Amino acid dipepetide frequency for Streptococcus satellite phage Javan156

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.799AlaAla: 1.799 ± 0.967
1.499AlaCys: 1.499 ± 0.526
1.799AlaAsp: 1.799 ± 0.704
5.396AlaGlu: 5.396 ± 1.532
1.799AlaPhe: 1.799 ± 0.567
2.698AlaGly: 2.698 ± 0.892
1.499AlaHis: 1.499 ± 0.905
2.698AlaIle: 2.698 ± 0.957
4.496AlaLys: 4.496 ± 1.191
5.396AlaLeu: 5.396 ± 1.317
1.199AlaMet: 1.199 ± 0.58
2.398AlaAsn: 2.398 ± 0.959
0.3AlaPro: 0.3 ± 0.343
2.998AlaGln: 2.998 ± 0.908
2.998AlaArg: 2.998 ± 0.891
3.297AlaSer: 3.297 ± 0.974
5.396AlaThr: 5.396 ± 0.946
5.096AlaVal: 5.096 ± 1.033
1.199AlaTrp: 1.199 ± 0.637
2.998AlaTyr: 2.998 ± 0.748
0.0AlaXaa: 0.0 ± 0.0
Cys
0.3CysAla: 0.3 ± 0.334
0.3CysCys: 0.3 ± 0.301
0.6CysAsp: 0.6 ± 0.42
0.3CysGlu: 0.3 ± 0.315
0.3CysPhe: 0.3 ± 0.315
0.6CysGly: 0.6 ± 0.351
0.3CysHis: 0.3 ± 0.297
0.3CysIle: 0.3 ± 0.265
0.3CysLys: 0.3 ± 0.267
0.3CysLeu: 0.3 ± 0.267
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.3CysArg: 0.3 ± 0.267
0.899CysSer: 0.899 ± 0.503
0.0CysThr: 0.0 ± 0.0
0.3CysVal: 0.3 ± 0.301
0.0CysTrp: 0.0 ± 0.0
0.899CysTyr: 0.899 ± 0.515
0.0CysXaa: 0.0 ± 0.0
Asp
0.899AspAla: 0.899 ± 0.427
0.6AspCys: 0.6 ± 0.388
5.995AspAsp: 5.995 ± 1.339
4.197AspGlu: 4.197 ± 1.295
2.698AspPhe: 2.698 ± 1.012
1.799AspGly: 1.799 ± 0.7
0.899AspHis: 0.899 ± 0.561
8.094AspIle: 8.094 ± 1.596
5.995AspLys: 5.995 ± 1.439
7.494AspLeu: 7.494 ± 1.34
3.297AspMet: 3.297 ± 1.028
1.499AspAsn: 1.499 ± 0.634
0.3AspPro: 0.3 ± 0.274
1.799AspGln: 1.799 ± 0.6
2.698AspArg: 2.698 ± 0.856
3.297AspSer: 3.297 ± 0.998
2.098AspThr: 2.098 ± 0.894
2.998AspVal: 2.998 ± 0.943
0.6AspTrp: 0.6 ± 0.379
4.496AspTyr: 4.496 ± 0.815
0.0AspXaa: 0.0 ± 0.0
Glu
5.695GluAla: 5.695 ± 1.836
0.6GluCys: 0.6 ± 0.668
3.897GluAsp: 3.897 ± 1.369
7.794GluGlu: 7.794 ± 2.286
1.499GluPhe: 1.499 ± 0.902
3.297GluGly: 3.297 ± 0.92
2.698GluHis: 2.698 ± 0.785
5.096GluIle: 5.096 ± 1.007
7.194GluLys: 7.194 ± 1.797
12.59GluLeu: 12.59 ± 2.236
4.496GluMet: 4.496 ± 0.968
4.197GluAsn: 4.197 ± 1.161
0.3GluPro: 0.3 ± 0.271
4.496GluGln: 4.496 ± 1.8
3.297GluArg: 3.297 ± 1.287
2.698GluSer: 2.698 ± 0.93
5.096GluThr: 5.096 ± 1.19
5.096GluVal: 5.096 ± 0.919
0.899GluTrp: 0.899 ± 0.421
3.297GluTyr: 3.297 ± 0.844
0.0GluXaa: 0.0 ± 0.0
Phe
1.499PheAla: 1.499 ± 0.587
0.3PheCys: 0.3 ± 0.301
3.297PheAsp: 3.297 ± 0.998
3.897PheGlu: 3.897 ± 0.879
3.297PhePhe: 3.297 ± 1.12
1.499PheGly: 1.499 ± 0.542
1.199PheHis: 1.199 ± 0.442
2.398PheIle: 2.398 ± 1.061
4.197PheLys: 4.197 ± 0.991
3.297PheLeu: 3.297 ± 0.841
0.6PheMet: 0.6 ± 0.37
2.098PheAsn: 2.098 ± 0.767
0.6PhePro: 0.6 ± 0.354
0.899PheGln: 0.899 ± 0.431
2.398PheArg: 2.398 ± 0.813
3.297PheSer: 3.297 ± 0.654
3.897PheThr: 3.897 ± 0.839
1.199PheVal: 1.199 ± 0.449
0.6PheTrp: 0.6 ± 0.503
0.899PheTyr: 0.899 ± 0.437
0.0PheXaa: 0.0 ± 0.0
Gly
1.799GlyAla: 1.799 ± 0.559
0.6GlyCys: 0.6 ± 0.362
2.998GlyAsp: 2.998 ± 0.704
2.998GlyGlu: 2.998 ± 0.934
1.499GlyPhe: 1.499 ± 0.779
2.098GlyGly: 2.098 ± 1.382
1.199GlyHis: 1.199 ± 0.526
4.496GlyIle: 4.496 ± 0.88
2.998GlyLys: 2.998 ± 0.965
4.496GlyLeu: 4.496 ± 1.082
0.3GlyMet: 0.3 ± 0.317
3.297GlyAsn: 3.297 ± 0.895
0.0GlyPro: 0.0 ± 0.0
2.098GlyGln: 2.098 ± 0.682
2.698GlyArg: 2.698 ± 1.46
0.6GlySer: 0.6 ± 0.408
2.398GlyThr: 2.398 ± 0.588
3.597GlyVal: 3.597 ± 1.103
0.3GlyTrp: 0.3 ± 0.301
3.597GlyTyr: 3.597 ± 0.851
0.0GlyXaa: 0.0 ± 0.0
His
1.799HisAla: 1.799 ± 0.708
0.0HisCys: 0.0 ± 0.0
0.6HisAsp: 0.6 ± 0.384
0.6HisGlu: 0.6 ± 0.456
0.899HisPhe: 0.899 ± 0.509
0.6HisGly: 0.6 ± 0.369
0.3HisHis: 0.3 ± 0.265
1.499HisIle: 1.499 ± 0.459
1.199HisLys: 1.199 ± 0.413
0.6HisLeu: 0.6 ± 0.391
0.899HisMet: 0.899 ± 0.428
1.499HisAsn: 1.499 ± 0.649
0.6HisPro: 0.6 ± 0.398
1.199HisGln: 1.199 ± 0.571
1.499HisArg: 1.499 ± 0.544
0.6HisSer: 0.6 ± 0.403
1.199HisThr: 1.199 ± 0.537
1.199HisVal: 1.199 ± 0.653
0.0HisTrp: 0.0 ± 0.0
1.199HisTyr: 1.199 ± 0.582
0.0HisXaa: 0.0 ± 0.0
Ile
5.695IleAla: 5.695 ± 1.277
0.899IleCys: 0.899 ± 0.503
4.197IleAsp: 4.197 ± 0.969
6.295IleGlu: 6.295 ± 1.148
3.597IlePhe: 3.597 ± 0.864
2.698IleGly: 2.698 ± 1.139
0.6IleHis: 0.6 ± 0.53
3.297IleIle: 3.297 ± 0.793
6.295IleLys: 6.295 ± 1.142
4.796IleLeu: 4.796 ± 0.77
0.899IleMet: 0.899 ± 0.416
2.398IleAsn: 2.398 ± 0.682
2.098IlePro: 2.098 ± 0.768
2.698IleGln: 2.698 ± 0.75
2.698IleArg: 2.698 ± 1.045
3.597IleSer: 3.597 ± 0.786
4.496IleThr: 4.496 ± 1.51
3.297IleVal: 3.297 ± 0.883
0.0IleTrp: 0.0 ± 0.0
2.098IleTyr: 2.098 ± 0.785
0.0IleXaa: 0.0 ± 0.0
Lys
6.894LysAla: 6.894 ± 1.363
0.0LysCys: 0.0 ± 0.0
5.096LysAsp: 5.096 ± 1.091
8.693LysGlu: 8.693 ± 1.479
3.897LysPhe: 3.897 ± 1.019
4.796LysGly: 4.796 ± 1.286
1.799LysHis: 1.799 ± 0.654
4.796LysIle: 4.796 ± 0.958
7.794LysLys: 7.794 ± 1.462
9.892LysLeu: 9.892 ± 1.628
2.098LysMet: 2.098 ± 0.852
4.496LysAsn: 4.496 ± 1.005
2.998LysPro: 2.998 ± 0.888
4.496LysGln: 4.496 ± 0.886
5.695LysArg: 5.695 ± 1.446
3.597LysSer: 3.597 ± 1.26
3.897LysThr: 3.897 ± 0.987
6.595LysVal: 6.595 ± 1.26
0.899LysTrp: 0.899 ± 0.425
2.998LysTyr: 2.998 ± 0.805
0.0LysXaa: 0.0 ± 0.0
Leu
4.796LeuAla: 4.796 ± 1.222
0.3LeuCys: 0.3 ± 0.265
8.393LeuAsp: 8.393 ± 0.846
11.091LeuGlu: 11.091 ± 2.043
2.998LeuPhe: 2.998 ± 1.07
5.396LeuGly: 5.396 ± 1.219
1.499LeuHis: 1.499 ± 0.553
4.496LeuIle: 4.496 ± 1.1
7.494LeuLys: 7.494 ± 1.14
8.993LeuLeu: 8.993 ± 1.507
2.098LeuMet: 2.098 ± 0.895
6.295LeuAsn: 6.295 ± 1.149
1.499LeuPro: 1.499 ± 0.595
3.597LeuGln: 3.597 ± 1.03
2.998LeuArg: 2.998 ± 0.721
10.192LeuSer: 10.192 ± 1.446
3.297LeuThr: 3.297 ± 0.867
4.496LeuVal: 4.496 ± 1.277
0.899LeuTrp: 0.899 ± 0.53
6.295LeuTyr: 6.295 ± 0.882
0.0LeuXaa: 0.0 ± 0.0
Met
2.698MetAla: 2.698 ± 0.854
0.0MetCys: 0.0 ± 0.0
0.899MetAsp: 0.899 ± 0.447
2.698MetGlu: 2.698 ± 0.976
0.6MetPhe: 0.6 ± 0.368
0.0MetGly: 0.0 ± 0.0
0.3MetHis: 0.3 ± 0.301
1.499MetIle: 1.499 ± 0.713
2.398MetLys: 2.398 ± 0.725
1.499MetLeu: 1.499 ± 0.657
0.0MetMet: 0.0 ± 0.0
1.799MetAsn: 1.799 ± 0.755
0.0MetPro: 0.0 ± 0.0
1.799MetGln: 1.799 ± 0.741
2.098MetArg: 2.098 ± 0.692
1.199MetSer: 1.199 ± 0.524
3.597MetThr: 3.597 ± 0.999
1.199MetVal: 1.199 ± 0.794
0.3MetTrp: 0.3 ± 0.328
1.199MetTyr: 1.199 ± 0.451
0.0MetXaa: 0.0 ± 0.0
Asn
3.897AsnAla: 3.897 ± 0.982
0.0AsnCys: 0.0 ± 0.0
2.098AsnAsp: 2.098 ± 0.723
2.698AsnGlu: 2.698 ± 1.13
2.098AsnPhe: 2.098 ± 0.852
2.998AsnGly: 2.998 ± 0.987
0.899AsnHis: 0.899 ± 0.4
3.597AsnIle: 3.597 ± 1.142
5.096AsnLys: 5.096 ± 1.125
2.698AsnLeu: 2.698 ± 0.871
0.899AsnMet: 0.899 ± 0.465
4.197AsnAsn: 4.197 ± 1.395
2.998AsnPro: 2.998 ± 0.687
4.197AsnGln: 4.197 ± 1.187
3.597AsnArg: 3.597 ± 0.984
3.597AsnSer: 3.597 ± 0.926
3.597AsnThr: 3.597 ± 0.927
2.098AsnVal: 2.098 ± 0.697
0.899AsnTrp: 0.899 ± 0.533
2.398AsnTyr: 2.398 ± 0.878
0.0AsnXaa: 0.0 ± 0.0
Pro
1.199ProAla: 1.199 ± 0.56
0.3ProCys: 0.3 ± 0.304
2.098ProAsp: 2.098 ± 0.61
2.398ProGlu: 2.398 ± 0.723
1.499ProPhe: 1.499 ± 0.588
0.3ProGly: 0.3 ± 0.265
0.0ProHis: 0.0 ± 0.0
0.899ProIle: 0.899 ± 0.455
3.597ProLys: 3.597 ± 0.999
1.499ProLeu: 1.499 ± 0.573
0.6ProMet: 0.6 ± 0.376
1.499ProAsn: 1.499 ± 0.571
1.499ProPro: 1.499 ± 1.014
0.6ProGln: 0.6 ± 0.4
1.199ProArg: 1.199 ± 0.514
1.199ProSer: 1.199 ± 0.539
2.098ProThr: 2.098 ± 0.774
0.899ProVal: 0.899 ± 0.431
0.0ProTrp: 0.0 ± 0.0
0.899ProTyr: 0.899 ± 0.707
0.0ProXaa: 0.0 ± 0.0
Gln
2.398GlnAla: 2.398 ± 0.777
0.0GlnCys: 0.0 ± 0.0
1.799GlnAsp: 1.799 ± 0.815
2.998GlnGlu: 2.998 ± 0.613
2.998GlnPhe: 2.998 ± 0.769
2.398GlnGly: 2.398 ± 0.944
0.6GlnHis: 0.6 ± 0.4
1.199GlnIle: 1.199 ± 0.627
4.197GlnLys: 4.197 ± 1.158
4.496GlnLeu: 4.496 ± 1.112
0.6GlnMet: 0.6 ± 0.419
2.998GlnAsn: 2.998 ± 0.833
2.398GlnPro: 2.398 ± 1.036
2.398GlnGln: 2.398 ± 1.073
1.199GlnArg: 1.199 ± 0.577
2.398GlnSer: 2.398 ± 0.82
3.597GlnThr: 3.597 ± 0.963
4.796GlnVal: 4.796 ± 1.327
0.3GlnTrp: 0.3 ± 0.274
1.799GlnTyr: 1.799 ± 0.863
0.0GlnXaa: 0.0 ± 0.0
Arg
2.998ArgAla: 2.998 ± 0.953
0.3ArgCys: 0.3 ± 0.317
4.197ArgAsp: 4.197 ± 0.965
2.698ArgGlu: 2.698 ± 0.815
1.199ArgPhe: 1.199 ± 0.621
0.6ArgGly: 0.6 ± 0.422
0.6ArgHis: 0.6 ± 0.337
2.698ArgIle: 2.698 ± 0.797
6.295ArgLys: 6.295 ± 1.157
5.995ArgLeu: 5.995 ± 1.178
0.899ArgMet: 0.899 ± 0.457
2.098ArgAsn: 2.098 ± 1.092
0.6ArgPro: 0.6 ± 0.53
4.197ArgGln: 4.197 ± 0.783
1.199ArgArg: 1.199 ± 0.638
2.998ArgSer: 2.998 ± 0.706
4.197ArgThr: 4.197 ± 1.323
2.998ArgVal: 2.998 ± 1.034
0.899ArgTrp: 0.899 ± 0.518
2.398ArgTyr: 2.398 ± 0.855
0.0ArgXaa: 0.0 ± 0.0
Ser
1.799SerAla: 1.799 ± 1.118
0.3SerCys: 0.3 ± 0.315
3.297SerAsp: 3.297 ± 0.932
4.197SerGlu: 4.197 ± 0.909
3.597SerPhe: 3.597 ± 0.882
2.998SerGly: 2.998 ± 1.269
0.0SerHis: 0.0 ± 0.0
4.197SerIle: 4.197 ± 0.862
6.295SerLys: 6.295 ± 1.725
4.197SerLeu: 4.197 ± 1.052
2.098SerMet: 2.098 ± 0.6
3.297SerAsn: 3.297 ± 1.021
2.398SerPro: 2.398 ± 0.815
2.098SerGln: 2.098 ± 0.767
3.297SerArg: 3.297 ± 1.039
2.398SerSer: 2.398 ± 0.647
1.499SerThr: 1.499 ± 0.498
2.698SerVal: 2.698 ± 0.92
1.199SerTrp: 1.199 ± 0.531
3.297SerTyr: 3.297 ± 0.708
0.0SerXaa: 0.0 ± 0.0
Thr
3.297ThrAla: 3.297 ± 0.982
0.0ThrCys: 0.0 ± 0.0
2.698ThrAsp: 2.698 ± 0.828
4.796ThrGlu: 4.796 ± 1.05
2.998ThrPhe: 2.998 ± 1.42
4.197ThrGly: 4.197 ± 0.754
1.499ThrHis: 1.499 ± 0.578
4.197ThrIle: 4.197 ± 1.452
4.496ThrLys: 4.496 ± 1.804
6.295ThrLeu: 6.295 ± 1.001
1.199ThrMet: 1.199 ± 0.51
2.998ThrAsn: 2.998 ± 0.987
3.597ThrPro: 3.597 ± 1.057
1.199ThrGln: 1.199 ± 0.697
1.799ThrArg: 1.799 ± 0.701
2.398ThrSer: 2.398 ± 0.647
4.796ThrThr: 4.796 ± 1.365
3.897ThrVal: 3.897 ± 0.977
0.0ThrTrp: 0.0 ± 0.0
5.096ThrTyr: 5.096 ± 0.928
0.0ThrXaa: 0.0 ± 0.0
Val
2.398ValAla: 2.398 ± 0.792
0.0ValCys: 0.0 ± 0.0
4.496ValAsp: 4.496 ± 0.982
6.295ValGlu: 6.295 ± 1.476
1.799ValPhe: 1.799 ± 0.662
2.398ValGly: 2.398 ± 1.021
0.3ValHis: 0.3 ± 0.267
5.695ValIle: 5.695 ± 1.058
5.396ValLys: 5.396 ± 1.219
6.595ValLeu: 6.595 ± 1.053
1.199ValMet: 1.199 ± 0.543
4.197ValAsn: 4.197 ± 0.798
1.499ValPro: 1.499 ± 0.586
0.3ValGln: 0.3 ± 0.283
2.998ValArg: 2.998 ± 0.668
5.096ValSer: 5.096 ± 0.938
4.496ValThr: 4.496 ± 1.674
3.297ValVal: 3.297 ± 1.041
0.6ValTrp: 0.6 ± 0.405
1.199ValTyr: 1.199 ± 0.438
0.0ValXaa: 0.0 ± 0.0
Trp
0.899TrpAla: 0.899 ± 0.676
0.0TrpCys: 0.0 ± 0.0
1.199TrpAsp: 1.199 ± 0.551
1.799TrpGlu: 1.799 ± 0.819
0.3TrpPhe: 0.3 ± 0.271
0.3TrpGly: 0.3 ± 0.265
0.0TrpHis: 0.0 ± 0.0
0.3TrpIle: 0.3 ± 0.286
0.6TrpLys: 0.6 ± 0.399
0.6TrpLeu: 0.6 ± 0.441
0.0TrpMet: 0.0 ± 0.0
0.3TrpAsn: 0.3 ± 0.271
0.0TrpPro: 0.0 ± 0.0
0.899TrpGln: 0.899 ± 0.469
0.6TrpArg: 0.6 ± 0.38
0.3TrpSer: 0.3 ± 0.267
0.3TrpThr: 0.3 ± 0.265
1.199TrpVal: 1.199 ± 0.555
0.3TrpTrp: 0.3 ± 0.267
0.3TrpTyr: 0.3 ± 0.334
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.197TyrAla: 4.197 ± 1.088
0.0TyrCys: 0.0 ± 0.0
2.098TyrAsp: 2.098 ± 0.8
2.398TyrGlu: 2.398 ± 0.741
1.799TyrPhe: 1.799 ± 0.595
2.398TyrGly: 2.398 ± 0.546
1.799TyrHis: 1.799 ± 0.55
1.199TyrIle: 1.199 ± 0.458
5.096TyrLys: 5.096 ± 1.272
5.695TyrLeu: 5.695 ± 0.858
2.098TyrMet: 2.098 ± 0.884
2.998TyrAsn: 2.998 ± 0.894
0.6TyrPro: 0.6 ± 0.428
3.597TyrGln: 3.597 ± 0.87
4.796TyrArg: 4.796 ± 1.086
1.499TyrSer: 1.499 ± 0.52
1.499TyrThr: 1.499 ± 0.648
3.297TyrVal: 3.297 ± 0.834
0.3TyrTrp: 0.3 ± 0.265
1.799TyrTyr: 1.799 ± 0.694
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 25 proteins (3337 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski