Amino acid dipepetide frequency for Microviridae Bog9017_22

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.953AlaAla: 13.953 ± 5.442
0.0AlaCys: 0.0 ± 0.0
6.977AlaAsp: 6.977 ± 0.91
3.101AlaGlu: 3.101 ± 1.748
2.326AlaPhe: 2.326 ± 1.252
6.977AlaGly: 6.977 ± 2.506
0.775AlaHis: 0.775 ± 0.747
3.876AlaIle: 3.876 ± 2.151
6.202AlaLys: 6.202 ± 4.994
4.651AlaLeu: 4.651 ± 1.552
2.326AlaMet: 2.326 ± 1.337
6.202AlaAsn: 6.202 ± 2.771
6.977AlaPro: 6.977 ± 3.232
3.876AlaGln: 3.876 ± 2.54
2.326AlaArg: 2.326 ± 0.992
5.426AlaSer: 5.426 ± 2.517
3.876AlaThr: 3.876 ± 1.35
6.977AlaVal: 6.977 ± 2.835
0.775AlaTrp: 0.775 ± 0.538
2.326AlaTyr: 2.326 ± 0.482
0.0AlaXaa: 0.0 ± 0.0
Cys
0.775CysAla: 0.775 ± 0.747
0.775CysCys: 0.775 ± 0.747
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.775CysGly: 0.775 ± 0.747
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
1.55CysLys: 1.55 ± 1.077
0.775CysLeu: 0.775 ± 0.538
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.775CysPro: 0.775 ± 0.747
1.55CysGln: 1.55 ± 0.594
0.775CysArg: 0.775 ± 0.747
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.775CysVal: 0.775 ± 0.747
1.55CysTrp: 1.55 ± 0.644
0.775CysTyr: 0.775 ± 0.747
0.0CysXaa: 0.0 ± 0.0
Asp
1.55AspAla: 1.55 ± 1.311
0.0AspCys: 0.0 ± 0.0
4.651AspAsp: 4.651 ± 1.498
2.326AspGlu: 2.326 ± 1.168
4.651AspPhe: 4.651 ± 2.482
2.326AspGly: 2.326 ± 1.929
2.326AspHis: 2.326 ± 0.923
3.101AspIle: 3.101 ± 1.142
0.775AspLys: 0.775 ± 1.185
7.752AspLeu: 7.752 ± 1.506
0.775AspMet: 0.775 ± 0.538
3.101AspAsn: 3.101 ± 0.953
2.326AspPro: 2.326 ± 1.615
1.55AspGln: 1.55 ± 0.594
4.651AspArg: 4.651 ± 1.845
4.651AspSer: 4.651 ± 1.604
3.876AspThr: 3.876 ± 2.151
6.977AspVal: 6.977 ± 1.923
2.326AspTrp: 2.326 ± 1.615
2.326AspTyr: 2.326 ± 0.482
0.0AspXaa: 0.0 ± 0.0
Glu
3.876GluAla: 3.876 ± 1.897
0.0GluCys: 0.0 ± 0.0
2.326GluAsp: 2.326 ± 1.615
0.0GluGlu: 0.0 ± 0.0
1.55GluPhe: 1.55 ± 1.077
0.775GluGly: 0.775 ± 0.538
2.326GluHis: 2.326 ± 0.923
0.0GluIle: 0.0 ± 0.0
0.0GluLys: 0.0 ± 0.0
5.426GluLeu: 5.426 ± 2.117
1.55GluMet: 1.55 ± 1.311
1.55GluAsn: 1.55 ± 1.077
3.876GluPro: 3.876 ± 1.861
3.101GluGln: 3.101 ± 2.109
2.326GluArg: 2.326 ± 1.384
2.326GluSer: 2.326 ± 0.482
0.775GluThr: 0.775 ± 0.538
1.55GluVal: 1.55 ± 1.093
0.0GluTrp: 0.0 ± 0.0
4.651GluTyr: 4.651 ± 1.594
0.0GluXaa: 0.0 ± 0.0
Phe
5.426PheAla: 5.426 ± 2.943
0.0PheCys: 0.0 ± 0.0
3.101PheAsp: 3.101 ± 1.587
1.55PheGlu: 1.55 ± 1.093
3.101PhePhe: 3.101 ± 2.002
1.55PheGly: 1.55 ± 0.644
2.326PheHis: 2.326 ± 1.286
0.775PheIle: 0.775 ± 0.538
1.55PheLys: 1.55 ± 0.862
3.876PheLeu: 3.876 ± 1.396
0.0PheMet: 0.0 ± 0.0
3.101PheAsn: 3.101 ± 1.392
0.775PhePro: 0.775 ± 0.747
3.101PheGln: 3.101 ± 1.587
2.326PheArg: 2.326 ± 1.286
3.876PheSer: 3.876 ± 1.35
3.876PheThr: 3.876 ± 1.35
1.55PheVal: 1.55 ± 0.644
0.0PheTrp: 0.0 ± 0.0
3.101PheTyr: 3.101 ± 1.187
0.0PheXaa: 0.0 ± 0.0
Gly
5.426GlyAla: 5.426 ± 1.952
0.775GlyCys: 0.775 ± 0.538
1.55GlyAsp: 1.55 ± 1.077
3.876GlyGlu: 3.876 ± 1.861
3.876GlyPhe: 3.876 ± 2.012
3.101GlyGly: 3.101 ± 0.55
2.326GlyHis: 2.326 ± 0.923
0.775GlyIle: 0.775 ± 0.655
1.55GlyLys: 1.55 ± 0.594
8.527GlyLeu: 8.527 ± 2.301
0.775GlyMet: 0.775 ± 0.538
2.326GlyAsn: 2.326 ± 0.924
0.775GlyPro: 0.775 ± 0.538
0.775GlyGln: 0.775 ± 0.747
1.55GlyArg: 1.55 ± 0.644
6.977GlySer: 6.977 ± 2.928
3.101GlyThr: 3.101 ± 0.55
3.101GlyVal: 3.101 ± 0.55
1.55GlyTrp: 1.55 ± 0.862
6.202GlyTyr: 6.202 ± 2.576
0.0GlyXaa: 0.0 ± 0.0
His
2.326HisAla: 2.326 ± 0.923
0.775HisCys: 0.775 ± 0.538
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
1.55HisPhe: 1.55 ± 1.077
3.101HisGly: 3.101 ± 1.412
0.0HisHis: 0.0 ± 0.0
1.55HisIle: 1.55 ± 0.644
1.55HisLys: 1.55 ± 1.077
1.55HisLeu: 1.55 ± 0.644
1.55HisMet: 1.55 ± 0.903
0.775HisAsn: 0.775 ± 0.747
0.0HisPro: 0.0 ± 0.0
1.55HisGln: 1.55 ± 1.493
2.326HisArg: 2.326 ± 1.929
0.775HisSer: 0.775 ± 0.538
1.55HisThr: 1.55 ± 0.644
0.775HisVal: 0.775 ± 0.747
0.0HisTrp: 0.0 ± 0.0
3.101HisTyr: 3.101 ± 1.628
0.0HisXaa: 0.0 ± 0.0
Ile
2.326IleAla: 2.326 ± 0.482
0.0IleCys: 0.0 ± 0.0
3.101IleAsp: 3.101 ± 1.142
3.101IleGlu: 3.101 ± 1.187
1.55IlePhe: 1.55 ± 0.644
2.326IleGly: 2.326 ± 1.615
0.0IleHis: 0.0 ± 0.0
2.326IleIle: 2.326 ± 0.482
3.101IleLys: 3.101 ± 1.841
3.101IleLeu: 3.101 ± 0.954
1.55IleMet: 1.55 ± 0.594
1.55IleAsn: 1.55 ± 0.594
3.876IlePro: 3.876 ± 0.975
2.326IleGln: 2.326 ± 0.924
0.775IleArg: 0.775 ± 0.655
3.876IleSer: 3.876 ± 0.975
0.775IleThr: 0.775 ± 0.655
0.775IleVal: 0.775 ± 0.655
0.0IleTrp: 0.0 ± 0.0
4.651IleTyr: 4.651 ± 1.498
0.0IleXaa: 0.0 ± 0.0
Lys
3.101LysAla: 3.101 ± 2.109
1.55LysCys: 1.55 ± 0.644
1.55LysAsp: 1.55 ± 1.093
4.651LysGlu: 4.651 ± 1.862
0.0LysPhe: 0.0 ± 0.0
3.101LysGly: 3.101 ± 1.288
0.775LysHis: 0.775 ± 1.185
2.326LysIle: 2.326 ± 0.992
1.55LysLys: 1.55 ± 1.416
1.55LysLeu: 1.55 ± 0.644
0.775LysMet: 0.775 ± 0.747
3.101LysAsn: 3.101 ± 2.109
0.0LysPro: 0.0 ± 0.0
3.101LysGln: 3.101 ± 1.723
1.55LysArg: 1.55 ± 1.416
6.977LysSer: 6.977 ± 3.5
2.326LysThr: 2.326 ± 2.215
3.101LysVal: 3.101 ± 0.55
0.0LysTrp: 0.0 ± 0.0
0.775LysTyr: 0.775 ± 0.747
0.0LysXaa: 0.0 ± 0.0
Leu
6.977LeuAla: 6.977 ± 1.664
0.775LeuCys: 0.775 ± 0.747
4.651LeuAsp: 4.651 ± 1.552
3.101LeuGlu: 3.101 ± 1.367
3.876LeuPhe: 3.876 ± 1.827
2.326LeuGly: 2.326 ± 1.104
1.55LeuHis: 1.55 ± 0.644
3.876LeuIle: 3.876 ± 0.975
5.426LeuLys: 5.426 ± 3.186
6.202LeuLeu: 6.202 ± 2.471
1.55LeuMet: 1.55 ± 0.8
7.752LeuAsn: 7.752 ± 3.12
6.977LeuPro: 6.977 ± 0.91
8.527LeuGln: 8.527 ± 2.301
5.426LeuArg: 5.426 ± 0.549
7.752LeuSer: 7.752 ± 2.741
3.876LeuThr: 3.876 ± 1.892
5.426LeuVal: 5.426 ± 1.303
0.775LeuTrp: 0.775 ± 0.538
0.775LeuTyr: 0.775 ± 0.538
0.0LeuXaa: 0.0 ± 0.0
Met
2.326MetAla: 2.326 ± 1.129
0.0MetCys: 0.0 ± 0.0
0.775MetAsp: 0.775 ± 0.655
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
0.775MetGly: 0.775 ± 0.538
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
3.101MetLeu: 3.101 ± 1.748
0.0MetMet: 0.0 ± 0.0
1.55MetAsn: 1.55 ± 1.248
1.55MetPro: 1.55 ± 0.862
3.101MetGln: 3.101 ± 0.954
0.0MetArg: 0.0 ± 0.0
3.876MetSer: 3.876 ± 1.498
2.326MetThr: 2.326 ± 1.129
0.775MetVal: 0.775 ± 0.655
0.775MetTrp: 0.775 ± 0.655
0.775MetTyr: 0.775 ± 0.538
0.0MetXaa: 0.0 ± 0.0
Asn
6.977AsnAla: 6.977 ± 2.404
1.55AsnCys: 1.55 ± 1.077
3.101AsnAsp: 3.101 ± 0.954
1.55AsnGlu: 1.55 ± 0.644
0.775AsnPhe: 0.775 ± 1.185
3.101AsnGly: 3.101 ± 1.108
0.775AsnHis: 0.775 ± 0.538
3.101AsnIle: 3.101 ± 1.187
0.775AsnLys: 0.775 ± 0.538
7.752AsnLeu: 7.752 ± 2.78
1.55AsnMet: 1.55 ± 0.594
2.326AsnAsn: 2.326 ± 1.129
0.775AsnPro: 0.775 ± 0.655
1.55AsnGln: 1.55 ± 0.594
3.876AsnArg: 3.876 ± 0.694
2.326AsnSer: 2.326 ± 1.129
3.101AsnThr: 3.101 ± 2.153
3.101AsnVal: 3.101 ± 2.109
0.775AsnTrp: 0.775 ± 1.185
3.101AsnTyr: 3.101 ± 1.288
0.0AsnXaa: 0.0 ± 0.0
Pro
3.101ProAla: 3.101 ± 1.748
2.326ProCys: 2.326 ± 1.473
5.426ProAsp: 5.426 ± 2.191
2.326ProGlu: 2.326 ± 0.923
3.101ProPhe: 3.101 ± 2.002
2.326ProGly: 2.326 ± 0.921
1.55ProHis: 1.55 ± 1.493
2.326ProIle: 2.326 ± 1.615
0.775ProLys: 0.775 ± 0.655
3.876ProLeu: 3.876 ± 1.127
1.55ProMet: 1.55 ± 0.644
3.101ProAsn: 3.101 ± 0.994
1.55ProPro: 1.55 ± 1.416
3.101ProGln: 3.101 ± 1.392
3.101ProArg: 3.101 ± 0.55
4.651ProSer: 4.651 ± 2.482
2.326ProThr: 2.326 ± 0.924
5.426ProVal: 5.426 ± 0.899
0.775ProTrp: 0.775 ± 0.538
1.55ProTyr: 1.55 ± 1.077
0.0ProXaa: 0.0 ± 0.0
Gln
3.876GlnAla: 3.876 ± 2.077
0.0GlnCys: 0.0 ± 0.0
0.775GlnAsp: 0.775 ± 0.655
3.876GlnGlu: 3.876 ± 1.564
3.101GlnPhe: 3.101 ± 1.108
3.876GlnGly: 3.876 ± 1.457
0.0GlnHis: 0.0 ± 0.0
2.326GlnIle: 2.326 ± 1.129
3.101GlnLys: 3.101 ± 0.55
4.651GlnLeu: 4.651 ± 2.673
2.326GlnMet: 2.326 ± 1.337
1.55GlnAsn: 1.55 ± 1.416
3.101GlnPro: 3.101 ± 2.832
4.651GlnGln: 4.651 ± 3.933
3.876GlnArg: 3.876 ± 0.975
2.326GlnSer: 2.326 ± 1.129
4.651GlnThr: 4.651 ± 1.219
4.651GlnVal: 4.651 ± 1.849
0.0GlnTrp: 0.0 ± 0.0
0.775GlnTyr: 0.775 ± 0.538
0.0GlnXaa: 0.0 ± 0.0
Arg
3.101ArgAla: 3.101 ± 1.108
0.775ArgCys: 0.775 ± 0.747
4.651ArgAsp: 4.651 ± 1.932
0.0ArgGlu: 0.0 ± 0.0
3.876ArgPhe: 3.876 ± 2.012
1.55ArgGly: 1.55 ± 0.644
3.101ArgHis: 3.101 ± 1.628
2.326ArgIle: 2.326 ± 0.923
3.876ArgLys: 3.876 ± 2.247
7.752ArgLeu: 7.752 ± 0.881
0.0ArgMet: 0.0 ± 0.0
1.55ArgAsn: 1.55 ± 0.594
3.101ArgPro: 3.101 ± 0.55
1.55ArgGln: 1.55 ± 2.369
4.651ArgArg: 4.651 ± 2.126
2.326ArgSer: 2.326 ± 1.384
2.326ArgThr: 2.326 ± 1.615
3.101ArgVal: 3.101 ± 0.953
0.775ArgTrp: 0.775 ± 0.538
3.876ArgTyr: 3.876 ± 0.93
0.0ArgXaa: 0.0 ± 0.0
Ser
4.651SerAla: 4.651 ± 3.174
0.0SerCys: 0.0 ± 0.0
7.752SerAsp: 7.752 ± 1.892
3.101SerGlu: 3.101 ± 1.392
3.101SerPhe: 3.101 ± 0.954
9.302SerGly: 9.302 ± 1.503
1.55SerHis: 1.55 ± 0.644
6.977SerIle: 6.977 ± 1.744
4.651SerLys: 4.651 ± 2.34
2.326SerLeu: 2.326 ± 1.286
1.55SerMet: 1.55 ± 0.879
3.101SerAsn: 3.101 ± 1.288
3.876SerPro: 3.876 ± 2.288
2.326SerGln: 2.326 ± 0.924
6.202SerArg: 6.202 ± 2.003
9.302SerSer: 9.302 ± 1.889
6.202SerThr: 6.202 ± 2.783
5.426SerVal: 5.426 ± 1.168
0.0SerTrp: 0.0 ± 0.0
1.55SerTyr: 1.55 ± 1.077
0.0SerXaa: 0.0 ± 0.0
Thr
6.202ThrAla: 6.202 ± 1.157
0.775ThrCys: 0.775 ± 0.747
1.55ThrAsp: 1.55 ± 0.594
1.55ThrGlu: 1.55 ± 1.077
1.55ThrPhe: 1.55 ± 1.093
4.651ThrGly: 4.651 ± 1.849
0.775ThrHis: 0.775 ± 0.538
2.326ThrIle: 2.326 ± 0.923
2.326ThrLys: 2.326 ± 1.384
6.202ThrLeu: 6.202 ± 2.654
2.326ThrMet: 2.326 ± 0.482
2.326ThrAsn: 2.326 ± 1.615
4.651ThrPro: 4.651 ± 1.781
2.326ThrGln: 2.326 ± 0.482
2.326ThrArg: 2.326 ± 0.923
5.426ThrSer: 5.426 ± 2.897
1.55ThrThr: 1.55 ± 1.077
5.426ThrVal: 5.426 ± 2.117
0.775ThrTrp: 0.775 ± 1.185
0.775ThrTyr: 0.775 ± 0.747
0.0ThrXaa: 0.0 ± 0.0
Val
9.302ValAla: 9.302 ± 5.125
0.0ValCys: 0.0 ± 0.0
3.876ValAsp: 3.876 ± 0.975
1.55ValGlu: 1.55 ± 1.077
3.101ValPhe: 3.101 ± 1.367
3.101ValGly: 3.101 ± 1.187
1.55ValHis: 1.55 ± 1.077
1.55ValIle: 1.55 ± 1.077
1.55ValLys: 1.55 ± 0.644
5.426ValLeu: 5.426 ± 1.303
1.55ValMet: 1.55 ± 1.311
4.651ValAsn: 4.651 ± 0.965
6.202ValPro: 6.202 ± 2.525
3.876ValGln: 3.876 ± 1.145
2.326ValArg: 2.326 ± 1.286
7.752ValSer: 7.752 ± 2.299
5.426ValThr: 5.426 ± 0.883
2.326ValVal: 2.326 ± 1.252
0.0ValTrp: 0.0 ± 0.0
2.326ValTyr: 2.326 ± 0.992
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.775TrpAsp: 0.775 ± 0.747
1.55TrpGlu: 1.55 ± 1.077
0.775TrpPhe: 0.775 ± 0.655
0.0TrpGly: 0.0 ± 0.0
0.775TrpHis: 0.775 ± 0.538
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.775TrpLeu: 0.775 ± 0.538
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
2.326TrpPro: 2.326 ± 1.252
0.775TrpGln: 0.775 ± 0.655
0.775TrpArg: 0.775 ± 1.185
0.775TrpSer: 0.775 ± 0.538
0.0TrpThr: 0.0 ± 0.0
1.55TrpVal: 1.55 ± 0.644
0.0TrpTrp: 0.0 ± 0.0
0.775TrpTyr: 0.775 ± 0.538
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.651TyrAla: 4.651 ± 2.501
0.775TyrCys: 0.775 ± 0.747
5.426TyrAsp: 5.426 ± 1.705
0.775TyrGlu: 0.775 ± 0.538
3.101TyrPhe: 3.101 ± 0.55
3.101TyrGly: 3.101 ± 1.108
2.326TyrHis: 2.326 ± 1.286
1.55TyrIle: 1.55 ± 0.644
1.55TyrLys: 1.55 ± 1.493
2.326TyrLeu: 2.326 ± 1.615
0.0TyrMet: 0.0 ± 0.0
2.326TyrAsn: 2.326 ± 0.924
0.775TyrPro: 0.775 ± 0.538
0.775TyrGln: 0.775 ± 0.538
3.101TyrArg: 3.101 ± 1.367
2.326TyrSer: 2.326 ± 1.252
3.876TyrThr: 3.876 ± 1.827
4.651TyrVal: 4.651 ± 1.04
0.775TyrTrp: 0.775 ± 0.538
2.326TyrTyr: 2.326 ± 1.286
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1291 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski