Amino acid dipepetide frequency for Poriferisphaera corsica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.582AlaAla: 8.582 ± 0.13	0.956AlaCys: 0.956 ± 0.033	5.022AlaAsp: 5.022 ± 0.084	5.263AlaGlu: 5.263 ± 0.099	3.086AlaPhe: 3.086 ± 0.056	6.58AlaGly: 6.58 ± 0.109	1.612AlaHis: 1.612 ± 0.035	6.006AlaIle: 6.006 ± 0.084	4.654AlaLys: 4.654 ± 0.073	7.411AlaLeu: 7.411 ± 0.095	2.806AlaMet: 2.806 ± 0.051	3.392AlaAsn: 3.392 ± 0.059	2.699AlaPro: 2.699 ± 0.059	2.99AlaGln: 2.99 ± 0.061	3.902AlaArg: 3.902 ± 0.068	5.317AlaSer: 5.317 ± 0.075	4.549AlaThr: 4.549 ± 0.079	5.954AlaVal: 5.954 ± 0.087	1.133AlaTrp: 1.133 ± 0.035	2.635AlaTyr: 2.635 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.842CysAla: 0.842 ± 0.03	0.212CysCys: 0.212 ± 0.014	0.7CysAsp: 0.7 ± 0.028	0.778CysGlu: 0.778 ± 0.026	0.404CysPhe: 0.404 ± 0.019	1.121CysGly: 1.121 ± 0.035	0.268CysHis: 0.268 ± 0.015	0.621CysIle: 0.621 ± 0.024	0.514CysLys: 0.514 ± 0.022	0.93CysLeu: 0.93 ± 0.029	0.276CysMet: 0.276 ± 0.017	0.384CysAsn: 0.384 ± 0.017	0.566CysPro: 0.566 ± 0.025	0.269CysGln: 0.269 ± 0.016	0.534CysArg: 0.534 ± 0.02	0.61CysSer: 0.61 ± 0.03	0.497CysThr: 0.497 ± 0.022	0.851CysVal: 0.851 ± 0.03	0.139CysTrp: 0.139 ± 0.011	0.323CysTyr: 0.323 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.203AspAla: 5.203 ± 0.076	0.566AspCys: 0.566 ± 0.021	3.756AspAsp: 3.756 ± 0.065	4.57AspGlu: 4.57 ± 0.088	2.351AspPhe: 2.351 ± 0.044	4.894AspGly: 4.894 ± 0.092	1.435AspHis: 1.435 ± 0.039	3.604AspIle: 3.604 ± 0.054	2.692AspLys: 2.692 ± 0.054	5.706AspLeu: 5.706 ± 0.082	1.519AspMet: 1.519 ± 0.037	2.252AspAsn: 2.252 ± 0.048	2.747AspPro: 2.747 ± 0.05	2.614AspGln: 2.614 ± 0.05	3.17AspArg: 3.17 ± 0.059	3.145AspSer: 3.145 ± 0.059	2.973AspThr: 2.973 ± 0.05	4.508AspVal: 4.508 ± 0.066	1.086AspTrp: 1.086 ± 0.03	1.875AspTyr: 1.875 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	5.378GluAla: 5.378 ± 0.094	0.516GluCys: 0.516 ± 0.022	3.357GluAsp: 3.357 ± 0.06	3.721GluGlu: 3.721 ± 0.08	1.927GluPhe: 1.927 ± 0.04	4.338GluGly: 4.338 ± 0.073	1.407GluHis: 1.407 ± 0.033	3.989GluIle: 3.989 ± 0.072	3.619GluLys: 3.619 ± 0.067	5.955GluLeu: 5.955 ± 0.07	2.091GluMet: 2.091 ± 0.048	2.474GluAsn: 2.474 ± 0.045	2.311GluPro: 2.311 ± 0.044	3.192GluGln: 3.192 ± 0.064	3.523GluArg: 3.523 ± 0.069	3.556GluSer: 3.556 ± 0.053	3.033GluThr: 3.033 ± 0.051	4.611GluVal: 4.611 ± 0.096	0.728GluTrp: 0.728 ± 0.025	1.806GluTyr: 1.806 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	3.219PheAla: 3.219 ± 0.062	0.455PheCys: 0.455 ± 0.02	2.766PheAsp: 2.766 ± 0.054	2.515PheGlu: 2.515 ± 0.052	1.512PhePhe: 1.512 ± 0.04	3.241PheGly: 3.241 ± 0.07	0.708PheHis: 0.708 ± 0.026	2.19PheIle: 2.19 ± 0.044	1.725PheLys: 1.725 ± 0.036	3.094PheLeu: 3.094 ± 0.065	0.905PheMet: 0.905 ± 0.027	1.75PheAsn: 1.75 ± 0.041	1.295PhePro: 1.295 ± 0.034	1.051PheGln: 1.051 ± 0.033	1.567PheArg: 1.567 ± 0.035	2.399PheSer: 2.399 ± 0.047	2.378PheThr: 2.378 ± 0.049	2.696PheVal: 2.696 ± 0.05	0.573PheTrp: 0.573 ± 0.025	1.216PheTyr: 1.216 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	5.429GlyAla: 5.429 ± 0.088	0.999GlyCys: 0.999 ± 0.03	4.62GlyAsp: 4.62 ± 0.089	5.089GlyGlu: 5.089 ± 0.096	3.185GlyPhe: 3.185 ± 0.056	6.532GlyGly: 6.532 ± 0.121	1.778GlyHis: 1.778 ± 0.044	4.904GlyIle: 4.904 ± 0.069	4.141GlyLys: 4.141 ± 0.072	7.153GlyLeu: 7.153 ± 0.091	2.697GlyMet: 2.697 ± 0.051	2.997GlyAsn: 2.997 ± 0.07	2.153GlyPro: 2.153 ± 0.045	2.814GlyGln: 2.814 ± 0.052	3.85GlyArg: 3.85 ± 0.065	4.726GlySer: 4.726 ± 0.077	3.835GlyThr: 3.835 ± 0.087	5.782GlyVal: 5.782 ± 0.101	1.218GlyTrp: 1.218 ± 0.033	2.683GlyTyr: 2.683 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.928HisAla: 1.928 ± 0.042	0.276HisCys: 0.276 ± 0.016	1.422HisAsp: 1.422 ± 0.039	1.46HisGlu: 1.46 ± 0.037	0.926HisPhe: 0.926 ± 0.028	1.663HisGly: 1.663 ± 0.038	0.767HisHis: 0.767 ± 0.028	1.417HisIle: 1.417 ± 0.035	0.954HisLys: 0.954 ± 0.03	2.133HisLeu: 2.133 ± 0.049	0.522HisMet: 0.522 ± 0.022	0.93HisAsn: 0.93 ± 0.028	1.191HisPro: 1.191 ± 0.034	0.883HisGln: 0.883 ± 0.028	1.2HisArg: 1.2 ± 0.034	1.062HisSer: 1.062 ± 0.034	1.286HisThr: 1.286 ± 0.033	1.525HisVal: 1.525 ± 0.036	0.368HisTrp: 0.368 ± 0.018	0.734HisTyr: 0.734 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.524IleAla: 6.524 ± 0.085	0.784IleCys: 0.784 ± 0.025	4.698IleAsp: 4.698 ± 0.065	4.551IleGlu: 4.551 ± 0.068	2.292IlePhe: 2.292 ± 0.055	5.132IleGly: 5.132 ± 0.081	1.416IleHis: 1.416 ± 0.037	3.877IleIle: 3.877 ± 0.066	3.189IleLys: 3.189 ± 0.058	5.373IleLeu: 5.373 ± 0.087	1.259IleMet: 1.259 ± 0.029	3.132IleAsn: 3.132 ± 0.065	2.814IlePro: 2.814 ± 0.05	2.213IleGln: 2.213 ± 0.04	3.089IleArg: 3.089 ± 0.054	3.965IleSer: 3.965 ± 0.066	4.195IleThr: 4.195 ± 0.08	4.332IleVal: 4.332 ± 0.066	0.765IleTrp: 0.765 ± 0.027	1.872IleTyr: 1.872 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.212LysAla: 4.212 ± 0.071	0.443LysCys: 0.443 ± 0.02	2.802LysAsp: 2.802 ± 0.052	2.666LysGlu: 2.666 ± 0.061	1.481LysPhe: 1.481 ± 0.037	3.057LysGly: 3.057 ± 0.06	1.404LysHis: 1.404 ± 0.036	3.145LysIle: 3.145 ± 0.056	3.113LysLys: 3.113 ± 0.077	5.035LysLeu: 5.035 ± 0.073	1.478LysMet: 1.478 ± 0.032	2.139LysAsn: 2.139 ± 0.042	2.581LysPro: 2.581 ± 0.05	2.75LysGln: 2.75 ± 0.06	3.308LysArg: 3.308 ± 0.061	2.976LysSer: 2.976 ± 0.059	2.874LysThr: 2.874 ± 0.053	3.133LysVal: 3.133 ± 0.059	0.64LysTrp: 0.64 ± 0.026	1.609LysTyr: 1.609 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	8.453LeuAla: 8.453 ± 0.098	1.097LeuCys: 1.097 ± 0.028	5.597LeuAsp: 5.597 ± 0.074	5.139LeuGlu: 5.139 ± 0.085	3.379LeuPhe: 3.379 ± 0.062	7.226LeuGly: 7.226 ± 0.086	1.877LeuHis: 1.877 ± 0.041	6.401LeuIle: 6.401 ± 0.09	4.693LeuLys: 4.693 ± 0.061	9.09LeuLeu: 9.09 ± 0.109	2.461LeuMet: 2.461 ± 0.047	4.178LeuAsn: 4.178 ± 0.068	4.607LeuPro: 4.607 ± 0.068	3.203LeuGln: 3.203 ± 0.066	4.906LeuArg: 4.906 ± 0.071	6.151LeuSer: 6.151 ± 0.075	5.695LeuThr: 5.695 ± 0.08	6.003LeuVal: 6.003 ± 0.075	1.121LeuTrp: 1.121 ± 0.034	2.467LeuTyr: 2.467 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.167MetAla: 2.167 ± 0.044	0.315MetCys: 0.315 ± 0.018	1.415MetAsp: 1.415 ± 0.04	1.162MetGlu: 1.162 ± 0.029	0.987MetPhe: 0.987 ± 0.033	2.292MetGly: 2.292 ± 0.052	0.601MetHis: 0.601 ± 0.023	1.909MetIle: 1.909 ± 0.038	1.594MetLys: 1.594 ± 0.037	2.857MetLeu: 2.857 ± 0.053	0.988MetMet: 0.988 ± 0.027	1.329MetAsn: 1.329 ± 0.032	1.37MetPro: 1.37 ± 0.031	1.122MetGln: 1.122 ± 0.034	1.781MetArg: 1.781 ± 0.037	1.897MetSer: 1.897 ± 0.037	1.74MetThr: 1.74 ± 0.039	1.796MetVal: 1.796 ± 0.04	0.347MetTrp: 0.347 ± 0.019	0.671MetTyr: 0.671 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.609AsnAla: 3.609 ± 0.066	0.354AsnCys: 0.354 ± 0.02	2.712AsnAsp: 2.712 ± 0.056	2.409AsnGlu: 2.409 ± 0.049	1.499AsnPhe: 1.499 ± 0.035	3.142AsnGly: 3.142 ± 0.077	1.065AsnHis: 1.065 ± 0.028	2.785AsnIle: 2.785 ± 0.063	2.016AsnLys: 2.016 ± 0.048	4.001AsnLeu: 4.001 ± 0.07	1.016AsnMet: 1.016 ± 0.03	2.188AsnAsn: 2.188 ± 0.062	2.393AsnPro: 2.393 ± 0.055	2.066AsnGln: 2.066 ± 0.048	2.166AsnArg: 2.166 ± 0.042	2.287AsnSer: 2.287 ± 0.055	2.615AsnThr: 2.615 ± 0.064	2.634AsnVal: 2.634 ± 0.052	0.589AsnTrp: 0.589 ± 0.024	1.285AsnTyr: 1.285 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	3.502ProAla: 3.502 ± 0.063	0.357ProCys: 0.357 ± 0.018	2.748ProAsp: 2.748 ± 0.06	3.148ProGlu: 3.148 ± 0.059	1.553ProPhe: 1.553 ± 0.034	2.854ProGly: 2.854 ± 0.052	1.006ProHis: 1.006 ± 0.033	2.991ProIle: 2.991 ± 0.056	2.044ProLys: 2.044 ± 0.04	3.561ProLeu: 3.561 ± 0.062	1.103ProMet: 1.103 ± 0.038	2.11ProAsn: 2.11 ± 0.045	1.668ProPro: 1.668 ± 0.049	1.674ProGln: 1.674 ± 0.044	1.858ProArg: 1.858 ± 0.046	2.728ProSer: 2.728 ± 0.054	2.764ProThr: 2.764 ± 0.058	2.822ProVal: 2.822 ± 0.054	0.578ProTrp: 0.578 ± 0.027	1.24ProTyr: 1.24 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.359GlnAla: 3.359 ± 0.062	0.347GlnCys: 0.347 ± 0.017	1.807GlnAsp: 1.807 ± 0.043	1.816GlnGlu: 1.816 ± 0.039	1.441GlnPhe: 1.441 ± 0.037	2.346GlnGly: 2.346 ± 0.048	0.957GlnHis: 0.957 ± 0.03	2.998GlnIle: 2.998 ± 0.06	1.948GlnLys: 1.948 ± 0.041	4.099GlnLeu: 4.099 ± 0.069	1.226GlnMet: 1.226 ± 0.032	1.736GlnAsn: 1.736 ± 0.045	1.821GlnPro: 1.821 ± 0.052	2.129GlnGln: 2.129 ± 0.059	2.106GlnArg: 2.106 ± 0.052	2.73GlnSer: 2.73 ± 0.059	2.531GlnThr: 2.531 ± 0.05	2.41GlnVal: 2.41 ± 0.042	0.523GlnTrp: 0.523 ± 0.023	1.325GlnTyr: 1.325 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	3.624ArgAla: 3.624 ± 0.061	0.563ArgCys: 0.563 ± 0.025	3.038ArgAsp: 3.038 ± 0.053	3.559ArgGlu: 3.559 ± 0.067	2.219ArgPhe: 2.219 ± 0.05	3.556ArgGly: 3.556 ± 0.069	1.149ArgHis: 1.149 ± 0.03	3.553ArgIle: 3.553 ± 0.06	2.917ArgLys: 2.917 ± 0.059	5.131ArgLeu: 5.131 ± 0.074	1.611ArgMet: 1.611 ± 0.035	1.954ArgAsn: 1.954 ± 0.038	1.877ArgPro: 1.877 ± 0.047	2.064ArgGln: 2.064 ± 0.044	3.191ArgArg: 3.191 ± 0.069	2.875ArgSer: 2.875 ± 0.05	2.485ArgThr: 2.485 ± 0.044	3.741ArgVal: 3.741 ± 0.076	0.828ArgTrp: 0.828 ± 0.028	1.879ArgTyr: 1.879 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	4.563SerAla: 4.563 ± 0.07	0.61SerCys: 0.61 ± 0.023	3.713SerAsp: 3.713 ± 0.059	3.665SerGlu: 3.665 ± 0.052	2.454SerPhe: 2.454 ± 0.047	5.063SerGly: 5.063 ± 0.097	1.392SerHis: 1.392 ± 0.034	3.977SerIle: 3.977 ± 0.066	2.902SerLys: 2.902 ± 0.05	5.652SerLeu: 5.652 ± 0.072	1.639SerMet: 1.639 ± 0.038	2.848SerAsn: 2.848 ± 0.062	2.657SerPro: 2.657 ± 0.05	2.386SerGln: 2.386 ± 0.042	3.019SerArg: 3.019 ± 0.058	4.026SerSer: 4.026 ± 0.08	3.42SerThr: 3.42 ± 0.061	3.91SerVal: 3.91 ± 0.063	0.827SerTrp: 0.827 ± 0.026	1.819SerTyr: 1.819 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	4.776ThrAla: 4.776 ± 0.066	0.547ThrCys: 0.547 ± 0.026	3.28ThrAsp: 3.28 ± 0.054	2.891ThrGlu: 2.891 ± 0.051	2.131ThrPhe: 2.131 ± 0.052	4.654ThrGly: 4.654 ± 0.085	1.401ThrHis: 1.401 ± 0.036	4.045ThrIle: 4.045 ± 0.08	2.613ThrLys: 2.613 ± 0.052	5.569ThrLeu: 5.569 ± 0.089	1.259ThrMet: 1.259 ± 0.032	2.425ThrAsn: 2.425 ± 0.056	3.055ThrPro: 3.055 ± 0.062	2.234ThrGln: 2.234 ± 0.051	2.41ThrArg: 2.41 ± 0.046	3.533ThrSer: 3.533 ± 0.068	3.62ThrThr: 3.62 ± 0.073	3.731ThrVal: 3.731 ± 0.061	0.716ThrTrp: 0.716 ± 0.028	1.727ThrTyr: 1.727 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	5.52ValAla: 5.52 ± 0.085	0.891ValCys: 0.891 ± 0.029	4.328ValAsp: 4.328 ± 0.068	4.35ValGlu: 4.35 ± 0.072	2.59ValPhe: 2.59 ± 0.057	5.514ValGly: 5.514 ± 0.099	1.301ValHis: 1.301 ± 0.032	4.605ValIle: 4.605 ± 0.066	3.579ValLys: 3.579 ± 0.06	6.501ValLeu: 6.501 ± 0.094	2.264ValMet: 2.264 ± 0.057	2.711ValAsn: 2.711 ± 0.049	2.635ValPro: 2.635 ± 0.049	2.034ValGln: 2.034 ± 0.045	3.6ValArg: 3.6 ± 0.07	4.138ValSer: 4.138 ± 0.062	3.724ValThr: 3.724 ± 0.059	5.705ValVal: 5.705 ± 0.112	1.011ValTrp: 1.011 ± 0.032	2.049ValTyr: 2.049 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	1.058TrpAla: 1.058 ± 0.03	0.187TrpCys: 0.187 ± 0.015	0.853TrpAsp: 0.853 ± 0.03	0.747TrpGlu: 0.747 ± 0.025	0.598TrpPhe: 0.598 ± 0.022	1.115TrpGly: 1.115 ± 0.034	0.368TrpHis: 0.368 ± 0.02	0.753TrpIle: 0.753 ± 0.027	0.588TrpLys: 0.588 ± 0.023	1.531TrpLeu: 1.531 ± 0.041	0.459TrpMet: 0.459 ± 0.019	0.539TrpAsn: 0.539 ± 0.021	0.58TrpPro: 0.58 ± 0.022	0.686TrpGln: 0.686 ± 0.024	0.796TrpArg: 0.796 ± 0.027	0.78TrpSer: 0.78 ± 0.028	0.651TrpThr: 0.651 ± 0.026	0.955TrpVal: 0.955 ± 0.035	0.297TrpTrp: 0.297 ± 0.019	0.46TrpTyr: 0.46 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.6TyrAla: 2.6 ± 0.053	0.362TyrCys: 0.362 ± 0.019	2.031TyrAsp: 2.031 ± 0.053	2.034TyrGlu: 2.034 ± 0.044	1.24TyrPhe: 1.24 ± 0.031	2.267TyrGly: 2.267 ± 0.054	0.736TyrHis: 0.736 ± 0.028	1.699TyrIle: 1.699 ± 0.035	1.35TyrLys: 1.35 ± 0.036	2.961TyrLeu: 2.961 ± 0.058	0.757TyrMet: 0.757 ± 0.026	1.362TyrAsn: 1.362 ± 0.036	1.289TyrPro: 1.289 ± 0.034	1.285TyrGln: 1.285 ± 0.035	1.839TyrArg: 1.839 ± 0.038	1.642TyrSer: 1.642 ± 0.04	1.753TyrThr: 1.753 ± 0.044	1.953TyrVal: 1.953 ± 0.044	0.515TyrTrp: 0.515 ± 0.02	1.041TyrTyr: 1.041 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3659 proteins (1197420 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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