Amino acid dipepetide frequency for Sulfurihydrogenibium azorense (strain Az-Fu1 / DSM 15241 / OCM 825)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.173AlaAla: 3.173 ± 0.118	0.477AlaCys: 0.477 ± 0.033	2.555AlaAsp: 2.555 ± 0.073	3.417AlaGlu: 3.417 ± 0.089	2.621AlaPhe: 2.621 ± 0.073	3.807AlaGly: 3.807 ± 0.109	0.825AlaHis: 0.825 ± 0.041	4.971AlaIle: 4.971 ± 0.103	5.235AlaLys: 5.235 ± 0.103	5.72AlaLeu: 5.72 ± 0.118	1.211AlaMet: 1.211 ± 0.055	2.009AlaAsn: 2.009 ± 0.065	1.434AlaPro: 1.434 ± 0.063	1.547AlaGln: 1.547 ± 0.062	1.907AlaArg: 1.907 ± 0.074	2.858AlaSer: 2.858 ± 0.08	2.484AlaThr: 2.484 ± 0.071	4.748AlaVal: 4.748 ± 0.114	0.329AlaTrp: 0.329 ± 0.028	2.298AlaTyr: 2.298 ± 0.07	0.0AlaXaa: 0.0 ± 0.0
Cys	0.325CysAla: 0.325 ± 0.024	0.096CysCys: 0.096 ± 0.015	0.397CysAsp: 0.397 ± 0.027	0.479CysGlu: 0.479 ± 0.031	0.336CysPhe: 0.336 ± 0.026	0.689CysGly: 0.689 ± 0.044	0.209CysHis: 0.209 ± 0.027	0.559CysIle: 0.559 ± 0.032	0.618CysLys: 0.618 ± 0.034	0.507CysLeu: 0.507 ± 0.03	0.17CysMet: 0.17 ± 0.02	0.354CysAsn: 0.354 ± 0.026	0.479CysPro: 0.479 ± 0.033	0.264CysGln: 0.264 ± 0.026	0.274CysArg: 0.274 ± 0.021	0.45CysSer: 0.45 ± 0.036	0.272CysThr: 0.272 ± 0.024	0.479CysVal: 0.479 ± 0.029	0.065CysTrp: 0.065 ± 0.013	0.323CysTyr: 0.323 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	2.455AspAla: 2.455 ± 0.08	0.344AspCys: 0.344 ± 0.025	2.015AspAsp: 2.015 ± 0.072	3.953AspGlu: 3.953 ± 0.107	3.365AspPhe: 3.365 ± 0.087	2.651AspGly: 2.651 ± 0.059	0.567AspHis: 0.567 ± 0.04	6.011AspIle: 6.011 ± 0.115	5.534AspLys: 5.534 ± 0.103	6.275AspLeu: 6.275 ± 0.12	0.982AspMet: 0.982 ± 0.047	2.253AspAsn: 2.253 ± 0.071	2.079AspPro: 2.079 ± 0.064	1.064AspGln: 1.064 ± 0.041	2.023AspArg: 2.023 ± 0.071	2.293AspSer: 2.293 ± 0.075	2.484AspThr: 2.484 ± 0.063	3.787AspVal: 3.787 ± 0.078	0.516AspTrp: 0.516 ± 0.031	3.012AspTyr: 3.012 ± 0.07	0.0AspXaa: 0.0 ± 0.0
Glu	4.09GluAla: 4.09 ± 0.108	0.43GluCys: 0.43 ± 0.031	4.652GluAsp: 4.652 ± 0.091	8.136GluGlu: 8.136 ± 0.175	3.554GluPhe: 3.554 ± 0.091	5.01GluGly: 5.01 ± 0.101	0.732GluHis: 0.732 ± 0.037	7.834GluIle: 7.834 ± 0.155	10.808GluLys: 10.808 ± 0.213	5.923GluLeu: 5.923 ± 0.113	1.465GluMet: 1.465 ± 0.056	5.284GluAsn: 5.284 ± 0.104	1.577GluPro: 1.577 ± 0.062	1.049GluGln: 1.049 ± 0.048	3.261GluArg: 3.261 ± 0.08	3.64GluSer: 3.64 ± 0.097	2.979GluThr: 2.979 ± 0.077	5.732GluVal: 5.732 ± 0.115	0.503GluTrp: 0.503 ± 0.036	2.889GluTyr: 2.889 ± 0.08	0.0GluXaa: 0.0 ± 0.0
Phe	2.43PheAla: 2.43 ± 0.074	0.379PheCys: 0.379 ± 0.027	2.67PheAsp: 2.67 ± 0.064	3.592PheGlu: 3.592 ± 0.083	2.774PhePhe: 2.774 ± 0.097	3.19PheGly: 3.19 ± 0.086	0.72PheHis: 0.72 ± 0.035	4.732PheIle: 4.732 ± 0.137	4.327PheLys: 4.327 ± 0.103	5.88PheLeu: 5.88 ± 0.174	1.019PheMet: 1.019 ± 0.048	2.428PheAsn: 2.428 ± 0.076	1.614PhePro: 1.614 ± 0.059	1.162PheGln: 1.162 ± 0.048	1.459PheArg: 1.459 ± 0.05	3.275PheSer: 3.275 ± 0.099	2.459PheThr: 2.459 ± 0.073	3.351PheVal: 3.351 ± 0.097	0.409PheTrp: 0.409 ± 0.033	2.623PheTyr: 2.623 ± 0.093	0.0PheXaa: 0.0 ± 0.0
Gly	3.048GlyAla: 3.048 ± 0.092	0.624GlyCys: 0.624 ± 0.043	2.923GlyAsp: 2.923 ± 0.069	3.926GlyGlu: 3.926 ± 0.092	3.721GlyPhe: 3.721 ± 0.092	3.84GlyGly: 3.84 ± 0.106	0.992GlyHis: 0.992 ± 0.049	5.792GlyIle: 5.792 ± 0.114	6.238GlyLys: 6.238 ± 0.128	5.849GlyLeu: 5.849 ± 0.12	1.338GlyMet: 1.338 ± 0.052	2.516GlyAsn: 2.516 ± 0.079	1.082GlyPro: 1.082 ± 0.051	1.446GlyGln: 1.446 ± 0.053	2.416GlyArg: 2.416 ± 0.088	3.425GlySer: 3.425 ± 0.098	2.756GlyThr: 2.756 ± 0.089	4.172GlyVal: 4.172 ± 0.093	0.556GlyTrp: 0.556 ± 0.033	3.093GlyTyr: 3.093 ± 0.084	0.0GlyXaa: 0.0 ± 0.0
His	0.657HisAla: 0.657 ± 0.043	0.174HisCys: 0.174 ± 0.019	0.595HisAsp: 0.595 ± 0.032	0.687HisGlu: 0.687 ± 0.034	0.739HisPhe: 0.739 ± 0.041	0.968HisGly: 0.968 ± 0.045	0.374HisHis: 0.374 ± 0.034	1.365HisIle: 1.365 ± 0.052	1.107HisLys: 1.107 ± 0.047	1.575HisLeu: 1.575 ± 0.064	0.27HisMet: 0.27 ± 0.025	0.636HisAsn: 0.636 ± 0.034	0.853HisPro: 0.853 ± 0.044	0.423HisGln: 0.423 ± 0.03	0.583HisArg: 0.583 ± 0.033	0.837HisSer: 0.837 ± 0.039	0.7HisThr: 0.7 ± 0.035	0.739HisVal: 0.739 ± 0.041	0.129HisTrp: 0.129 ± 0.016	0.718HisTyr: 0.718 ± 0.04	0.0HisXaa: 0.0 ± 0.0
Ile	5.123IleAla: 5.123 ± 0.114	0.601IleCys: 0.601 ± 0.038	5.307IleAsp: 5.307 ± 0.1	7.49IleGlu: 7.49 ± 0.13	4.255IlePhe: 4.255 ± 0.119	5.278IleGly: 5.278 ± 0.112	1.338IleHis: 1.338 ± 0.053	6.747IleIle: 6.747 ± 0.127	9.155IleLys: 9.155 ± 0.128	9.566IleLeu: 9.566 ± 0.173	1.352IleMet: 1.352 ± 0.058	4.548IleAsn: 4.548 ± 0.099	4.124IlePro: 4.124 ± 0.084	2.412IleGln: 2.412 ± 0.079	2.836IleArg: 2.836 ± 0.083	5.293IleSer: 5.293 ± 0.12	5.196IleThr: 5.196 ± 0.094	6.326IleVal: 6.326 ± 0.121	0.507IleTrp: 0.507 ± 0.03	3.734IleTyr: 3.734 ± 0.083	0.0IleXaa: 0.0 ± 0.0
Lys	5.589LysAla: 5.589 ± 0.103	0.487LysCys: 0.487 ± 0.031	6.79LysAsp: 6.79 ± 0.137	10.751LysGlu: 10.751 ± 0.185	3.527LysPhe: 3.527 ± 0.082	5.297LysGly: 5.297 ± 0.115	1.352LysHis: 1.352 ± 0.06	8.916LysIle: 8.916 ± 0.128	9.169LysLys: 9.169 ± 0.159	8.57LysLeu: 8.57 ± 0.164	1.813LysMet: 1.813 ± 0.066	5.767LysAsn: 5.767 ± 0.129	3.472LysPro: 3.472 ± 0.09	3.04LysGln: 3.04 ± 0.093	3.529LysArg: 3.529 ± 0.079	5.141LysSer: 5.141 ± 0.107	4.605LysThr: 4.605 ± 0.093	7.625LysVal: 7.625 ± 0.129	0.714LysTrp: 0.714 ± 0.037	3.904LysTyr: 3.904 ± 0.088	0.0LysXaa: 0.0 ± 0.0
Leu	5.559LeuAla: 5.559 ± 0.129	0.583LeuCys: 0.583 ± 0.037	5.309LeuAsp: 5.309 ± 0.121	8.05LeuGlu: 8.05 ± 0.13	4.491LeuPhe: 4.491 ± 0.114	5.753LeuGly: 5.753 ± 0.115	1.371LeuHis: 1.371 ± 0.048	8.318LeuIle: 8.318 ± 0.158	11.483LeuLys: 11.483 ± 0.173	8.646LeuLeu: 8.646 ± 0.146	1.817LeuMet: 1.817 ± 0.058	5.446LeuAsn: 5.446 ± 0.11	3.901LeuPro: 3.901 ± 0.098	2.776LeuGln: 2.776 ± 0.09	3.468LeuArg: 3.468 ± 0.098	7.132LeuSer: 7.132 ± 0.141	4.998LeuThr: 4.998 ± 0.096	5.417LeuVal: 5.417 ± 0.109	0.773LeuTrp: 0.773 ± 0.043	3.822LeuTyr: 3.822 ± 0.095	0.002LeuXaa: 0.002 ± 0.002
Met	1.459MetAla: 1.459 ± 0.063	0.133MetCys: 0.133 ± 0.016	0.89MetAsp: 0.89 ± 0.04	1.628MetGlu: 1.628 ± 0.062	0.943MetPhe: 0.943 ± 0.039	1.211MetGly: 1.211 ± 0.049	0.231MetHis: 0.231 ± 0.022	1.624MetIle: 1.624 ± 0.055	1.991MetLys: 1.991 ± 0.064	1.604MetLeu: 1.604 ± 0.064	0.432MetMet: 0.432 ± 0.027	0.751MetAsn: 0.751 ± 0.037	0.749MetPro: 0.749 ± 0.041	0.374MetGln: 0.374 ± 0.029	0.802MetArg: 0.802 ± 0.043	1.06MetSer: 1.06 ± 0.047	0.771MetThr: 0.771 ± 0.039	1.389MetVal: 1.389 ± 0.048	0.164MetTrp: 0.164 ± 0.018	0.7MetTyr: 0.7 ± 0.039	0.0MetXaa: 0.0 ± 0.0
Asn	2.199AsnAla: 2.199 ± 0.069	0.424AsnCys: 0.424 ± 0.032	1.974AsnAsp: 1.974 ± 0.07	2.807AsnGlu: 2.807 ± 0.084	2.883AsnPhe: 2.883 ± 0.089	2.402AsnGly: 2.402 ± 0.069	0.628AsnHis: 0.628 ± 0.036	5.143AsnIle: 5.143 ± 0.103	4.116AsnLys: 4.116 ± 0.088	6.195AsnLeu: 6.195 ± 0.142	0.765AsnMet: 0.765 ± 0.037	2.105AsnAsn: 2.105 ± 0.079	3.02AsnPro: 3.02 ± 0.08	1.987AsnGln: 1.987 ± 0.069	1.573AsnArg: 1.573 ± 0.065	2.4AsnSer: 2.4 ± 0.075	2.381AsnThr: 2.381 ± 0.07	3.349AsnVal: 3.349 ± 0.081	0.473AsnTrp: 0.473 ± 0.033	2.529AsnTyr: 2.529 ± 0.082	0.0AsnXaa: 0.0 ± 0.0
Pro	1.807ProAla: 1.807 ± 0.074	0.26ProCys: 0.26 ± 0.025	2.318ProAsp: 2.318 ± 0.069	2.999ProGlu: 2.999 ± 0.085	2.056ProPhe: 2.056 ± 0.067	1.608ProGly: 1.608 ± 0.062	0.665ProHis: 0.665 ± 0.039	3.208ProIle: 3.208 ± 0.087	2.999ProLys: 2.999 ± 0.084	3.194ProLeu: 3.194 ± 0.071	0.663ProMet: 0.663 ± 0.035	1.743ProAsn: 1.743 ± 0.057	1.43ProPro: 1.43 ± 0.059	1.307ProGln: 1.307 ± 0.059	1.007ProArg: 1.007 ± 0.052	2.183ProSer: 2.183 ± 0.064	1.911ProThr: 1.911 ± 0.057	2.938ProVal: 2.938 ± 0.089	0.282ProTrp: 0.282 ± 0.024	1.794ProTyr: 1.794 ± 0.071	0.0ProXaa: 0.0 ± 0.0
Gln	1.649GlnAla: 1.649 ± 0.058	0.121GlnCys: 0.121 ± 0.016	1.626GlnAsp: 1.626 ± 0.06	2.846GlnGlu: 2.846 ± 0.068	0.974GlnPhe: 0.974 ± 0.042	1.322GlnGly: 1.322 ± 0.054	0.389GlnHis: 0.389 ± 0.03	2.502GlnIle: 2.502 ± 0.076	2.649GlnLys: 2.649 ± 0.084	2.611GlnLeu: 2.611 ± 0.083	0.595GlnMet: 0.595 ± 0.033	1.473GlnAsn: 1.473 ± 0.061	0.966GlnPro: 0.966 ± 0.042	0.955GlnGln: 0.955 ± 0.057	0.949GlnArg: 0.949 ± 0.049	1.367GlnSer: 1.367 ± 0.058	1.385GlnThr: 1.385 ± 0.053	1.876GlnVal: 1.876 ± 0.068	0.268GlnTrp: 0.268 ± 0.023	0.935GlnTyr: 0.935 ± 0.045	0.0GlnXaa: 0.0 ± 0.0
Arg	1.643ArgAla: 1.643 ± 0.063	0.25ArgCys: 0.25 ± 0.027	1.884ArgAsp: 1.884 ± 0.063	3.353ArgGlu: 3.353 ± 0.091	2.011ArgPhe: 2.011 ± 0.061	1.919ArgGly: 1.919 ± 0.069	0.495ArgHis: 0.495 ± 0.032	3.034ArgIle: 3.034 ± 0.084	3.474ArgLys: 3.474 ± 0.09	3.502ArgLeu: 3.502 ± 0.084	0.798ArgMet: 0.798 ± 0.041	1.573ArgAsn: 1.573 ± 0.049	1.303ArgPro: 1.303 ± 0.05	1.16ArgGln: 1.16 ± 0.053	1.493ArgArg: 1.493 ± 0.059	1.581ArgSer: 1.581 ± 0.055	1.307ArgThr: 1.307 ± 0.058	2.476ArgVal: 2.476 ± 0.069	0.352ArgTrp: 0.352 ± 0.031	1.569ArgTyr: 1.569 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	2.563SerAla: 2.563 ± 0.069	0.556SerCys: 0.556 ± 0.033	2.69SerAsp: 2.69 ± 0.073	3.073SerGlu: 3.073 ± 0.077	3.443SerPhe: 3.443 ± 0.103	3.687SerGly: 3.687 ± 0.093	0.829SerHis: 0.829 ± 0.039	5.282SerIle: 5.282 ± 0.12	5.35SerLys: 5.35 ± 0.091	6.316SerLeu: 6.316 ± 0.125	1.135SerMet: 1.135 ± 0.048	2.404SerAsn: 2.404 ± 0.083	2.025SerPro: 2.025 ± 0.057	1.919SerGln: 1.919 ± 0.064	1.745SerArg: 1.745 ± 0.056	3.222SerSer: 3.222 ± 0.099	2.42SerThr: 2.42 ± 0.067	3.762SerVal: 3.762 ± 0.087	0.45SerTrp: 0.45 ± 0.031	2.784SerTyr: 2.784 ± 0.081	0.0SerXaa: 0.0 ± 0.0
Thr	2.946ThrAla: 2.946 ± 0.078	0.327ThrCys: 0.327 ± 0.023	2.437ThrAsp: 2.437 ± 0.068	2.655ThrGlu: 2.655 ± 0.073	2.445ThrPhe: 2.445 ± 0.07	3.376ThrGly: 3.376 ± 0.075	0.636ThrHis: 0.636 ± 0.035	3.592ThrIle: 3.592 ± 0.081	3.597ThrLys: 3.597 ± 0.088	4.793ThrLeu: 4.793 ± 0.09	0.708ThrMet: 0.708 ± 0.037	1.88ThrAsn: 1.88 ± 0.059	2.177ThrPro: 2.177 ± 0.071	1.518ThrGln: 1.518 ± 0.053	1.264ThrArg: 1.264 ± 0.055	2.298ThrSer: 2.298 ± 0.069	2.4ThrThr: 2.4 ± 0.077	4.071ThrVal: 4.071 ± 0.1	0.268ThrTrp: 0.268 ± 0.023	2.015ThrTyr: 2.015 ± 0.073	0.0ThrXaa: 0.0 ± 0.0
Val	4.417ValAla: 4.417 ± 0.104	0.673ValCys: 0.673 ± 0.037	3.981ValAsp: 3.981 ± 0.079	6.09ValGlu: 6.09 ± 0.123	3.588ValPhe: 3.588 ± 0.085	4.544ValGly: 4.544 ± 0.119	0.923ValHis: 0.923 ± 0.049	6.694ValIle: 6.694 ± 0.127	7.113ValLys: 7.113 ± 0.112	6.94ValLeu: 6.94 ± 0.136	1.483ValMet: 1.483 ± 0.064	3.419ValAsn: 3.419 ± 0.074	2.066ValPro: 2.066 ± 0.063	1.129ValGln: 1.129 ± 0.045	2.578ValArg: 2.578 ± 0.087	4.403ValSer: 4.403 ± 0.096	1.36ValThr: 1.36 ± 0.059	5.622ValVal: 5.622 ± 0.122	0.52ValTrp: 0.52 ± 0.031	3.153ValTyr: 3.153 ± 0.079	0.0ValXaa: 0.0 ± 0.0
Trp	0.376TrpAla: 0.376 ± 0.028	0.072TrpCys: 0.072 ± 0.013	0.432TrpAsp: 0.432 ± 0.035	0.628TrpGlu: 0.628 ± 0.038	0.438TrpPhe: 0.438 ± 0.028	0.499TrpGly: 0.499 ± 0.031	0.153TrpHis: 0.153 ± 0.017	0.853TrpIle: 0.853 ± 0.043	0.696TrpLys: 0.696 ± 0.043	0.743TrpLeu: 0.743 ± 0.035	0.198TrpMet: 0.198 ± 0.023	0.37TrpAsn: 0.37 ± 0.03	0.166TrpPro: 0.166 ± 0.015	0.344TrpGln: 0.344 ± 0.024	0.284TrpArg: 0.284 ± 0.026	0.36TrpSer: 0.36 ± 0.026	0.34TrpThr: 0.34 ± 0.027	0.415TrpVal: 0.415 ± 0.03	0.108TrpTrp: 0.108 ± 0.013	0.295TrpTyr: 0.295 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.119TyrAla: 2.119 ± 0.061	0.333TyrCys: 0.333 ± 0.027	2.222TyrAsp: 2.222 ± 0.073	2.989TyrGlu: 2.989 ± 0.085	2.328TyrPhe: 2.328 ± 0.078	2.698TyrGly: 2.698 ± 0.076	0.7TyrHis: 0.7 ± 0.035	4.012TyrIle: 4.012 ± 0.087	4.399TyrLys: 4.399 ± 0.113	4.705TyrLeu: 4.705 ± 0.116	0.691TyrMet: 0.691 ± 0.041	2.396TyrAsn: 2.396 ± 0.089	1.856TyrPro: 1.856 ± 0.056	1.584TyrGln: 1.584 ± 0.06	1.725TyrArg: 1.725 ± 0.066	2.433TyrSer: 2.433 ± 0.078	2.195TyrThr: 2.195 ± 0.066	2.422TyrVal: 2.422 ± 0.08	0.385TyrTrp: 0.385 ± 0.028	2.103TyrTyr: 2.103 ± 0.074	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1708 proteins (511207 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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