: 1.694 ± 0.061
0.324AsnTrp: 0.324 ± 0.019
0.651AsnTyr: 0.651 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
8.357ProAla: 8.357 ± 0.165
0.313ProCys: 0.313 ± 0.019
3.149ProAsp: 3.149 ± 0.061
4.19ProGlu: 4.19 ± 0.089
1.485ProPhe: 1.485 ± 0.045
5.523ProGly: 5.523 ± 0.105
1.374ProHis: 1.374 ± 0.048
1.965ProIle: 1.965 ± 0.052
1.459ProLys: 1.459 ± 0.053
4.718ProLeu: 4.718 ± 0.092
1.089ProMet: 1.089 ± 0.031
1.194ProAsn: 1.194 ± 0.04
2.599ProPro: 2.599 ± 0.077
2.509ProGln: 2.509 ± 0.063
3.415ProArg: 3.415 ± 0.073
2.763ProSer: 2.763 ± 0.064
4.204ProThr: 4.204 ± 0.082
4.772ProVal: 4.772 ± 0.091
0.866ProTrp: 0.866 ± 0.043
1.008ProTyr: 1.008 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
4.733GlnAla: 4.733 ± 0.1
0.213GlnCys: 0.213 ± 0.017
1.627GlnAsp: 1.627 ± 0.045
1.806GlnGlu: 1.806 ± 0.049
0.866GlnPhe: 0.866 ± 0.038
2.497GlnGly: 2.497 ± 0.054
0.741GlnHis: 0.741 ± 0.034
1.358GlnIle: 1.358 ± 0.043
0.791GlnLys: 0.791 ± 0.036
3.812GlnLeu: 3.812 ± 0.083
0.761GlnMet: 0.761 ± 0.027
0.631GlnAsn: 0.631 ± 0.031
2.059GlnPro: 2.059 ± 0.057
1.577GlnGln: 1.577 ± 0.063
2.579GlnArg: 2.579 ± 0.063
1.352GlnSer: 1.352 ± 0.042
1.277GlnThr: 1.277 ± 0.04
2.86GlnVal: 2.86 ± 0.061
0.602GlnTrp: 0.602 ± 0.028
0.601GlnTyr: 0.601 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
8.324ArgAla: 8.324 ± 0.135
0.45ArgCys: 0.45 ± 0.024
3.733ArgAsp: 3.733 ± 0.073
3.631ArgGlu: 3.631 ± 0.077
1.977ArgPhe: 1.977 ± 0.048
5.08ArgGly: 5.08 ± 0.096
1.579ArgHis: 1.579 ± 0.048
3.057ArgIle: 3.057 ± 0.069
1.599ArgLys: 1.599 ± 0.052
6.135ArgLeu: 6.135 ± 0.094
1.618ArgMet: 1.618 ± 0.043
1.487ArgAsn: 1.487 ± 0.042
3.421ArgPro: 3.421 ± 0.076
2.18ArgGln: 2.18 ± 0.055
5.549ArgArg: 5.549 ± 0.125
3.103ArgSer: 3.103 ± 0.058
4.218ArgThr: 4.218 ± 0.073
4.929ArgVal: 4.929 ± 0.087
0.982ArgTrp: 0.982 ± 0.037
1.534ArgTyr: 1.534 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.284SerAla: 6.284 ± 0.097
0.42SerCys: 0.42 ± 0.024
2.689SerAsp: 2.689 ± 0.052
2.283SerGlu: 2.283 ± 0.056
1.872SerPhe: 1.872 ± 0.055
4.782SerGly: 4.782 ± 0.091
1.108SerHis: 1.108 ± 0.041
2.092SerIle: 2.092 ± 0.057
1.242SerLys: 1.242 ± 0.049
4.757SerLeu: 4.757 ± 0.081
1.295SerMet: 1.295 ± 0.039
1.157SerAsn: 1.157 ± 0.046
3.026SerPro: 3.026 ± 0.066
1.605SerGln: 1.605 ± 0.046
3.382SerArg: 3.382 ± 0.069
3.25SerSer: 3.25 ± 0.082
3.744SerThr: 3.744 ± 0.068
3.859SerVal: 3.859 ± 0.071
0.774SerTrp: 0.774 ± 0.026
1.162SerTyr: 1.162 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
8.148ThrAla: 8.148 ± 0.118
0.609ThrCys: 0.609 ± 0.048
3.358ThrAsp: 3.358 ± 0.064
2.721ThrGlu: 2.721 ± 0.064
1.947ThrPhe: 1.947 ± 0.049
5.746ThrGly: 5.746 ± 0.107
1.634ThrHis: 1.634 ± 0.048
3.114ThrIle: 3.114 ± 0.071
1.546ThrLys: 1.546 ± 0.049
5.927ThrLeu: 5.927 ± 0.1
1.344ThrMet: 1.344 ± 0.04
1.391ThrAsn: 1.391 ± 0.054
5.535ThrPro: 5.535 ± 0.106
2.023ThrGln: 2.023 ± 0.053
3.799ThrArg: 3.799 ± 0.073
3.469ThrSer: 3.469 ± 0.065
5.1ThrThr: 5.1 ± 0.105
5.73ThrVal: 5.73 ± 0.123
0.976ThrTrp: 0.976 ± 0.034
1.426ThrTyr: 1.426 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
11.762ValAla: 11.762 ± 0.152
0.905ValCys: 0.905 ± 0.037
5.891ValAsp: 5.891 ± 0.109
5.009ValGlu: 5.009 ± 0.093
2.736ValPhe: 2.736 ± 0.067
6.711ValGly: 6.711 ± 0.106
1.703ValHis: 1.703 ± 0.047
3.629ValIle: 3.629 ± 0.079
1.921ValLys: 1.921 ± 0.061
8.278ValLeu: 8.278 ± 0.133
1.612ValMet: 1.612 ± 0.052
1.907ValAsn: 1.907 ± 0.056
4.611ValPro: 4.611 ± 0.093
2.086ValGln: 2.086 ± 0.053
4.964ValArg: 4.964 ± 0.086
4.257ValSer: 4.257 ± 0.076
5.72ValThr: 5.72 ± 0.122
8.434ValVal: 8.434 ± 0.153
1.138ValTrp: 1.138 ± 0.043
1.591ValTyr: 1.591 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
1.741TrpAla: 1.741 ± 0.05
0.149TrpCys: 0.149 ± 0.017
0.7TrpAsp: 0.7 ± 0.029
0.861TrpGlu: 0.861 ± 0.032
0.51TrpPhe: 0.51 ± 0.023
1.014TrpGly: 1.014 ± 0.036
0.267TrpHis: 0.267 ± 0.016
0.535TrpIle: 0.535 ± 0.025
0.343TrpLys: 0.343 ± 0.02
1.589TrpLeu: 1.589 ± 0.05
0.362TrpMet: 0.362 ± 0.024
0.374TrpAsn: 0.374 ± 0.021
0.667TrpPro: 0.667 ± 0.031
0.571TrpGln: 0.571 ± 0.024
1.075TrpArg: 1.075 ± 0.038
0.656TrpSer: 0.656 ± 0.028
0.695TrpThr: 0.695 ± 0.032
1.284TrpVal: 1.284 ± 0.046
0.385TrpTrp: 0.385 ± 0.026
0.272TrpTyr: 0.272 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.533TyrAla: 2.533 ± 0.064
0.192TyrCys: 0.192 ± 0.014
1.303TyrAsp: 1.303 ± 0.044
1.122TyrGlu: 1.122 ± 0.046
0.681TyrPhe: 0.681 ± 0.031
1.914TyrGly: 1.914 ± 0.049
0.417TyrHis: 0.417 ± 0.02
0.823TyrIle: 0.823 ± 0.035
0.461TyrLys: 0.461 ± 0.028
2.115TyrLeu: 2.115 ± 0.047
0.34TyrMet: 0.34 ± 0.018
0.577TyrAsn: 0.577 ± 0.025
1.244TyrPro: 1.244 ± 0.042
0.813TyrGln: 0.813 ± 0.031
1.574TyrArg: 1.574 ± 0.052
1.201TyrSer: 1.201 ± 0.042
1.408TyrThr: 1.408 ± 0.044
1.616TyrVal: 1.616 ± 0.042
0.335TyrTrp: 0.335 ± 0.022
0.55TyrTyr: 0.55 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2382 proteins (817481 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski