Amino acid dipepetide frequency for Acidiferrobacter thiooxydans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.764AlaAla: 16.764 ± 0.2	1.498AlaCys: 1.498 ± 0.05	6.218AlaAsp: 6.218 ± 0.093	5.902AlaGlu: 5.902 ± 0.095	4.254AlaPhe: 4.254 ± 0.074	10.592AlaGly: 10.592 ± 0.166	3.752AlaHis: 3.752 ± 0.07	6.009AlaIle: 6.009 ± 0.098	2.825AlaLys: 2.825 ± 0.075	15.722AlaLeu: 15.722 ± 0.191	2.893AlaMet: 2.893 ± 0.056	2.548AlaAsn: 2.548 ± 0.071	5.853AlaPro: 5.853 ± 0.1	4.442AlaGln: 4.442 ± 0.086	11.663AlaArg: 11.663 ± 0.165	5.852AlaSer: 5.852 ± 0.112	5.88AlaThr: 5.88 ± 0.125	9.533AlaVal: 9.533 ± 0.112	1.875AlaTrp: 1.875 ± 0.053	3.009AlaTyr: 3.009 ± 0.064	0.0AlaXaa: 0.0 ± 0.0
Cys	1.406CysAla: 1.406 ± 0.041	0.159CysCys: 0.159 ± 0.014	0.599CysAsp: 0.599 ± 0.033	0.599CysGlu: 0.599 ± 0.024	0.261CysPhe: 0.261 ± 0.018	1.153CysGly: 1.153 ± 0.038	0.342CysHis: 0.342 ± 0.023	0.332CysIle: 0.332 ± 0.02	0.203CysLys: 0.203 ± 0.015	0.974CysLeu: 0.974 ± 0.035	0.177CysMet: 0.177 ± 0.015	0.211CysAsn: 0.211 ± 0.017	0.71CysPro: 0.71 ± 0.032	0.343CysGln: 0.343 ± 0.019	0.817CysArg: 0.817 ± 0.032	0.396CysSer: 0.396 ± 0.023	0.476CysThr: 0.476 ± 0.025	0.79CysVal: 0.79 ± 0.035	0.101CysTrp: 0.101 ± 0.01	0.286CysTyr: 0.286 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	5.714AspAla: 5.714 ± 0.084	0.497AspCys: 0.497 ± 0.021	2.598AspAsp: 2.598 ± 0.075	2.99AspGlu: 2.99 ± 0.075	1.909AspPhe: 1.909 ± 0.044	4.329AspGly: 4.329 ± 0.08	1.463AspHis: 1.463 ± 0.044	2.828AspIle: 2.828 ± 0.059	1.427AspLys: 1.427 ± 0.048	5.848AspLeu: 5.848 ± 0.095	1.119AspMet: 1.119 ± 0.037	1.086AspAsn: 1.086 ± 0.037	3.088AspPro: 3.088 ± 0.066	1.374AspGln: 1.374 ± 0.043	4.129AspArg: 4.129 ± 0.077	1.904AspSer: 1.904 ± 0.056	2.587AspThr: 2.587 ± 0.07	3.803AspVal: 3.803 ± 0.067	0.838AspTrp: 0.838 ± 0.033	1.57AspTyr: 1.57 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	7.069GluAla: 7.069 ± 0.117	0.475GluCys: 0.475 ± 0.027	2.499GluAsp: 2.499 ± 0.061	2.737GluGlu: 2.737 ± 0.073	1.537GluPhe: 1.537 ± 0.045	4.27GluGly: 4.27 ± 0.083	1.293GluHis: 1.293 ± 0.039	3.069GluIle: 3.069 ± 0.064	1.482GluLys: 1.482 ± 0.047	4.363GluLeu: 4.363 ± 0.086	1.099GluMet: 1.099 ± 0.041	1.178GluAsn: 1.178 ± 0.043	2.236GluPro: 2.236 ± 0.06	1.884GluGln: 1.884 ± 0.055	5.338GluArg: 5.338 ± 0.105	2.439GluSer: 2.439 ± 0.056	2.881GluThr: 2.881 ± 0.062	3.796GluVal: 3.796 ± 0.081	0.698GluTrp: 0.698 ± 0.03	1.137GluTyr: 1.137 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.309PheAla: 4.309 ± 0.085	0.427PheCys: 0.427 ± 0.024	1.889PheAsp: 1.889 ± 0.044	1.72PheGlu: 1.72 ± 0.049	1.336PhePhe: 1.336 ± 0.042	3.163PheGly: 3.163 ± 0.061	0.901PheHis: 0.901 ± 0.033	1.376PheIle: 1.376 ± 0.046	0.784PheLys: 0.784 ± 0.033	3.728PheLeu: 3.728 ± 0.072	0.782PheMet: 0.782 ± 0.027	0.84PheAsn: 0.84 ± 0.033	1.631PhePro: 1.631 ± 0.046	0.976PheGln: 0.976 ± 0.038	2.353PheArg: 2.353 ± 0.057	1.866PheSer: 1.866 ± 0.05	1.844PheThr: 1.844 ± 0.049	2.917PheVal: 2.917 ± 0.066	0.551PheTrp: 0.551 ± 0.027	1.0PheTyr: 1.0 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.463GlyAla: 9.463 ± 0.145	1.046GlyCys: 1.046 ± 0.037	4.148GlyAsp: 4.148 ± 0.068	4.143GlyGlu: 4.143 ± 0.075	3.373GlyPhe: 3.373 ± 0.068	6.97GlyGly: 6.97 ± 0.127	2.685GlyHis: 2.685 ± 0.065	4.297GlyIle: 4.297 ± 0.071	2.298GlyLys: 2.298 ± 0.056	9.961GlyLeu: 9.961 ± 0.127	2.108GlyMet: 2.108 ± 0.047	1.909GlyAsn: 1.909 ± 0.087	4.102GlyPro: 4.102 ± 0.072	2.872GlyGln: 2.872 ± 0.062	7.417GlyArg: 7.417 ± 0.109	4.165GlySer: 4.165 ± 0.106	4.355GlyThr: 4.355 ± 0.115	6.774GlyVal: 6.774 ± 0.087	1.201GlyTrp: 1.201 ± 0.04	2.579GlyTyr: 2.579 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	3.312HisAla: 3.312 ± 0.062	0.33HisCys: 0.33 ± 0.019	1.514HisAsp: 1.514 ± 0.045	1.489HisGlu: 1.489 ± 0.043	0.97HisPhe: 0.97 ± 0.035	2.603HisGly: 2.603 ± 0.059	0.871HisHis: 0.871 ± 0.034	1.393HisIle: 1.393 ± 0.045	0.832HisLys: 0.832 ± 0.032	2.621HisLeu: 2.621 ± 0.061	0.656HisMet: 0.656 ± 0.024	0.667HisAsn: 0.667 ± 0.028	1.741HisPro: 1.741 ± 0.046	0.679HisGln: 0.679 ± 0.03	1.886HisArg: 1.886 ± 0.057	1.053HisSer: 1.053 ± 0.035	1.22HisThr: 1.22 ± 0.039	2.015HisVal: 2.015 ± 0.052	0.457HisTrp: 0.457 ± 0.026	1.018HisTyr: 1.018 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	6.371IleAla: 6.371 ± 0.101	0.408IleCys: 0.408 ± 0.023	2.962IleAsp: 2.962 ± 0.058	2.989IleGlu: 2.989 ± 0.057	1.372IlePhe: 1.372 ± 0.044	4.4IleGly: 4.4 ± 0.073	1.28IleHis: 1.28 ± 0.043	1.932IleIle: 1.932 ± 0.06	1.348IleLys: 1.348 ± 0.045	4.685IleLeu: 4.685 ± 0.084	0.999IleMet: 0.999 ± 0.036	1.288IleAsn: 1.288 ± 0.045	2.648IlePro: 2.648 ± 0.062	1.338IleGln: 1.338 ± 0.041	3.265IleArg: 3.265 ± 0.068	2.19IleSer: 2.19 ± 0.048	2.638IleThr: 2.638 ± 0.065	3.934IleVal: 3.934 ± 0.081	0.47IleTrp: 0.47 ± 0.026	1.146IleTyr: 1.146 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	3.819LysAla: 3.819 ± 0.067	0.16LysCys: 0.16 ± 0.016	1.533LysAsp: 1.533 ± 0.051	1.469LysGlu: 1.469 ± 0.054	0.562LysPhe: 0.562 ± 0.026	2.448LysGly: 2.448 ± 0.059	0.484LysHis: 0.484 ± 0.023	1.41LysIle: 1.41 ± 0.047	1.076LysLys: 1.076 ± 0.044	2.073LysLeu: 2.073 ± 0.057	0.576LysMet: 0.576 ± 0.026	0.701LysAsn: 0.701 ± 0.033	1.546LysPro: 1.546 ± 0.041	0.759LysGln: 0.759 ± 0.033	2.239LysArg: 2.239 ± 0.055	1.354LysSer: 1.354 ± 0.047	1.941LysThr: 1.941 ± 0.055	1.945LysVal: 1.945 ± 0.053	0.27LysTrp: 0.27 ± 0.02	0.519LysTyr: 0.519 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	15.549LeuAla: 15.549 ± 0.189	1.124LeuCys: 1.124 ± 0.032	5.367LeuAsp: 5.367 ± 0.1	5.047LeuGlu: 5.047 ± 0.088	3.807LeuPhe: 3.807 ± 0.073	8.916LeuGly: 8.916 ± 0.111	2.551LeuHis: 2.551 ± 0.056	4.698LeuIle: 4.698 ± 0.081	3.491LeuLys: 3.491 ± 0.072	10.586LeuLeu: 10.586 ± 0.166	2.445LeuMet: 2.445 ± 0.053	2.34LeuAsn: 2.34 ± 0.058	5.704LeuPro: 5.704 ± 0.086	2.848LeuGln: 2.848 ± 0.063	8.509LeuArg: 8.509 ± 0.107	6.004LeuSer: 6.004 ± 0.092	6.095LeuThr: 6.095 ± 0.101	8.164LeuVal: 8.164 ± 0.124	1.595LeuTrp: 1.595 ± 0.055	2.636LeuTyr: 2.636 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	3.12MetAla: 3.12 ± 0.059	0.158MetCys: 0.158 ± 0.014	1.069MetAsp: 1.069 ± 0.036	1.085MetGlu: 1.085 ± 0.034	0.488MetPhe: 0.488 ± 0.025	1.961MetGly: 1.961 ± 0.051	0.522MetHis: 0.522 ± 0.026	1.036MetIle: 1.036 ± 0.037	0.798MetLys: 0.798 ± 0.033	1.954MetLeu: 1.954 ± 0.048	0.498MetMet: 0.498 ± 0.024	0.635MetAsn: 0.635 ± 0.027	1.28MetPro: 1.28 ± 0.04	0.702MetGln: 0.702 ± 0.03	2.09MetArg: 2.09 ± 0.051	1.395MetSer: 1.395 ± 0.048	1.545MetThr: 1.545 ± 0.043	1.623MetVal: 1.623 ± 0.044	0.189MetTrp: 0.189 ± 0.013	0.349MetTyr: 0.349 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.724AsnAla: 2.724 ± 0.093	0.199AsnCys: 0.199 ± 0.014	1.186AsnAsp: 1.186 ± 0.045	1.105AsnGlu: 1.105 ± 0.041	0.728AsnPhe: 0.728 ± 0.026	2.047AsnGly: 2.047 ± 0.049	0.601AsnHis: 0.601 ± 0.025	1.259AsnIle: 1.259 ± 0.047	0.626AsnLys: 0.626 ± 0.028	2.197AsnLeu: 2.197 ± 0.049	0.491AsnMet: 0.491 ± 0.027	0.695AsnAsn: 0.695 ± 0.047	1.746AsnPro: 1.746 ± 0.052	0.612AsnGln: 0.612 ± 0.028	1.695AsnArg: 1.695 ± 0.043	0.966AsnSer: 0.966 ± 0.049	1.309AsnThr: 1.309 ± 0.05	1.709AsnVal: 1.709 ± 0.059	0.292AsnTrp: 0.292 ± 0.017	0.57AsnTyr: 0.57 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	6.213ProAla: 6.213 ± 0.101	0.47ProCys: 0.47 ± 0.023	3.11ProAsp: 3.11 ± 0.061	3.217ProGlu: 3.217 ± 0.065	1.882ProPhe: 1.882 ± 0.048	4.978ProGly: 4.978 ± 0.093	1.416ProHis: 1.416 ± 0.042	2.257ProIle: 2.257 ± 0.056	1.401ProLys: 1.401 ± 0.05	5.532ProLeu: 5.532 ± 0.088	1.347ProMet: 1.347 ± 0.041	1.099ProAsn: 1.099 ± 0.043	2.811ProPro: 2.811 ± 0.077	1.73ProGln: 1.73 ± 0.045	3.817ProArg: 3.817 ± 0.087	2.592ProSer: 2.592 ± 0.062	2.49ProThr: 2.49 ± 0.052	4.457ProVal: 4.457 ± 0.085	0.933ProTrp: 0.933 ± 0.035	1.518ProTyr: 1.518 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	4.819GlnAla: 4.819 ± 0.083	0.292GlnCys: 0.292 ± 0.02	1.601GlnAsp: 1.601 ± 0.041	1.636GlnGlu: 1.636 ± 0.041	0.909GlnPhe: 0.909 ± 0.032	3.046GlnGly: 3.046 ± 0.063	0.72GlnHis: 0.72 ± 0.029	1.538GlnIle: 1.538 ± 0.043	1.0GlnLys: 1.0 ± 0.033	2.369GlnLeu: 2.369 ± 0.055	0.705GlnMet: 0.705 ± 0.028	0.723GlnAsn: 0.723 ± 0.038	1.421GlnPro: 1.421 ± 0.042	0.954GlnGln: 0.954 ± 0.037	2.521GlnArg: 2.521 ± 0.064	1.574GlnSer: 1.574 ± 0.053	1.663GlnThr: 1.663 ± 0.043	2.361GlnVal: 2.361 ± 0.055	0.557GlnTrp: 0.557 ± 0.029	0.758GlnTyr: 0.758 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	10.25ArgAla: 10.25 ± 0.151	0.729ArgCys: 0.729 ± 0.036	4.201ArgAsp: 4.201 ± 0.076	4.786ArgGlu: 4.786 ± 0.085	3.301ArgPhe: 3.301 ± 0.061	5.593ArgGly: 5.593 ± 0.088	2.73ArgHis: 2.73 ± 0.065	4.123ArgIle: 4.123 ± 0.062	2.178ArgLys: 2.178 ± 0.056	9.987ArgLeu: 9.987 ± 0.157	1.878ArgMet: 1.878 ± 0.047	1.727ArgAsn: 1.727 ± 0.048	4.536ArgPro: 4.536 ± 0.093	2.745ArgGln: 2.745 ± 0.062	7.404ArgArg: 7.404 ± 0.116	3.482ArgSer: 3.482 ± 0.066	3.581ArgThr: 3.581 ± 0.065	5.901ArgVal: 5.901 ± 0.091	1.176ArgTrp: 1.176 ± 0.041	2.695ArgTyr: 2.695 ± 0.067	0.0ArgXaa: 0.0 ± 0.0
Ser	5.999SerAla: 5.999 ± 0.144	0.556SerCys: 0.556 ± 0.028	2.297SerAsp: 2.297 ± 0.057	2.413SerGlu: 2.413 ± 0.055	1.718SerPhe: 1.718 ± 0.049	5.081SerGly: 5.081 ± 0.113	1.179SerHis: 1.179 ± 0.033	1.905SerIle: 1.905 ± 0.063	0.962SerLys: 0.962 ± 0.037	5.467SerLeu: 5.467 ± 0.085	1.1SerMet: 1.1 ± 0.037	1.014SerAsn: 1.014 ± 0.052	2.73SerPro: 2.73 ± 0.06	1.549SerGln: 1.549 ± 0.053	3.726SerArg: 3.726 ± 0.067	2.35SerSer: 2.35 ± 0.08	2.213SerThr: 2.213 ± 0.068	3.654SerVal: 3.654 ± 0.08	0.789SerTrp: 0.789 ± 0.03	1.378SerTyr: 1.378 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	5.973ThrAla: 5.973 ± 0.12	0.49ThrCys: 0.49 ± 0.027	2.454ThrAsp: 2.454 ± 0.057	2.333ThrGlu: 2.333 ± 0.063	1.727ThrPhe: 1.727 ± 0.042	4.985ThrGly: 4.985 ± 0.125	1.469ThrHis: 1.469 ± 0.04	2.589ThrIle: 2.589 ± 0.063	1.234ThrLys: 1.234 ± 0.044	6.439ThrLeu: 6.439 ± 0.107	1.026ThrMet: 1.026 ± 0.036	1.198ThrAsn: 1.198 ± 0.051	3.203ThrPro: 3.203 ± 0.069	1.569ThrGln: 1.569 ± 0.048	3.82ThrArg: 3.82 ± 0.07	2.43ThrSer: 2.43 ± 0.069	2.774ThrThr: 2.774 ± 0.088	4.39ThrVal: 4.39 ± 0.095	0.601ThrTrp: 0.601 ± 0.031	1.241ThrTyr: 1.241 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	9.843ValAla: 9.843 ± 0.108	0.814ValCys: 0.814 ± 0.025	3.861ValAsp: 3.861 ± 0.068	3.668ValGlu: 3.668 ± 0.07	2.887ValPhe: 2.887 ± 0.072	5.958ValGly: 5.958 ± 0.094	1.893ValHis: 1.893 ± 0.047	3.948ValIle: 3.948 ± 0.075	1.967ValLys: 1.967 ± 0.059	8.445ValLeu: 8.445 ± 0.123	1.791ValMet: 1.791 ± 0.05	1.874ValAsn: 1.874 ± 0.063	4.091ValPro: 4.091 ± 0.083	2.04ValGln: 2.04 ± 0.053	6.238ValArg: 6.238 ± 0.095	4.202ValSer: 4.202 ± 0.092	4.462ValThr: 4.462 ± 0.083	6.454ValVal: 6.454 ± 0.106	0.955ValTrp: 0.955 ± 0.032	1.734ValTyr: 1.734 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	1.433TrpAla: 1.433 ± 0.04	0.155TrpCys: 0.155 ± 0.013	0.596TrpAsp: 0.596 ± 0.03	0.63TrpGlu: 0.63 ± 0.027	0.47TrpPhe: 0.47 ± 0.021	0.976TrpGly: 0.976 ± 0.034	0.438TrpHis: 0.438 ± 0.026	0.67TrpIle: 0.67 ± 0.029	0.3TrpLys: 0.3 ± 0.019	1.725TrpLeu: 1.725 ± 0.05	0.315TrpMet: 0.315 ± 0.022	0.361TrpAsn: 0.361 ± 0.02	0.833TrpPro: 0.833 ± 0.03	0.72TrpGln: 0.72 ± 0.03	1.522TrpArg: 1.522 ± 0.043	0.701TrpSer: 0.701 ± 0.027	0.69TrpThr: 0.69 ± 0.026	1.038TrpVal: 1.038 ± 0.036	0.245TrpTrp: 0.245 ± 0.021	0.362TrpTyr: 0.362 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.933TyrAla: 2.933 ± 0.055	0.347TyrCys: 0.347 ± 0.02	1.4TyrAsp: 1.4 ± 0.045	1.526TyrGlu: 1.526 ± 0.045	0.901TyrPhe: 0.901 ± 0.031	2.402TyrGly: 2.402 ± 0.057	0.735TyrHis: 0.735 ± 0.03	0.994TyrIle: 0.994 ± 0.036	0.65TyrLys: 0.65 ± 0.031	2.799TyrLeu: 2.799 ± 0.068	0.49TyrMet: 0.49 ± 0.025	0.663TyrAsn: 0.663 ± 0.032	1.361TyrPro: 1.361 ± 0.045	1.032TyrGln: 1.032 ± 0.037	2.553TyrArg: 2.553 ± 0.066	1.165TyrSer: 1.165 ± 0.041	1.298TyrThr: 1.298 ± 0.044	1.868TyrVal: 1.868 ± 0.047	0.389TyrTrp: 0.389 ± 0.024	0.86TyrTyr: 0.86 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2872 proteins (873618 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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