Amino acid dipepetide frequency for Haloarchaeobius iranensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.152AlaAla: 14.152 ± 0.189	0.772AlaCys: 0.772 ± 0.028	9.965AlaAsp: 9.965 ± 0.121	8.513AlaGlu: 8.513 ± 0.102	3.854AlaPhe: 3.854 ± 0.067	10.097AlaGly: 10.097 ± 0.13	1.812AlaHis: 1.812 ± 0.044	4.051AlaIle: 4.051 ± 0.066	1.725AlaLys: 1.725 ± 0.044	10.388AlaLeu: 10.388 ± 0.133	2.161AlaMet: 2.161 ± 0.043	2.427AlaAsn: 2.427 ± 0.045	4.169AlaPro: 4.169 ± 0.068	2.187AlaGln: 2.187 ± 0.05	6.275AlaArg: 6.275 ± 0.092	5.619AlaSer: 5.619 ± 0.083	7.639AlaThr: 7.639 ± 0.102	11.554AlaVal: 11.554 ± 0.138	1.211AlaTrp: 1.211 ± 0.033	2.642AlaTyr: 2.642 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.604CysAla: 0.604 ± 0.024	0.101CysCys: 0.101 ± 0.01	0.666CysAsp: 0.666 ± 0.025	0.636CysGlu: 0.636 ± 0.024	0.221CysPhe: 0.221 ± 0.015	0.891CysGly: 0.891 ± 0.035	0.166CysHis: 0.166 ± 0.014	0.266CysIle: 0.266 ± 0.014	0.109CysLys: 0.109 ± 0.01	0.623CysLeu: 0.623 ± 0.022	0.109CysMet: 0.109 ± 0.01	0.203CysAsn: 0.203 ± 0.012	0.55CysPro: 0.55 ± 0.026	0.181CysGln: 0.181 ± 0.015	0.485CysArg: 0.485 ± 0.022	0.441CysSer: 0.441 ± 0.018	0.44CysThr: 0.44 ± 0.02	0.53CysVal: 0.53 ± 0.023	0.108CysTrp: 0.108 ± 0.01	0.232CysTyr: 0.232 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	10.535AspAla: 10.535 ± 0.13	0.814AspCys: 0.814 ± 0.033	8.487AspAsp: 8.487 ± 0.117	8.492AspGlu: 8.492 ± 0.114	1.895AspPhe: 1.895 ± 0.049	9.193AspGly: 9.193 ± 0.11	1.785AspHis: 1.785 ± 0.051	3.121AspIle: 3.121 ± 0.063	0.86AspLys: 0.86 ± 0.027	6.635AspLeu: 6.635 ± 0.093	1.261AspMet: 1.261 ± 0.038	1.23AspAsn: 1.23 ± 0.04	4.612AspPro: 4.612 ± 0.068	1.682AspGln: 1.682 ± 0.044	6.302AspArg: 6.302 ± 0.077	3.846AspSer: 3.846 ± 0.068	4.217AspThr: 4.217 ± 0.07	7.578AspVal: 7.578 ± 0.094	1.189AspTrp: 1.189 ± 0.038	1.922AspTyr: 1.922 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	8.435GluAla: 8.435 ± 0.119	0.502GluCys: 0.502 ± 0.024	5.509GluAsp: 5.509 ± 0.099	6.121GluGlu: 6.121 ± 0.112	3.147GluPhe: 3.147 ± 0.055	5.358GluGly: 5.358 ± 0.081	2.198GluHis: 2.198 ± 0.053	2.878GluIle: 2.878 ± 0.063	1.638GluLys: 1.638 ± 0.047	7.863GluLeu: 7.863 ± 0.101	1.758GluMet: 1.758 ± 0.042	2.207GluAsn: 2.207 ± 0.049	4.468GluPro: 4.468 ± 0.085	2.739GluGln: 2.739 ± 0.056	7.507GluArg: 7.507 ± 0.103	4.959GluSer: 4.959 ± 0.068	6.262GluThr: 6.262 ± 0.093	5.879GluVal: 5.879 ± 0.084	1.042GluTrp: 1.042 ± 0.031	2.554GluTyr: 2.554 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.715PheAla: 3.715 ± 0.069	0.273PheCys: 0.273 ± 0.017	3.439PheAsp: 3.439 ± 0.061	3.221PheGlu: 3.221 ± 0.059	0.971PhePhe: 0.971 ± 0.03	3.281PheGly: 3.281 ± 0.06	0.613PheHis: 0.613 ± 0.024	0.905PheIle: 0.905 ± 0.031	0.43PheLys: 0.43 ± 0.023	2.834PheLeu: 2.834 ± 0.069	0.485PheMet: 0.485 ± 0.022	0.661PheAsn: 0.661 ± 0.024	1.29PhePro: 1.29 ± 0.033	0.859PheGln: 0.859 ± 0.029	1.761PheArg: 1.761 ± 0.039	1.674PheSer: 1.674 ± 0.034	1.89PheThr: 1.89 ± 0.043	3.442PheVal: 3.442 ± 0.059	0.402PheTrp: 0.402 ± 0.021	0.819PheTyr: 0.819 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	8.203GlyAla: 8.203 ± 0.123	0.8GlyCys: 0.8 ± 0.027	7.335GlyAsp: 7.335 ± 0.111	7.109GlyGlu: 7.109 ± 0.09	3.183GlyPhe: 3.183 ± 0.063	8.169GlyGly: 8.169 ± 0.12	1.738GlyHis: 1.738 ± 0.044	3.868GlyIle: 3.868 ± 0.066	1.596GlyLys: 1.596 ± 0.041	7.755GlyLeu: 7.755 ± 0.116	1.693GlyMet: 1.693 ± 0.042	1.945GlyAsn: 1.945 ± 0.046	3.436GlyPro: 3.436 ± 0.056	2.192GlyGln: 2.192 ± 0.046	5.085GlyArg: 5.085 ± 0.075	5.567GlySer: 5.567 ± 0.081	6.304GlyThr: 6.304 ± 0.087	7.916GlyVal: 7.916 ± 0.117	1.167GlyTrp: 1.167 ± 0.035	2.726GlyTyr: 2.726 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.069HisAla: 2.069 ± 0.044	0.224HisCys: 0.224 ± 0.016	1.954HisAsp: 1.954 ± 0.049	1.84HisGlu: 1.84 ± 0.043	0.53HisPhe: 0.53 ± 0.022	1.97HisGly: 1.97 ± 0.045	0.569HisHis: 0.569 ± 0.023	0.632HisIle: 0.632 ± 0.027	0.267HisLys: 0.267 ± 0.015	1.714HisLeu: 1.714 ± 0.042	0.297HisMet: 0.297 ± 0.019	0.432HisAsn: 0.432 ± 0.02	1.156HisPro: 1.156 ± 0.032	0.451HisGln: 0.451 ± 0.023	1.369HisArg: 1.369 ± 0.033	0.878HisSer: 0.878 ± 0.031	1.02HisThr: 1.02 ± 0.032	2.063HisVal: 2.063 ± 0.044	0.233HisTrp: 0.233 ± 0.015	0.548HisTyr: 0.548 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	3.94IleAla: 3.94 ± 0.06	0.231IleCys: 0.231 ± 0.013	3.122IleAsp: 3.122 ± 0.061	3.476IleGlu: 3.476 ± 0.081	0.814IlePhe: 0.814 ± 0.032	3.13IleGly: 3.13 ± 0.062	0.682IleHis: 0.682 ± 0.023	1.037IleIle: 1.037 ± 0.033	0.573IleLys: 0.573 ± 0.025	2.5IleLeu: 2.5 ± 0.052	0.432IleMet: 0.432 ± 0.022	0.709IleAsn: 0.709 ± 0.03	1.721IlePro: 1.721 ± 0.039	0.982IleGln: 0.982 ± 0.034	2.164IleArg: 2.164 ± 0.049	1.841IleSer: 1.841 ± 0.047	1.929IleThr: 1.929 ± 0.049	3.239IleVal: 3.239 ± 0.061	0.302IleTrp: 0.302 ± 0.016	0.811IleTyr: 0.811 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	1.591LysAla: 1.591 ± 0.047	0.114LysCys: 0.114 ± 0.011	0.947LysAsp: 0.947 ± 0.03	1.142LysGlu: 1.142 ± 0.038	0.492LysPhe: 0.492 ± 0.02	1.232LysGly: 1.232 ± 0.036	0.483LysHis: 0.483 ± 0.022	0.623LysIle: 0.623 ± 0.03	0.461LysLys: 0.461 ± 0.023	1.546LysLeu: 1.546 ± 0.039	0.36LysMet: 0.36 ± 0.018	0.481LysAsn: 0.481 ± 0.024	0.867LysPro: 0.867 ± 0.029	0.723LysGln: 0.723 ± 0.027	1.511LysArg: 1.511 ± 0.039	1.001LysSer: 1.001 ± 0.031	1.18LysThr: 1.18 ± 0.034	1.179LysVal: 1.179 ± 0.038	0.212LysTrp: 0.212 ± 0.015	0.514LysTyr: 0.514 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	11.638LeuAla: 11.638 ± 0.144	0.62LeuCys: 0.62 ± 0.025	7.888LeuAsp: 7.888 ± 0.106	6.014LeuGlu: 6.014 ± 0.094	3.133LeuPhe: 3.133 ± 0.067	7.895LeuGly: 7.895 ± 0.102	1.557LeuHis: 1.557 ± 0.041	2.015LeuIle: 2.015 ± 0.057	1.435LeuLys: 1.435 ± 0.043	8.668LeuLeu: 8.668 ± 0.137	1.228LeuMet: 1.228 ± 0.036	1.754LeuAsn: 1.754 ± 0.048	4.203LeuPro: 4.203 ± 0.063	2.186LeuGln: 2.186 ± 0.053	5.529LeuArg: 5.529 ± 0.073	5.497LeuSer: 5.497 ± 0.076	5.263LeuThr: 5.263 ± 0.072	9.461LeuVal: 9.461 ± 0.123	0.866LeuTrp: 0.866 ± 0.03	2.153LeuTyr: 2.153 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.815MetAla: 1.815 ± 0.048	0.092MetCys: 0.092 ± 0.009	1.319MetAsp: 1.319 ± 0.037	1.122MetGlu: 1.122 ± 0.035	0.513MetPhe: 0.513 ± 0.022	1.376MetGly: 1.376 ± 0.041	0.359MetHis: 0.359 ± 0.016	0.489MetIle: 0.489 ± 0.022	0.441MetLys: 0.441 ± 0.019	1.503MetLeu: 1.503 ± 0.04	0.284MetMet: 0.284 ± 0.017	0.576MetAsn: 0.576 ± 0.025	0.795MetPro: 0.795 ± 0.031	0.589MetGln: 0.589 ± 0.026	1.114MetArg: 1.114 ± 0.03	1.518MetSer: 1.518 ± 0.041	1.528MetThr: 1.528 ± 0.037	1.338MetVal: 1.338 ± 0.038	0.146MetTrp: 0.146 ± 0.011	0.397MetTyr: 0.397 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.447AsnAla: 2.447 ± 0.041	0.244AsnCys: 0.244 ± 0.015	1.631AsnAsp: 1.631 ± 0.044	1.844AsnGlu: 1.844 ± 0.05	0.66AsnPhe: 0.66 ± 0.028	1.942AsnGly: 1.942 ± 0.045	0.466AsnHis: 0.466 ± 0.022	0.837AsnIle: 0.837 ± 0.029	0.386AsnLys: 0.386 ± 0.021	1.846AsnLeu: 1.846 ± 0.042	0.391AsnMet: 0.391 ± 0.02	0.543AsnAsn: 0.543 ± 0.025	1.442AsnPro: 1.442 ± 0.039	0.668AsnGln: 0.668 ± 0.029	1.628AsnArg: 1.628 ± 0.037	1.029AsnSer: 1.029 ± 0.043	1.26AsnThr: 1.26 ± 0.034	2.253AsnVal: 2.253 ± 0.048	0.323AsnTrp: 0.323 ± 0.017	0.637AsnTyr: 0.637 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.063ProAla: 5.063 ± 0.087	0.288ProCys: 0.288 ± 0.016	4.831ProAsp: 4.831 ± 0.063	4.496ProGlu: 4.496 ± 0.068	1.596ProPhe: 1.596 ± 0.044	4.062ProGly: 4.062 ± 0.064	0.865ProHis: 0.865 ± 0.031	1.46ProIle: 1.46 ± 0.041	0.802ProLys: 0.802 ± 0.032	3.563ProLeu: 3.563 ± 0.051	0.886ProMet: 0.886 ± 0.028	1.149ProAsn: 1.149 ± 0.038	2.313ProPro: 2.313 ± 0.05	1.009ProGln: 1.009 ± 0.03	2.261ProArg: 2.261 ± 0.048	2.731ProSer: 2.731 ± 0.055	3.467ProThr: 3.467 ± 0.062	4.549ProVal: 4.549 ± 0.069	0.524ProTrp: 0.524 ± 0.024	1.124ProTyr: 1.124 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	2.538GlnAla: 2.538 ± 0.046	0.178GlnCys: 0.178 ± 0.013	1.466GlnAsp: 1.466 ± 0.041	1.728GlnGlu: 1.728 ± 0.044	1.062GlnPhe: 1.062 ± 0.033	1.806GlnGly: 1.806 ± 0.04	0.586GlnHis: 0.586 ± 0.024	0.904GlnIle: 0.904 ± 0.03	0.503GlnLys: 0.503 ± 0.024	2.435GlnLeu: 2.435 ± 0.05	0.523GlnMet: 0.523 ± 0.024	0.687GlnAsn: 0.687 ± 0.028	1.28GlnPro: 1.28 ± 0.033	1.11GlnGln: 1.11 ± 0.045	2.068GlnArg: 2.068 ± 0.044	1.632GlnSer: 1.632 ± 0.036	1.628GlnThr: 1.628 ± 0.046	2.072GlnVal: 2.072 ± 0.047	0.349GlnTrp: 0.349 ± 0.02	0.86GlnTyr: 0.86 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	6.453ArgAla: 6.453 ± 0.096	0.468ArgCys: 0.468 ± 0.021	5.142ArgAsp: 5.142 ± 0.086	6.509ArgGlu: 6.509 ± 0.099	2.43ArgPhe: 2.43 ± 0.05	4.411ArgGly: 4.411 ± 0.066	1.296ArgHis: 1.296 ± 0.036	2.625ArgIle: 2.625 ± 0.048	1.313ArgLys: 1.313 ± 0.038	5.976ArgLeu: 5.976 ± 0.075	1.269ArgMet: 1.269 ± 0.03	1.625ArgAsn: 1.625 ± 0.043	2.602ArgPro: 2.602 ± 0.053	1.84ArgGln: 1.84 ± 0.043	5.011ArgArg: 5.011 ± 0.083	3.581ArgSer: 3.581 ± 0.058	4.305ArgThr: 4.305 ± 0.075	5.687ArgVal: 5.687 ± 0.09	0.798ArgTrp: 0.798 ± 0.031	1.955ArgTyr: 1.955 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.322SerAla: 5.322 ± 0.087	0.357SerCys: 0.357 ± 0.019	4.265SerAsp: 4.265 ± 0.076	4.102SerGlu: 4.102 ± 0.067	2.019SerPhe: 2.019 ± 0.047	5.298SerGly: 5.298 ± 0.089	1.053SerHis: 1.053 ± 0.032	2.102SerIle: 2.102 ± 0.045	1.076SerLys: 1.076 ± 0.037	4.911SerLeu: 4.911 ± 0.066	1.117SerMet: 1.117 ± 0.036	1.423SerAsn: 1.423 ± 0.038	2.607SerPro: 2.607 ± 0.048	1.373SerGln: 1.373 ± 0.043	3.305SerArg: 3.305 ± 0.063	3.048SerSer: 3.048 ± 0.077	3.826SerThr: 3.826 ± 0.069	5.396SerVal: 5.396 ± 0.069	0.653SerTrp: 0.653 ± 0.026	1.503SerTyr: 1.503 ± 0.043	0.001SerXaa: 0.001 ± 0.001
Thr	7.536ThrAla: 7.536 ± 0.104	0.39ThrCys: 0.39 ± 0.018	5.8ThrAsp: 5.8 ± 0.085	4.796ThrGlu: 4.796 ± 0.08	2.231ThrPhe: 2.231 ± 0.047	6.008ThrGly: 6.008 ± 0.078	1.196ThrHis: 1.196 ± 0.036	2.319ThrIle: 2.319 ± 0.046	0.992ThrLys: 0.992 ± 0.031	5.912ThrLeu: 5.912 ± 0.081	1.073ThrMet: 1.073 ± 0.031	1.477ThrAsn: 1.477 ± 0.038	3.249ThrPro: 3.249 ± 0.061	1.425ThrGln: 1.425 ± 0.039	3.319ThrArg: 3.319 ± 0.062	2.899ThrSer: 2.899 ± 0.062	4.568ThrThr: 4.568 ± 0.084	7.963ThrVal: 7.963 ± 0.111	0.661ThrTrp: 0.661 ± 0.026	1.778ThrTyr: 1.778 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	11.489ValAla: 11.489 ± 0.124	0.731ValCys: 0.731 ± 0.024	8.407ValAsp: 8.407 ± 0.11	8.478ValGlu: 8.478 ± 0.108	2.998ValPhe: 2.998 ± 0.061	8.47ValGly: 8.47 ± 0.124	1.871ValHis: 1.871 ± 0.044	2.49ValIle: 2.49 ± 0.055	1.394ValLys: 1.394 ± 0.04	8.602ValLeu: 8.602 ± 0.122	1.384ValMet: 1.384 ± 0.038	1.974ValAsn: 1.974 ± 0.046	4.545ValPro: 4.545 ± 0.062	2.115ValGln: 2.115 ± 0.053	5.697ValArg: 5.697 ± 0.071	5.126ValSer: 5.126 ± 0.066	6.587ValThr: 6.587 ± 0.093	10.477ValVal: 10.477 ± 0.137	0.959ValTrp: 0.959 ± 0.029	2.227ValTyr: 2.227 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	1.0TrpAla: 1.0 ± 0.029	0.12TrpCys: 0.12 ± 0.011	0.841TrpAsp: 0.841 ± 0.031	0.847TrpGlu: 0.847 ± 0.027	0.462TrpPhe: 0.462 ± 0.022	0.811TrpGly: 0.811 ± 0.031	0.252TrpHis: 0.252 ± 0.014	0.333TrpIle: 0.333 ± 0.018	0.262TrpLys: 0.262 ± 0.014	1.331TrpLeu: 1.331 ± 0.039	0.23TrpMet: 0.23 ± 0.013	0.347TrpAsn: 0.347 ± 0.017	0.479TrpPro: 0.479 ± 0.026	0.382TrpGln: 0.382 ± 0.019	0.915TrpArg: 0.915 ± 0.031	0.648TrpSer: 0.648 ± 0.029	0.878TrpThr: 0.878 ± 0.031	0.959TrpVal: 0.959 ± 0.03	0.212TrpTrp: 0.212 ± 0.015	0.409TrpTyr: 0.409 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.667TyrAla: 2.667 ± 0.058	0.244TyrCys: 0.244 ± 0.015	2.642TyrAsp: 2.642 ± 0.048	2.538TyrGlu: 2.538 ± 0.05	0.75TyrPhe: 0.75 ± 0.027	2.386TyrGly: 2.386 ± 0.05	0.67TyrHis: 0.67 ± 0.025	0.679TyrIle: 0.679 ± 0.025	0.401TyrLys: 0.401 ± 0.021	2.4TyrLeu: 2.4 ± 0.053	0.372TyrMet: 0.372 ± 0.016	0.625TyrAsn: 0.625 ± 0.025	1.256TyrPro: 1.256 ± 0.034	0.724TyrGln: 0.724 ± 0.028	1.989TyrArg: 1.989 ± 0.042	1.221TyrSer: 1.221 ± 0.035	1.404TyrThr: 1.404 ± 0.035	2.484TyrVal: 2.484 ± 0.043	0.358TyrTrp: 0.358 ± 0.019	0.839TyrTyr: 0.839 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.003

Statistics based on 3852 proteins (1096490 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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